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Salivary Glands/Dry Mouth

Looking Anew
(November 2011)

Roberto Weigert, Ph.D.Scientists observed a key subcellular process through an IVM microscope and caught a telling new glimpse of how the biology works.  more......

The Impossible Will Take a Little While: Defining a Key Developmental Pathway in the Salivary Gland
(October 2010)
Branched salivary glandSalivary glands form in large part via a process called branching morphogenesis.  NIDCR scientists have now defined several of its key biochemical details. Find out how they did it.  more....

Scientists Discover Candidate Salivary Markers for Sjogren's Syndrome
(November 2007)
David Wong, DMD, DMScThree years ago, scientists supported by the NIDCR began taking the first full inventory of the proteins that normally are produced in our salivary glands.  Now, one of those scientists and his colleagues offer a first glimpse into how this new research tool can be applied to detect subtle changes in the protein content of a person’s saliva that may be linked to an oral or systemic disease.  As reported in the November issue of the journal Arthritis and Rheumatism, the scientists detected 42 proteins and 16 peptides in saliva that clinically discriminated between people with the primary form of Sjőgren’s syndrome and healthy volunteers.  These data far surpass previous efforts to identify protein biomarkers for primary Sjőgren’s syndrome, a chronic autoimmune condition of the salivary and tear glands that affects about two million Americans, mainly women.  more...

Study May Help Head and Neck Cancer Patients Find Relief From Dry Mouth
(March 2007)
Bruce Baum, D.M.D., Ph.D.By the late 1980s, NIDCR scientist Dr. Bruce Baum was frustrated. He had been searching for new drugs and other treatments that might help restore adequate salivary flow in people whose salivary glands had been damaged by radiation treatment for cancer. Yet, despite all of his hard work, Baum said he had not come close to solving the problem.  That's when he decided to turn to gene transfer, sometimes called gene therapy.  If a fluid-transporting gene could be transferred into the damaged glands, he could potentially restore some degree of salivary flow and secretion into the mouth.  more...

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This page last updated: February 26, 2014