Differentiation of Mesenchymal Stem Cells
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Title:
Differentiation of Mesenchymal Stem Cells
Description:
Differentiation of mesenchymal stem cells towards fibroblasts and myofibroblasts is a multi-step process. Connective tissue growth factors (CCN2/CTGF) stimulate mesenchymal cells to differentiate into fibroblasts but not into myofibroblasts. CCN2/CTGF fibroblasts are likely involved in wound healing, and tendon/ligament regeneration. Sequential exposure to CCN2/CTGF and TGFβ1 transforms fibroblasts into myofibroblasts that are implicated in scarring and cancer stroma. Scale: 100 μm.
Credit:
Chang Hun Lee, Bhranti Shah, Eduardo K. Moioli, Jeremy J. Mao (2010) Journal of Clinical Investigation 120:3340-9.
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