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Niki Moutsopoulos, D.D.S., Ph.D.

Niki Moutsopoulos, D.D.S., Ph.D.Assistant Clinical Investigator
Oral Immunity and Infection Unit

NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30 ROOM 327
30 CONVENT DR MSC 4320
BETHESDA MD 20892-4320

Phone: (301) 435-7182
E-mail: nmoutsop@mail.nih.gov

Biographical Sketch

Education:

1998 D.D.S., Aristotle University of Thessaloniki, Greece
2003 Certificate in Periodontics, Baltimore College of Dental Surgery, University of Maryland
2006 Ph.D., Department of Diagnostic Sciences and Pathology, Baltimore College of Dental Surgery, University of Maryland/National Institutes of Health

Brief Chronology of Employment:

2004-2006 Intramural Research Trainee Award (IRTA), NIDCR
2006-2008 Research Fellow, NIDCR
2008-2010 Clinical Fellow, NIDCR
2007-Present Adjunct Clinical Assistant Professor, Department of Periodontics, University of Maryland
2010-Present Assistant Clinical Investigator, NIDCR

Research Interests/Scientific Focus

Dr. Moutsopoulos is a dentist, specialized in periodontics and holding a Ph.D. in immunology. Her doctorate and post doctorate work has focused on immune-mediated pathologies that present in the oral cavity including Sjogren’s syndrome, periodontal disease and chronic wound healing. While these are distinct disease entities, they share as a salient feature non-resolving inflammation and immune mediated tissue destruction of which the mechanisms have been in the center of her research interest.  Activation of chronic inflammatory pathways in various disease entities have been linked to genetic susceptibility of the host, though emerging evidence implicates microbial factors for the initiation of disease pathogenesis for the majority of chronic inflammatory and autoimmune pathologies.

Dr. Moutsopoulos’s program is focusing on host-microbial interactions that can drive chronic inflammatory responses and tissue destruction in the oral cavity. In her laboratory host-microbial interactions are interrogated through the use of in vitro culture systems and animal models, but her primary focus is on the study of immune-microbial interactions in humans. For this her laboratory is interrogating the oral microbiome and immune responses in the oral cavity in patient populations with oral inflammatory conditions.

Selected Publications

  1. Moutsopoulos NM, Kling HM, Angelov N, Jin W, Palmer RJ, Nares S, Osorio M, Wahl SM. 2012 . Porphyromonasgingivalis promotes Th17 inducing pathways in chronic periodontitis. J Autoimmun. 2012 May 3. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22560973 
  2. Nares, S., Moutsopoulos, N.M., Angelov, N., Rangel, Z., Munson, P.J., Sinha, N., Wahl, S.M.: 2009. Rapid Myeloid Cell Transcriptional and Proteomic Responses to Periodontopathogenic Porphyromonas gingivalis. American Journal of Pathology 174:1400-1414.  http://www.ncbi.nlm.nih.gov/pubmed/19264901 
  3. Katsifis, G., Rekka, S., Moutsopoulos, N.M., Pillemer, S., Wahl, S.M.: 2009. Systemic and local IL-17 and linked cytokines associated with Sjogren’s Syndrome immunopathogenesis. American Journal of Pathology 175:1167-1177.  http://www.ncbi.nlm.nih.gov/pubmed/19700754 
  4. Greenwell-Wild1, T., Moutsopoulos1, N.M., Gliozzi, M., Kapsogeorgou, E., Rangel, Z., Munson, P., Moutsopoulos, H.M. and Wahl, S.M. 2011. Chitinases in salivary glands and circulation in Sjögren’s Syndrome ­– macrophage harbingers of disease severity. Arth. Rheum. 63(10):3103-15. 1Equally contributed.      http://www.ncbi.nlm.nih.gov/pubmed/21618203 
  5. Moutsopoulos, N.M. and Madianos, P.N.: 2006. Low Grade Inflammation in Chronic Infectious Diseases: The Paradigm of Periodontal Infections. Annals NYAS 1088:251-264.  http://www.ncbi.nlm.nih.gov/pubmed/17192571 
  6. Moutsopoulos, N.M., Katsifis, G.E., Angelov, N., Leakan, R.A., Sankar, V., Pillemer, S., Wahl, S.M..: 2008. Lack of Efficacy in Sjögren’s Syndrome correlates with failed suppression of TNF-α and systemic immune activation. Ann Rheum Dis 67: 1437-1443.  http://www.ncbi.nlm.nih.gov/pubmed/18198195

 

 

 

 

 

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This page last updated: May 28, 2014