News from NIDCR (National Institute of Dental and Craniofacial Research, NIH)

E-Newsletter: October 2, 2012

In this Issue:

 


 

NIDCR News

Development of Proposed Research Initiatives for FY2014
hands on keyboardAs part of the budget planning process for Fiscal Year 2014, NIDCR identified topical themes for development into research initiatives.  During the planning process, NIDCR welcomed input from our scientific advisory boards, the extramural community, interested organizations, and the public at large. The proposed NIDCR FY2014 research themes included:


  • Developing a Multi-disciplinary Oral Health Research Workforce
  • Development and Characterization of Animal Models for Studying Osteonecrosis of the Jaw
  • Epigenomics of Viral Associated Oral Diseases
  • Establishing Measures of Clinical Outcomes and Mechanisms of Action of Behavioral Interventions for Clinical Trials and Studies of Oral and Craniofacial Diseases and Conditions
  • Functional Characterization of Oral Cancer Initiating Cells
  • Osteoimmunomodulation for Oral Bone Healing and Regeneration
  • The Role of Uncultivable Bacteria in the Oral Microbiome

NIDCR would like to thank all who provided input, and is pleased to announce that considerably more comments were received than in previous years. Comments were supportive, positive, detailed, and often provided recommendations to modify, or augment proposed themes. NIDCR is still in the early planning stages for the fiscal year 2014 initiatives.  It is important to note that initiatives are not a complete picture of the Institute’s planned research portfolio for the year indicated, nor do they signal that themes highlighted the previous year have been abandoned.  Several initiatives from last year have become formal funding opportunities and are posted on NIDCR’s website: http://www.nidcr.nih.gov/GrantsAndFunding/
Proposed FY 2014 Initiatives will be integrated into this larger landscape as they are considered for funding.

Dr. Margherita Fontana Receives Prestigious PECASE Award
Margherita Fontana, D.D.S., Ph.D.
Margherita Fontana, D.D.S., Ph.D., from the University of Michigan School of Dentistry, is one of 20 NIH-supported researchers selected to receive the prestigious Presidential Early Career Award for Scientists and Engineers (PECASE). The award is the highest honor bestowed by the U.S. government to outstanding scientists and engineers beginning their independent careers.

Dr. Fontana, who is an associate professor in the Department of Cariology, Restorative Sciences and Endodontics at Michigan's dental school, was recognized for her studies on predicting caries risk for underserved toddlers in primary health care settings. 

Awardees were honored by President Barack Obama at a White House ceremony.

Applications Now Accepted for NIDCR Dental Public Health Residency Program
Evelyn Lucas-Perry, D.D.S., M.P.H, and Ronke Akinkugbe, B.D.S., M.P.H. NIDCR is accepting applications through December 31, 2012 for its Residency Program in Dental Public Health.  The 12-month full-time or 12-month equivalent part-time program provides a formal training opportunity for dentists planning careers in dental public health with an emphasis on oral and craniofacial, health-related epidemiologic research.  The Residency Program is accredited by the Commission on Dental Accreditation of the American Dental Association.  Program graduates receive a certificate of completion and are qualified educationally to apply for examination by the American Board of Dental Public Health for specialty certification. 

While emphasizing research training and oral disease prevention and health promotion, the residency also provides experience in other areas of dental public health, i.e. public health administration and management, the organization and financing of dental care programs, and the development of resources.  Residents develop an individualized training plan that describes activities to be undertaken during the residency and conduct at least one research project under the guidance of NIDCR staff and other qualified mentors.  The application and additional information are found at:
http://go.usa.gov/8J4

A Unique Training Program: NIDCR Clinical Research Fellowship
James E. Melvin, D.D.S., Ph.D.
NIDCR recently held a ribbon-cutting ceremony to mark a new start and look for the NIDCR Dental Clinic, located in NIH's Clinical Center.  Among the new faces are a D.D.S./M.D. and three D.D.S./Ph.D. students participating in the NIDCR Clinical Research Fellowship.  Read NIDCR's Science Spotlight interview with Dr. James E. Melvin, D.D.S., Ph.D., NIDCR Clinical Director, about the latest progress at the clinic and his vision for the revived fellowship program:
http://go.usa.gov/Yx5H


NIH News

NIH Invites Pioneer Award and New Innovator Award Proposals
Pioneer Award logo
NIH is accepting proposals for the 2013 NIH Director's Pioneer Awards and New Innovator Awards, which support innovative approaches to major challenges in biomedical or behavioral research.

To be considered for a Pioneer Award, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigator’s research program or elsewhere.  Applications are due by October 9, 2012.  NIH intends to commit approximately $6 million for at least 7 awards in fiscal year 2013. The number of awards is contingent upon NIH appropriations, the submission of a sufficient number of meritorious applications, and the availability of funds.  See additional details:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-015.html 

The NIH Director's New Innovator Award addresses two important goals: stimulating highly innovative research and supporting promising new investigators. New investigators may have exceptionally innovative research ideas, but not the preliminary data required to fare well in the traditional NIH peer review system. As part of NIH's commitment to increasingNew Innovator Award logo opportunities for new scientists, the NIH Director's New Innovator Award program was started to support exceptionally creative new investigators who propose highly innovative research projects that have the potential for unusually high impact. This award complements ongoing efforts by NIH to fund new investigators through R01 grants and other mechanisms.  Applications are due by October 17, 2012.  NIH intends to commit approximately $80 million for approximately 33 awards in FY 2013. The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. See additional details:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-016.html

Applications Now Being Accepted for NIH Loan Repayment Programs
Young female researcher in lab
Applications are now being accepted through November 15 for the 2013 NIH Loan Repayment Programs (LRPs).  The LRPs encourage outstanding health professionals to pursue careers in biomedical, behavioral, social, and clinical research. In exchange for committing at least two years to conducting qualified research funded by a domestic nonprofit organization or U.S. federal, state, or local government entity, NIH may repay up to $35,000 of qualified student loan debt per year, including most undergraduate, graduate, and medical school loans. Loan repayment benefits are in addition to the institutional salary received for research.  The five extramural Loan Repayment Programs include Clinical Research, Pediatric Research, Health Disparities Research, Contraception and Infertility Research, and Clinical Research for Individuals from Disadvantaged Backgrounds.  Additional details are found at:
http://www.lrp.nih.gov/index.aspx

Apply Now for the Medical Research Scholars Program
Young male researcher
October 1st is the start of the application cycle for the 2013-2014 NIH Medical Research Scholars Program (MRSP).  The MRSP is a year-long enrichment program for research-oriented medical, dental, and veterinary students designed to provide mentored training on the NIH campus. The program enables scholars to engage in a basic, clinical, or translational research project that matches their personal interests and research goals. In addition, MRSP scholars attend courses, seminars, a structured lecture series and clinical teaching rounds, and present their research over the course of the academic year to the NIH community and at professional conferences.  Each scholar has an assigned tutor (advisor) and works under the guidance of a research mentor.  Candidates must be U.S. citizens or permanent residents.  A stipend is provided.  

NIH selected a talented pool of 45 medical, dental, and veterinary students representing 34 different U.S.-accredited universities for its inaugural MRSP class (2012-2013).  Four of the scholars are dental students.  The goal is to eventually have a capacity of 70 students in the program.

For additional information about the MRSP program and to apply see:
http://clinicalcenter.nih.gov/training/mrsp/

NIH Opens Pathways for Collaborations between Intramural and Extramural Investigators
NIH Clinical CenterNIH is taking steps to expand engagement with extramural investigators interested in collaborating with intramural researchers to use the unique resources of the NIH Clinical Center. 

A new grant program, Opportunities for Collaborative Research at the NIH Clinical Center will support these partnerships:
http://grants.nih.gov/grants/guide/notice-files/NOT-HD-12-025.html.
In addition, extramural investigators may access Clinical Center resources through previously existing formal funding relationships, such as contracts, grants, and cooperative agreements.  Until now, the Clinical Center has served exclusively the NIH Intramural Research Program.

The Clinical Center has launched a new website illustrating the hospital's research resources, such as its metabolic unit, pharmaceutical development capabilities, and advanced research-related radiology imaging services:
http://clinicalcenter.nih.gov/translational-research-resources/index.html
The website offers a toolkit that outlines steps for extramural researchers interested in working with NIH intramural investigators to use the Clinical Center and its research infrastructure.

NIH Announces New Program in Metabolomics
NIH will invest $14.3 million this year, potentially investing more than $51.4 million over five years, to accelerate the emerging field of biomedical research known as metabolomics. Metabolomics is the study of small molecules called metabolites, found within cells and biological systems. Metabolites are produced or consumed in the chemical reactions that take place in the body to sustain life. The awards are supported by the NIH Common Fund.

Three Regional Comprehensive Metabolomics Resource Cores have been awarded from the first round of applications, with the potential to award 2-3 additional at a later date. The cores, which will increase the national capacity to provide metabolomics profiling and data analysis services to investigators, are located at the University of Michigan, the University of California, Davis, and the Research Triangle Institute in Research Triangle Park, N.C.  In addition, NIH is funding a data repository and Coordination Center (DRCC) at the University of California, San Diego. 

Dr. Christopher Austin Named Director, National Center for Advancing Translational Sciences
Christopher P. Austin, M.D.Christopher P. Austin, M.D., will serve as director of NIH’s newest center, the National Center for Advancing Translational Sciences (NCATS).  NIH Director Francis S. Collins made the announcement at the inaugural meetings of the NCATS Advisory Council and Cures Acceleration Network Review Board.   

Dr. Austin had been serving as director of NCATS’ Division of Pre-Clinical Innovation since the NCATS launch in December 2011.  A developmental neurogeneticist by training, he came to NIH in 2002 from Merck, where his work focused on genome-based discovery of novel targets and drugs.  He began his NIH career as senior advisor to the director for translational research at the National Human Genome Research Institute, where he initiated the Knockout Mouse Project and the Molecular Libraries Roadmap Initiative.  Other NIH roles have included serving as director of the NIH Therapeutics for Rare and Neglected Diseases program and the NIH Chemical Genomics Center, and as scientific director of NIH’s Center for Translational Therapeutics.   

Dr. Janine Clayton Appointed Director, Office of Research on Women’s Health
Janine A. Clayton, M.D.Janine A. Clayton, M.D., has been appointed Director for the Office of Research on Women’s Health (ORWH) and Associate Director for Research on Women's Health, NIH. Dr. Clayton has been serving as ORWH Acting Director since the retirement of Vivian Pinn, M.D., in August 2011. Prior to her tenure as Acting Director, Dr. Clayton was the ORWH Deputy Director for three years. She currently co-chairs the NIH Working Group on Women in Biomedical Careers.  A board certified ophthalmologist, Dr. Clayton’s research interests include autoimmune ocular diseases, and the role of sex and gender in health and disease.

 

Renowned Researcher to Lead New Multidisciplinary Pain Program at NIH
Catherine Bushnell, Ph.D.Catherine Bushnell, Ph.D., an internationally recognized pain and neuroscience researcher, has been appointed scientific director of a new research program focusing on the role of the brain in perceiving, modifying and managing pain. Based in the NIH’s National Center for Complementary and Alternative Medicine, this collaborative effort will complement basic science and clinical research efforts of other ongoing intramural neuroscience, imaging and mental and behavioral health research programs.

 


SCIENCE ADVANCES

Building a Case for Biglycan
Agnes Berendsen, Ph.D. Here's a look inside an NIDCR lab, a glimpse at a budding research career, and a story about how decades of biglycan research are pointing to its potential in healing fractures and treating osteoporosis:
http://go.usa.gov/rPnP






FUNDING OPPORTUNITY NEWS

PROGRAM ANNOUNCEMENTS

Behavioral Research

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Tobacco Control Regulatory Research  - R01 8/23/12 PAR-12-267 David Clark
301-594-4814
1/17/15
Tobacco Control Regulatory Research - R03 8/23/12 PAR-12-268 David Clark
301-594-4814
1/17/15

Biotechnology/Regenerative Medicine/Biomaterials 

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Exploratory/Developmental Bioengineering Research Grants (EBRG) [R21] 9/11/12 PA-12-284 Nadya Lumelsky
301-594-7703
1/08/16
Cancer
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Specialized Programs of Research Excellence (SPORES) in Human Cancer for Years 2013 and 2014 (P50) 9/25/12 PAR-12-296 Sundar Venkatachalam
301-594-4812
9/24/14
Career Development
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Dentist-Scientist Pathway to Independence Award (K99/R00) 9/11/12 PAR-12-283 Leslie Frieden
301-496-4263
9/08/15
Research Mechanisms
Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Change of Grantee Organization (Type 7 Parent) 8/24/12 PA-12-270 Dede Rutberg
301-594-4798
8/16/15
Successor-in-Interest (Type 6 Parent) 8/24/12 PA-12-269 Dede Rutberg
301-594-4798
8/16/15


REQUESTS FOR APPLICATIONS

Behavioral
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Basic Social and Behavioral Research on Culture, Health, and Wellbeing (R24) 9/11/12 RFA-LM-12-002 David Clark
301-594-4814
12/17/12
Basic Behavioral Research on Multisensory Processing (R21) 8/31/12 RFA-EY-13-001 David Clark
301-594-4814
10/31/12
NIH Roadmap
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Development and Application of Systems Approaches for Analyzing the Impact of Genomic Variation on Tissue Transcriptomes (R01)  8/07/12 RFA-RM-12-019 Emily Harris
301-594-4846
11/21/12
2013 NIH Director's New Innovator Award Program (DP2) 8/07/12 RFA-RM-12-016 Alicia Dombroski
301-594-4805
10/17/12
2013 NIH Director's Pioneer Award Program (DP1) 8/07/12 RFA-RM-12-015 Alicia Dombroski
301-594-4805
10/09/12
Teeth and Bone
Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Design and Development of Novel Dental Composite Restorative Systems (U01) 9/12/12 RFA-DE-13-001 James Drummond
301-402-4243
1/31/13

 NOTICES

Title NIH
Guide
Notice Number
NIH Announces Plans to Transition to Electronic Submission of Multi-Project Applications 9/28/12 NOT-OD-12-161
Interim Guidance for Videos Submitted as NIH Application Materials 9/27/12 NOT-OD-12-141
Publication of the Revised NIH Grants Policy Statement (Rev. 10/1/2012): Policy Changes and Clarifications Notice 9/24/12 NOT-OD-12-157
Proactive Compliance Oversight Program - Financial Conflict of Interest Requirements for NIH-Supported Institutions  9/21/12 NOT-OD-12-159
Revised Pre- and Post-Award Forms and Instructions Available 9/20/12 NOT-OD-12-152
Review of Grants Information for Fiscal Year 2012 9/18/12 NOT-OD-12-155
Revision of the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines) to Include Synthetic Nucleic Acids and to Clarify Criteria for Section III-A-1-a Experiments 9/11/12 NOT-OD-12-150
Guidance on Departures from the Provisions of the Guide for the Care and Use of Laboratory Animals 9/10/12 NOT-OD-12-148
NIH Offers Niche Assessment Program to SBIR and STTR Phase I Awardees  8/31/12 NOT-OD-12-146
NIH Announces One-time Financial Conflict of Interest (FCOI) Reporting Guidance for Certain Fiscal Year 2012 Awards Issued on or After August 24, 2012  8/24/12 NOT-OD-12-143
Research Performance Progress Report (RPPR) Module and Training Webinar Available to NIH Grantees 8/23/12 NOT-OD-12-142
Notice of Pilot Processes for Submitting of Post-Award Relinquishing Statements to NIH 8/24/12 NOT-OD-12-132
Notice of Pilot for Processing Post-Award Changes in Grantee Organizational Status: Successor-in-Interest 8/24/12 NOT-OD-12-133
Notice of Pilot Processes for Post-Award Change of Grantee Organization Applications to NIH 8/24/12 NOT-OD-12-134
Notice of NIH Special Council Review of Research Applications from PDs/PIs With More than $1.0 Million Direct Costs in Annual NIH Support 8/20/12 NOT-OD-12-140
Notice of Change to Policies and Procedures for FY2013 NIH Awards to Foreign Institutions 8/17/12 NOT-OD-12-139
Notice of New Process for Requesting dbGaP Access to Aggregate Genomic Data for General Research Use Purposes 8/10/12 NOT-OD-12-136
Prior NIH Approval of Human Subjects Research in Active Awards Initially Submitted without Definitive Plans for Human Subjects Involvement (Delayed Onset Awards)  8/02/12 NOT-OD-12-130
Guidance on Changes That Involve Human Subjects in Active Awards That Will Require Prior NIH Approval 8/02/12 NOT-OD-12-129
Clarification: Time Limit on NIH Resubmission Applications  8/01/12 NOT-OD-12-128
Extramural Loan Repayment Program for Clinical Researchers (LRP-CR) 7/20/12 NOT-OD-12-123
Extramural Clinical Research Loan Repayment Program for Clinical Researchers from Disadvantaged Backgrounds (LRP-IDB) 7/20/12 NOT-OD-12-124
Extramural Loan Repayment Program for Pediatric Research(LRP-PR) 7/20/12 NOT-OD-12-125
Extramural Loan Repayment Program for Health Disparities Research (LRP-HDR) 7/20/12 NOT-OD-12-126
Notice of Change in the Directions for the Submission of Plans for Instruction in the Responsible Conduct of Research for NIDCR Institutional T32 and T90/R90 Applications in Response to PAR-10-171 and PAR-10-170   7/18/12 NOT-DE-12-002

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National Institute of Dental and Craniofacial Research
National Institutes of Health
Bethesda, MD 20892-2190
301-496-4261

Department of Health and Human Services (HHS)   National Institutes of Health (NIH)   USA.gov