Antibody Technique Shows Diagnostic Promise
In the February 1 issue of the journal Biochemical and Biophysical Research Communications
, a team of NIH researchers report early results with a tremendously sensitive and accurate new diagnostic technique to quantify antibodies in blood and saliva. Known by the acronym LIPS, the technique performed without error in a small validation study involving a well-known antigen that is frequently elevated in people with a rare disorder called Stiff-Person Syndrome. Additional articles will be published in the months ahead for more common autoimmune conditions, ranging from primary Sjögren’s syndrome to type-1 diabetes. The Inside Scoop
spoke to two of the authors to learn more about the technique and its potential. They are NIDCR scientists Dr. Peter Burbelo, lead author on the study, and Dr. Michael Iadarola, the paper’s senior author. more...Scientists Discover Candidate Salivary Markers for Sjogren's Syndrome
Three years ago, scientists supported by the NIDCR began taking the first full inventory of the proteins that normally are produced in our salivary glands. Now, one of those scientists and his colleagues offer a first glimpse into how this new research tool can be applied to detect subtle changes in the protein content of a person’s saliva that may be linked to an oral or systemic disease. As reported in the November issue of the journal Arthritis and Rheumatism, the scientists detected 42 proteins and 16 peptides in saliva that clinically discriminated between people with the primary form of Sjőgren’s syndrome and healthy volunteers. These data far surpass previous efforts to identify protein biomarkers for primary Sjőgren’s syndrome, a chronic autoimmune condition of the salivary and tear glands that affects about two million Americans, mainly women. more...
A Closer Look at Developing a Lab on a Chip for Oral Cancer
Dr. John McDevitt, a scientist at the University of Texas at Austin, is one of several NIDCR grantees currently developing a first generation of miniaturized, fully automated saliva-based diagnostic devices. As part of the NIDCR grant, the McDevitt laboratory published in the August issue of the journal Lab on a Chip the results of proof-of-principle experiments for a rapid chip-based diagnostic test for oral cancer. McDevitt spoke to the Inside Scoop about the device, its status, and future prospects. more...Bringing the Promise of Molecular Medicine to Oral Cancer Screening
In 2005, according to the American Cancer Society (ACS), an estimated 29,370 new cases of oral and pharyngeal cancer were diagnosed, while an estimated 7,320 Americans died from these diseases. Recently, the Inside Scoop spoke with NIDCR grantee Dr. Miriam Rosin, a senior staff scientist at the British Columbia Cancer Agency in Canada. She and her colleagues in British Columbia are now developing a novel, province-wide oral cancer screening program that integrates for the first time telltale molecular features of a developing tumor with more traditional cancer screening tools. This project offers a glimpse of the much-touted promise of molecular medicine and serves as a template for future molecular-based cancer screening programs elsewhere in the world, including the United States. more...