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Acting Director's Report to Council: May 2011

APPOINTMENT OF NEW NIDCR DIRECTOR

Martha J. Somerman, D.D.S., Ph.D., has been appointed as director of the NIDCR by NIH Director Francis S. Collins, M.D., Ph.D.  She is currently dean of the University of Washington School of Dentistry, Seattle, a position she has held since 2002. She will begin her duties as NIDCR director on August 29, 2011.  

"I am delighted that Dr. Somerman will be bringing her exceptional research expertise and administrative skills to this leadership position at the NIDCR," said Collins. "I would also like to thank Dr. Isabel Garcia for her outstanding service as acting director of NIDCR since August 2010."

An internationally known researcher and educator, Somerman's research has focused on defining the key regulators controlling development, maintenance and regeneration of oral-dental-craniofacial tissues. Her work has been recognized with numerous honors and awards.

Before joining the University of Washington, Somerman was on the faculty of the School of Dentistry, University of Michigan, Ann Arbor, from 1991 to 2002. There, she served as a professor and chair of periodontics/prevention and geriatrics, and also held an appointment as professor of pharmacology at the School of Medicine. From 1984 to 1991, Somerman was on the faculty of the Baltimore College of Dental Surgery.

Somerman has been a long-standing member of the NIH and NIDCR communities, having received her first NIH grant in 1987. In the early 1980s, she was a staff fellow in the dental institute's intramural research program. She served on the National Advisory Dental and Craniofacial Research Council from 1999 to 2002.

A native of Brooklyn, N.Y., Somerman holds a bachelor's degree in biology and a D.D.S. from New York University, a master's degree in environmental health from Hunter College, New York City, and a Ph.D. in pharmacology from the University of Rochester, N.Y. She completed her periodontal residency at the Eastman Dental Center in Rochester.


ACTIVITIES OF THE NIDCR ACTING DIRECTOR AND DEPUTY DIRECTOR

Since the last meeting of the National Advisory Dental and Craniofacial Research Council, NIDCR Acting Director Isabel Garcia participated in a briefing on Capitol Hill, delivered presentations about the future of oral, dental, and craniofacial research at scientific symposia and meetings, met with dental and professional organizations, and continued to serve as the NIH representative to the HHS Secretary's Tribal Advisory Committee.  She also continued to represent NIH on the PHS Oral Health Coordinating Committee, to co-chair the NIH Pain Consortium, and to serve on trans-NIH committees.

American Association for Dental Research (AADR)-American Dental Education Association (ADEA) Deans' Advocacy Day on Capitol Hill
At the invitation of the AADR, Dr. Garcia delivered a presentation entitled "Investments in Science and Research for Improved Oral Health" to an audience of dental research deans and advocates at the AADR-ADEA Deans' Advocacy Day on Capitol Hill on April 4.  The meeting is an annual event convened by AADR and ADEA to update participants on issues in oral health, dental research, and dental education and increase awareness of the importance of NIH and NIDCR research.

International Association for Dental Research (IADR) Annual Meeting
On March 16, Dr. Garcia participated in a symposium entitled "Will Dental Institutions Lead Dental and Craniofacial Research in the Future?" sponsored by ADEA and AADR during the IADR annual meeting, which was held in San Diego, CA.  The symposium focused on trends in NIH research funding to dental institutions and implications for dental research and dental education.  Dr. Garcia spoke about "Trends in Dental Funding to U.S. Institutions."  In addition, she gave a presentation to NIDCR-supported trainees and junior scientists attending the IADR meeting.

American Dental Association (ADA) Council on Scientific Affairs
On March 23, Dr. Garcia gave a brief update about NIDCR activities to the ADA Council on Scientific Affairs, which met in Chicago.  Topics included the short-term budgetary outlook, proposed and ongoing NIDCR scientific initiatives, and selected examples of significant findings from NIDCR-funded research. 

Friends of the NIDCR (FNIDCR)/University of Maryland Town Hall Meeting
Dr. Garcia participated in a Town Hall meeting on April 25th organized by the Friends of the NIDCR and the University of Maryland Dental School.  Designed to underscore the value oral health research brings to communities, the event was entitled "Bring Oral Health Home" and took place at the University of Maryland Dental School in Baltimore.  In addition to giving a presentation on the "NIDCR: Improving Health through Oral Health Research," Dr. Garcia participated in a panel session on "Imperatives to Eliminate Health Disparities."   The target audience included dental school students, dentists, state legislators and staff, and residents from the greater Baltimore Area.

Howard University Student Chapter of the National Dental Association (NDA)
At the invitation of the Howard University Student Chapter of the NDA, Dr. Garcia delivered the keynote speech at their Spring General Body meeting held February 17 on the Howard University campus in Washington, D.C.  The theme of the meeting was "Research - and its many opportunities."  Dr. Garcia discussed highlights of current NIDCR research and future scientific opportunities and implications for the dental research profession.

Meeting of the Tribal Advisory Committee
At the request of NIH Director Francis S. Collins, Dr. Garcia attended the 2nd meeting of the HHS Secretary's Tribal Advisory Committee, held March 2 in Washington, D.C.  Dr. Garcia has been asked to serve as the NIH point of contact for activities related to this committee. The purpose of the advisory committee is to keep the HHS Secretary apprised on matters related to American Indians and Alaska Natives.

NIH Pain Consortium 6th Annual Symposium on Advances in Pain Research
Dr. Garcia provided an update on pain-related provisions of the Patient Protection and Affordable Care Act (for which NIH has lead responsibilities) during the Pain Consortium's 6th annual symposium on April 14.  Dr. Garcia co-chairs the consortium together with Drs. Story Landis, director of the National Institute of Neurological Disorders and Stroke, Patricia Grady, director of the National Institute of Nursing Research, Nora Volkow, director of the National Institute on Drug Abuse, and Josephine Briggs, director of the National Center for Complementary and Alternative Medicine.  The symposium was entitled "Mechanisms and Management of Overlapping Chronic Pain and Associated Conditions."  It included presentations and discussions of neurological mechanisms and psychosocial factors that may contribute to co-morbid pain conditions, and treatment strategies and obstacles to managing overlapping pain conditions.  The presenters were NIH-funded investigators who have made significant contributions to advancing the field of pain research.  The symposium was attended by researchers, health care providers, and the public. 

Memorandum Of Understanding (MOU) Signed with the Pan American Health Organization
The Pan American Health Organization/World Health Organization (PAHO/WHO) and NIDCR have signed an agreement under which PAHO/WHO will host residents enrolled in NIDCR's Residency Program in Dental Public Health for short-term internships in the area of international oral health.  The internship program will give NIDCR dental public health residents valuable field experience while advancing global oral health through PAHO programs such as the Caries Free Communities Initiative. The establishment of this official relationship between PAHO and NIDCR also will promote awareness of the importance of oral health and community-wide efforts to prevent oral and dental diseases and conditions. 

On May 10, Dr. Garcia, together with Dr. Amit Chattopadhyay, co-director of the NIDCR Dental Public Health Residency Program, joined Dr. Saskia Estupiñán-Day, regional advisor for oral health for PAHO, in a signing ceremony for the MOU at PAHO's headquarters in Washington DC.

 

BUDGET UPDATE

FY 2011

The FY 2011 Appropriation provided approximately $409.6 million for NIDCR.  An approved distribution by budget mechanism is not yet available.


FY 2012

The President's Budget Request would provide $420.4 million for NIDCR.  See the table below for distribution by budget mechanism.  See the complete NIDCR budget justification to Congress
 


National Institute of Dental and Craniofacial Research
Budget Mechanism – Total

(Dollars in Thousands)





MECHANISMFY 2012
President's Budget
No.Amount
Research Grants  
Research Projects  
Noncompeting442$184,920
Administrative Supplements(13)1,500
Competing:  
Renewal4319,800
New11651,062
Supplements1880
Subtotal, Competing160$71,742
Subtotal, RPGs602$258,162
SBIR/STTR28$9,099
Research Project Grants630$267,261
   
Research Centers6$14,690
Other Research  
Research Careers63$7,810
Other171,164
Other Research80$8,974
Total Research Grants716$290,925
   
Research TrainingFTTPs 
Individual Awards95$5,436
Institutional Awards21810,615
Total Research Training313$16,051
Research & Development Contracts28$24,918
(SBIR/STTR)         0$0
 FTEs 
Intramural Research158$63,950
Research Management and Support8324,525
Total, NIDCR241$420,369

 

NIH/DHHS UPDATE

NIH Proposes New National Center for Advancing Translational Sciences
NIH is proposing the formation of a Center focused on accelerating the development and delivery of new, more effective therapeutics. The Center is envisioned to be a resource for the entire translational science community.  It would develop and offer innovative services and expertise in moving promising products through the development pipeline, as well as develop novel approaches to therapeutics development, stimulate new avenues for basic scientific discovery, and complement the strengths of existing NIH research activities.  The proposed Center would be formed initially by integrating selected translational research programs now located within the National Human Genome Research Institute (NHGRI), the National Center for Research Resources (NCRR), and the NIH Director's Common Fund.  NIH hopes to have the reorganization take effect on October 1, 2011.  See FAQs about the new National Center for Advancing Translational Sciences. 
 
NIH Establishes Working Group on the Future Biomedical Research Workforce
A new NIH working group will examine the future of the biomedical research workforce in the U.S. The group will recommend actions to the Advisory Committee to the Director to ensure a diverse and sustainable biomedical and behavioral research workforce. Questions to be considered include:

  • What is the right size of the workforce?
  • What are the appropriate types of positions that should be supported to allow people to have successful careers and to continue to advance biomedical and behavioral sciences?
  • What is the best way to support these various positions?
  • What types of training should be provided?

The group will gather input from the extramural community, including students, postdoctoral fellows, investigators, scientific societies, and grantee institutions. In addition, the group will develop a model for a sustainable and diverse U.S. biomedical research workforce using appropriate expertise from NIH and external sources. The model can help inform decisions about how to train the optimal number of people for the appropriate types of positions that will advance science and promote health.  See additional details about members of the Working Group on the Future Biomedical Research Workforce.

Scientific Community Leaders Meet to Begin Advising NIH's Center for Scientific Review
Scientific experts from across the country have joined a new council that began meeting May 2nd  to advise NIH's Center for Scientific Review (CSR) on the peer review of NIH grant applications in scientific review groups at CSR.  The new council will focus on enhancing CSR's operations.  The CSR Advisory Council (CSRAC) replaces the NIH Peer Review Advisory Committee, which advised the CSR Director as well as the NIH Director and NIH Associate Director for Extramural Research.  CSRAC will meet twice a year. The council also will provide input concerning CSR's policies and practices related to the receipt and referral of NIH grant applications to CSR review groups.  CSRAC meetings are open to the public.  See additional information on the CSR Advisory Council and its first meeting

New NIH Council of Councils Members Named
NIH has announced the appointments of 20 individuals to the NIH Council of Councils. The council was established by the NIH Reform Act of 2006 to advise the NIH Director on cutting edge, trans-NIH priorities and matters related to policies and activities of the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), also established by the act.

The council is made up of 27 members selected from the NIH Institute and Center (IC) advisory councils and the Council of Public Representatives, an advisory committee to the NIH Office of the Director.  See additional information about the NIH Council of Council appointments.

New Strategic Plan for NIH Obesity Research Seeks to Curb Epidemic
To combat the obesity epidemic, NIH is encouraging diverse scientific investigations through a new Strategic Plan for NIH Obesity Research.  More than one-third of adults in the U.S. and nearly 17 percent of the nation's children are now obese, which increases a person's chance of developing many health problems, including type 2 diabetes, heart disease, high blood pressure, fatty liver disease, and some cancers. 

NIH funds research to reduce the prevalence of obesity and its health consequences (an investment of $824 million in fiscal year 2010, plus awards totaling $147 million made in the same year through the Recovery Act). The NIH strategic plan, developed by the NIH Obesity Research Task Force, recognizes that eating less and exercising more is easier said than done.  Highlighting the crucial role of research in efforts to reduce obesity, the plan emphasizes moving science from laboratory to clinical trials to practical solutions, and is designed to help target efforts and resources in areas most likely to help.  See more about the obesity strategic plan.

NIH Launches Largest Oil Spill Health Study:
GuLF STUDY to follow 55,000 cleanup workers and volunteers for up to 10 years
A new study that will look at possible health effects of the Gulf of Mexico's Deepwater Horizon oil spill on 55,000 cleanup workers and volunteers has begun in towns across Louisiana, Mississippi, Alabama, and Florida.

The GuLF STUDY (Gulf Long-term Follow-up Study) is the largest health study of its kind ever conducted among cleanup workers and volunteers, and is one component of a comprehensive federal response to the Deepwater Horizon oil spill. The study is being conducted by the National Institute of Environmental Health Sciences, part of the NIH, and is expected to last up to 10 years.  Over time, the GuLF STUDY will generate important data that may help inform policy decisions on health care and health services in the region.  View additional information on the GuLF STUDY website.

NIH Researchers Create Comprehensive Collection of Approved Drugs to Identify New Therapies for Rare and Neglected Diseases
Researchers have begun screening the first definitive collection of thousands of approved drugs for clinical use against rare and neglected diseases. They are hunting for additional uses of the drugs hoping to find off-label therapies for some of the 6,000 rare diseases that afflict 25 million Americans. The effort is coordinated by NIH's Chemical Genomics Center (NCGC).

The researchers assembled the collection of approved drugs for screening based on information from the NCGC Pharmaceutical Collection database browser.  This publicly available, Web-based application described in a paper appearing in the April 27 issue of Science Translational Medicine, provides complete information on the nearly 27,000 active pharmaceutical ingredients, including 2,750 small molecule drugs that have been approved by regulatory agencies from the U.S., Canada, Europe and Japan, as well as all compounds that have been registered for human clinical trials.

New Robot System to Test 10,000 Chemicals for Toxicity
Several federal agencies, including the NIH, have unveiled a new high-speed robot screening system--called Tox21--that will test 10,000 different chemicals for potential toxicity. The chemicals to be screened include compounds found in industrial and consumer products, food additives, and drugs. Tox21 is located at the NIH Chemical Genomics Center and merges existing agency resources (research, funding, and testing tools) to develop ways to more effectively predict how chemicals will affect human health and the environment.  The screening system is a collaborative effort among the National Institute of Environmental Health Sciences, the National Toxicology Program, the National Human Genome Research Institute, the U.S. Environmental Protection Agency, and the U.S. Food and Drug Administration. 

Training Institute on Dissemination and Implementation Research
On August 1-5, NIH will hold a five-day training session on dissemination and implementation health research.  One of the most critical issues impeding improvements in public health today is the enormous gap between the best evidence-based strategies to improve health and what actually gets used and implemented in everyday practice.  The science of dissemination and implementation seeks to address this gap by understanding how to best ensure that evidence-based strategies to improve health and prevent disease are effectively delivered in clinical and public health practice. 

The Training Institute for Dissemination and Implementation Research in Health will feature a faculty of leading experts from a variety of behavioral and social science disciplines. The University of North Carolina at Chapel Hill's Center for Health Promotion and Disease Prevention will host the institute.  View additional information about the training institute

Summer Institute on mHealth
NIH has announced the creation of the first NIH mHealth, or mobile health, Summer Institute. Scheduled for the summer of 2011, this week-long workshop will bring together leaders in mobile health technologies, behavioral science researchers, federal health officials, and members of the medical community to provide early career investigators with an opportunity to learn about mHealth research. 

Mobile technologies have the potential to transform medical research and enable health care providers to more rapidly and accurately assess biological processes, behavior, attitudes, and the environment. These technologies also allow providers to help patients improve their health in real time—enabling them to personalize health care options and monitor progress.  NIH's mHealth Summer Institute will provide an overview of the engineering, behavioral science and clinical aspects of wireless research. 

Dr. Rajesh Ranganathan Appointed Senior Advisor for Translational Research
NIH Director Francis S. Collins has announced the appointment of Rajesh Ranganathan, Ph.D., as senior advisor for translational research.  Dr. Ranganathan will provide leadership and expertise in planning and establishing NIH-wide program priorities that focus on accelerating the translation of scientific discoveries from the bench to the bedside.  He comes to the NIH from Novartis Institutes for Biomedical Research Inc., where he was the global head of the Scientific Education Office and a director in the Scientific Portfolio Management and Strategy Office.  

 

NIDCR UPDATE

NIDCR Supplement to the Journal of Public Health Dentistry
NIDCR supported a supplemental issue of the Journal of Public Health Dentistry, which focused on behavioral and social intervention research essentials. This supplemental issue was published in March 2011 and featured seven topical, peer-reviewed articles on essential elements of intervention research.  These essential elements are: the use of an intervention planning model to guide a program of intervention research; the appropriate use of health behavior theory to guide intervention research; ensuring that behavioral or social interventions are delivered with fidelity in research studies; the importance of testing for mediation in intervention research; ensuring that interventions will be acceptable to the target community; following a systematic model to move implement interventions in community settings; and integrating cost analyses into intervention research.  Each of these topical articles was written by leaders in their respective fields, and accompanying each article were several brief commentaries from other thought leaders.  NIDCR hopes that this supplemental issue will be a useful resource for investigators interested in behavioral and social intervention research to improve oral and craniofacial health.

Sjögren's Syndrome Genetic Resource
NIDCR is working with Institute-funded investigators to develop a resource for studying the genetics of Sjögren's Syndrome. Initially, this resource will be based on the Sjögren's Syndrome International Collaborative Clinical Alliance (SICCA) Registry, housed at the University of California, San Francisco (PIs: Lindsey Criswell & Caroline Shiboski).  DNA specimens from more than 2,400 individuals with signs or symptoms of Sjögren's Syndrome, their biologic relatives, and controls will be used to generate high-density genome-wide genotyping at the Center for Inherited Disease Research (CIDR) at Johns Hopkins University.  This genetic information, in conjunction with the extensive clinical information available from SICCA Registry participants, will accelerate genetic research in Sjögren's Syndrome by providing resources to identify regions of the genome and genetic variants that affect the risk of developing Sjögren's Syndrome. The genetic and clinical information will be available through NIH's database of Genotypes and Phenotypes (dbGaP) to maximize the benefit to the research community and the public.  Later in 2011, this resource will likely include participants from the natural history study of Sjögren's Syndrome in NIDCR's Intramural Program (PI: Gabor Illei) and additional participants from the SICCA Registry. 

NIDCR Launches New Website Homepage
The NIDCR homepage has a new look.  This updated version provides faster access to science news, researcher interviews, funding opportunities, and popular oral health publications.  Additional features include fly-out menus in the top navigation to help users quickly accomplish key tasks, an image gallery, and a toolbar that highlights NIDCR's social media presence.  The A-Z index is also higher up on the page where visitors can more readily find it. 

Thanks in part to the recent homepage improvements, user satisfaction with the NIDCR website is at an all-time high.  NIDCR's current score on the American Customer Satisfaction Index (ACSI) survey is an 81.  On ACSI's 100-point scale, a score of 80 or better is considered a superior score and can only be achieved if the website meets or exceeds user expectations.  NIDCR is one of the top 33 government sites that scored 80 or higher in the first quarter of 2011.  Visit the new homepage at http://www.nidcr.nih.gov/


Training and Career Development News

Highlights
Former NIDCR K08 awardee Ophir Klein, MD, PhD, has received his first R01 (R01 DE021420) entitled "The role of Bmi1 in regulation of dental stem cells."  Dr. Klein is an assistant professor in the Departments of Orofacial Sciences and Pediatrics at the University of California, San Francisco, and the director of the UCSF Program in Craniofacial and Mesenchymal Biology.  Dr. Klein also has been awarded NIH R03, R21 and DP2 awards.

Former NIDCR T32 postdoctoral trainee Mark Macek, DDS, MPH, DrPH, has received his first R01 (R01 DE020858) entitled "Multi-Center Assessment of Health Literacy and Oral Health."  Dr. Macek is the contact PI in this multi-PI (Macek, Atchison) project, which will comprehensively study the associations between health literacy and oral health.  Dr. Macek, who had a previous NIDCR R03, is an associate professor, Program in Health Services Research, Department of Health Promotion and Policy at the University of Maryland Dental School.

Former NIDCR T32 postdoctoral trainee Martha Nunn, DDS, PhD, has received her first R01 (R01 DE019656) entitled "Multivariate CART for survival with dental applications."  Dr. Nunn received her Ph.D. in biostatistics through the NIDCR T32 at the University of Washington and is now an associate professor in periodontics and the director of the Center for Oral Health Research, School of Dentistry, Creighton University.  She had a previous NIDCR R03 to develop the preliminary data for this R01 and was the PI on a U54 Biometry Core for the NIDCR-funded Northeast Center for Research to Reduce Oral Health Disparities.

The following K99 awardees have successfully transitioned to the independent phase of their awards:

  • Samantha Brugmann, PhD, has accepted a tenure track position as assistant professor in the Division of Plastic Surgery at the Cincinnati Children's Hospital Medical Center.  Her R00 research project is entitled, "The role of primary cilia in craniofacial development."
  • Jeffrey Bush, PhD, has accepted a tenure track position as assistant professor in the Department of Cell and Tissue Biology at the University of California, San Francisco School of Dentistry.  His R00 research project is entitled, "Eph/ephrin signaling in craniofacial development and disease."
  • Andrew Fribley, PhD, has accepted a tenure track position as assistant professor in the Department of Pediatrics at Wayne State University School of Medicine.  His R00 research project is entitled, "Genomic screening to identify novel stress-inducing chemotherapies for cancer."
  • Manika Govil, PhD, has accepted a tenure track position as assistant professor in the Department of Oral Biology at the University of Pittsburgh School of Dental Medicine.  Her R00 research project is entitled, "Statistical Genetic Analysis of Complex Craniofacial and Dental Genetic Disorders."
  • Juhee Jeong, PhD, has accepted a tenure track position as assistant professor in the Department of Basic Science and Craniofacial Biology at New York University, College of Dentistry.  Her R00 research project is entitled, "Function and Regulation of Lhx Genes in Craniofacial Development." 

A goal of the Research Training and Career Development Branch is to encourage trainees to move from institutional training positions to independent funding.  Several trainees on NIDCR institutional training grants have successfully transitioned to individual NRSA fellowships:

  • Four dual-degree DSTP trainees on T32 institutional training grants-- Bryan Chai and Katelyn Niu at the University of Maryland Dental School, Angela Gullard at the University of Alabama, Birmingham, and Albert Yamoah at the Baylor College of Dentistry, Texas A&M University Health Science Center--have been awarded NIDCR F30 fellowships.
  • Three predoctoral trainees on institutional training grants-- Katherine Regan at Baylor, Jami Saloman at University of Maryland Dental School, and Delma Thompson at San Antonio-- were awarded NIDCR F31 fellowships.
  • Francis Smith, a NIDCR T32 trainee at the University of California, San Francisco, was awarded a predoctoral NIDCR F31 Fellowship to Promote Diversity in Health-Related Research.
  • Maria Serrano, a postdoctoral NIDCR T32 trainee at the Baylor College of Dentistry, Texas A&M University Health Science Center, was awarded an NIDCR F32 fellowship.

K25 awardee Enciso Reyes (R25 DE 016391) received the Arthur Wuehrmann Prize for Best Oral Radiology Article, awarded by the American Academy of Oral and Maxillofacial Radiology for 2010, for her paper "Enciso R, Nguyen M, Shigeta Y, Ogawa T, and Clark G. Comparison of cone-beam CT parameters and sleep questionnaires in sleep apnea patients and control subjects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:285-93. PMCID: PMC2900776."   Dr. Enciso is in the Department of Orthodontics at the University of Southern California.  Her K25 project is entitled, "3D CT Cephalometrics and Family History in Sleep Apnea."

Intramural Research Program
Agnes Berendsen, Ph.D., a postdoctoral fellow, received a travel award from the American Society of Matrix Biology to attend the Extracellular Matrix in Health and Disease Symposium held at Harvard Medical School on April 14-15.  She was selected for an oral presentation entitled, "A Novel Mechanism for Modulation of Canonical Wnt Signaling by the ECM Component Biglycan."  

Alison Boyce, M.D., an Inter-institute Endocrine Training Program (IETP) fellow, was selected to participate in the Presidential Poster Session at the annual meeting of the Endocrine Society, to be held in Boston, MA, in June.  William Chong, M.D., an IETP fellow in the Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, was given a travel award to participate in Trainee Day at the meeting. 

Meetings, Conferences, and Lectures

David E. Barmes Global Health Lecture
On February 15, Dr. Rajiv Shah, Administrator of the U.S. Agency for International Development, delivered the David E. Barmes Global Health Lecture on the NIH campus.  The title of his speech was "Addressing Grand Challenges:  The Role of Science in Global Health Development."  His talk offered a forward-looking vision of global development by articulating the belief that we can accelerate progress in global health by harnessing the power of science, technology, and innovation.  In his comments, Dr. Shah issued a challenge to the development community around a set of ambitious transformational goals and reaffirmed USAID's commitment to the President's Global Health Initiative:                 

  • Save the lives of over 3 million children
  • Prevent more than 12 million HIV infections
  • Avert 700,000 malaria deaths
  • Ensure nearly 200,000 pregnant women can safely give birth
  • Prevent 54 million unintended pregnancies
  • Cure 2.5 million people infected with TB

He noted progress that the Global Health Initiative has made on the ground.  His speech also clearly made the point that in global health, saving money and driving efficiencies can save more lives.

Meeting of the International Association for Dental Research/American Association for Dental Research
NIDCR staff co-chaired several sessions and participated in multiple events at the Joint 89th General Session of the International Association for Dental Research, 40th Annual Meeting of the American Association for Dental Research, and the 35th Annual Meeting of the Canadian Association for Dental Research (IADR/AADR/CADR), held March 16-19 in San Diego, CA.  Among these were:

  • A session on "Innate Immunity in Microbial and Neoplastic Oral Diseases" and "The OPPERA Case-Control Study: Putative Risk Factors and Mechanisms for Persistent TMJD Pain," co-chaired by Division of Extramural Research (DER) staff.
  • A symposium on "Three Essential Principles in Behavioral and Social Intervention Research," organized by DER staff.  The symposium highlighted the role of health behavior theory, fidelity monitoring, and mechanisms of action in intervention research.
  • The NIDCR Trainee Day Poster Session. Over 90 NIDCR-supported trainees, fellows, and career development awardees presented their research. Dr. Garcia, NIDCR Acting Director, met with the trainees following the poster session.
  • A workshop on "Essentials in Grant Writing," attended by approximately 100 participants.
  • A session on "NIDCR Research Training and Career Development Opportunities," presented by Drs. Leslie Frieden, NIDCR extramural training officer, and Kevin Hardwick, chief, Research Training and Career Development Branch.
  • Finally, IADR/AADR attendees also took advantage of the opportunity for individual consultation at the NIDCR booth in the Exhibit Hall.

First International Conference on Dental and Craniofacial Stem Cells
NIDCR staff participated in "The First International Conference on Dental and Craniofacial Stem Cells" held April 27-29 at the New York Academy of Sciences in New York City.  The goal of the conference was to discuss the current state-of-the-art of stem/progenitor cells identified in dental, oral, and craniofacial tissues and to identify gaps in knowledge and other barriers for the translation of these cells into tissue engineering- and regenerative medicine- based therapeutic modalities.   The conference was supported by U13-DE019994-01A1. 

American Association for Bone and Mineral Research (ASBMR)
NIDCR staff, together with representatives from the National Institute of Arthritis and Musculoskeletal and Skin Disorders, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, the National Cancer Institute, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, participated in the ASBMR Dialogue on the Future of Bone and Mineral Research, held February 16 in Washington, D.C.  NIH staff, American Association for Bone and Mineral Research (ASBMR) Council members, and ASBMR committee chairs engaged in a discussion about the future course of bone and mineral research, the Institutes' priorities, and strategic directions.

Communications Update

Science Updates and Interviews with Oral Health Researchers
Since the last meeting of the NADCRC, NIDCR communications staff produced a number of "Science News in Brief" summaries of recent research findings.  Topics included the discovery of a microRNA that serves as an on-off switch to promote either cell death or survival, an experimental technique called LIPS and its potential to streamline the diagnosis of Sjögren's syndrome, and the safety of dental treatment during pregnancy.  Staff interviewed a dental student who--as a participant in NIH's International Clinical Research Scholars and Fellows Program--studied the prevalence of oral HPV in a low-income area of Lima, Peru. Staff also wrote a feature article on how a postdoc in NIDCR's Proteases and Tissue Remodeling Section developed an experimental model for Netherton syndrome.

Exhibits
Over the past few months, Institute staff exhibited and distributed NIDCR patient and health professional education materials at the following meetings:

  • Hinman Dental Conference in Atlanta, GA, March 24-26
  • National Head Start Association meeting in Kansas City, MO, April 4-8
  • Developmental Disabilities Nurses Association in Hartford, CT, May 14-15

NIDCR materials were also displayed at the National American Indian & Alaska Native Child Care Conference in Minneapolis, MN, April 6-7.


NIDCR Staff Honored for Communication Products
NIDCR staff recently won NIH Plain Language Awards for a video and three radio PSAs that are part of the campaign "Oral Cancer:  What African American Men Need to Know."  Staff were also honored with an award for the online article, "Recovery Act Funds Help to Haul In a Gene of Interest."

The Plain Language Awards are part of the NIH Plain Language Initiative, which is meant to improve communication between the government and the public.  The 2011 awards ceremony took place on May 17th.

Communications staff also recently won a Blue Pencil/Gold Screen award from the National Association for Government Communicators for two online publications:  "Recovery Act Helps Build a Second Career" and "Recovery Act Funds Help to Haul in a Gene of Interest." The NAGC Blue Pencil/Gold Screen awards honor high quality, creative products produced by government communicators.  The award ceremony took place May 11 in St. Paul, MN.

 

FUNDING UPDATE

New Requests for Applications

Lasker Clinical Research Scholars Program (SI2)
http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-11-001.html

NIH Blueprint for Neuroscience Research Grand Challenge: Developing Novel Drugs for Disorders of the Nervous System (U01)
http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-12-002.html

Blueprint for Neuroscience Research Science Education Award (R25)
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-013.html

NIH-HMO Collaboratory Coordinating Center Limited Competition (U54)
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-003.html

NLM Institutional Training Grants for Research Training in Biomedical Informatics (T-15)
http://grants.nih.gov/grants/guide/rfa-files/RFA-LM-11-001.html

 

New Program Announcements

Center for Inherited Disease Research (CIDR) High Throughput Genotyping and Sequencing Resource Access (X01)
http://grants.nih.gov/grants/guide/pa-files/PAR-11-210.html

Research on Ethical Issues in Biomedical, Social, and Behavioral Research (R03)
http://grants.nih.gov/grants/guide/pa-files/PA-11-181.html

Research on Ethical Issues in Biomedical, Social, and Behavioral Research (R21)
http://grants.nih.gov/grants/guide/pa-files/PA-11-182.html

Nanoscience and Nanotechnology in Biology and Medicine (R21)
http://grants.nih.gov/grants/guide/pa-files/PA-11-149.html

Nanoscience and Nanotechnology in Biology and Medicine (R01)
http://grants.nih.gov/grants/guide/pa-files/PA-11-148.html

Biomarkers of Infection-Associated Cancers (R21)
http://grants.nih.gov/grants/guide/pa-files/PA-11-159.html

Biomarkers of Infection-Associated Cancers (R01)
http://grants.nih.gov/grants/guide/pa-files/PA-11-158.html

Genetic Screens to Enhance Zebrafish Research (R01)
http://grants.nih.gov/grants/guide/pa-files/PAR-11-130.html

Enhancing Zebrafish Research with Research Tools and Techniques (R01)
http://grants.nih.gov/grants/guide/pa-files/PAR-11-131.html

PHS 2011-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
http://grants.nih.gov/grants/guide/pa-files/PA-11-097.html

PHS 2011-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
http://grants.nih.gov/grants/guide/pa-files/PA-11-096.html

Competitive Revision Applications for NIDCR-funded Cooperative Agreements (U01)
http://grants.nih.gov/grants/guide/pa-files/PAR-11-144.html

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30)
http://grants.nih.gov/grants/guide/pa-files/PA-11-110.html

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31)
http://grants.nih.gov/grants/guide/pa-files/PA-11-111.html

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31- Diversity)
http://grants.nih.gov/grants/guide/pa-files/PA-11-112.html

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32)
http://grants.nih.gov/grants/guide/pa-files/PA-11-113.html

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33)
http://grants.nih.gov/grants/guide/pa-files/PA-11-114.html

Independent Scientist Award (Parent K02)
http://grants.nih.gov/grants/guide/pa-files/PA-11-191.html

Mentored Clinical Scientist Research Career Development Award (Parent K08)
http://grants.nih.gov/grants/guide/pa-files/PA-11-193.html

Mentored Patient-Oriented Research Career Development Award (Parent K23)
http://grants.nih.gov/grants/guide/pa-files/PA-11-194.html

Mentored Quantitative Research Development Award (Parent K25)
http://grants.nih.gov/grants/guide/pa-files/PA-11-196.html

NIH Pathway to Independence Award (Parent K99/R00)
http://grants.nih.gov/grants/guide/pa-files/PA-11-197.html

 

SCIENCE ADVANCES

Flipping the Switch
Targeted therapy is a buzzword in oncology.  It's also fast becoming a clinical reality.  In the February 1 issue of The Journal of Clinical Investigation, a team of NIDCR grantees report on a newly identified target with implications for a common oral cancer – squamous cell carcinomas.  The team offers a remarkable glimpse into the powerful biochemical information to be gleaned from p63, p73, and its microRNAs.  The scientists discovered a microRNA called miR-193a that p63 and p73 directly regulate and which serves as an on-off switch to promote either cell death or survival. According to the researchers, this discovery is particularly interesting because the go-to platinum-based chemotherapy drug cisplatin appears to inadvertently eliminate p63 from the mix, flicking the microRNA switch into the pro-survival "on" position, and helping squamous cell carcinoma tumor cells to withstand the drug's deadly effects.

In a proof-of-principle test of their initial data, the scientists measured the expression levels of miR-193a in 23 head and neck squamous cell carcinomas - all of which were treated preoperatively with the same cisplatin-containing chemotherapy regimen.  They found the two most treatment-resistant tumors ranked in the top three for highest expression levels of miR-193a.  Although their data are preliminary, the scientists say the results suggest that further research is needed to determine whether disrupting the miR-193a switch will assist cisplatin and other chemotherapy drugs to kill squamous cell carcinoma cells in p53-negative tumors.  The authors of the study are Ory B, Ramsey MR, Wilson C, Vadysirisack DD, Forster N, Rocco JW, Rothenberg SM, and Ellisen LW at the Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA.

A  Few Discoveries Away
In the February issue of the FASEB Journal, NIDCR grantees report that in mouse studies the salivary glands can be induced to serve as an inductive site of mucosal immunity.  Until now, scientists knew that immune cells circulated to the salivary glands from others tissues (one of the scientific rationales for salivary diagnostics), but surprisingly no group had tested their inductive capability.

As described in their paper, the scientists directly injected live cytomegalovirus into submandibular salivary glands of several mice and thereafter detected the formation of ectopic follicles.  Subsequent analyses showed that these follicles functioned as impromptu germinal centers, allowing antigen-presenting follicular dendritic cells to interact with B and T cells and set in motion the maturation and proliferation of white blood cells.  Importantly, the scientists found that the immune response ultimately stopped the spread of the infection to other tissues.  The authors noted that their findings suggested that there may be two distinct types of inductive sites within the mucosal immune system.  The first is a "natural" inductive site, such as those found in the gut or nasal passage.  These sites come equipped naturally with M cells (antigen-transporting immune cells), large populations of white blood cells, and distinct germinal centers.  The second are "induced" inductive sites, such as those arising in the salivary and mammary glands.  An induced site must be inoculated to generate new localized tissue, or follicles, and the needed responses of acquired immunity. 

According to the authors, "The results reported in these studies support the concept that deliberate salivary gland immunization can serve as an alternative mucosal route for administering vaccines."  More research, however, will be needed to establish how this alternative route can best be exploited.  Collaborating on the study were Grewal JS, Pilgrim MJ, Grewal S, Kasman L, Werner P, Bruorton ME, London SD, and London L at the School of Dental Medicine, Stony Brook University, NY.  

Detecting Early Tooth Decay
The first step to avoid drilling and filling a tooth is to catch decay early.  Scientists show for the first time that a promising imaging technique can do just that.  In the December issue of the journal Lasers in Surgery and Medicine, NIDCR grantees report that polarization sensitive-optical coherence tomography -- or PS-OCT as it is known--can be used to assess early tooth demineralization.  In a study of 20 orthodontic patients, the researchers imaged pairs of structurally sound premolars that needed to be extracted. The investigators found that they could measure early demineralization on both the buccal and occlusal surfaces.  They explained that an area of demineralization produces a rise in reflectivity or intensity in the PS-OCT image.  This, in turn, causes a loss of intensity from the tooth's lower layers, and the dentinal enamel junction may no longer be visible below the lesion area.  The extent of demineralization can be calculated by measuring the depth and intensity of the lesion area in the cross-polarization PS-OCT image.  In most cases, the dentinal enamel junction was visible, indicating that PS-OCT penetrated sufficiently enough through the full thickness of the tooth enamel to acquire high quality images.  The researchers concluded, "We believe the ability to acquire complete 3D images and monitor the lesion development over longer periods of time will greatly facilitate these studies and we plan future studies along these lines."  The research was conducted by Louie T, Lee C, Hsu D, Hirasuna K, Manesh S, Staninec M, Darling CL, Fried D in the Department of Orofacial Sciences, University of California, San Francisco.

Challenging Innate Immunity
A hard-to-study oral bacterium has now entered the genomic era and the evolutionary tales written into some of its genes are surprising scientists.  In the January issue of the journal Molecular Microbiology, an NIDCR supported researcher and colleagues take another fascinating look at a previously unknown component of T. forsythia's weaponry.  It's a unique protease that they found encoded in T. forsythia's genome and later named karilysin.  Proteases are scissor-like enzymes that all forms of life use to snip specific cellular proteins and start, stop, or otherwise synchronize a range of biological activities.  But microbes also secrete proteases as weapons, for instance, to degrade peptides that their host produces as a first-line of defense against infection, called innate immunity.  These pathogenic proteases, which poisonous snakes and insects also secrete in their venom, often belong to a family of enzymes called matrix metalloproteinases, or MMPs.

The researchers reported previously that karilysin closely resembles an MMP structurally.  They also found that the protease inactivates the LL-37 antimicrobial peptide, suggesting one way that karilysin may contribute to chronic periodontitis.  Now, they go further and elucidate the structure of one of karilysin's main catalytic domains, called Kly18, and take a remarkable turn into evolutionary biology.   Comparing similar gene sequences across species, they found that the structure of Kly18 is evolutionarily much closer to the MMPs found in winged insects or mammals than those in bacteria.  They concluded that the gene sequence encoding Kly18 must have been transferred from humans or another animal or insect to the bacterium, a biological phenomenon called horizontal gene transfer, or HGT.  "This proposed example of HGT entailing the shuffling of a metazoan [part of the animal kingdom] MMP to a human pathogenic bacterium, which involves distinct domains of life, is both a short circuit of Darwinian evolution and a testimony to the compatibility of proteins and cellular mechanisms despite evolutionary divergence over billions of years."  Collaborating on the study were Cerdà-Costa N, Guevara T, Karim AY, Ksiazek M, Nguyen KA, Arolas JL, Potempa J, and Gomis-Rüth FX from: the University of Louisville School of Dentistry, Louisville, KY; the Faculty of Dentistry, University of Sydney, Australia; the Institute of Dental Research, Westmead Centre for Oral Health, Sydney, Australia; Jagiellonian University, Krakow, Poland; and the Molecular Biology Institute of Barcelona, Spain.

LIPS and Saliva
Previously, a team of NIDCR scientists published a series of research articles on a promising experimental technique called LIPS (an acronym for luciferase immunoprecipitation technology) and its potential to streamline the diagnosis of Sjögren's syndrome.  Their work involved detecting specific autoantibodies in serum. This raised the question of whether the extremely sensitive LIPS technique would also work using saliva, which mirrors virtually everything present in blood serum but at concentrations 1,000 to 10,000 times lower.  As published online on January 6 in the Journal of Dental Research, the researchers provide a preliminary answer in the affirmative.  The study involved 27 healthy controls and 27 people previously diagnosed with Sjögren's syndrome.  The researchers collected whole saliva from the participants and examined the samples for the presence of two autoantibodies, Ro52 and Ro60.  Both are strongly associated with Sjögren's syndrome and commonly tested for in people suspected of having the condition.  However, about 30 percent of Sjögren's patients don't have autoantibodies in their serum for Ro52 or Ro60, suggesting the syndrome may have more than one biological trigger.  The researchers report that LIPS detected Ro60 autoantibodies in 70 percent of the saliva of Sjögren's patients with 96 percent specificity.  The technique detected R052 autoantibodies in 67 percent of the saliva of Sjögren's patients with 100 percent specificity.  Specificity measures the proportion of healthy people who are correctly identified as not having the disease.  The authors noted that autoantibody titers for both antigens were 4,000 fold lower by volume than in serum.  The study was conducted by Ching KH, Burbelo PD, Gonzalez-Begne M, Roberts ME, Coca A, and Iadarola MJ from the Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, NIDCR, and Sanz I from the University of Rochester. 

 

NIDCR PERSONNEL UPDATE

Dr. Jason Wan Appointed Program Director, Mineralized Tissue Physiology Program
In March, Dr. Jason Wan assumed the responsibilities as director of the Mineralized Tissue Physiology Program, Integrative Biology and Infectious Diseases Branch (IBIDB).  As program director, he manages a portfolio of grants on biomineralization, matrix biology, and structural and functional properties of teeth and craniofacial bones.  Dr. Wan joined IBIDB two years ago as a health program specialist.  In this capacity, he assisted in the implementation of the American Recovery and Reinvestment Act and Clinical Terms of Award, as well as in the coordination of  workshops/meetings and portfolio analyses and other activities.  Dr. Wan earned his Ph.D. in biochemistry and molecular biophysics from the University of Pennsylvania and received postdoctoral training in the Laboratory of Molecular Biology, NIDDK under the tutelage of Dr. Jeremy Berg (currently the NIGMS Director). 

Dr. Matthew Hoffman Appointed Senior Investigator
Dr. Matthew Hoffman, head of the Matrix and Morphogenesis Section in the Laboratory of Cell and Developmental Biology, was converted to tenure on April 4. Dr. Hoffman received his B.D.S. in 1986 from the University of Otago School of Dentistry in New Zealand and his Ph.D. in 1994 from the University of Rochester School of Medicine and Dentistry.  After completing a six-year postdoctoral fellowship at the NIDCR, he then became a staff scientist.  In 2004 he was selected in a national/international search to be a tenure-track investigator.  Dr. Hoffman and his research group have conducted seminal research on the diverse regulatory inputs that drive salivary gland development. They currently investigate how cells are directed along a series of cell fate decisions and the interactions among the various stem/progenitor cell types and their extracellular matrix microenvironment, or niche. They aim to design therapeutic approaches for the functional regeneration of damaged adult salivary tissue by understanding the developmental mechanisms that occur during organogenesis.

Dr. Wanjun Chen Appointed Senior Investigator
Dr. Wanjun Chen, chief of the Mucosal Immunology Unit in the Oral Infection and Immunity Branch, was named a senior investigator on May 2.  Dr. Chen received his M.D. in China and after completing a postdoctoral fellowship at Harvard, he then joined NIDCR's Oral Infection and Immunity Branch as a fellow in 1997.  In 2004, after an international search, he was selected for a tenure-track position in that branch where he has continued his research on understanding the mechanisms and regulation of immune suppression and tolerance, with particular emphasis on TGF-b and regulatory T cells.   His studies are applicable not only to autoimmunity, but also to understanding transplantation, infectious diseases, and cancer.  Dr. Chen has emerged as a leader in the field of immune regulation and tolerance. 

OCHE Welcomes New Staff

NIDCR's Office of Communications and Health Education (OCHE) recently welcomed two new staff members--Matilde Gonzalez-Flores and Valerie Lambros.

Ms. Gonzalez-Flores has an M.P.H. in social and behavioral sciences and a certificate in health disparities from the Johns Hopkins School of Public Health.  Most recently she was a research and social marketing specialist on contract to the HHS Office of Minority Health Resource Center (OMHRC).  Prior to her work with OMHRC, Ms. Gonzalez-Flores was a health programs manager for the Los Angeles office of the American Cancer Society.  She is also a member of the executive committee for the American Public Health Association's Latino Health Caucus.

Ms. Lambros comes to OCHE from the NIH Office of Communications and Public Liaison where she was a writer for the NIH Record and often lent a hand to Director's projects and special events.  She has an M.A. in English with a concentration in professional writing and editing and is completing an M.F.A. in nonfiction writing.  Her work before arriving at NIH in June 2009 includes newspaper reporting, technical editing with a government contractor, and communications and outreach work with a cancer prevention nonprofit.

Dr. Larry Fisher Receives IADR Isaac Schour Award
Dr. Larry Fisher, chief of the Matrix Biochemistry Section, Craniofacial and Skeletal Diseases Branch, received the IADR Isaac Schour Memorial Award for his contributions to the understanding of the biochemistry of dental and bone tissues.  The award was presented during the annual IADR/AADR meeting held in San Diego, CA. The award honors Dr. Isaac Schour, an early leader in international dental research and the 18th IADR president (1941-42). It recognizes outstanding scientific contributions in the anatomic sciences, including tissue engineering, tissue regeneration, and stem cell research as it relates to the oral, dental, or craniofacial complex.

Dr. Abner Notkins Honored
Dr. Abner Notkins was elected into American Academy of Microbiology.  Dr. Notkins is chief of the Experimental Medicine Section, Oral Infection and Immunity Branch.

 

PUBLICATIONS

Division of Intramural Research

Andreopoulou P, Dumitrescu CE, Kelly MH, Brillante BA, Peck CM, Wodajo FM, Chang R, Collins MT. Selective venous catheterization for the localization of phosphaturic mesenchymal tumors. J Bone Miner Res. 2010 Dec 16. [Epub ahead of print].

Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind JS, and Rusling JF. Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond), 5:1535-1546, 2010.

Brown JM, Nemeth K, Kushnir-Sukhov NM, Metcalfe DD, Mezey E. Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism. Clin Exp Allergy. 2011 Apr;41(4):526-34.

Burbelo PD, Browne SK, Sampaio EP, Giaccone G, Zaman R, Kristosturyan E, Rajan A, Ding L, Ching KH, Berman A, Oliveira JB, Hsu AP, Klimavicz CM, Iadarola MJ, Holland SM (2010) Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia. Blood 116, 23, 4848-4858.

Cheng KT, Liu X, Ong HL, Swaim W, Ambudkar IS. (2011) Local Ca Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca Signals Required for Specific Cell Functions. PLoS Biol. 2011 Mar;9(3):e1001025. Epub 2011 Mar 8. 

Ching KH, Burbelo PD, Gonzalez-Begne M, Roberts ME, Coca A, Sanz I, Iadarola MJ (2011) Salivary anti-Ro60 and anti-Ro52 Antibody Profiles to Diagnose Sjogren's Syndrome.  J Dent Res. 90, 4, 445-449.

Hakkinen KM, Harunaga JS, Doyle AD, Yamada KM. Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng Part A. 17:713-24, 2011.

Hong JH, Li Q, Kim MS, Shin DM, Feske S, Birnbaumer L, Cheng KT, Ambudkar IS, Muallem S. Polarized but differential localization and recruitment of STIM1/Orai1 and STIM1/TRPC channels in secretory cells. Traffic. 12:232-245, 2011

Konkel JE, Maruyama T, Carpenter AC, Xiong Y, Zamarron BF, Hall BE, Kulkarni AB, Zhang P, Bosselut R, Chen W. Control of the development of CD8αα(+) intestinal intraepithelial lymphocytes by TGF-β.  Nat Immunol. 2011 Apr;12(4):312-9. Epub 2011 Feb 6.

Lee SB, Park JH, Folk JE, Deck JA, Pegg AE, Sokabe M, Fraser CS, and Park MH. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J. 433:205-213, 2010.

Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, and Chen W. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat. Immunol. 12:86-95, 2011.

Mitchell, K, Bates BD, Keller JM, Lopez M, Scholl L, Navarro J, Madian N, Haspel G, Nemenov MI, Iadarola MJ (2010) Ablation of rat TRPV1-expressing A-/C-fibers with resiniferatoxin: analysis of withdrawal behaviors, recovery of function and molecular correlates. Molec Pain 6, 94.

Siraganian RP, Castro RO, Barbu EA and Zhang L.  Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants.  FEBS Lett. 584:4933-4940, 2010.

Szabo R, Rasmussen AL, Moyer AB, Kosa P, Schafer JM, Molinolo AA, Gutkind JS, and Bugge TH. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011 Jan 10. [Epub ahead of print]

Szabova L, Son MY, Shi J, Sramko M, Yamada SS, Swaim WD, Zerfas P, Kahan S, Holmbeck K. Membrane-type MMPs are indispensable for placental labyrinth formation and development.  Blood. 2010 116(25):5752-5761.

Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 121:956-965, 2011.


Reviews:

Amornphimoltham P, Masedunskas A, and Weigert R. Intravital microscopy as a tool to study drug delivery in preclinical studies.  Adv. Drug Deliv. Rev. 63:119-128, 2011

Geiger B, Yamada KM. Molecular Architecture and Function of Matrix Adhesions.
Cold Spring Harb Perspect Biol
. doi: 10.1101/cshperspect.a005033, 2011 [Epub ahead of print]

Hsu JC, Yamada KM. Salivary gland branching morphogenesis -- Recent progress and
future opportunities
. Int J Oral Sci 2:117-26, 2010.

 

Recent publications from K awardees:

Albesiano E, Davis M, See AP, Han JE, Lim M, Pardoll DM, Kim Y.  Immunologic consequences of signal transducers and activators of transcription 3 activation in human squamous cell carcinoma.  Cancer Res. 2010 Aug 15;70(16):6467-76.

Bedran-Russo AK, Castellan CS, Shinohara MS, Hassan L, Antunes A.  Characterization of biomodified dentin matrices for potential preventive and reparative therapies.  Acta Biomater. 2011 Apr;7(4):1735-41.

Birgfeld CB, Luquetti DV, Gougoutas AJ, Bartlett SP, Low DW, Sie KC, Evans KN, Heike CL.  A phenotypic assessment tool for craniofacial microsomia.  Plast Reconstr Surg. 2011 Jan;127(1):313-20.

Chi DL, Momany ET, Neff J, Jones MP, Warren JJ, Slayton RL, Weber-Gasparoni K, Damiano PC.  Impact of chronic condition status and severity on dental utilization for Iowa Medicaid-enrolled children.  Med Care. 2011 Feb;49(2):180-92.

Coolidge T, Skaret E, Heima M, Johnson EK, Hillstead MB, Farjo N, Asmyhr O, Weinstein P.  Thinking about going to the dentist: a Contemplation Ladder to assess dentally-avoidant individuals' readiness to go to a dentist.  BMC Oral Health. 2011 Jan 27;11:4.

Jiang L, Dai Y, Liu X, Wang C, Wang A, Chen Z, Heidbreder CE, Kolokythas A, Zhou X.  Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma.  Hum Genet. 2011 Feb;129(2):189-97

Nguyen CQ, Yin H, Lee BH, Carcamo WC, Chiorini JA, Peck AB.  Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer.  Arthritis Res Ther. 2010;12(6):R220.

Nguyen CQ, Yin H, Lee BH, Chiorini JA, Peck AB.  IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer.  Lab Invest. 2011 Jan;91(1):54-62.

Shao C, Bai W, Junn JC, Uemura M, Hennessey PT, Zaboli D, Sidransky D, Califano JA, Ha PK.  Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma.  Oral Oncol. 2011 Apr;47(4):251-5.

Shigeta Y, Ogawa T, Ando E, Clark GT, Enciso R.  Influence of tongue/mandible volume ratio on oropharyngeal airway in Japanese male patients with obstructive sleep apnea.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Feb;111(2):239-43.

 

Recent publications from F awardees:

Alby K, Bennett RJ.  Interspecies pheromone signaling promotes biofilm formation and same-sex mating in Candida albicans.  Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2510-5. 

Anderson JM, Vines JB, Patterson JL, Chen H, Javed A, Jun HW.  Osteogenic differentiation of human mesenchymal stem cells synergistically enhanced by biomimetic peptide amphiphiles combined with conditioned medium.  Acta Biomater. 2011 Feb;7(2):675-82.

Costa-Guda J, Marinoni I, Molatore S, Pellegata NS, Arnold A.  Somatic Mutation and Germline Sequence Abnormalities in CDKN1B, Encoding p27Kip1, in Sporadic Parathyroid Adenomas.  J Clin Endocrinol Metab. 2011 Apr;96(4):E701-6.

Nichols RJ, Sen S, Choo YJ, Beltrao P, Zietek M, Chaba R, Lee S, Kazmierczak KM, Lee KJ, Wong A, Shales M, Lovett S, Winkler ME, Krogan NJ, Typas A, Gross CA.  Phenotypic landscape of a bacterial cell.  Cell. 2011 Jan 7;144(1):143-56.

Niu KY, Ro JY.  Changes in intramuscular cytokine levels during masseter inflammation in male and female rats.  Neurosci Lett. 2011 Jan 7;487(2):223-7.

Ramsey MM, Rumbaugh KP, Whiteley M.  Metabolite cross-feeding enhances virulence in a model polymicrobial infection.  PLoS Pathog. 2011 Mar;7(3):e1002012.

Valm AM, Welch JL, Rieken CW, Hasegawa Y, Sogin ML, Oldenbourg R, Dewhirst FE, Borisy GG.  From the Cover: Systems-level analysis of microbial community organization through combinatorial labeling and spectral imaging.  Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4152-7.

Wietecha MS, Chen L, Ranzer MJ, Anderson K, Ying C, Patel TB, DiPietro LA.  Sprouty2 downregulates angiogenesis during mouse skin wound healing.  Am J Physiol Heart Circ Physiol. 2011 Feb;300(2):H459-67.

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This page last updated: January 28, 2014