News from NIDCR (National Institute of Dental and Craniofacial Research, NIH)

E-Newsletter: September 28, 2011

In this Issue:
1. NIDCR News
2. HHS/NIH News
3. Science Advances
4. Funding Opportunity News
5. NIDCR Personnel News


NIDCR News

NIDCR Welcomes New Director

Martha J. Somerman, D.D.S., Ph.D.The NIDCR is delighted to welcome Martha J. Somerman, D.D.S., Ph.D., as the eighth Director of the Institute. Dr. Somerman began her duties as NIDCR Director on August 29, 2011. She was officially sworn in by NIH Director Francis S. Collins at noon on August 31st. Dr. Somerman comes to the NIDCR from the University of Washington School of Dentistry, Seattle, where she served as dean since 2002.

After having been on the job for one month now, Dr. Somerman said she is thoroughly enjoying her new challenge as NIDCR Director.  She describes the NIDCR as "a very vibrant and exciting place with incredibly committed, knowledgeable and energized staff."

On September 19, Dr. Somerman led her first meeting of the National Advisory Dental and Craniofacial Research Council.  Read her Director's Report to Council:
http://go.usa.gov/8pT

Upcoming Lecture: Ambassador Eric Goosby to Present 2011 David E. Barmes Global Health Lecture

Eric Goosby, U.S. Global AIDS Coordinator Dr. Eric Goosby, U.S. Global AIDS Coordinator, will present the 2011 David E. Barmes Global Health Lecture on Tuesday, December 13 at 11:00 a.m. in Masur Auditorium (Bldg. 10) on the NIH campus.

Ambassador Goosby has over 25 years of experience with HIV/AIDS, ranging from his early years treating patients at San Francisco General Hospital when AIDS first emerged, to engagement at the highest level of policy leadership. As the leader of all U.S. government international HIV/AIDS efforts, he oversees implementation of the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), in addition to government participation with the Global Fund to Fight AIDS, Tuberculosis and Malaria. Together with the heads of the U.S. Agency for International Development and the Centers for Disease Control and Prevention, he also serves on the operations committee that leads the U.S. Global Health Initiative.

Jointly sponsored by NIDCR and the Fogarty International Center, the annual lecture series honors the late David E. Barmes, a longstanding World Health Organization employee, special expert for international health at NIDCR, and ardent spokesman for global health.


HHS/NIH News

HHS Tightens Financial Conflict of Interest Rules for Researchers

Federal RegisterHHS has issued an updated Final Rule on conflict of interest that provides a framework for identifying, managing, and ultimately avoiding investigators' financial conflicts of interest. NIH staff worked with HHS to revise the 1995 regulations to update and enhance the objectivity and integrity of the research process. The Final Rule was published August 25, 2011 in the Federal Register.

The revised regulations:

--Require investigators to disclose to their institutions all of their significant financial interests (SFI) related to their institutional responsibilities.
--Lower the monetary threshold at which significant financial interests require disclosure, generally from $10,000 to $5,000.
--Require institutions to report to the Public Health Service awarding component additional information on identified financial conflicts of interest and how they are being managed.
--Require institutions to make certain information accessible to the public concerning identified SFIs held by senior/key personnel.
--Require investigators to complete training related to the regulations and their institution's financial conflict of interest policy.

Additional details about the major changes to the regulations can be found at: http://grants.nih.gov/grants/FCOI_Final_Rule_inspection_Desk.pdf
Also see the Financial Conflict of Interest website:
http://grants.nih.gov/grants/policy/coi/

NIH-Commissioned Study Identifies Gaps in NIH Funding Success Rates for Black Researchers

Black applicants from 2000-2006 were 10 percentage points less likely than white applicants to be awarded research project grants from the NIH after controlling for factors that influence the likelihood of a grant award, according to an NIH-commissioned study in the journal Science. In an accompanying commentary, NIH Director Francis Collins, M.D., Ph.D., and Principal Deputy Director Lawrence Tabak, D.D.S, Ph.D., call the findings unacceptable and commit to immediate action by the NIH.

The study is part of a larger effort by NIH to examine and improve the diversity (including race, ethnicity, gender, age, disabilities, and socioeconomic status) of its funded biomedical research workforce. Also of concern to NIH is the low number of applications for NIH R01 grants from non-white applicants. Of the 40,069 individual applicants included in the 2000 to 2006 study, 1.5 percent self-identified as black or African-American (598), 3.3 percent as Hispanic (1,319), 13.5 percent as Asian (5,402), 71 percent as white (28,456), and 11 percent as other/unknown. These figures are consistent with data showing that the number of underrepresented populations in the fields of science and medicine remains small.

NIH has developed and is implementing a framework for action to: increase the number of early career reviewers, including those from underrepresented populations; examine the grant review process for bias and develop interventions; improve support for grant applicants; and gather expert advice on additional action steps. Dr. Collins' statement about diversity is found at:
http://www.nih.gov/about/director/08182011_statement_diversity.htm

Working Group on the Future Biomedical Research Workforce Seeks Input

Young female and male researcherThe working group established by the Advisory Committee to the NIH Director (ACD) to examine the future of the U.S. biomedical research workforce invites input from the extramural community to ensure a thorough and comprehensive evaluation of the issues involved.
Comments are sought from students, postdoctoral fellows, scientists, scientific societies, and NIH grantee institutions, as well as from the general public, and should be submitted electronically by October 7, 2011 to:
http://grants.nih.gov/grants/guide/rfi_files/bmw/add.cfm
Details about the request for input are available at:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-106.html

The working group, which will recommend actions to the ACD and the NIH Director, is charged with developing a model for a sustainable, diverse, and productive U.S. biomedical research workforce. The model will help inform decisions about how to train the optimal number of people for the appropriate types of positions that will advance science and promote health. 

NIH Launches Medical Research Scholars Program

NIH Clinical CenterA new Medical Research Scholars Program for medical and dental students will begin in September 2012 in Bethesda, Maryland, NIH has announced. The year-long program will offer research experiences with intramural investigators from across NIH in basic science laboratories, and in clinical and translational research conducted at the NIH Clinical Center. The program is made possible through a partnership with the Foundation for the National Institutes of Health supported by a grant from Pfizer Inc and contributions from the Howard Hughes Medical Institute. Program applications will be accepted October 1, 2011 through mid-January 2012. About 40 students are expected to be admitted during the program's first year. The goal is to accept up to 70 students as the program grows. Support for selected students will include a stipend and resources for education enrichment, such as travel to scientific meetings. Additional details are found at:
http://www.cc.nih.gov/training/mrsp/index.html

2012 NIH Director's Award Programs Now Accepting Applications

Transformative Research Award Program
NIH Transformative Award program logoNIH welcomes proposals for the NIH Director's Transformative Research Awards (R01).  The awards provide support for individual scientists or collaborative investigative teams who propose exceptionally innovative, original, and/or unconventional research, which, if successful, would have a major impact in a broad area of biomedical or behavioral research. To be considered transformative, projects must have the potential to create or overturn fundamental scientific paradigms through the use of novel approaches, or lead to major improvements in health through the development of highly innovative therapies, diagnostic tools, or preventive strategies.

The NIH Common Fund intends to commit $25 million in FY 2012 for this initiative.  Up to one-third of this budget will be reserved for projects exceeding $1 million dollars in direct costs per year.  Letters of intent are due by December 12, 2011; applications are due by January 12, 2012:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-006.html 
Read more about the Transformative Research Award Program:
http://commonfund.nih.gov/TRA/index.aspx 

Pioneer Award and New Innovator Award Programs
Pioneer Award program logoNIH also welcomes proposals for the 2012 NIH Director's Pioneer Awards and New Innovator Awards, which support innovative approaches to major challenges in biomedical or behavioral research. Pioneer Awards provide up to $2.5 million in direct costs over 5 years and are open to scientists at any career stage. New Innovator Awards provide up to $1.5 million in direct costs over 5 years and are designed specifically to support exceptionally creative new investigators at an early stage of their career when they may lack the preliminary data required for an R01 grant.

Applications for the 2012 NIH Director's Pioneer Award Program (DP1) are due by October 7, 2011:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-004.html
See further details about the program:
http://commonfund.nih.gov/pioneer/

Applications for the 2012 NIH Director's New Innovator Award Program (DP2) are due by October 14, 2011:
http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-005.html
See more about this program: New Innovator Award program logo
http://commonfund.nih.gov/newinnovator/

Recipients of 2011 Awards:

On September 20th, NIH announced the recipients of the 2011 Pioneer Awards, New Innovator Awards, and Transformative Research Project Awards.  Read more about the 79 recipients:
http://www.nih.gov/news/health/sep2011/od-20.htm

Invitation for Nominations: Presidential Awards for Excellence in Science, Mathematics and Engineering Mentoring

National Science Foundation logoParticipants in NIH research with a strong history of mentoring are encouraged to apply for the Presidential Awards for Excellence in Science, Mathematics, and Engineering Mentoring (PAESMEM). Established by the White House in 1996, the PAESMEM program is administered by the National Science Foundation (NSF) and is intended to identify outstanding individual and institutional mentoring efforts in all scientific fields. Awardees are selected based on their track record of enhancing participation and retention of individuals who might not otherwise have considered careers in science, technology, engineering, and mathematics. The PAESMEM is the highest national mentoring award.

Candidates can be nominated by a colleague, administrator, or a student. Self-nominations also are accepted. Individual and organizational nominees must have demonstrated outstanding and sustained mentoring for underrepresented and other students at the K-12, college, or graduate levels for periods of at least 5 years. Details about eligibility, the nomination process, review, and the nature of the award are available in the Program Solicitation:
http://www.nsf.gov/pubs/2011/nsf11563/nsf11563.htm .

The NSF estimates that 16 new awards will be made in FY 2012. The application receipt date is October 5, 2011.

NIH, DARPA, and FDA Collaborate to Develop Cutting-Edge Technologies to Predict Drug Safety

President Obama has announced that NIH will collaborate with the Defense Advanced Research Projects Agency (DARPA) and the Food and Drug Administration (FDA) to develop a chip to screen for safe and effective drugs far more swiftly and efficiently than current methods, and before they are tested in humans. The chip will be loaded with specific cell types that reflect human biology and will be designed to allow multiple different readouts that can indicate whether a particular compound is likely to be safe or toxic for humans. This fall, NIH and DARPA, in coordination with the FDA, will solicit proposals from industry, government labs, academic institutions, and other research organizations on how best to develop the chip, bringing together the latest advances in engineering, biology, and toxicology to bear on this complex problem. NIH plans to commit up to $70 million to this effort over the next five years; DARPA will commit a comparable amount.

NIH Releases Best Practices for Combining Qualitative and Quantitative Research

NIH has released best practices for scientists conducting mixed methods health research--research that combines the strengths of both quantitative and qualitative research. Despite the increased interest in mixed methods research in health fields and at NIH, prior to this report, there was limited guidance to help scientists developing applications for NIH funding that featured mixed methods designs, nor was there guidance for the reviewers at NIH who assess the quality of these applications. Additional information about Best Practices for Mixed Methods Research in the Health Sciences is found at:
http://obssr.od.nih.gov/scientific_areas/methodology/mixed_methods_research/index.aspx

2nd International Human Microbiome Congress to Be Held in March

The 2nd International Human Microbiome Congress will take place March 19-21, 2012 in Paris, France. The congress is an international event organized by MetaHIT that is cosponsored by the Human Microbiome Project, of which NIDCR is a member. Topics to be discussed at this year's meeting include lessons learned from early studies in the human microbiome, microbiome composition of the healthy human, clinical and functional studies of the human microbiome, computational methods for microbiome research, and the future of microbiome research. To learn more, visit the meeting website at:
http://www.metahit.eu/index.php?id=paris-2012


SCIENCE ADVANCES

Native FhbB crystalsMaking Crystals

Researchers are making progress solving the 3-D structure of a key protein in T. denticola.

FMN-fluorescent protein expression in transformed P. gingivalisNo Air Required

NIDCR grantees just made anaerobic bacteria a whole lot greener and easier to see in the laboratory. 

MicroparticlesA Small Step Forward

Scientists report initial success using microparticles to resolve chronic inflammation.


FUNDING OPPORTUNITY NEWS

PROGRAM ANNOUNCEMENTS

AIDS/HIV

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Immunopathogenesis of HIV/AIDS-related Oral Manifestations and Host Immunity (R01) 9/08/11 PA-11-334

Isaac Rodriguez-Chavez
301-594-7985

9/08/14
Immunopathogenesis of HIV/AIDS-related Oral Manifestations and Host Immunity (R21) 9/08/11 PA-11-333

Isaac Rodriguez-Chavez
301-594-7985

9/08/14

Behavioral/Social Sciences

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Systems Science and Health in the Behavioral and Social Sciences (R01) 8/17/11 PAR-11-314 David Clark
301-594-4814
9/08/14
Systems Science and Health in the Behavioral and Social Sciences (R21) 8/17/11 PAR-11-315 David Clark
301-594-4814
9/08/14

Career Development

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Institutional Career Development Award for Enhancing Research Capacity in Temporomandibular Joint Disorders and Orofacial Pain (K12)

Also see Neurobiology/Pain
8/03/11 PAR-11-289 John Kusiak
301-594-7984

Kevin Hardwick
301-594-2765
10/13/13

Clinical Research/Clinical Trials

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Clinical Trial or Biomarker Clinical Evaluation Study Planning Grant (R34) 9/16/11 PAR-11-338 Jane Atkinson
301-435-7908

9/08/14
NIDCR Clinical Trial Implementation or Biomarker Clinical Evaluation Study Cooperative Agreement (U01) 9/16/11 PAR-11-339 Jane Atkinson
301-435-7908

1/08/15

Genes/Genetics

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
Building a Genetic and Genomic Knowledge Base in Dental, Oral, and Craniofacial Diseases and Disorders (R01) 8/19/11 PA-11-317 Emily Harris
301-594-4846
9/08/14
Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01) 7/18/11 PAR-11-257 Steve Scholnick
301-594-3077
10/05/13

Neurobiology/Pain

Title NIH
Guide
PA
Number
NIDCR Contact Expiration
Date
NIDCR Limited Competition: Renewals of Existing Cooperative Agreement Awards, Prospective Studies on Craniofacial Pain and Dysfunction RFA-DE-05-007 (U01) 9/27/11 PAR-11-348 John Kusiak
301-594-7984
12/02/11
NIDCR Institutional Career Development Award for Enhancing Research Capacity in Temporomandibular Joint Disorders and Orofacial Pain (K12)

Also see Career Development
8/03/11 PAR-11-289 John Kusiak
301-594-7984

Kevin Hardwick
301-594-2765
10/13/13

REQUESTS FOR APPLICATIONS

Behavioral/Social Sciences

Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Mechanistic Pathways Linking Psychosocial Stress and Behavior (R01) 9/22/11 RFA-HL-12-037 David Clark
301-594-4814
12/19/11
Basic Research on Decision Making: Cognitive, Affective, and Developmental Perspectives (R01) 9/02/11 RFA-MH-12-130 David Clark
301-594-4814
1/18/12

Neurobiology/Pain

Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01) 6/30/11 RFA-DE-12-008 John Kusiak
301-594-7984
10/04/11

NIH Roadmap Initiatives

Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
NIH Director's Transformative Research Awards (R01) 9/21/11 RFA-RM-11-006

Alicia Dombroski
301-594-4805

1/12/12
Economic Research on Incentives for Efficient Use of Preventive Services (R01) 8/22/11 RFA-RM-11-012 David Clark
301-594-4814
11/15/11
2012 NIH Director's New Innovator Award Program (DP2) 8/10/11 RFA-RM-11-005

Alicia Dombroski
301-594-4805

10/14/11
2012 NIH Director's Pioneer Award Program (DP1) 8/05/11 RFA-RM-11-004

Alicia Dombroski
301-594-4805

10/07/11

Saliva/Salivary Glands

Title NIH
Guide
RFA
Number
NIDCR Contact Application Receipt Date
Functional Restoration of Salivary Glands (R01) 8/01/11 RFA-DE-12-004 Penny Wung Burgoon
301-594-4825
11/29/11
Functional Restoration of Salivary Glands (R21) 8/01/11 RFA-DE-12-005 Penny Wung Burgoon
301-594-4825
11/29/11

NOTICES

Title NIH
Guide
Notice Number
Revised Multiple Program Director(s)/Principal Investigator(s) Policy to Allow Change with Prior Approval  9/28/11 NOT-OD-11-118
Revised Policy: Managing Conflict of Interest in the Initial Peer Review of NIH Grant and Cooperative Agreement Applications 9/26/11 NOT-OD-11-120
Notice of Correction to the Proposed Project Start and End Dates (Item 13; SF 424 R&R Cover Component) for the 2012 NIH Director's Pioneer Award Program (RFA-RM-11-004) 9/20/11 NOT-RM-11-026
Review of Grants Information for Fiscal Year 2011 9/16/11 NOT-OD-11-117
Notice of Request for Nomination of Human Cell Lines for Gene Expression Profiling in Response to Perturbing Agents in the Library of Integrated Network-Based Cellular Signatures (LINCS) Program 9/06/11 NOT-RM-11-023
Outstanding Mentors are Eligible for Presidential Awards for Excellence in Science, Mathematics and Engineering Mentoring (PAESEM) 9/02/11 NOT-OD-11-115
Extension of Expiration Date for PA-08-090: Research Supplements to Promote Diversity in Health-Related Research 9/01/11 NOT-OD-11-113
Extension of Expiration Date for PA-08-091: Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers 9/01/11 NOT-OD-11-112
Clarification to Notice NOT-OD-11-106: Request for Information (RFI): Input into the Deliberations of the Advisory Committee to the NIH Director Working Group on the Future Biomedical Research Workforce 8/30/11 NOT-OD-11-114
Request for Information (RFI): Expansion of sharing and standardization of NIH-funded human brain imaging data 8/26/11 NOT-DA-11-021
Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2012-1) Now Available 8/25/11 NOT-OD-11-108
Issuance of the Final Rule - Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors 8/22/11 NOT-OD-11-109
Request for Information (RFI): Input into the Deliberations of the Advisory Committee to the NIH Director Working Group on the Future Biomedical Research Workforce 8/17/11 NOT-OD-11-106
Notice of Addition of Eligibility Criterion for the 2012 NIH Director's New Innovator Award Program (RFA-RM-11-005) 8/16/11 NOT-RM-11-005
Notice of Correction for PA-11-148 Nanoscience and Nanotechnology in Biology and Medicine (R01) 8/01/11 NOT-EB-11-007
Resubmission of Applications with Pending Appeals of NIH Initial Peer Review 7/29/11 NOT-OD-11-101
Modification of NOT-RM-11-017: Institutional Clinical and Translational Science Award (CTSA) (U54) 7/20/11 NOT-RM-11-021
Modification of Eligibility Criteria for Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) 7/15/11 NOT-OD-11-097
Mandating Use of the Commons to Submit No-Cost Extension Notifications 7/15/11 NOT-OD-11-098
NIH Offers SBIR Niche Assessment Program to Phase I Awardees 7/15/11 NOT-OD-11-094
New NIDCR Policy: Investigator-Initiated Clinical Trials Include Biomarker Clinical Evaluation Studies 7/14/11 NOT-DE-11-002
NIH, AHRQ, CDC, FDA and NIOSH to Release Updated Electronic Application Forms - ADOBE-FORMS-B2 7/13/11 NOT-OD-11-096
Change in the NIH Continuous Submission Policy for Reviewers with Recent Substantial Service 7/08//11 NOT-OD-11-093

NIDCR Personnel News

Dr.Sundar Venkatachalam Appointed Director of Epithelial Cell Regulation and Transformation Program
Dr. Sundar Venkatachalam joined the NIDCR in June as director of the Epithelial Cell Regulation and Transformation Program in the Integrative Biology and Infectious Diseases Branch, Division of Extramural Research (DER).  Prior to joining the NIDCR, he was assistant professor in the Department of Biochemistry, Cellular and Molecular Biology at the University of Tennessee, Knoxville, where he conducted NIH-supported research. At the NIDCR, he manages a portfolio of grants and cooperative agreements in basic and translational research on the molecular mechanisms of oral epithelial cell regulation as they relate to the onset and progression of diseases of the oral mucosa, head and neck cancers (including oral/oropharyngeal), and salivary gland cancers. 

Dr. Dena Fischer Appointed Director of Clinical Research and Epidemiology Program
Dr. Dena Fischer joined the DER Center for Clinical Research in August as director of the Clinical Research and Epidemiology Program.  Previously, she was a faculty member at the University of Illinois at Chicago College of Dentistry for the past five years.  Dr. Fischer has experience providing oral health care to medically complex patients, patients with HIV-infection, TMJD patients, adult patients with severe disabilities, and patients with dysplastic oral lesions.  Her past research includes studies of the reliability of histopathologic diagnosis of oral pre-malignant and malignant lesions, studies of oral pain, and oral health issues at the end of life.  

We encourage you to distribute this newsletter to any colleagues whom you think may be interested. If someone forwarded this issue to you and you would like to receive future copies, please click here:

http://list.nih.gov/cgi-bin/wa.exe?SUBED1=nidcr-newsletter&A=1

Thank you.



See archived e-newsletters

 


National Institute of Dental and Craniofacial Research
National Institutes of Health
Bethesda, MD 20892-2190
301-496-4261

Department of Health and Human Services (HHS)   National Institutes of Health (NIH)   USA.gov