Matthew P. Hoffman, BDS, PhD

Matrix and Morphogenesis Unit, LCDB  

NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30 ROOM 430
30 CONVENT DR MSC 4370
BETHESDA MD 20892-4370

Phone: (301) 496-1660
Fax: (301) 402-0897
E-mail: Dr. Matthew P. Hoffman

Research Interests

To understand the developmental mechanisms of salivary gland development with emphasis on growth factor/matrix interactions, progenitor cell function, and the genetic regulation of branching morphogenesis; we aim to develop therapeutic approaches for the functional regeneration of damaged adult salivary tissue.

Education

1986: BDS, University of Otago School of Dentistry, Dunedin, New Zealand
1994: PhD, University of Rochester School of Medicine and Dentistry, Department
            of Microbiology and Immunology, Rochester, NY

Recent Publications

Hoffman, M.P., Kidder, B.L., Steinberg, Z.L., Lakhani, S., Ho, S., Kleinman, H.K., and Larsen, M. Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development 129: 5767-5778, 2002.

Corey, D.P., Garcia-Anoveros, J., Holt, J.R., Kwan, K.Y., Lin, S.Y., Vollrath, M.A., Amalfitano, A., Cheung, E.L., Derfler, B.H., Duggan, A., Géléoc, G.S.G., Gray, P.A., Hoffman, M.P., Rehm, H.L.,  Tamasauskas, D., and Zhang, D.S. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432: 723-730, 2004.

Steinberg, Z., Myers, C., Heim, V.M., Lathrop, C.A., Rebustini, I.T., Stewart, J.S., Larsen, M., and Hoffman, M.P. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development 132: 1223-1234, 2005.

Patel, V.N., Rebustini, I.T., and Hoffman, M.P. Salivary gland branching morphogenesis. Differentiation 74: 349-364, 2006.

Rebustini, I.T., Patel, V.N., Stewart, J.S., Layvey, A., Georges-Labouesse, E., Miner, J.H., and Hoffman, M.P. Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev. Biol. 308: 15-29, 2007.

Patel, V.N., Knox, S.M., Likar, K.M., Lathrop, C.A., Hossain, R., Eftekhari, S., Whitelock, J.M., Elkin, M., Vlodavsky, I., and Hoffman, M.P. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development 134: 4177-4186, 2007.

Patel, V.N., Likar, K.M., Zisman-Rozen, S., Cowherd, S.N., Lassiter, K.S., Sher, I., Yates, E.A., Turnbull, J.E., Ron, D., and Hoffman, M.P. Specific Heparan Sulfate Structures Modulate FGF10-mediated Submandibular Gland Epithelial Morphogenesis and Differentiation. J. Biol. Chem. 283: 9308-9317, 2008.

Rebustini, I.T., Myers, C., Lassiter, K.S., Surmak, A., Szabova, L., Holmbeck, K., Pedchenko, V., Hudson, B.G., Hoffman, M.P.  MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev. Cell. 17:482-493, 2009.

Lombaert, I.M.A., and Hoffman, M.P. Epithelial Stem/Progenitor Cells in the Embryonic Mouse Submandibular Gland. Salivary Glands: Development, Adaptations and Disease. Front Oral Biol. Basel, Karger, 14: 90–106, 2010.

Knox, S.M., Lombaert, I.M.A., Reed, X., Vitale-Cross, L., Gutkind, J.S., and Hoffman MP. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science, in press, 2010.