News from NIDCR (National Institute of Dental and Craniofacial Research, NIH)

E-Newsletter: June 19, 2013

In this Issue:

 


NIDCR News 

NIDCR 2014-2019 Strategic Plan Update
NIDCR Strategic Plan icon Development of the NIDCR 2014-2019 Strategic Plan continues. Two Strategic Plan listening sessions (one general, one training-specific) were held during the March IADR/AADR meeting in Seattle.  In addition, NIDCR is hosting two roundtable discussions over the summer as part of the Strategic Planning process. One will focus on health disparities, a critical area because of persistent disparities in the health status of underserved Americans. The other will concentrate on fostering bidirectional collaborations between clinicians and researchers. An online Request for Information also will be posted on the NIDCR website, providing an opportunity for all stakeholders --including clinicians, researchers, educators, patients, advocates, and members of the public--to share their opinions about areas of research emphasis, future research approaches, and needs and opportunities. The initial framework of the Strategic Plan will be completed by fall 2013, and the Plan completed in early 2014.

NIDCR FY 2013 Funding Plan
NIDCR's FY 2013 extramural funding plan is now available at:
http://go.usa.gov/bRdV 
The Institute plan is consistent with NIH's fiscal policy for grant awards:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-13-064.html

Also see NIDCR's FY 2014 Congressional Justification:
http://go.usa.gov/bRv4


NIDCR Director's Report to the National Advisory Dental and Craniofacial Research Council Provides NIDCR/NIH Snapshot
To learn about NIDCR programmatic news and activities, the budget, recent science advances, and NIH highlights, read the report the NIDCR Director presented at the May 21, 2013 meeting of the National Advisory Dental and Craniofacial Research Council:
http://go.usa.gov/bRvP
 
Ms. Dede Rutberg to Become New Grants Management Chief
Ms. Dede Rutberg, MBAMs. Dede Rutberg, MBA, will become NIDCR's new Grants Management Officer and Chief, Grants Management Branch. She replaces Ms. Mary Greenwood, who will retire at the end of July. Ms. Rutberg has served as NIDCR's Lead Grants Management Specialist since 2006.  In this role she oversees the business management function for a variety of grant mechanisms (approximately 1,100 research project grants and 350 research trainees) totaling over $300 million. She has ensured that grant awards are processed accurately and timely and within NIH/DHHS policies and has provided expert advice to grantees and internal NIH staff on all grant-related issues.  Ms. Rutberg also is responsible for the workload oversight of five other grant specialists.  She serves on many trans-NIH committees, including the Central Service Advisory Committee (CSAC), NIH Intern Committees, and several SBIR/STTR workgroups. 

NIDCR Mourns Dr. Lynne Angerer 
Lynne Angerer, Ph.D.NIDCR is deeply saddened by the loss of Dr. Lynne Angerer, chief of NIDCR's Developmental Mechanisms Section, who died March 30 after a long illness. Dr. Angerer was a world-renowned expert in the field of developmental biology. Using sea urchins, close cousins of vertebrates, she unraveled the core regulatory processes that direct the early development of animal embryos. She led her NIDCR lab to numerous pioneering discoveries. Among these was the revelation that some neurons are of a unique tissue origin, differentiating de novo from cells in the gut; this finding was a challenge to prevailing dogma that nerves develop only from another embryonic tissue. Her group also found numerous unexpected complex regulatory interactions that are required to prevent most cells of the embryo from adopting neural fate (Wnt signaling). One of Dr. Angerer’s major scientific accomplishments was the microarray she helped develop from the newly obtained sea urchin genome sequence, an important tool for genome-wide screens to identify genes and signaling molecules involved in early embryonic development.

Dr. Angerer was an outstanding and inspiring mentor, training many graduate students and postdocs who went on to their own successful research careers.  An NIH Director's Award was presented posthumously to her on June 12th in recognition of her mentoring work. Accepting the award on her behalf, Dr. Kelly Ten Hagen, chief of the NIDCR Developmental Glycobiology Section, remembered Dr. Angerer as someone who "truly cared about the people she mentored and felt personally responsible for helping them realize their full potential. Her advice and encouragement over the years has made a huge difference in my life and career."


NIH News

Impact of Sequestration on the National Institutes of Health
See the new fact sheet on the impact of sequestration on the NIH:
http://www.nih.gov/news/health/jun2013/nih-03.htm

Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative
image of brainOn April 2, President Barack Obama announced a pioneering project to explore the complex workings of the human brain: the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. NIH-supported scientists will be among those at the forefront of this endeavor.
The initiative promises to accelerate the invention of new technologies that will help researchers produce real-time pictures of complex neural circuits and visualize the rapid-fire interactions of cells that occur at the speed of thought. Such cutting-edge capabilities, applied to both simple and complex systems, will open new doors to understanding how brain function is linked to human behavior and learning, and the mechanisms of brain disease. The Brain Initiative is launching with approximately $100 million in funding for research supported by the NIH, the Defense Advanced Research Projects Agency, and the National Science Foundation in the President’s Fiscal Year 2014 budget. In total, NIH intends to allocate $40 million in FY14. Given the cross-cutting nature of this project, the NIH Blueprint for Neuroscience Research—an initiative spanning 14 NIH Institutes and Centers, including the NIDCR—will be the leading NIH contributor to its implementation in FY14.

Lasker Clinical Research Scholars Program Accepts NIH Clinical CenterApplications
Applications will be accepted until June 24, 2013 for the Lasker Clinical Research Scholars Program. This two-phase program supports research activities during the early stage careers of independent clinical researchers and offers a unique bridge between the NIH intramural and extramural research communities. In the first phase, Lasker scholars receive appointments for up to 5-7 years as tenure-track investigators within the NIH Intramural Research Program with independent research budgets. In the second phase, successful scholars will be eligible to apply for up to 5 years of NIH support for their research at an extramural research facility, or the scholar can be considered to remain as an investigator within the intramural program. It is anticipated that up to 5 awards will be made each year. Over time, the program is expected to achieve a steady state of approximately 20-30 scholars. Candidates must have an MD, MD/PhD, DO, DDS, DMD, or equivalent clinical doctoral degree from an accredited domestic or foreign institution and must have a professional license to practice in the United States. NIDCR’s research interest in this program is in the area of oral and craniofacial function and dysfunction.  See additional information:
http://www.nih.gov/science/laskerscholar/

NIDCR to Participate in NIH Summer Research Experience Programs (R25)
NIDCR is one of eight NIH Institutes supporting the NIH Summer Research Experience Programs, which provide high quality research experiences for high school and college students and for science teachers during the summer academic break. The programs aim to attract young students to careers in science, provide opportunities for college students to gain valuable research experience to help prepare them for graduate school, and enhance the skills of science teachers so they can more effectively communicate the nature of the scientific process to their students. NIDCR will support summer research experiences focused on oral, dental or craniofacial research.

NIH and the Weight of the Nation
Weight of the Nation logoDuring the month of May, HBO aired three films for youths and their families entitled “The Weight of the Nation for Kids.” The family-friendly series--a collaboration among NIH, HBO and other partners— highlighted youth improving their own health and that of their communities.

May 2012 marked the premiere of the Emmy-nominated HBO documentary film series on obesity, “The Weight of the Nation.” The four-part series—on Consequences, Choices, Children in Crisis, and Challenges—highlighted several NIH research advances and addressed the factors contributing to the country’s obesity problem. Together, the films are the centerpiece of a public awareness campaign, which also includes 12 short films, a website and social media, and a nationwide community-based outreach effort using free film discussion guides and other tools. Additional information is found at:
http://theweightofthenation.hbo.com/

Dr. John Lorsch Named Director, National Institute of General Medical Sciences 
Jon Lorsch, Ph.D.NIH Director Francis S. Collins has announced the selection of Jon R. Lorsch, Ph.D., as Director of the National Institute of General Medical Sciences. Dr. Lorsch is expected to join the NIH this summer. He comes from Johns Hopkins University, where he is a professor in the Department of Biophysics and Biophysical Chemistry. As NIGMS director, Dr. Lorsch will oversee the institute’s $2.4 billion budget, which primarily funds basic research in the areas of cell biology, biophysics, genetics, developmental biology, pharmacology, physiology, biological chemistry, biomedical technology, bioinformatics and computational biology. The institute also supports a substantial amount of research training and programs designed to increase the diversity of the biomedical and behavioral research workforce .


SCIENCE ADVANCES

Nfingers scratching an armIH Scientists Discover Molecule Triggers Sensation of Itch
Scientists have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of itch:
http://go.usa.gov/bRvG








Landscape of an Enigma
Adenoid cystic carcinomaAdenoid cystic carcinoma of the salivary glands is one of the most enigmatic cancers.  But researchers now have a better genomic view of this troubling tumor: 
http://go.usa.gov/bRwW 








Commensal Damage
Aggregatibacter actinomycetemcomitansMost oral bacteria fall into the category of commensals, microbes long thought to live peacefully in the mouth. But some commensals can turn bad, and a recent mouse study shows how it can happen:
http://go.usa.gov/bUeQ





Pathway to Prevention

mouse tongue exposed to radiationResearchers have discovered a signaling pathway that holds promise for targeted therapy of oral mucositis:
http://go.usa.gov/bRwd









Beating the Spread
Human squamous cell carcinomaScientists have discovered a common enzyme is critical for the metastasis of squamous cell carcinoma cells:
http://go.usa.gov/bRf3 









HeadingAndrew Wilkie, M.D. in the Right DirectioRob Maxson, Ph.D.n

Research into the genetics of craniosynostosis continues to progress. A recent case in point is the gene TCF12:
http://go.usa.gov/bRfT







The Last SIBLING
Larry Fisher, Ph.D.DSPP was the last of the SIBLING proteins in evolution.  Today, DSPP is the last SIBLING to be studied in detail.  But the last continues to tell a first-rate scientific story with plenty of surprises:
http://go.usa.gov/bRf9


FUNDING OPPORTUNITY NEWS

PROGRAM ANNOUNCEMENTS

Gene Studies
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Small Research Grants for Secondary Analysis of FaceBase Data (R03) 4/02/13 PAR-13-178 Steven Scholnick
301-594-3977
9/08/16
Health Disparities
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Native American Research Centers for Health (NARCH) (S06) 5/31/13 PAR-13-239 Ruth Nowjack-Raymer
301-594-5394
8/07/13
Research Mechanisms
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Small Research Grants for Secondary Analysis of FaceBase Data (R03) 4/02/13 PAR-13-178 Steven Scholnick
301-594-3977
9/08/16
Small Business
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Reissue PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) 5/30/13 PA-13-235 R. Dwayne Lunsford
301-594-2421
1/08/14
Reissue PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) 5/30/13 PA-13-234 R. Dwayne Lunsford
301-594-2421
1/08/14
REQUESTS FOR APPLICATIONS
Behavioral/Social Science Research
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Research on the Role of Epigenetics in Social, Behavioral, Environmental and Biological Relationships, throughout the Life-Span and across Generations (R21)  5/17/13 RFA-TW-13-002 David Clark
301-594-4814
11/13/13
Short Courses on Innovative Methodologies in the Behavioral and Social Sciences (R25) 5/03/13 RFA-OD-13-009 Melissa Riddle
301-451-3888
11/14/13
Limited Competition: Revision Applications for Basic Behavioral Research on the Social, Cultural, Biological, and Psychological Mechanisms of Stigma (R01)  3/20/13 RFA-MD-13-005 David Clark
301-594-4814
8/02/13
Cancer
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Functional Characterization of Oral Cancer Initiating Cells (R01) 3/27/13 RFA-DE-14-001 Sundar Venkatachalam
301-594-4812
8/15/13
Functional Characterization of Oral Cancer Initiating Cells (R21) 3/27/13 RFA-DE-14-002 Sundar Venkatachalam
301-594-4812
8/15/13
Gene Studies
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
FaceBase 2: Craniofacial Development and Dysmorphology -Dataset, Tool, and Resource Development (U01) 4/05/13 RFA-DE-14-004 Steven Scholnick
301-594-3977
8/22/13
FaceBase 2: Craniofacial Development and Dysmorphology - Data Management and Integration Hub (U01)  4/05/13 RFA-DE-14-005 Steven Scholnick
301-594-3977
8/22/13
Microbiology
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Innovative Approaches and Technologies for Examining the Uncultivable Bacteria of the Oral Microbiota (R01)   5/20/13 RFA-DE-14-003 R. Dwayne Lunsford
301-594-2421
9/18/13
Research Mechanisms
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
NIH Administrative Supplements to Recover Losses Due to Hurricane Sandy Under the Disaster Relief Appropriations Act - Non-Construction (Admin Supp)  4/15/13 RFA-OD-13-199 Lillian Shum
301-594-0618
6/12/13; 9/27/13

 NOTICES

Title NIH
Guide
Notice Number
NIH Announces an Adjustment to Transition Timeline for Electronic Submission of Multi-Project Applications 5/30/13 NOT-OD-13-075
NIH to Require Use of Updated Electronic Application Forms for Due Dates on or after September 25, 2013 5/30/13 NOT-OD-13-074
HHS Reissues PHS 2013-02 SBIR and STTR Omnibus Grant Solicitations Implementing Venture Capital Provision and SBA Company Registry Requirement of the SBIR/STTR Reauthorization Act of 2011 5/30/13 NOT-OD-13-071
Reminder of Lobbying Prohibition on Federal Funds for All NIH-Supported Institutions 5/24/13 NOT-OD-13-072
NIH Fiscal Policy for Grant Awards - FY 2013 5/08/13 NOT-OD-13-064
NIH Reminds Grantee Institutions of the Requirement to Use the Research Performance Progress Report (RPPR) for All SNAP and Fellowship Progress Reports for Awards with Start Dates On or After July 1, 2013   4/19/13 NOT-OD-13-061
Notice of Clarification of the Funded Extension Option in RFA-OD-13-199 "NIH Administrative Supplements to Recover Losses Due to Hurricane Sandy Under the Disaster Relief Appropriations Act -Non-Construction (Admin Supp)"  4/17/13 NOT-OD-13-060
Discontinuation of Form Using the 1977 Office of Management and Budget (OMB) Racial Standards  4/16/13 NOT-OD-13-058
Notice Regarding Upcoming Changes in Eligibility for PAR-12-283 "NIDCR Dentist Scientist Pathway to Independence Award (K99/R00)" 4/11/13 NOT-DE-13-004
Reminder of NIH's Policy for Handling Electronic System Issues that Threaten On-Time Grant Application Submission  4/09/13 NOT-OD-13-054
FAQs for Costing of NIH-Funded Core Facilities 4/08/13 NOT-OD-13-053
Notice of Information on the Reissuance of Funding Opportunity Announcement "NIH Pathway to Independence Award (Parent K99/R00) 3/22/13 NOT-OD-13-050

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National Institute of Dental and Craniofacial Research
National Institutes of Health
Bethesda, MD 20892-2190
301-496-4261

Department of Health and Human Services (HHS)   National Institutes of Health (NIH)   USA.gov