Cleft Lip and Palate: Van der Woude Syndrome
After a nearly 20-year search, a team of scientists report in the October 2002 issue of Nature Genetics
that it has discovered a gene involved in causing Van der Woude Syndrome, the most common form of syndromic cleft lip and palate. The Inside Scoop recently spoke with two authors on the paper: NIDCR grantees Jeff Murray, M.D., and Brian Schutte, Ph.D., both of whom are scientists in the Department of Pediatrics at the University of Iowa. They shared their thoughts on the difficulty in identifying the Van der Woude Syndrome gene, the possible scientific benefits of studying twins, and the implications of this gene discovery on the more common non syndromic cleft lip and palate. more...