Director's Report to Council: January 2015



Since the last meeting of the National Advisory Dental and Craniofacial Research Council (NADCRC) in September, NIDCR Director Martha J. Somerman, DDS, PhD, has delivered lectures and presentations to numerous stakeholders and has attended meetings and symposia with several working groups and professional organizations. In addition, Dr. Somerman continued to play an active role in pain-related activities, such as serving as an NIH representative on the Interagency Pain Research Coordinating Committee.

After the announcement in September that Deputy Director Isabel Garcia, DDS, MPH, will become the dean of the University of Florida College of Dentistry in February 2015, Dr. Somerman selected John Kusiak, PhD, as Senior Advisor to the Director to assist her while a new deputy director is recruited. Previously, Dr. Kusiak was acting chief of NIDCR’s Integrative Biology and Infectious Diseases Branch. Dr. Kusiak joined NIDCR in 2003 and is an exceptional scientist and administrator. In addition to leading the Integrative Biology and Infectious Diseases Branch, he is also the program officer for the Molecular and Cellular Neuroscience Program, which focuses on the pathogenesis of pain. Before joining NIDCR, he was with the National Institute of Neurological Diseases and Stroke and the National Institute of Aging. He received his PhD in biochemistry from George Washington University Medical School. 

In January, Dr. Somerman, other NIH staff, and special guests attended a retirement event for Dr. Garcia to show appreciation for her uncompromising commitment to public health and for her exceptional judgment as a leader and to reflect on her many accomplishments since joining NIDCR in 1995. Dr. Garcia was appointed NIDCR’s deputy director in 2007. From 2010 to 2011, she served as acting director of NIDCR. 

Northern Virginia Dental Society Executive Meeting

Dr. Somerman gave a presentation about NIDCR to the Northern Virginia Dental Society at their executive meeting in September in Tysons Corner, Virginia. The Society is a regional component of the Virginia Dental Association, which in turn is a member of the American Dental Association. Dr. Somerman was joined by Dave Vannier, PhD, a consultant with NIDCR’s Office of Communications and Health Education. 

Dr. Somerman’s presentation focused on the mission of NIDCR, ongoing research efforts, and the short- and long-term impact of research findings on clinical practice. She emphasized the importance of establishing a bidrectional knowledge exchange between clinicians and basic scientists so that insights regarding biological mechanisms and disease processes inform and spur new clinical interventions and, conversely, so that clinical observations about the nature and progression of disease stimulate new basic investigations. 

2nd Annual National Dental Practice-based Research Network Meeting

In September, Dr. Somerman, Dr. Lillian Shum, director of NIDCR’s Division of Extramural Research, Dr. Donald Denucci, director of NIDCR’s Dental PBRN Program, and Dr. Dena Fischer, director of NIDCR’s Clinical Research and Epidemiology Program, attended the third annual meeting of the National Dental Practice-based Research Network in Rochester, NY.  

On the first day, the meeting included NIDCR staff, PBRN regional directors and deputy directors, regional coordinators, executive committee staff, Westat coordinating center project staff, and University of Alabama at Birmingham central administrative staff. The purpose was to discuss reports from the regional directors and committee chairs. Updates were provided about program and performance planning, study ideas, collaborations with other organizations, and status of network plans.

On the second day, an executive committee meeting was held, which included EC attendees and NIDCR program officers. Topics of discussion included review of the previous year’s activities and an overview of the upcoming year. Concurrently, there was a joint steering committee/regional coordinator meeting. NIDCR staff met with the regional staff as well as University of Rochester faculty and administration and University of Rochester research collaborators.

Schulich Dentistry’s Annual Research Day at Western University

On October 7, Dr. Somerman delivered the 2014 John T. Hamilton Lecture, which is the centerpiece of Schulich Dentistry’s Annual Research Day at Western University, in London, Ontario, Canada. The lecture was attended by dental school students, faculty, and other members of the Western University community. In addition to providing an overview of NIDCR and NIH funding mechanisms and research directions, Dr. Somerman discussed her laboratory’s research on defining the key regulators controlling development, homeostasis, and regeneration of periodontal tissues.

Columbia University Visiting Professor Program

Columbia University College of Dental Medicine honored Dr. Somerman by selecting her as their 2014 Visiting Professor. Launched in 1980, the Columbia Visiting Professorship Program selects a Visiting Professor each year based on nominations from an advisory committee. The committee chair is Dr. Ralph Kaslick, professor and dean emeritus at Fairleigh Dickinson University, and other committee members include Columbia faculty, alumni, and private industry representatives.  

On October 29, Dr. Somerman delivered two lectures on personalized medicine. She emphasized that enabling personalized oral health care through research advances is one of the four areas of focus in NIDCR’s 2014-2019 Strategic Plan. Her first lecture was targeted to dental students and faculty and was titled “Enabling Precision Medicine through Research: Implications and Challenges for NIDCR.”  Her second lecture had a larger audience that included alumni as well. She spoke about “Advancing Personalized Oral Healthcare: Gaps and Opportunities for NIDCR.”

American Dental Association

On December 17, Dr. Somerman met with American Dental Association (ADA) Executive Director and Chief Operating Officer Dr. Kathleen O’Loughlin, ADA Senior Vice President of Professional Affairs Dr. Daniel Meyer, and American Dental Association Foundation Executive Director Gene Wurth on the NIH campus in Bethesda, Maryland. Other NIDCR representatives who took part in the meeting included Dr. Garcia, Dr. Kusiak, and Dr. Jane Atkinson, chief of NIDCR’s Center for Clinical Research.

Funders Oral Health Policy Group – Washington, DC

On January 8, Dr. Somerman spoke at a meeting of the Funders Oral Health Policy Group at The Pew Charitable Trusts offices in Washington, DC.  The policy group includes nearly two dozen representatives from state- and national-level philanthropies that invest in oral health research and policy issues. Dr. Somerman took part in a panel titled, “Dental Innovations on the Horizon.” She described areas of oral health research that have the potential to impact dental care providers, consumers, and payers.

Rutgers School of Dental Medicine 

On January 13, Dr. Somerman discussed NIDCR’s research goals and recent NIDCR-supported scientific advances at Rutgers School of Dental Medicine (RSDM) in Newark, New Jersey. RSDM basic scientists, clinical researchers, and postgraduate students attended the oral health seminar. 

NIH Native American Scholars 

In honor of Native American Heritage Month, Dr. Isabel Garcia participated in a Traditional Foods Luncheon program provided by the NIH Native American Scholars on the NIH campus on November 21. Three postdoctoral fellows and five postbaccalaureate fellows were among the participants sharing traditional Native American dishes. A total of nine different Native American tribes were represented at the event, and NIDCR’s AAAS Fellow Dr. Tamara James was among the participants. 

Croatian Minister of Health

On December 10 on the NIH campus, Dr. Garcia met with the Croatian Minister of Health, Dr. Siniša Varga, an oral surgeon who directed the Croatian Health Insurance Fund. Joining in the meeting were Dr. John Kusiak, NIDCR’s senior advisor to the director, Dr. Jane Atkinson, chief of NIDCR’s Center for Clinical Research, Dr. Margo Adesanya, acting director of NIDCR’s Office of Science Policy and Analysis, and Dr. Emily Harris, chief of NIDCR’s Translational Genomics Research Branch. Earlier in the day, Dr. Varga toured the NIH Clinical Center and met with Dr. Bob Angerer, NIDCR’s scientific director, Dr. Jim Melvin, NIDCR’s clinical director, and Dr. Janice Lee, NIDCR’s deputy clinical director.


FY 2014

The Consolidated Appropriations Act of 2014 provided an operating budget of $397.8 million for NIDCR. See the table below for distribution by budget mechanism. 

National Institute of Dental and Craniofacial Research

Budget Mechanism

FY 2014 Actuals

(Dollars in Thousands)

  Research Grants




Research Projects




















        Subtotal, RPG








Research Centers








Other Research

  Research Careers




  Biomedical Research Support








        Subtotal, Other Research








  TOTAL Research Grants











  Research Training







  Research & Development Contracts















  Intramural Research







  Research Management and Support












FY 2015

On December 17, 2014, President Barack Obama signed the $1.1 trillion spending bill from Congress for the fiscal year 2015 budget. NIH will be funded through September 2015. The NIH appropriations total $30.1 billion. The appropriations provide the National Institute of Allergy and Infectious Disease with $238 million to remain available until September 30, 2016, in emergency funding to prevent, prepare for, and respond to Ebola in the United States and abroad.

The FY 2015 enacted budget for NIDCR is $399,886,000. This amount is reduced by a transfer out of $2.186 million for HIV/AIDS, which results in an operating level of $397,700,000.

FY 2016 

Currently, no budget information for 2016 is available.    


Diversity in the Biomedical Research Workforce

In October, NIH awarded about $31 million to develop new approaches that will engage researchers from diverse backgrounds in biomedical research and prepare them to thrive in the NIH-funded workforce. These awards are part of a projected five-year program to support more than 50 awardees and partnering institutions in establishing a national consortium to develop, implement, and evaluate approaches to encourage individuals to initiate and succeed in biomedical research careers.

NIH Pain Consortium Update 

On September 24, the Interagency Pain Research Coordinating Committee (IPRCC) held a meeting on the NIH campus in Bethesda, Maryland. Participants discussed the IPRCC’s National Pain Strategy, which is a plan for population-focused pain research, prevention, treatment, and management. More than 80 experts drafted the Pain Strategy, which will soon be released for public comment. 

NIH BRAIN Initiative Update

NIH has invested $46 million to support the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. More than 100 investigators in 15 states and several countries will work to develop new tools and technologies to understand neural circuit function and capture a dynamic view of the brain in action.

Highlights from 2014 of NIH-supported Research 

Descriptions of 2014’s NIH-supported research accomplishments, including promising medical advances and noteworthy advances in basic research, are available on the NIH website at

NIH Rare Diseases Clinical Research Network 

To accelerate the development of new approaches for diagnosing and treating rare diseases, NIH has expanded the Rare Diseases Clinical Research Network (RDCRN) with nearly $29 million in awards. RDCRN is led by the National Center for Advancing Translational Sciences.

NIH High-Risk, High-Reward Research 

In October, NIH awarded 85 grants to scientists with highly innovative approaches to major contemporary challenges in biomedical research. High-risk, high-reward research approaches are selected for funding if they have the potential to lead to breakthroughs and transform scientific fields.

NIH Big Data to Knowledge

NIH made an initial investment of almost $32 million in October to increase utility of biomedical research data. These awards are intended for the development of software, training programs, or other strategies to improve access to complex biomedical data sets. 

Single Cell Analysis Program

In 2014, NIH awarded grants totaling $7.9 million to 25 research teams who are unraveling the workings of single cells, as part of an effort to spur development of personalized treatments that target disease at the cellular level. The grants are supported by the NIH Common Fund’s Single Cell Analysis Program, which is funded through the NIH Common Fund, and managed by the NIH Office of the Director in partnership with the National Institute of Biomedical Imaging and Bioengineering and National Institute of Mental Health.

Clinical Trial Result Reporting

In November, the U.S. Department of Health and Human Services (HHS) issued a Notice of Proposed Rulemaking, which proposes regulations to implement reporting requirements for certain clinical trials. The proposed rule clarifies requirements for registering clinical trials and submitting summary trial results information to

Single Institutional Review Board for Multi-site Clinical Trials

In December, NIH issued a draft policy to promote the use of single institutional review boards (IRBs) in NIH-funded multi-site clinical trials. The use of a single IRB in multi-site studies would reduce duplication of effort, save time, and lower costs.

Amgen Scholars Program 

To prepare students for careers in science, NIH and 16 other facilities are taking part in the Amgen Scholars Program in the summer of 2015. As a host institution, NIH will appoint candidates who meet both the NIH and Amgen Scholars requirements. The program is made possible by an $850,000 grant to the Foundation for the NIH from the Amgen Foundation of Thousand Oaks, California.

C-SPAN’s Washington Journal

On September 24, C-SPAN Washington Journal visited the NIH campus in Bethesda to speak with NIH leadership about medical research. Topics included Ebola research, diabetes research, and the role of nurses in management of chronic illness.

National Oral History Project 

In early December, representatives of StoryCorps, a national oral history project, visited the NIH campus to record the stories of patients, their loved ones, researchers, and others in the community. Their goal was to capture stories that reflected different aspects of the NIH research experience.

Bill and Melinda Gates Foundation

In October, the NIH and the Bill & Melinda Gates Foundation entered into a new phase of cooperation to develop interventions to reduce major global health burdens that disproportionately affect populations in low- and middle-income countries. Interventions will be developed to reduce HIV, tuberculosis, malnutrition, premature births, and other health problems.

2014 Nobel Prize 

NIH grantee William E. Moerner, PhD, of Stanford University shared the 2014 Nobel Prize in Chemistry for his work on optical microscopy. To date, 145 NIH-supported researchers, including staff scientists, have been awarded a Nobel Prize for achievements in physiology or medicine, chemistry, physics, and economic sciences.

National Center for Complementary and Integrative Health

In December, NIH announced that an institute has been renamed. The National Center for Complementary and Integrative Health (NCCIH) is the new name for the National Center for Complementary and Alternative Medicine (NCCAM). The name change was mandated as part of the omnibus budget measure signed by President Obama. Earlier in 2014, public comments indicated overall support for the change.

Walter J. Koroshetz, MD, Acting NINDS Director

In October, Walter J. Koroshetz, MD, assumed the role of Acting Director of the National Institute of Neurological Diseases and Stroke. After 19 years of service at NIH, NINDS Director Story C. Landis, PhD, retired at the end of September.


Institute News

NIDCR Veterinary Resources Core Update
The Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International notified NIDCR that the NIDCR Animal Program completed the triennial site visit successfully and earned Continued Full Accreditation. In the summer of 2014, the AALAC conducted a triennial site visit of the NIH Intramural Animal Program, including the NIDCR Animal Program. AALAC evaluated the NIDCR Animal Program, including all research animal housing facilities and its Animal Care and Use Committee. NIDCR successfully completed the inspection with no suggestions for improvement. The NIDCR program and the NIH intramural animal program were complimented on exceptional efforts for this year’s AAALAC site visit.

Evaluation of Oral Health Care Expenditures and Utilization
Frequently cited in the public health literature is a paper commissioned by NIDCR and published in the 1990s about U.S. dental service utilization. Federal agencies that fund biomedical research rely on cost and utilization data about preventive care and treatment to help establish research priorities, assess the value of funded research and research training, and communicate the value of programs and projects to stakeholders. Currently, NIDCR is funding an evaluation of 1996 through 2010 data to update the earlier published findings. Sue Hamann, PhD, science evaluation officer in NIDCR’s Office of Science Policy and Analysis, is the project officer for a one-year contract awarded in September 2014 to Health Research and Analysis (HRA) of Bethesda, MD, for the study of oral health care expenditures and utilization.  

Personnel Update

Lillian R. Shum, PhD, Selected as Director of Division of Extramural Research
After a national search, Lillian R. Shum, PhD, was selected in September to be the director of NIDCR’s Division of Extramural Research (DER). Dr. Shum is an exceptional scientist administrator with broad knowledge and experience in dental, oral, and craniofacial sciences, and as the director of DER, she will provide leadership and guidance for the planning, development, implementation, and evaluation of NIDCR’s investment in biomedical and behavioral sciences.

Dr. Shum has been with NIH for 19 years and has held leadership positions for the past 11 years. She has been with NIDCR since 2003. Dr. Shum earned her PhD from the University of North Carolina Chapel Hill, specializing in Cell Biology, Developmental Biology and Anatomy. She completed two postdoctoral fellowships: one at the Center for Craniofacial Molecular Biology at the University of Southern California and another at the University of California San Francisco School of Dentistry.

Kathleen G. Stephan, MBA, Selected as NIDCR Executive Officer
On December 29, Kathleen G. Stephan, MBA, joined NIDCR as the associate director for management. Over the past 21 years, Ms. Stephan has held key leadership positions with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute, and the National Center for Complementary and Alternative Medicine. She earned a bachelor of science in business and a master of business administration at the University of Baltimore.

While the position was open for two years, NIDCR was extremely fortunate to have the capable leadership of George Coy, who served as NIDCR’s Acting Associate Director for Management, and also Carol Loose, who served as the Acting Branch Chief of the Financial Management Branch (FMB). Mr. Coy and Ms. Loose have resumed their previous roles in FMB.

Kathryn A. Atchison, DDS, MPH, Appointment at NIDCR Extended
Dr. Kathryn Atchison, the Vice Provost for New Collaborative Initiatives at the University of California, Los Angeles (UCLA) and Professor at the UCLA School of Dentistry, has agreed to extend her NIDCR appointment through July 31, 2015. Dr. Atchison is devoting a percentage of her time to NIDCR to help formulate a strategy to strengthen the translational pipeline for new product development and to help identify potential public-private and public-public partnerships. She received a DDS at Marquette University School of Dentistry and an MPH at Boston University School of Public Health.

Dental Epidemiologist Bruce A. Dye, DDS, MPH, Joined NIDCR
Dr. Bruce A. Dye, a captain in the U.S. Public Health Service (USPHS), recently joined NIDCR‘s Office of Science Policy and Analysis as a dental epidemiology officer. An active diplomate of the American Board of Dental Public Health, Dr. Dye is the new director of NIDCR’s Dental Public Health Residency Program. In addition, he will direct and conduct dental epidemiology and public health research. For the past 12 years, he has been a dental epidemiology officer and dental public health consultant at the National Center for Health Statistics of the Centers for Disease Control and Prevention. 

After earning a DDS from the Ohio State University College of Dentistry, Dr. Dye began his USPHS career with the Indian Health Service in South Dakota and Michigan. He earned an MPH at the University of Michigan, pursued epidemiology training at Johns Hopkins University, and completed a dental public health residency at NIDCR. 

Khara M. Ramos, PhD, Leaves NIDCR for NINDS
On December 16, Khara M. Ramos, PhD, transferred to the Office of Scientific Liaison at the National Institute of Neurological Disorders and Stroke to become a Senior Science Policy Analyst. Since August 2013, she had been the Special Assistant to NIDCR's Deputy Director, and from September 2012 until August 2013, Dr. Ramos was an American Association for the Advancement of Science (AAAS) Science and Technology Policy Fellow in NIDCR’s Office of Science Policy and Analysis. She earned her PhD in neuroscience from the University of California at San Diego.

Wendy M. Knosp, PhD, Joined the Office of Science Policy and Analysis
In January, Dr. Wendy M. Knosp joined the Office of Science Policy and Analysis as a Health Science Policy Analyst. She had been a senior postdoctoral fellow in NIDCR’s Laboratory of Cell and Developmental Biology since 2010. Dr. Knosp received her PhD in Molecular and Medical Genetics from Oregon Health & Science University in Portland, Oregon, focusing on the genetic regulation of limb development. She completed a postdoctoral fellowship at the University of California, San Francisco, in the area of growth factor signaling and organogenesis. 

Murat Sincan, MD, Joined Office of the Clinical Director
Dr. Murat Sincan has joined the Office of the Clinical Director in NIDCR’s Division of Intramural Research (DIR). Dr. Sincan will provide unique expertise and in-depth knowledge of bioinformatics and information systems to support genomic analysis of diseases and development of research information infrastructure. He has extensive experience and expertise in the fields of medicine, bioinformatics, and medical informatics as well as information systems in general. His experience in these fields will allow NIDCR to advance intramural research by enabling better analysis of genomic data and also by designing and implementing a research information system infrastructure for all NIDCR researchers.  

Dr. Sincan obtained his MD from Hacettepe University Faculty of Medicine in 1999. He later worked at the Department of Medical Education and Informatics and then came to the NIH Undiagnosed Diseases Program as a Research Fellow in 2009. He completed his fellowship in August 2014.

Taleva Hall Joined the Office of Administrative Management
Ms. Taleva Hall joined NIDCR on November 1 as a Workforce Management Specialist in the Office of Administrative Management. She has 10 years of experience in human resources and workforce management. Ms. Hall earned her degree in business administration from Trinity University.   
Bernadette Wright Joined the Division of Intramural Research 
Ms. Bernadette Wright recently joined the purchasing staff within the Division of Intramural Research. Ms. Wright has 22 years of acquisitions experience working for both intramural and extramural areas at NIH. For the last two years she has worked in the acquisitions office for the National Institute of Diabetes and Digestive and Kidney Diseases as a purchasing agent, prior to which she was with the National Institute on Deafness and other Communication Disorders for 22 years.   

Dorothy Honemond Joined the Division of Intramural Research
In November, Ms. Dorothy Honemond joined NIDCR’s Division of Intramural Research as an Administrative Officer. Ms. Honemond has worked at NIH for over fifteen years. She spent thirteen years working for the National Heart, Lung and Blood Institute as a Secretary. In her most recent position, Ms. Honemond worked as an Administrative Officer for the Intramural Administrative Management Branch at the National Institute of Diabetes and Digestive and Kidney Diseases. 

NIH Pathways Internship Program Intern Candice Isaac
Candice Isaac has joined the Scientific Review Branch to support activities related to peer review. Ms. Isaac is an intern with the NIH Pathways Internship Program, which provides students with an opportunity to join NIH and gain valuable experience while pursuing a degree. Candice recently earned a bachelor’s degree in Legal Studies and will soon start a Master’s program in Public Policy and Law. 

Joanne Shi, MS, and Kenn Holmbeck, PhD, Receive “Best Basic Science” Abstract Award from the American Society for Bone and Mineral Research
At the annual meeting of the American Society for Bone and Mineral Research (ASBMR) in Houston, Texas, the abstract titled “Conditional ablation of MT1-MMP in SM22a-expressing cells identifies vascular-associated progenitors cells as essential for skeletal homeostasis,” authored by Ms. Joanne Shi and Dr. Kenn Holmbeck, received the 2014 ASBMR Most Outstanding Basic Abstract Award.  

Mary Scott Ramnitz, MD, Selected to Attend ASBMR Training Forum
Dr. Mary Scott Ramnitz was selected to participate in the Endocrine Fellows Foundation/ ASBMR Eighth Fellows Forum on Metabolic Bone Diseases in Houston, TX.  

Andrea Burke, MD, Receives ASBMR Young Investigator Travel Grant
Dr. Andrea Burke was selected to receive a 2014 ASBMR Young Investigator Travel Grant to attend the annual meeting in Houston, TX, for her abstract presentation titled “RANKL Inhibition in the Pathogenesis and Treatment of Fibrous Dysplasia.”

Jason Horton, PhD, Receives K99 award
Dr. Jason Horton, a post-doc IRTA in the Craniofacial and Skeletal Diseases Branch, received a K99 award to support his project on the pathophysiology of radiation-induced bone loss.  

Michael T. Collins, MD, Selected for NIH Inter-Institute Internal Medicine Endocrine Training Program
Michael T. Collins, MD, chief of NIDCR’s Skeletal Clinical Studies Unit, studies and treats patients with rare disorders of bone and mineral metabolism. In January, Dr. Collins assumed the additional responsibility for training fellows in the NIH Inter-Institute Endocrinology Fellowship Program, which provides a comprehensive training experience in both research and clinical endocrinology. 

Timothy Iafolla, DMD, MPH, Expert on Assessment of Dental Fluorosis
Dr. Timothy Iafolla, public health analyst in NIDCR’s Office of Science Policy and Analysis, is the interagency liaison for the oral health component of the Center for Disease Control and Prevention’s National Health and Nutrition Examination Survey. In late September, staff at the University of Manchester in Manchester, UK, hosted a training event so that personnel could be trained to examine and score images produced by a dental fluorosis imaging method that the university developed under contract to the National Center for Health Statistics. The new imaging method for measuring dental fluorosis will replace the current subjective clinical method of dental fluorosis assessment. Dr. Iafolla was invited to assist with training, to act as a training standard for the other trainees, and to ensure programmatic quality control and continuity. 

Science Evaluation Officer Sue Hamann, PhD
From September through December, Sue Hamann, PhD, NIDCR’s Science Evaluation Officer, taught a new course at NIH for the Foundation for Advanced Education in the Sciences. The name of the course is Advanced Seminar in the Evaluation of Research (Public Health 591).

Training and Career Development News

The NIDCR Research Training and Career development branch continues to reach out to the extramural research community to encourage predoctoral and postdoctoral students and junior investigators to apply for NIDCR research training and career development funding. 

In addition, the NIDCR Office of Education participates in many activities to recruit student and postdoctoral researchers. An example of current outreach is collection of applications from dental students for the 2015 NIDCR Summer Dental Student Award. NIDCR provides a competitive stipend for all summer researchers who work in intramural labs. 

Recent outreach included the following activities:

  • Dr. Lynn King, chief of the Research Training and Career Development Branch, attended the general meeting of The American Society for Bone and Mineral Research held September 12 to 15 in Houston, Texas. Dr. King participated in the NIH K Awardee Meeting and served as mentor during the Speed Networking Evening and the Networking Breakfast. She encouraged graduate students, postdocs, and junior faculty to apply for NIDCR funding and met with potential applicants at the NIH Exhibit Booth. 
  • From October 16 to 18, Dr. Philp attended the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) Annual Conference in Los Angeles. NIDCR was among 14 institutes that participated in the NIH exhibit at this conference. Dr. Philp met with students, professors, and researchers who were interested in research opportunities at NIDCR, and she disseminated training and research opportunity materials.
  • On October 21, Dr. Frieden participated in an NIH outreach event at Howard University. She met with undergraduate and graduate students to discuss research career paths in dental, oral, and craniofacial research.
  • On October 28, Dr. Frieden gave a videocast presentation on “NIDCR Research Training and Career Development Opportunities” to residents at the Lutheran Medical Center. This videocast was hosted by the American Association for Dental Research.   
  • From November 12 to 15 in San Antonio, Dr. Philp attended the Annual Biomedical Research Conference for Minority Students (ABRCMS). NIDCR was a part of the NIH exhibit at this conference. She met with students, professors, and researchers who were interested in research opportunities at NIDCR, and she disseminated training and research opportunity materials. In addition, Dr. Philp provided information in a panel discussion and smaller round table meetings on career paths with a doctoral degree. She spoke with the audience about the research experience at NIDCR and NIH. Many attendees were interested in career avenues in government.
  • Dr. Leslie Frieden attended The Society for Neuroscience Annual Meeting held November 15 to 19 in Washington, DC. She met with potential applicants at the NIH Exhibit Booth. 
  • Dr. Frieden attended the TERMIS AMERICAS 2014 Annual Conference and Exposition held December 13 to 16 in Washington, DC. She presented a poster titled, “NIDCR Research Training and Career Development Opportunities.” 

Opportunities for Postdoctoral Fellows 
Dr. Deborah Philp, director of the NIDCR Office of Education, continues to support the needs of the postdoctoral fellows. On December 3, she collaborated with the Eunice Kennedy Shriver National Institute of Child Health and Human Development’s Intramural Training Office to offer a half-day workshop titled “Introduction to Leadership and Management.”  The goal of the workshop, which was led by Dr. David Dilts, was to help trainees identify the traits of a successful manager and to develop skills needed to become successful leaders. Topics covered in this workshop included leadership rights and wrongs, management vs. leadership, and team development. Of the 23 attendees, 10 were from NIDCR. The workshop was positively received.

New Investigator Highlights
Former NIDCR T32 postdoctoral trainee, Flavia Teles, DDS, MS, DMSc, has received her first R01 (DE024767) titled, “Targeted Cultivation of New Periodontal Pathogens.” Dr. Teles is a Research Associate Professor in the Department of Periodontology at the University of North Carolina Chapel Hill.  

Two NIDCR Diversity Supplement Recipients, Oelisoa Mireille Andriankaja DDS, PhD, from the University of Puerto Rico and Bianca Dearing DDS, from New York University participated in a Diversity Scholars Workshop sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and co-sponsored by the NIDCR. Dr. Lynn King was involved in the development of the workshop and participated in the activities. This event was held at NIH on November 13 and 14, 2014, and featured an intensive course on grant writing, a poster session, and the opportunity to network with NIH extramural program staff. 

Meetings and Conferences 

Annual Conference and the Exposition of Tissue Engineering and Regenerative Medicine International Society (TERMIS)
Dr. Lumelsky, director of NIDCR’s Tissue Engineering and Regenerative Medicine Research Program, attended the TERMIS Annual Conference and Exposition held in Washington, DC, on December 13-16, 2014, and served as a part of an organizing committee for a pre-conference workshop titled: “Government Efforts on the Path to Patients for Regenerative Medicine Therapies: A MATES Symposium.” The workshop illustrated the catalytic effect of federal government involvement in the development of the field. Dr. Lumelsky also served as an invited discussant at a luncheon titled "Avoiding traps: Women in Tissue Engineering and Regenerative Medicine.” The purpose of the luncheon was to foster support and professional development of junior women investigators in the field. 

American Public Health Association
Dr. David Clark, health scientist administrator in NIDCR’s Behavioral and Social Sciences Research Branch, co-hosted and presented at a panel session titled “Addressing Disparities in Older Adult Oral Health: Research, Intervention, Information Access, and Access to Care” at the 142nd Annual Meeting and Exposition held in New Orleans, LA on November 15-19, 2014. The purpose of this session was to highlight disparities in oral health of older adults, to identify promising intervention research approaches to improve older adult oral health and hygiene, to highlight policy changes required to make a significant difference in the oral health status of low income adults, and to review existing funding opportunities for further research in these areas.  

7th World Workshop on Oral Health and Disease in AIDS
Dr. Rodriguez-Chavez, director of NIDCR’s AIDS and Immunosuppression Program, attended the 7th World Workshop on Oral Health and Disease in AIDS in Hyderabad, India on November 6-9, 2014. The workshop included more than 250 international delegates representing all continents. Dr. Rodriguez-Chavez served as part of the International Steering Committee that co-organized the scientific agenda for the workshops. He co-chaired the plenary session called “Protection of the oral cavity by innate and specific immunity,” gave the plenary talk called “HIV vaccine research: lessons and successes,” and co-chaired the workshop called “Immunity including innate epithelial and non-specific host factors.” The workshop was supported in part by an NIDCR conference grant, U13-DE024696, to issue travel awards to junior scientists and students who presented abstracts.

The Glycoscience Program
Dr. Amanda Melillo, acting director of the Salivary Biology and Immunology Program, and NIH colleagues held a technical assistance workshop on October 20 for potential applicants to Common Fund Glycoscience Funding Opportunities. The Glycoscience Common Fund program addresses the need to develop accessible new tools and technologies that will make the study of glycans possible for any biomedical investigator. Glycans are involved in many fundamental cellular mechanisms that contribute to health and disease, yet they are difficult for many researchers to study. The Glycoscience Program encourages new strategies and high-risk approaches for methods and tool development with the ultimate goal of rapid transition of successful projects to commercialization. Four FOAs were released on September 30 (RFA-RM14-012RFA-RM14-013RFA-RM14-014, and RFA-RM14-015). Dr. Somerman and Dr. Jon Lorsch, director of the National Institute of General Medical Sciences, are the Institute leaders of this effort. Dr. Amanda Melillo is the communications point of contact for the program.

The FaceBase Consortium
The FaceBase website was moved successfully to its new host at the University of Southern California Information Sciences Institute and an enhanced version of the site is under development. The FaceBase Consortium met for its first annual research meeting on January 8 and 9, 2015, in Los Angeles, CA. This meeting included oral presentations by Consortium members, as well as poster presentations by junior investigators and trainees. Additional breakout groups to identify synergies among the research projects and to develop standard operating procedures took place.

Meetings Related to Genomics Research
In October, Dr. Emily Harris, chief of NIDCR’s Translational Genomics Research Branch, attended the American Society of Human Genetics and the Society for Developmental Biology and Craniofacial Genetics annual meetings in San Diego, California. She provided guidance to investigators on NIDCR’s interests in and initiatives related to genomics research. Dr. Harris also attended investigator meetings for funded projects, including genomics-focused OPPERA 2 (Chapel Hill, North Carolina, December 5, 2014) and Structural Birth Defects (Rockville, Maryland, December 8-9, 2014).

Inter-Society Coordinating Committee for Practitioner Education in Genomics 
The Inter-Society Coordinating Committee for Practitioner Education in Genomics Annual Meeting was held on November 18 in Bethesda, Maryland. The aim of the committee is to improve genomic literacy of physicians and other practitioners and enhance the practice of genomic medicine through sharing educational approaches and identifying educational needs. Dr. Harris participates in the working group that developed case study formats and is facilitating their use by professional societies.

3-D Human Tissue Models to Study Musculoskeletal and Skin Physiology and Pathophysiology
Dr. Lumelsky took part as an invited participant in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Roundtable discussion titled “3-D Human Tissue Models to Study Musculoskeletal and Skin Physiology and Pathophysiology.” This meeting was held on November 24 at the NIAMS extramural program offices in Bethesda, MD. The purpose of this roundtable was to explore the utility of 3-D tissue models in research of health and disease, challenges in developing these tissue models, and solutions to overcome these obstacles.

“Science in Motion” 
“Science in Motion” was sponsored by the Canadian Institutes of Health Research, Institute of Musculoskeletal Health and Arthritis (IMHA), and was held on October 30, in Toronto, Ontario, Canada. The objective of IMHA’s meeting was to roll out the 2014-18 Strategic Plan, which highlights three strategic priorities: Chronic Pain and Fatigue; Inflammation and Tissue Repair; and Disability, Mobility, and Health. Dr. Jason Wan, director of NIDCR’s Mineralized Tissue Physiology Program, provided input on how to implement those priorities and to seek network and partnership opportunities. The ideas provided by attendees will set the stage for how IMHA will implement the Strategic Plan for the next four years.

Visit to the American Dental Association, Washington, DC 
In September, Drs. Sayo Adunola and Marushka Silveira, current dental public health residents, visited the Washington office of the American Dental Association to learn about their efforts to promote oral health and to support NIDCR in its mission. The visit was an activity of NIDCR’s Dental Public Health Residency Program, which provides a formal training opportunity for dentists planning careers in dental public health. They met with Mary Dietrich, director of Congressional Affairs, Dr. Frank Kyle Jr., manager of legislative and regulatory policy, and other legislative and policy experts. Dr. Khara Ramos, special assistant to NIDCR’s deputy director, Dr. Tamara James, AAAS fellow, Dr. Deborah Philp, training director in the Division of Intramural Research, Dr. Dave Vannier, consultant for the Office of Communications and Health Education, and Matthew Moore, post baccalaureate-IRTA, accompanied the residents.

American Evaluation Association
On October 17 in Denver, Colorado, Dr. Sue Hamann, science evaluation officer in NIDCR’s Office of Science Policy and Analysis, presented a paper at the annual meeting of the American Evaluation Association. The paper was called, “Post Docs Say the Darndest Things: Introducing Evaluation to Highly Qualified Professionals.”

Federal Innovation & Research Evaluation (FIRE) Affinity Group
On October 30 in Washington, DC, Dr. Hamann presented the inaugural address for the AAAS S&T Fellows Federal Innovation & Research Evaluation (FIRE) Affinity Group. The presentation was called, “Introducing Evaluation to Highly Qualified Professionals.”

Other meetings/conferences/workshops attended by staff:

  • In Honor of Judith G. Levin – HIV research, NIH, held November 19 in Bethesda, MD
  • 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, held November 18-21 in Barcelona, Spain
  • IL-10 Family of Cytokines in Inflammation and Disease Symposium, NCI, held November 17 in Bethesda, MD
  • American College of Rheumatology held November 15-19 in Boston, MA
  • Annual Meeting of the Society of Neuroscience, held November 15-19 in Washington, DC
  • IOM workshop on Policy Issues in the Development and Adoption of Molecularly Targeted Therapies for Cancer, held November 10 in Washington, DC
  • 3rd NIH Common Fund Extracellular RNA Communication Consortium Investigators Meeting, held November 6-7 in Rockville, MD
  • Big Data to Knowledge (BD2K) Project Team for the kickoff of the Data Discovery Index Coordinating Center (DDICC) held November 3-4 in Bethesda, MD
  • HIV Drug Resistance Program Conference on 'Virus Structure: Putting the Pieces Together’ held October 21 at NCI in Frederick, MD
  • American Society of Human Genetics Annual meeting, held October 18-22 in San Diego, CA
  • American Society for Matrix Biology held October 12-15 in Cleveland, OH
  • Chromatin Control of Viral Infection, NIH, held September 18-19 in Bethesda, MD
  • Innovations in the Prevention and Treatment of early Childhood Caries, held October 23-24 in Ellicott City, MD
  • 10th NICHD Structural Birth Defects Meeting, held Dec 8-10, in Bethesda, MD
  • 2014 Common Fund High-Risk High-Reward Program Symposium, held December 15-17 in Bethesda, MD

Communications Update

News Releases, Science Briefs, and Interviews with Oral Health Researchers 
In October, NIDCR issued a news release, “Shaking Up Cell Biology,” about the intramural program’s scientific advance with the imaging of mitochondrial oscillations using intravital microscopy. In addition, NIH issued several news releases this fall that mentioned NIDCR research funding support:

  • Mouse study reveals potential clue to extra fingers or toes
  • NIH Funds Research Consortia to Study More Than 200 Rare Diseases
  • NIH Common Fund announces 2014 High-Risk, High-Reward Research Awardees
In November, NIDCR communications staff released a Science Spotlight called “The Oral Microbiome: From Bad Bugs to Bad Biofilm Behaviors: Casting a wide investigative net to define microbial behaviors that lead to periodontitis.” In December, communications staff released “Improving Dental Care Through Research,” which is about the NIDCR-funded national dental practice-based research network. 

In addition, staff collaborated with the National Institute of Arthritis and Musculoskeletal and Skin Diseases on brief content about NIDCR-supported research. The brief was called “Research on Keratins Reveals Unexpected Link Between Hair Disorders and Dental Decay.”

Grantee News Releases
The most recent group of grantee news releases about NIDCR-supported research posted on the NIDCR website includes the following:

Public Inquiry Response, Publication Distribution, and Exhibits 

NIDCR and its National Oral Health Information Clearinghouse responded to more than 9,900 public inquiries in 2014. In addition to making all of its health information available online, the Institute also distributed 1.5 million publications. Among the most popular publications were “A Healthy Mouth for Your Baby” and “Seal Out Tooth Decay” in English and Spanish. Most of these publications are disseminated to underserved communities via health departments and organizations like Head Start or the Women, Infants, and Children (WIC) program. 

In September, NIDCR sent patient and health professional education materials to the Mid-Maryland Mission of Mercy and Health Equity Festival hosted by Catholic Charities of DC and the University of Maryland Center for Health Equity School of Public Health, and in November, NIDCR shipped materials to the 10th Annual Community Fair hosted by First Rising Mt. Zion Baptist Church, Howard University, and Howard University College of Dentistry.   


Selected Division of Intramural Research Publications: Peer-Reviewed

Afione S, DiMattia MA, Halder S, Di Pasquale G, Agbandje-McKenna M, Chiorini JA.  Identification and mutagenesis of the AAV5 sialic acid binding region. J Virol.  2014 Nov 19. pii: JVI.02503-14. 

Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa, Sworder BJ, Cherman N, Kuznetsov SA, Bianco P, Giri N, Savage SA, Merlino G, Dumitriu B, Dunbar CE, Young NS, Alter BP, Robey PGBone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.  Blood. 2014 Dec 12. pii: blood-2014-06-566810. [Epub ahead of print] 

Barretto RP, Gillis-Smith S, Chandrashekar J, Yarmolinsky DA, Schnitzer MJ, Ryba NJP, Zuker CS. The Neural Representation of Taste Quality at the Periphery. Nature.2014 Nov 5. doi: 10.1038/nature13873. [Epub ahead of print]

Betts K, Abusleme L,  Freeman AF, Sarmadi M, Fahle G, Pittaluga S, Cuellar-Rodriguez J, Hickstein D, Holland SM, Su H, Moutsopoulos NM. A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis – A case of virally induced periodontitis? Journal of Clinical Virology 2014 Dec 5; [Epub Ahead of Print].  

Boyce AM, Kelly MH, Brillante BA, Kushner H, Wientroub S, Riminucci M, Bianco P, Robey PG, Collins MT 2014 A randomized, double blind, placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone. J Clin Endocrinol Metab. 2014 Nov;99(11):4133-40. doi: 10.1210/jc.2014-1371. Epub 2014 Jul 17.

Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB J, 2014 Dec 2. pii: fj.14-260083 [Epub ahead of print].  

Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC. Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.. Oncotarget 2014 Oct 30;5(20):9626-40.   

Goswami SC, Mishra SK, Maric D, Kaszas K, Gonnella GL, Clokie SJ, Kominsky HD, Gross JR, Keller JM, Mannes AJ, Hoon MA, Iadarola MJ. Molecular Signatures of Mouse TRPV1-Lineage Neurons Revealed by RNA-Seq Transcriptome Analysis. J Pain. 2014; 15: 1338-59.  doi: 10.1016/j.jpain.2014.09.010. 

Harunaga JS, Doyle AD, Yamada KM. Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility. Dev Biol. 2014 Oct 15;394(2):197-205. 

Kutys ML, Yamada KM. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014 Sep;16(9):909-17. 

Mandal A, Mandal S, Park MH. Genome-wide analyses and functional classification of proline repeat-rich proteins: potential role of eIF5A in eukaryotic evolution.
PLoS ONE 2014 Nov 3: 9(11); e111800 doi 10.1371/journal.pone.0111800.  

Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS. The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies. 2014 Oct 15;5(19):8906-23.

Porat-Shliom N, Chen Y, Tora M, Shitara A, Masedunskas A, Weigert R, In vivo tissue-wide synchronization of mitochondrial metabolic oscillations. Cell Reports 2014, Oct 23;9(2):514-21.  

Qi S, O’Hayre M, Gutkind JS, Hurley JH. Insights into β2-Adrenergic Receptor Binding from Structures of the N-Terminal Lobe of ARRDC3. Protein Sci 2014, 23(12):1708-1716. doi: 10.1002/pro.2549. Epub 2014 Sep 26.

Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NP. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility. Genes. PLoS Genet. 2014 Nov 20;10(11):e1004809. doi: 10.1371/ journal.pgen.1004809.

Yoshizaki Y, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y.  2014, Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One 2014 Jun 20;9(6):e99991.

Recent Publications from K Awardees
Boyle M, Chun C, Strojny C, Narayanan R, Bartholomew A, Sundivakkam P, Alapati S.  Chronic inflammation and angiogenic signaling axis impairs differentiation of dental-pulp stem cells.  PLoS One. 2014 Nov 26;9(11):e113419.

Lin Y, Luo J, Zhu WE, Srivastava M, Schaue D, Elashoff DA, Dubinett SM, Sharma S, Wu B, St John MA.  A cytokine-delivering polymer is effective in reducing tumor burden in a head and neck squamous cell carcinoma murine model.  Otolaryngol Head Neck Surg. 2014 Sep;151(3):447-53.

Palasuk J, Kamocki K, Hippenmeyer L, Platt JA, Spolnik KJ, Gregory RL, Bottino MC.  Bimix antimicrobial scaffolds for regenerative endodontics.  J Endod. 2014 Nov;40(11):1879-84.

Recent Publications from F Fellows 

Albataineh MT, Lazzell A, Lopez-Ribot JL, Kadosh D  Ppg1, a PP2A-Type Protein Phosphatase, Controls Filament Extension and Virulence in Candida albicans.  Eukaryot Cell. 2014 Dec;13(12):1538-47.

Conti HR, Peterson AC, Brane L, Huppler AR, Hernández-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL.  Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections.  J Exp Med.  2014 Sep 22;211(10):2075-84.

Davis, SE, Hopke, A, Minkin Jr, SC, Montedonico, AE, Wheeler, RT, Reynolds, TB.  Masking of beta(1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine. Infect Immun.  2014 Oct; 82(10):4405-13.

Grasman JM, Pumphrey LM, Dunphy M, Perez-Rogers J, Pins GD.  Static axial stretching enhances the mechanical properties and cellular responses of fibrin microthreads.  Acta Biomater. 2014 Oct;10(10):4367-76.

Holman SD, Gierbolini-Norat EM, Lukasik SL, Campbell-Malone R, Ding P, German RZ.  J Vet Dent. 2014 Summer;31(2):92-5.

Marcinkiewicz KM, Gudas LJ.  Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma.  J Cell Physiol. 2014 Oct;229(10):1405-16.

Powder KE, Cousin H, McLinden GP, Craig Albertson R.  A Nonsynonymous Mutation in the Transcriptional Regulator lbh Is Associated with Cichlid Craniofacial Adaptation and Neural Crest Cell Development.  Mol Biol Evol. 2014 Dec;31(12):3113-24.

Tabler JM, Bolger TG, Wallingford J, Liu KJ.  Hedgehog activity controls opening of the primary mouth.  Dev Biol. 2014 Dec 1;396(1):1-7.

Vasudevan HN, Soriano P.  SRF Regulates Craniofacial Development through Selective Recruitment of MRTF Cofactors by PDGF Signaling.  Dev Cell. 2014 Nov 10;31(3):332-44.

Recent Publications from T32/T90/R90 Trainees and K12 Scholars

Akinkugbe A, Iafolla T, Chattopadhyay A, Garcia I, Adams A, Kingman A.  The role of partial recording protocols in reporting prevalence and severity of dental fluorosis.  Community Dent Oral Epidemiol. 2014 Dec;42(6):563-71.

Aubrecht TG, Weil ZM, Ariza ME, Williams M, Reader BF, Glaser R, Sheridan JF, Nelson RJ.  Epstein-Barr virus (EBV)-encoded dUTPase and chronic restraint induce impaired learning and memory and sickness responses.  Physiol Behav. 2014 Oct;137:18-24.

Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Hagen FK, Abranches J, Lemos JA.  Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence.  J Bacteriol. 2014 Aug;196(15):2789-97.

Benson RW, Cafarelli TM, Rands TJ, Lin I, Godoy VG.  Selection of dinB alleles suppressing survival loss upon dinB overexpression in Escherichia coli.  J Bacteriol. 2014 Aug 15;196(16):3023-35.

Cox MK, Appelboom BL, Ban GI, Serra R.  Erg cooperates with TGF-β to control mesenchymal differentiation.  Exp Cell Res. 2014 Nov 1;328(2):410-8.

Jang ATLin JD, Choi RM, Choi EM, Seto ML, Ryder MI, Gansky SA, Curtis DA, Ho SP.  Adaptive properties of human cementum and cementum dentin junction with age.  J Mech Behav Biomed Mater. 2014 Nov;39:184-96.

Jhun E, He Y, Yao Y, Molokie RE, Wilkie DJ, Wang ZJ.  Dopamine D3 Receptor Ser9Gly and Catechol-O-Methyltransferase Val158Met Polymorphisms and Acute Pain in Sickle Cell Disease. Anesth Analg. 2014 Nov;119(5):1201-7.

Katsura KA, Horst JA, Chandra D, Le TQ, Nakano Y, Zhang Y, Horst OV, Zhu L, Le MH, DenBesten PK.  WDR72 models of structure and function: a stage-specific regulator of enamel mineralization.  Matrix Biol. 2014 Sep;38:48-58.

Kranz AM, Lee J, Divaris K, Baker AD, Vann W Jr.  North Carolina physician-based preventive oral health services improve access and use among young medicaid enrollees.  Health Aff (Millwood). 2014 Dec 1;33(12):2144-52.

Kuzynski M, Goss M, Bottini M, Yadav MC, Mobley C, Winters T, Poliard A, Kellermann O, Lee B, Millan JL, Napierala D.  Dual role of the Trps1 transcription factor in dentin mineralization.  J Biol Chem. 2014 Oct 3;289(40):27481-93.

Nasse JS.  A novel slice preparation to study medullary oromotor and autonomic circuits in vitro.  J Neurosci Methods. 2014 Nov 30;237:41-53.

Neben CL, Idoni B, Salva JE, Tuzon CT, Rice JC, Krakow D, Merrill AE.  Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription.  Hum Mol Genet. 2014 Nov 1;23(21):5659-71.

Saputo S, Kumar A, Krysan DJ.  Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.  Eukaryot Cell. 2014 Sep;13(9):1169-80

Valerio MS, Herbert BA, Basilakos DS, Browne C, Yu H, Kirkwood KL.  Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2.  Cytokine. 2015 Jan;71(1):71-80.

Warner BM, Casto BC, Knobloch TJ, Accurso BT, Weghorst CM.  Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.  Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Dec;118(6):674-83.

Wilson CG, Martín-Saavedra FM, Padilla F, Fabiilli ML, Zhang M, Baez AM, Bonkowski CJ, Kripfgans OD, Voellmy R, Vilaboa N, Fowlkes JB, Franceschi RT.  Patterning expression of regenerative growth factors using high intensity focused ultrasound.  Tissue Eng Part C Methods. 2014 Oct;20(10):769-79.

Selected Extramurally Funded Science Advances 

Choi EY, Lim JH, Neuwirth A, Economopoulou M, Chatzigeorgiou A, Chung KJ, Bittner S, Lee SH, Langer H, Samus M, Kim H, Cho GS, Ziemssen T, Bdeir K, Chavakis E, Koh JY, Boon L, Hosur K, Bornstein SR, Meuth SG, Hajishengallis G, Chavakis T (2014). Developmental Endothelial Locus-1 Is a Homeostatic Factor in the Central Nervous System Limiting Neuroinflammation and Demyelination.  Mol Psychiatry, Nov 11. doi: 10.1038/mp.2014.146 [Epub ahead of print].

Dayer MJ, Jones S, Prendergast B, Baddour LM, Lockhart PB, Thornhill MH (2014). Incidence of infective endocarditis in England, 2000-13: a secular trend, interrupted time-series analysis. Lancet, Nov 18, 2014: doi: 10.1016/S0140-6736(14)62007-9. [Epub ahead of print] 

Fakhry C, Gillison ML and D'Souza G (2014). Tobacco use and oral HPV-16 infection.  JAMA, 312(14):1465-7. 

Harrel SK, Abraham CM, Rivera-Hidalgo F, Shulman JD, Nunn ME (2014). Videoscope-assisted minimally invasive periodontal surgery (V-MIS).  J Clin Periodontol, 41(9):900-7. 

Li C, Yang Y, Liu S, Fang H, Zhang Y, Furmanski O, Skinner J, Xing Y, Johns RA, Huganir RL, Tao F (2014). Stress induces pain transition by potentiation of AMPA receptor phosphorylation.  J Neurosci, 34(41):13737-4

Parker HJ, Bronner ME, and Krumlauf R (2014). A Hox regulatory network of hindbrain segmentation is conserved to the base of vertebrates. Nature, 514:490–3.

Wang H, Zhou H, Duan X, Jotwani R, Vuddaraju H, Liang S, Scott DA, Lamont RJ (2014). Porphyromonas gingivalis-Induced Reactive Oxygen Species Activate JAK2 and Regulate Production of Inflammatory Cytokines through C-Jun. Infect Immun, 82(10):4118-26.

Yoshitaka T, Mukai T, Kittaka M, Alford LM, Masrani S, Ishida S, Yamaguchi K, Yamada M, Mizuno N, Olsen BR, Reichenberger EJ, Ueki Y (2014). Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep, 8(6):1752-66. 


Program Announcements

NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22)

NIH Pathway to Independence Award (Parent K99/R00)

NIDCR Clinical Trial or Biomarker Clinical Validation Study Cooperative Agreement (U01)

NIDCR Clinical Trial or Biomarker Clinical Validation Study Planning Grant (R34)

Systems Science and Health in the Behavioral and Social Sciences (R01)

Systems Science and Health in the Behavioral and Social Sciences (R21)

NIDCR Behavioral or Social Intervention Clinical Trial Planning Grant (R34)

Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)

Building Genetics and Genomic Knowledge about Dental, Oral, and Craniofacial Diseases and Disorders (R01)

Biology of the Temporomandibular Joint in Health and Disease (R21)

Biology of the Temporomandibular Joint in Health and Disease (R01)

Requests for Applications

Pharmacogenomics of Orofacial Pain Management (R01)

Science of Behavior Change: Assay Development and Validation for Self-Regulation Targets (UH2/UH3)

Science of Behavior Change: Assay Development and Validation for Stress Reactivity and Stress Resilience Targets (UH2/UH3)

Science of Behavior Change: Assay Development and Validation for Interpersonal and Social Processes Targets (UH2/UH3)

NIH Science of Behavior Change Resource and Coordinating Center (U24)

Pediatric HIV/AIDS Cohort Study (PHACS) Data and Operations Center (DOC) (U01)

Pediatric HIV/AIDS Cohort Study (PHACS) Coordinating Center (CC)  (U01) 

Planning Grants for Dental, Oral and Craniofacial Tissue Regeneration Consortium Resource Centers (R34)

NIH Big Data to Knowledge Initiative

NIH Director's Early Independence Awards (DP5)

Building Interdisciplinary Research Careers in Women's Health (K12)

Model Organisms Screening Center for the Undiagnosed Diseases Network (UDN) (U54)

4D Nucleome Network Data Coordination and Integration Center (U01)

4D Nucleome Network Organizational Hub (U01)

4D Nucleome Imaging Tools (U01)

Study of Nuclear Bodies and Compartments (U01)

Nucleomics Tools (U01)

Nuclear Organization and Function Interdisciplinary Consortium (NOFIC)(U54)

Last Reviewed on
February 2018