News from NIDCR (National Institute of Dental and Craniofacial Research, NIH)

E-Newsletter: September 27, 2013

In this Issue:


NIDCR News

NIDCR 2014-2019 Strategic Plan Update  
NIDCR Strategic Plan iconDevelopment of the NIDCR 2014-2019 Strategic Plan continues. In June, NIDCR hosted two roundtable discussions as part of the Strategic Planning process. One focused on fostering bidirectional communication between clinicians and researchers, exploring strategies to allow observations about the nature and progression of disease made in the course of patient care and clinical research to stimulate new basic research investigations. Participants discussed individual experiences with bidirectional research, areas of research that are ripe for the application of bidirectional approaches, devising models for such research, and NIDCR’s role in its facilitation. The other focused on health disparities, a critical area because of persistent disparities in the health status of underserved Americans. The health disparities roundtable summary is found at:
http://go.usa.gov/DnaV
The bidirectional research roundtable summary may be viewed at:
http://go.usa.gov/DnCk

In addition, an online Request for Information was posted on the NIDCR website from July 18 -September 20, providing an opportunity for all stakeholders – including clinicians, researchers, educators, patients, advocates, and members of the public – to share their opinions about areas of research emphasis, future research approaches, and needs and opportunities.  An NIDCR  Strategic Plan Steering Committee has now been formed that will assess the comments received and provide input into the development of the Plan. The initial framework of the Strategic Plan will be completed by fall 2013, and the final Plan will be released in early 2014. 

NIDCR Director's Report to the National Advisory Dental and Craniofacial Research Council Provides NIDCR/NIH Snapshot
To learn about NIDCR programmatic news and activities, the budget, recent science advances, and NIH highlights, read the report the NIDCR Director presented at the September 9, 2013 meeting of the National Advisory Dental and Craniofacial Research Council:
http://go.usa.gov/DfNT

Roundtable on the Temporomandibular Joint in Health and Disease
On May 3rd, NIDCR sponsored a roundtable meeting on the biology of the temporomandibular joint, together with the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute of Biomedical Imaging and Bioengineering.  The meeting brought together scientists with expertise in areas related to the structures and tissues of the temporomandibular joint to explore new research approaches to advance our understanding of temporomandibular joint function.  The goal was to provide a set of research recommendations to the scientific community that will develop and create a path forward in contemporary, multidisciplinary research on temporomandibular joint function in health and disease. See the research recommendations and meeting summary:
http://go.usa.gov/DnYT   

Bill Gates to Present 2013 David E. Barmes Bill GatesGlobal Health Lecture
Bill Gates, co-chair and trustee of the Bill & Melinda Gates Foundation, will deliver the annual David E. Barmes Global Health Lecture on Monday, October 7th, at 1:00 p.m. in the Masur Auditorium on the NIH campus in Bethesda, MD.  The title of his lecture is, "Why the Future Needs Biomedical Innovation."  While on the NIH campus, he also will meet with senior leadership, including NIDCR Director Martha Somerman.

The Barmes Lecture will be videocast at:
http://videocast.nih.gov

Known for his philanthropy, Mr. Gates advocates for research and innovation to help people live healthy and productive lives.  He also is an outspoken supporter of federal investment in basic science research.

In 2000, he and his wife established the Bill & Melinda Gates Foundation to improve international public health through the development of vaccines, therapies, diagnostics, agricultural products, and other technologies.  The foundation partners with the private and public sectors to ensure that those technologies can be delivered successfully to the people who need them.  In the U.S., the Gates Foundation supports innovations that improve public education.  To date, the Gates Foundation has invested $27.6 billion in grants.
 
The David E. Barmes Global Health Lecture Series honors the late David Edward Barmes, special expert for international health at the NIDCR.  The lecture series is sponsored by the NIDCR and the Fogarty International Center.  Read more:
http://go.usa.gov/DVVC

Register Now for "Science and Dentistry in Action: Leading the Way Towards Better Health"
Male and female researcherNIDCR, the Delta Dental Plans Association, and the Institute for Oral Health are joining forces to bring together top researchers and clinicians for a day of interactive learning and stimulating discussion of current areas of dental science and practice.  "Science and Dentistry in Action: Leading the Way Towards Better Health" will take place November 14-15 in Bethesda, Maryland. Be there to learn, share your thoughts, and take home knowledge of how new and exciting developments in science and technology are improving oral health.  Program participants will have the opportunity to discuss and explore the scientific rationale/underpinnings of clinical issues commonly encountered in dental practice; identify dental preventive, diagnostic, or treatment modalities for which better evidence and clinical-decision tools could be developed; identify areas requiring more in-depth basic research; and discuss emerging new tools and technologies with the potential to improve dental practice and patient outcomes.

Conference participants will receive 5 Continuing Education Credits.  To view the agenda and register, go to: 
http://www.cvent.com/d/w4q79f

Applications Accepted for NIDCR Dental Public Health Residency Program
NIDCR is accepting applications October 1- December 31, 2013 for its Residency Program in Dental Public Health. The 12-month full-time or 12-month equivalent part-time program provides a formal training opportunity for dentists planning careers in dental public health with an emphasis on oral and craniofacial, health-related epidemiologic research. The Residency Program is accredited by the Commission on Dental Accreditation of the American Dental Association. Program graduates receive a certificate of completion and are qualified educationally to apply for examination by the American Board of Dental Public Health for specialty certification.

While emphasizing research training and oral disease prevention and health promotion, the residency also provides experience in other areas of dental public health, i.e. public health administration and management, the organization and financing of dental care programs, and the development of resources. Residents develop an individualized training plan that describes activities to be undertaken during the residency and conduct at least one research project under the guidance of NIDCR staff and other qualified mentors. The application and additional information are found at:
http://go.usa.gov/8J4


NIH Funds Six Grants to Fund Next Generation Dental Composite
Scanning electron micrograph of generic composite fillerNIDCR has awarded $2.8 million this year for six research projects to pursue a longer-lasting dental composite. The six projects, each funded for five years, will allow a select group of scientists around the country to work independently toward the common goal of doubling the service life of dental composites. In the U.S., dentists currently place more than 122 million dental composites per year. But they fail on average in less than eight years and must be replaced, often with another dental composite.  The research projects will team for one of the first times material scientists, polymer chemists, and microbiologists. Another possible area of study will be to characterize whether the natural enzymes in saliva also play a role in degrading restorative dental materials.  Read more:
http://go.usa.gov/Dv4h

Dr. Janice Lee Appointed NIDCR Intramural Deputy Clinical Director
Janice Lee, D.D.S., M.D., M.S.Janice S. Lee, D.D.S., M.D., M.S., is the new Deputy Clinical Director in the Division of Intramural Research at NIDCR.  A board-certified oral and maxillofacial surgeon, she comes to NIDCR from the University of California, San Francisco, where she was an associate professor of Clinical Oral and Maxillofacial Surgery in the School of Dentistry. She was promoted to full professor on July 1st.  Her extensive research interests include bone regeneration and stem cell biology, craniofacial congenital anomalies, fibrous dysplasia, and McCune-Albright syndrome. Dr. Lee earned her D.D.S. from the UCLA School of Dentistry in 1994, and also received her M.S. there.  She then headed to Harvard Medical School, where she earned her M.D. in 1997. Dr. Lee also completed a two-year research fellowship in NIDCR's Craniofacial and Skeletal Diseases Branch.


 

NIH News

NIH Commits $24 Million Annually for Big Data Centers of Excellence
NIH will fund up to $24 million per year for four years to establish six to eight investigator-initiated Big Data to Knowledge Centers of Excellence. The centers will improve the ability of the research community to use increasingly large and complex datasets through the development and distribution of innovative approaches, methods, software, and tools for data sharing, integration, analysis and management. The centers will also provide training for students and researchers to use and develop data science methods.  NIH launched the Big Data to Knowledge (BD2K) initiative in December. This initiative supports research, implementation, and training in data science that will enable biomedical scientists to capitalize on the transformative opportunities that large datasets provide. The investigator-initiated BD2K Center of Excellence funding opportunity is the first of several BD2K funding opportunities that will be announced in coming months. Applications are due November 20, 2013.  Additional details about the initiative are found at:
http://bd2k.nih.gov

NIH's New Neuroscience Research Center to Open Soon
NIH's John Edward Porter Neuroscience Research Center will soon be opening. The building will officially be dedicated on October 21-22 with a  ceremony and two-day symposium commemorating the event.  
 
NIH, Lacks Family Reach Understanding to Share Genomic Data on HeLa Cells
Henrietta LacksNIH announced in Nature on August 7th that it has reached an understanding with the family of the late Henrietta Lacks to allow biomedical researchers controlled access to the whole genome data of cells derived from her tumor, commonly known as HeLa cells. These cells have already been used extensively in scientific research and have helped make possible some of the most important medical advances of the past 60 years. These include the development of modern vaccines, cancer treatments, in vitro fertilization techniques, and many others.

Mrs. Henrietta Lacks, an African-American woman who was 31 at the time of her death, was being treated for cervical cancer at Baltimore’s Johns Hopkins Hospital in 1951. Cells were extracted from the biopsy of her tumor sample for use in research without her knowledge or consent. At the time, there were no federal regulations or restrictions on the use of patients’ cells in research. Although Lacks died shortly afterwards from her aggressive disease, scientists were able to keep her cancer cells alive and replicating under laboratory conditions. The understanding reached with the Lacks family respects their wishes to enable scientific progress while ensuring public acknowledgement of the enormous contribution made by Henrietta Lacks. Read more about the agreement:
http://www.nih.gov/news/health/aug2013/nih-07.htm

NIH Encourages Institutions to Develop Individual Development Plans for Graduate Students and Postdoctoral Researchers
NIH is encouraging institutions to assist graduate students and postdoctoral researchers (scholars, trainees and fellows, and individuals in other postdoctoral positions) to achieve their career goals within the biomedical research workforce through the use of Individual Development Plans (IDPs).  Institutions are encouraged to report on this in all progress reports submitted on or after October 1, 2014, using the Research Performance Progress Report.  NIH does not expect institutions to include the actual IDPs; instead the report should outline current practices that document that IDPs are used to help manage the training for graduate students and postdoctoral researchers. See the related Notice:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-13-093.html  

The recommendation to develop IDPs stems from the Working Group of the Advisory Committee to the NIH Director, which recently completed a study of the future of the biomedical research workforce in the U.S. The working group made recommendations about funding and training of graduate students and postdoctoral researchers to attract and retain the best and most diverse students, engineers and physicians from around the world.  A goal of the working group was also to better prepare biomedical graduate students and postdoctoral scientists to successfully participate in a broad-based and evolving economy.  

Apply Now for the NIH Loan Repayment Programs
Applications are now being accepted through November 15 for the 2014 NIH Loan Repayment Programs (LRPs). The LRPs encourage outstanding health professionals to pursue careers in biomedical, behavioral, social, and clinical research. In exchange for committing at least two years to conducting qualified research funded by a domestic nonprofit organization or U.S. federal, state, or local government entity, NIH may repay up to $35,000 of qualified student loan debt per year, including most undergraduate, graduate, and medical school loans. Loan repayment benefits are in addition to the institutional salary received for research. The five extramural Loan Repayment Programs include Clinical Research, Pediatric Research, Health Disparities Research, Contraception and Infertility Research, and Clinical Research for Individuals from Disadvantaged Backgrounds. Additional details are found at:
http://www.lrp.nih.gov/index.aspx

NIH Offers Funding Opportunities for High Risk-High Reward Research
To enhance support for high risk-high reward research, the NIH Common Fund offers several unique funding opportunities for scientists with exceptional creativity who propose highly innovative approaches to major contemporary challenges in biomedical research.  The following programs are accepting applications:

NIH Director's Early Independence Awards (DP5)
Early Independence Awards logoEarly Independence Awards enable exceptional junior scientists to accelerate their entry into an independent research career by forgoing the traditional postdoctoral training period. For these select investigators who have established a record of scientific innovation and research productivity and who have demonstrated unusual leadership, drive, and maturity, postdoctoral training would unnecessarily delay their entry into performing independent research.  At the time of application, the Early Independence Award candidate must be within 12 months before or after the completion of their medical residency (or equivalent training).  Letters of intent are due by December 31, 2013; applications are due by January 31, 2014.  See the announcement:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-009.html    


NIH Director's New Innovator Awards (DP2)
New Innovator Award logoNew Innovator Awards support a small number of early stage investigators who propose highly innovative new research approaches with the potential to produce a major impact on broad, important problems in biomedical and behavioral research.  Applications will be accepted from September 25 - October 25, 2013; September 17, 2014 - October 17, 2014; and September 16, 2015 - October 16, 2015.  NIH intends to commit approximately $80 million for approximately 33 awards in each of the fiscal years 2014-2016.  See the announcement:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-007.html 


NIH Pioneer Awards (DP1) 

Pioneer Awards support individual scientists of exceptional creativity who propose pioneering and possibly transforming approaches to addressing major biomedical or behavioral challenges. To be considered pioneering, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigator's research program or elsewhere.  Applications will be accepted September 18-October 18, 2013; September 10, 2014-October 10, 2014; and September 9, 2015 - October 9, 2015.  See the announcement:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-006.html 









SCIENCE ADVANCES


Minimally Invasive
The videoscopeIn a preview of possible things to come, researchers report on a technological advance to make minimally invasive surgery a more realistic option for advanced periodontal disease:
http://go.usa.gov/DvTW






One, Two, Three
Aggregatibacter actinomycetemcomitants (Aa)An oral bacterium once thought to cause Localized Aggressive Periodontitis doesn’t act alone. A new study shows the bacterium relies on help from at least two of its microbial friends:
http://go.usa.gov/DvTd










Making Fish Faces
ThFishFacee minnow-like zebrafish is one of modern science’s model organisms of choice to define the biology of craniofacial development in vertebrates, including people. The FishFace Atlas, a free, NIDCR-supported resource for scientists, shows how and why this is so:
http://go.usa.gov/DvTF







Running Interference
RAcinar cellsadiation-induced dry mouth is a major side effect of radiation therapy for head and neck cancers.  NIDCR supported scientists report early success in mice at reducing this side effect using nanoparticles and a targeted short-interfering RNA: 
http://go.usa.gov/Dvb3






FUNDING OPPORTUNITY NEWS

PROGRAM ANNOUNCEMENTS

Behavioral/Social Science Research
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) 8/02/13 PA-13-288

Ruth Nowjack-Raymer
301-594-5394

9/08/16
Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01) 8/02/13 PA-13-292

Ruth Nowjack-Raymer
301-594-5394

9/08/16
Health Disparities
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) 8/02/13 PA-13-288

Ruth Nowjack-Raymer
301-594-5394

9/08/16
Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01) 8/02/13 PA-13-292

Ruth Nowjack-Raymer
301-594-5394

9/08/16
Research Mechanisms
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Small Grant Program for New Investigators (R03) 9/11/13 PAR-13-348 Amanda Melillo
301-594-9718
9/08/16
Academic Research Enhancement Award (Parent R15) 9/11/13 PA-13-313

Alicia Dombroski
301-594-4805

9/08/16
NIH Support for Conferences and Scientific Meetings (Parent R13/U13) 9/11/13 PA-13-347

Alicia Dombroski
301-594-4805

9/08/16
Research Project Grant (Parent R01)                                                8/02/13 PA-13-302 Lillian Shum
301-594-0618;
Jane Atkinson
301-435-7908;
Emily Harris
301-594-4846;
Melissa Riddle
301-451-3888;
Lynn King
301-594-5006
9/08/16
NIH Exploratory/Developmental Research Grant Program (Parent R21) 8/02/13 PA-13-303 Lillian Shum
301-594-0618;
Jane Atkinson
301-435-7908;
Emily Harris
301-594-4846;
Melissa Riddle
301-451-3888;
9/08/16
Research Supplements
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NLM Administrative Supplements for Informationist Services in NIH-funded Research Projects (Admin Supp) 7/19/13 PA-13-276 Contact the program
officer assigned to the
parent grant
11/06/13

REQUESTS FOR APPLICATIONS
Behavioral/Social Research
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Tobacco Control Regulatory Research (R01) 6/20/13 RFA-OD-13-011 David Clark
301-594-4814
1/15/14; 6/17/14; 1/16/15
Tobacco Control Regulatory Research (R03) 6/20/13 RFA-OD-13-012 David Clark
301-594-4814
1/15/14; 6/17/14; 1/16/15
Tobacco Control Regulatory Research (R21) 6/20/13 RFA-OD-13-010 David Clark
301-594-4814
1/15/14; 6/17/14; 1/16/15
Career Development Awards
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Pathway to Independence Award in Tobacco Control Regulatory Research (K99/R00) 6/28/13 RFA-OD-13-016 Lynn Mertens King
301-594-5006
10/02/13
Mentored Clinical Scientist Research Career Development Award in Tobacco Control Regulatory Research (K08) 6/28/13 RFA-OD-13-013 Lynn Mertens King
301-594-5006
10/02/13
Clinical Research & Epidemiology/Clinical Trials 
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Rare Diseases Clinical Research Consortia (RDCRC) for Rare Diseases Clinical Research Network (U54) 8/14/13 RFA-TR-13-002 Jane Atkinson
301-435-7908

11/07/13
Computational Science
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Centers of Excellence for Big Data Computing in the Biomedical Sciences (U54)  7/22/13 RFA-HG-13-009 Steven Scholnick
301-594-3977
11/20/13
NIH Roadmap Initiatives
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Development of a Knowledge Management Center for Illuminating the Druggable Genome (U54) 9/16/13 RFA-RM-13-011

Alicia Dombroski
301-594-4805

12/11/13
Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01) 9/16/13 RFA-RM-13-010

Alicia Dombroski
301-594-4805

12/11/13
NIH Director's Early Independence Awards (DP5) 8/14/13 RFA-RM-13-009 Dede Rutberg
301-594-4798
1/31/14
NIH Director's New Innovator Award Program (DP2) 8/08/13 RFA-RM-13-007

Alicia Dombroski
301-594-4805

10/25/13; 10/17/14; 10/16/15
NIH Pioneer Award Program (DP1) 8/08/13 RFA-RM-13-006

Alicia Dombroski
301-594-4805

10/18/13; 10/10/14; 10/09/15
NIH Transformative Research Awards (R01) 7/26/13 RFA-RM-13-008

Alicia Dombroski
301-594-4805

10/04/13

 NOTICES

Title NIH
Guide
Notice Number
New Program Certifications Required for SBIR and STTR Awards 9/17/13 NOT-OD-13-116
Notice of Intent to Reissue the Funding Opportunity Announcement "Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (Parent T32)  9/17/13 NOT-OD-13-115
Availability of a Test (Beta) Version of the Science Experts Network (SciENcv) 9/17/13 NOT-OD-13-114
NIH Opens the Research Performance Progress Report (RPPR) Phase II Pilot to Federal Demonstration Partnership Members 9/12/13 NOT-OD-13-113
NIH Domestic Awards to Transition to Payment Management Systems Subaccounts in FY 2014 9/03/13 NOT-OD-13-112
NIH to Transition Payment for Individual Fellowships at Foreign and Federal Sponsoring Institutions, and Awards to Federal Institutions to Payment Management System Subaccounts in FY 2014  9/03/13 NOT-OD-13-111
Notice of Clarification to NIH Policy on Mitigating Risks of Life Sciences Dual Use Research of Concern 8/30/13 NOT-OD-13-110
NIH Offers Niche Assessment Program to SBIR and STTR Phase I Awardees 8/28/13 NOT-OD-13-109
Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2014-1) Now Available  8/28/13 NOT-OD-13-108
NIH Policy on Mitigating Risks of Life Sciences Dual Research of Concern 8/28/13 NOT-OD-13-107
Notice of Special Terms and Conditions for NIH Hurricane Sandy Recovery Awards 8/28/13 NOT-OD-13-106
Notice of NIH Guidance on the Family Acknowledgement and Use of HeLa Cell Whole Genome Sequence Data 8/14/13 NOT-OD-13-099
Grant and Contract Submission Requirements Regarding the AVMA Guidelines for the Euthanasia of Animals: 2013 Edition 8/07/13 NOT-OD-13-098
Extension of eRA Commons User IDs to Individuals in Graduate and Undergraduate Student Project Roles with Measurable Effort on an NIH Annual Progress Report (PHS2590 & RPPR)  8/02/13 NOT-OD-13-097
Implementation of the Revised International Guiding Principles for Biomedical Research Involving Animals 8/02/13 NOT-OD-13-096
Now Available: PHS 398 Application Forms and Instructions for Application Due Dates on or after September 25, 2013 and Updated Application Guides for Electronic Application Forms 7/26/13 NOT-OD-13-091
Modifications to NIH's Planned and Cumulative Inclusion Enrollment Forms 7/26/13 NOT-OD-13-092
NIH Encourages Institutions to Develop Individual Development Plans for Graduate Students and Postdoctoral Researchers 7/23/13 NOT-OD-13-093
Request for Information (RFI): The National Institute of Dental and Craniofacial Research (NIDCR) Request for Information on the 2014-2019 Strategic Plan 7/22/13 NOT-DE-13-005
Public Comments on Implementation of the Updated AVMA Guidelines for the Euthanasia of Animals: 2013 Edition 7/22/13 NOT-OD-13-090
Notice Announcing Pre-Application Webinar and FAQ page for Career Awards in Tobacco Control Regulatory Research (K08, K01, K22 & K99/R00) 7/16/13 NOT-OD-13-088
Extramural Loan Repayment Program for Health Disparities (LRP-HDR) 7/16/13 NOT-OD-13-085
Extramural Loan Repayment Program for Pediatric Research (LRP-PR) 7/16/13 NOT-OD-13-083
Extramural Clinical Research Loan Repayment Program for Clinical Researchers from Disadvantaged Backgrounds (LRP-IDB) 7/16/13 NOT-OD-13-082
Extramural Loan Repayment Program for Clinical Researchers (LRP-CR) 7/16/13 NOT-OD-13-081
NIH Anticipates Transition to Payment Management System Subaccounts in FY 2014 7/03/13 NOT-OD-13-079
Request for Information (RFI): Inviting Comments and Suggestions on the Health and Health Research Needs, Specific Health Issues and Concerns for Lesbian, Gay, Bisexual, Transgender, and Intersex (LGBTI) Populations 6/27/13 NOT-OD-13-076
Announcement of Agency Decision: Recommendations on the Use of Chimpanzees in NIH-Supported Research 6/26/13 NOT-OD-13-078
Notice of Change to Earliest Start Date for Applications Submitted to RFA-DA-14-002 "Short-term Mentored Career Enhancement Awards in the Basic Behavioral and Social Sciences: Cross-Training at the Intersection of Animal Models and Human Investigation (K18)" 6/24/13 NOT-DA-13-040

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National Institute of Dental and Craniofacial Research
National Institutes of Health
Bethesda, MD 20892-2190
301-496-4261

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