News from NIDCR (National Institute of Dental and Craniofacial Research, NIH)

E-Newsletter: October 29, 2009

In this Issue:
1. American Reinvestment and Recovery Act News
2. Funding Opportunity News
3. NIDCR News
4. NIH/HHS News
5. Science Advances

 

 


AMERICAN REINVESTMENT AND RECOVERY ACT NEWS

Recovery Act Limited Competition: Building Community-Linked Infrastructure to Enable Health Science Research (RC4)
ARRA logoNIH is seeking applications for a new program entitled Building Sustainable Community-Linked Infrastructure to Enable Health Science Research, also known as the "Community Infrastructure" grants program:
http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-09-010.html
U.S. institutions/organizations may apply who propose to develop or expand needed infrastructures that will fundamentally transform collaboration and communication between academic health centers and local communities.

This RFA is not intended to fund research or evaluation projects, clinical trials, or public health campaigns. Rather, the intent is to fund projects to develop infrastructure for productive and sustainable academic-community research partnerships that can be leveraged in the future for efficiently conducting research that includes--and is relevant to--affected communities. NIH strongly encourages applicants to propose infrastructures that may build upon or be linked to existing infrastructures supported by other Federal agencies.  NIH has designated up to $30 million in FY 2009-2010 to fund 30 or more grants, contingent upon the submission of a sufficient number of scientifically meritorious applications.  Letters of intent are due November 12, 2009; applications are due December 11, 2009.

Also see the related Notice:
Clarification of Eligibility as Primary Applicant for the RFA-OD-09-010
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-006.html  

Notice About NIH Population Tracking Requirements for ARRA Awards
NIH released a Notice on October 16 that describes expectations for implementing Population Tracking requirements for clinical research protocols supported or conducted with ARRA funds.  For additional information see:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-003.html
 

FUNDING OPPORTUNITY NEWS

Major Changes for Applications Submitted for January 25, 2010 and Beyond

Enhancing Peer Review at NIH banner



A number of changes will take effect for applications submitted for January 25, 2010 and beyond.  The changes, which are a result of the Enhancing Peer Review at NIH Initiative, include: 

*Restructured application forms (applicants will need to download the new forms)
*New instructions, including shorter page limits

The timeline for these changes was announced in an NIH Guide Notice on December 2, 2008:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-023.html

Applicants are advised to read about requirement changes now so they can begin writing the Research Strategy section of the application.  In December, applicants should go back to the updated Funding Opportunity Announcement (FOA) or reissued Parent Announcement and download the new application package and instructions.  For due dates on or after January 25, applicants should submit applications using the new application form and instructions.

Additional information about the application changes is available at:
http://enhancing-peer-review.nih.gov/restructured_applications.html 
Also see the flyer:
http://enhancing-peer-review.nih.gov/docs/flyer_for_application_changes.pdf
and a detailed one-pager:
http://enhancing-peer-review.nih.gov/docs/information_for_applicants.pdf

Many mechanisms, including the R01, will shorten from a 25-page research plan to a 12-page research strategy section.  The research strategy sections of other activity codes (e.g. R21, R03) will be reduced from 15 to 6 pages.  Multi-component applications (e.g. P01s) will generally have 12 or 6 pages for each project and core.  There will be a “jumbo” option allowing for a 30-page research strategy that will be used on a limited basis and will require approval through the OER Office of Extramural Programs. 

The new page limits will apply to all applications, including competing continuations, competitive revisions, and resubmissions (amended applications).  In late October/early November, changes will be made to all FY2011 funding opportunity announcements that have receipt dates of January 25, 2010 or later, to ensure that instructions in the funding opportunity announcements are consistent with the new application instructions.


Proposals Welcome for 2010 NIH Director’s Transformative Research Projects Program
Transformative Research Projects Program designA major goal of the NIH is to foster bold and creative investigator-initiated research. In pursuit of this goal, the Transformative Research Projects Program has been created under the auspices of the NIH Roadmap for Medical Research to enhance submission and support of exceptionally innovative, high risk, original and/or unconventional research that has the potential to have a profound impact in clinical, basic, and or behavioral/social science arenas.

NIH Roadmap Transformative Research Awards provide up to $25 million total costs per year for a single project.  The NIH encourages applications for the Transformative Research Projects Program from scientists representing all disciplines relevant to the NIH mission, including the biological, behavioral, clinical, social, physical, chemical, computational, engineering, and mathematical sciences. Interdisciplinary teams as well as individual investigators with bold ideas are encouraged to apply.

The deadline for submitting Transformative Research Project applications is January 22, 2010, with Letters of Intent due by December 22, 2009.  See the instructions in the RFA:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-022.html

Additional information, including Frequently Asked Questions, is available at:
http://nihroadmap.nih.gov/T-R01/

NIH Blueprint for Neuroscience Research Announces New Funding Opportunity
NIH Blueprint for Neuroscience banner




The NIH Blueprint for Neuroscience Research has announced a new funding opportunity that will support partnerships between scientists from the pain and neuroplasticity fields.  These partnerships are expected to lead to insights into the neuroplastic changes that occur during the transition from acute to chronic pain.  Funding is available through competitive revisions that add a collaborative, one-year pilot study or a new specific aim to an active NIH grant.  Applications are due November 23, 2009.  See the announcement at:
http://grants.nih.gov/grants/guide/pa-files/PAR-09-264.html

In the next two years, this Blueprint initiative will be expanded to promote larger collaborative projects on the transition from acute to chronic pain, and to train new investigators in state-of-the-art methods for studying pain.


NEW PROGRAM ANNOUNCEMENTS

Biotechnology/Regenerative Medicine/Biomaterials

Title

NIH
Guide

PA
Number

NIDCR Contact

Expiration
Date

Bioengineering Research Grants (BRG) (R01) 10/14/09 PA-10-009 Nadya Lumelsky
301-594-7703
1/08/13
Exploratory/Developmental Bioengineering Research Grants (EBRG) [R21] 10/14/09 PA-10-010 Nadya Lumelsky
301-594-7703
1/08/13
Bioengineering Nanotechnology Initiative
(STTR [R41/R42])
10/02/09 PA-09-266 Nadya Lumelsky
301-594-7703
1/08/10
Bioengineering Nanotechnology Initiative (SBIR [R43/R44]) 10/02/09 PA-09-267 Nadya Lumelsky
301-594-7703
1/08/10


Cancer

Title

NIH
Guide

PA
Number

NIDCR Contact

Expiration
Date

Specialized Programs of Research Excellence (SPORES) in Human Cancer for Years 2010, 2011, and 2012 (P50) 10/02/09 PAR-10-003 Yasaman Shirazi
301-594-4812
9/21/12


Neurobiology/Pain

Title

NIH
Guide

PA
Number

NIDCR Contact

Expiration
Date

NIH Blueprint for Neuroscience Research Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01)  9/22/09 PAR-09-264 John Kusiak
301-594-7984
11/24/09
Mechanisms, Models, Measurement, & Management in Pain Research (R01) 10/05/09 PA-10-006 John Kusiak
301-594-7984
1/08/13
Mechanisms, Models, Measurement, & Management in Pain Research (R21) 10/05/09 PA-10-007 John Kusiak
301-594-7984
1/08/13
Mechanisms, Models, Measurement, & Management in Pain Research (R03) 10/05/09 PA-10-008 John Kusiak
301-594-7984
1/08/13


NEW REQUESTS FOR APPLICATIONS



AIDS

Title

NIH
Guide

RFA Number

NIDCR Contact

Application Receipt Date

Metagenomic Evaluation of Oral Polymicrobial Disease (R01)

Also see Microbiology
10/23/09 RFA-DE-10-003 Isaac Rodriguez-Chavez
301-594-7985
(For HIV/AIDS-related applications)

R. Dwayne Lunsford
301-594-2421
(For non-HIV/AIDS related applications)
3/02/10


All Dental and Craniofacial Research



Title

NIH
Guide

RFA Number

NIDCR Contact

Application Receipt Date

Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) 9/17/09 RFA-GM-10-009 Alicia Dombroski
301-594-4805
11/24/09


American Recovery and Reinvestment Act

Title

NIH
Guide

RFA Number

NIDCR Contact

Application Receipt Date

Recovery Act Limited Competition: Building Sustainable Community-Linked Infrastructure to Enable Health Science Research (RC4) 9/18/09 RFA-OD-09-010 Donald Denucci
301-451-5096
12/11/09


Microbiology

Title

NIH
Guide

RFA Number

NIDCR Contact

Application Receipt Date

Metagenomic Evaluation of Oral Polymicrobial Disease (R01)

Also see AIDS
10/23/09 RFA-DE-10-003 R. Dwayne Lunsford
301-594-2421
(For non-HIV/AIDS related applications)

Isaac Rodriguez-Chavez
301-594-7985
(For HIV/AIDS-related applications)
3/02/10


NIH Roadmap Initiatives

Title

NIH
Guide

RFA Number

NIDCR Contact

Application Receipt Date

Roadmap Transformative Research Projects Program (R01) 10/23/09 RFA-RM-09-022 Alicia Dombroski
301-594-4805
1/22/10


 

NOTICES


 

Title

NIH
Guide

Notice Number

Announcing the Transition of Institutional Training and Institutional Career Development Programs to Electronic Submission for due dates on/after January 25, 2010 10/26/09 NOT-OD-10-008
Clarification of Registration in ClinicalTrials.gov According to Date of Initiation and Status as an "Ongoing" Trial  10/23/09 NOT-OD-10-007
Notice of Intent to Publish a Request for Applications for the Blueprint for Neuroscience Grand Challenge: New Drugs for Diseases and Disorders of the Nervous System (U01) 10/16/09 NOT-NS-10-002
Amendment to the Institutional Eligibility Criteria for Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowships 10/16/09 NOT-OD-10-004
NIH Population Tracking Requirements for ARRA Awards 10/16/09 NOT-OD-10-003
Clarification on Timing and Page Limits for Restructured Application Forms and Instructions that are required for Due Dates on or after January 25, 2010 10/08/09 NOT-OD-10-002
Notice of Intent to Publish a Request for Applications on Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (R25) 10/09/09 NOT-MH-10-003
Notice to Update the Data Release Policy for the Molecular Libraries Program 10/01/09 NOT-RM-09-020
Extension of Modified Application Submission, Referral and Review for Reviewers with Recent Substantial Service 10/01/09 NOT-OD-09-155
Extension of the Expiration Date for PA-06-042 the Academic Research Enhancement Award (AREA): R15 9/22/09 NOT-OD-09-152
Clarification of All Personnel Report in the Revised PHS 2590 (DHHS Public Health Service Noncompeting Continuation Progress Report) 9/22/09 NOT-OD-09-150
Restructured Application Forms and Instructions for Submissions for FY2011 Funding 9/16/09 NOT-OD-09-149

Correction to Required Components for the 2010 NIH Director's Pioneer Award Program (DP1); RFA-RM-09-010

9/10/09

NOT-RM-09-018

Correction to Required Components for the 2010 NIH Director's New Innovator Award Program (DP2); RFA-RM-09-011

9/10/09 NOT-RM-09-019



New Concept Clearances
Concepts represent early planning stages for initiatives in which NIDCR seeks to support research in an understudied and significant area of science. Approval by the National Advisory Dental and Craniofacial Research Council does not guarantee that a concept will become a program announcement (PA), request for applications (RFA), or request for proposals (RFP). NIDCR bases this determination on scientific and programmatic priorities balanced with the amount of funds available.  The following concept clearances were approved at the September 2009 Council meeting: 

Collaborative Research on the Transition From Acute to Chronic Pain: New Models and Measures in Clinical and Preclinical Pain Research

Pathophysiology and Clinical Studies of Osteonecrosis of the Jaw (ONJ)

Building a Genetic and Genomic Knowledge Base in Dental and Craniofacial Conditions and Diseases

Formative Research Towards the Development of Effective Behavioral and Social Interventions to Improve Oral and Craniofacial Health 


Find more details about these Concept Clearances at:  
http://www.nidcr.nih.gov/AboutUs/Councils/NADCRC/RecentlyClearedConcepts/ 
 

NIDCR NEWS

NIDCR to Accept Applications for Summer Dental Student Awards
To enable future dentists to experience careers in research, the NIDCR offers an outstanding summer training opportunity for dental students.  The NIDCR Summer Dental Student Award is designed to give talented dental students hands-on research experience and exposure to the latest advances in oral health research.  Selected candidates are assigned to mentors who conduct research in the students’ areas of interest.  Participation in the program may result in presentation of research findings at a scientific meeting or co-authorship of scientific publications.

The NIDCR provides a competitive stipend for all summer researchers.  Acceptance of this reward requires a minimum eight-week commitment.  The nominating dental school must agree to support air or ground transportation for their students.  NIDCR will accept online applications for the Summer Dental Student Award from November 15, 2009 – January 15, 2010.  For additional information on how to apply, please visit: http://www.nidcr.nih.gov/CareersAndTraining/Fellowships/DentalMedicalStudents/
or contact Dr. Deborah Philp, Program Director, dphilp@dir.nidcr.nih.gov, (301) 594-6578.

Also read the story: "Who Wants to Be a Researcher?  Summer Students Make their Choice at NIDCR":
http://www.nidcr.nih.gov/CareersAndTraining/CareersinDentalResearch/ 

Dr. Julio Frenk to Deliver 2009 David E. Barmes Global Health Lecture
Dr. Julio FrenkOn Tuesday, December 15 at 11:30 a.m., Dr. Julio Frenk, Dean of the Harvard School of Public Health, will deliver the 2009 David E. Barmes Global Health Lecture.  An eminent authority on global health, Dr. Frenk will talk about "Globalization and Health: The Role of Knowledge in an Interdependent World."  The lecture will be held in the Masur Auditorium in the Clinical Center (Building 10) on the NIH campus and is free and open to the public.  It will be followed by a reception hosted by the Friends of the NIDCR.

The lecture also will be videocast at:
http://videocast.nih.gov/  

Jointly sponsored by the NIDCR and the Fogarty International Center, the annual lecture series honors the late David E. Barmes, a longstanding World Health Organization employee, special expert for international health at NIDCR, and ardent spokesman for global health.  

 

NIH/HHS News

NIH Opens Website for Submission of Human Embryonic Stem Cell Lines for Approval
Stem cellsNIH is now accepting requests for human embryonic stem cell (hESC) lines to be approved for use in NIH-funded research.  Information may be submitted through NIH Form 2890, an interactive Web form, which is found at:   
http://stemcells.nih.gov/ 


NIH Establishes Working Group for Human Embryonic Stem Cell Eligibility Review
NIH Director Francis S. Collins, M.D., Ph.D., announced on September 21 the members of a new working group of the Advisory Committee to the Director (ACD): the Working Group for Human Embryonic Stem Cell Eligibility Review.  The group is chaired by Jeffrey R. Botkin, M.D., M.P.H., a professor at University of Utah's School of Medicine.   Included among its members is NIDCR grantee Jeffrey Murray, M.D., from the University of Iowa.  The Working Group will consider categories of hESCs and make recommendations to the ACD regarding their eligibility for use in NIH-funded research.  See additional information about the new working group:
http://www.nih.gov/news/health/sep2009/od-21.htm

NIH published its Guidelines for Human Stem Cell Research on July 7, 2009:
http://stemcells.nih.gov/policy/2009guidelines.htm
The Guidelines establish policy and procedures under which the NIH will fund human stem cell research and help ensure that NIH-funded research in this area is ethically responsible, scientifically worthy, and conducted in accordance with applicable law. 

NIH Announces 115 Awards to Encourage High-Risk Research and Innovation
On September 24, NIH announced that it is awarding $348 million to encourage investigators to explore bold ideas that have the potential to catapult fields forward and speed the translation of research into improved health.  The full complement of awards is granted under three innovative research programs supported by the NIH Common Fund's Roadmap for Medical Research: the NIH Director's Transformative R01 (T-R01) Awards, Pioneer Awards, and New Innovator Awards.  The Common Fund, enacted into law by Congress through the 2006 NIH Reform Act, supports cross-cutting, trans-NIH programs with a particular emphasis on innovation and risk taking.  A portion of these New Innovator Awards is also supported by funding from the American Recovery and Reinvestment Act.  See additional details:
http://www.nih.gov/news/health/sep2009/od-24.htm

NIH Announces Expansion of Rare Diseases Clinical Research Network
NIH has announced a second phase of the Rare Diseases Clinical Research Network (RDCRN), including funds for 19 research consortia.  The Rare Diseases Clinical Research Consortia and a Data Management Coordinating Center (DMCC) will be awarded a total of just over $117 million over the next five years.  The research conducted with the new funding will explore the natural history, epidemiology, diagnosis, and treatment of more than 95 rare diseases.  NIDCR is one of the NIH Institutes providing funding and scientific oversight for the Rare Diseases Clinical Research Network.  Additional details are found at:
http://www.nih.gov/news/health/oct2009/od-05.htm

NIH Grantees Win 2009 Nobel Prize in Physiology or Medicine
Elizabeth Blackburn, Ph.D.The 2009 Nobel Prize in physiology or medicine is shared by three NIH grantees:   Elizabeth H. Blackburn, Ph.D., of University of California, San Francisco; Carol W. Greider, Ph.D., of Johns Hopkins University School of Medicine; and Jack W. Szostak, Ph.D., of MassachusJack W. Szostak, Ph.D.etts General Hospital, Harvard Medical School and Howard
 Hughes Medical Institute. The three researchers, supported by NIH funding for decades, are honored for discovering how telomeres, through the enzyme telomerase, protect chromosomes against degradation. Their discoveries added a Carol Greider, Ph.D.new dimension to the scientific community’s understanding of the cell, shed light on disease mechanisms, and introduced new directions for the development of potential new therapies.  NIDCR has previously supported the research of Dr. Blackburn. 


SCIENCE ADVANCES

Scientists Discover Protein Receptor for Carbonation Taste
CarbonationEver wonder why you can taste the bubbles in a soda?  Researchers report that they have discovered how the process of tasting carbonation begins in the mouth.





NIDCR Launches the FaceBase Consortium
Quail embryo with neural crest cells in greenAlthough about half of all birth defects involve the face and skull, scientists remain unclear about why most occur.  The NIDCR's new FaceBase Consortium will build needed research infrastructure and begin to bring greater clarity to this intriguing area of biology.




Rapid Test for Sjögren’s Syndrome
http://www.nidcr.nih.gov/Research/ResearchResults/ScienceBriefs/
schematic of antibodiesScientists have developed a promising but still experimental diagnostic test for primary Sjögren’s syndrome.  This rapid test just got faster.






Immune Peptide Shows Potential to Help Diagnose Oral Cancer
http://www.nidcr.nih.gov/Research/ResearchResults/ScienceBriefs/
Linkage disequilibrium log for HBD-1When microbes invade oral tissues, they often receive a blast of an antimicrobial peptide called  β-defensin.  Scientists found that oral cancer cells are less adept at producing  β-defensins, suggesting a new way to detect a developing cancer.




Scientists Generate Skin-like Replacement Tissues
http://www.nidcr.nih.gov/Research/ResearchResults/ScienceBriefs/
Epithelial-like coloniesScientists used pluripotent human stem cells to engineer complex, three-dimensional skin-like tissues.  With further research and refinement, these fabricated tissues have the potential to replace badly damaged oral mucosa.





Study Confirms Dentin Grows More Brittle With Age
http://www.nidcr.nih.gov/Research/ResearchResults/ScienceBriefs/
Young dentinBones are not the only mineralized tissue in the body that grows more brittle with age.  Dentin, the core material of our teeth, also becomes brittle.  A new study explains some of the changes.  





Scientists Discover Another RNA in Saliva
http://www.nidcr.nih.gov/Research/ResearchResults/ScienceBriefs/
Stability of endogenous and exogenous miRNA in salivaScientists found previously that measuring mRNA levels in saliva could be used to detect oral cancer. Now, another type of RNA might help to further improve the accuracy of this investigational test.


 


National Institute of Dental and Craniofacial Research
National Institutes of Health
Bethesda, MD 20892-2190
301-496-4261

Department of Health and Human Services (HHS)   National Institutes of Health (NIH)   USA.gov