Scientists Discover Candidate Salivary Markers for Sjogren's Syndrome
Three years ago, scientists supported by the NIDCR began taking the first full inventory of the proteins that normally are produced in our salivary glands. Now, one of those scientists and his colleagues offer a first glimpse into how this new research tool can be applied to detect subtle changes in the protein content of a person’s saliva that may be linked to an oral or systemic disease. As reported in the November issue of the journal Arthritis and Rheumatism
, the scientists detected 42 proteins and 16 peptides in saliva that clinically discriminated between people with the primary form of Sjőgren’s syndrome and healthy volunteers. These data far surpass previous efforts to identify protein biomarkers for primary Sjőgren’s syndrome, a chronic autoimmune condition of the salivary and tear glands that affects about two million Americans, mainly women. more...Scientists Elucidate Function of Novel Protein Involved in Head and Neck Cancer
In the September issue of the journal Cancer Cell
, a team of NIDCR-supported scientists and their colleagues report on a novel protein called LZAP. Discovered by the group in 2005, LZAP appears to be a new growth-inhibiting tumor suppressor gene. In the latest paper, the scientists show that LZAP has biological activity that relates to tumor suppression, they define a biological function in the nucleus that correlates with that activity, and they move into clinical tumor samples to show that LZAP is frequently inactivated in squamous cell carcinomas of the head and neck. more...
A Closer Look at Developing a Lab on a Chip for Oral Cancer
Dr. John McDevitt, a scientist at the University of Texas at Austin, is one of several NIDCR grantees currently developing a first generation of miniaturized, fully automated saliva-based diagnostic devices. As part of the NIDCR grant, the McDevitt laboratory published in the August issue of the journal Lab on a Chip
the results of proof-of-principle experiments for a rapid chip-based diagnostic test for oral cancer. McDevitt spoke to the Inside Scoop about the device, its status, and future prospects. more...Periodontal Research: Pathways to Progress
In the June issue of the Journal of Proteome Research
, a team of NIDCR supported scientists and colleagues take a closer look at how a monocyte senses live bacteria, LPS, or FimA. The Inside Scoop spoke to the paper’s senior author, Dr. Salomon Amar, a scientist in the Department of Periodontology and Oral Biology at the Boston University School of Dental Medicine. As Amar noted, his data mark a starting point in using comprehensive protein-profiling, or proteomic, approaches to map out signaling pathways in the monocyte and, hopefully, to identify new ways to control the destructive inflammation of chronic periodontitis. more...