ACTIVITIES OF THE NIDCR DIRECTOR AND DEPUTY DIRECTOR
Since the last meeting of the National Advisory Dental and Craniofacial Research Council (NADCRC) in January 2015, NIDCR Director Martha J. Somerman, DDS, PhD, and acting Deputy Director John Kusiak, PhD, maintained an active schedule of attending annual conferences, delivering presentations to stakeholders, and meeting with working groups and other organizations. In addition, Drs. Somerman and Kusiak continued to play an active role in pain-related activities, such as serving on the Interagency Pain Research Coordinating Committee.
Administrative Board of the Council of Deans of the American Dental Education Association – Washington, DC
At the invitation of Dr. Richard Valachovic, DMD, MPH, president and chief executive officer of the American Dental Education Association (ADEA), Dr. Somerman spoke to ADEA’s Administrative Board of the Council of Deans at their annual meeting in Washington, DC, on January 22. She discussed NIDCR’s current research portfolio and funding opportunities, ways in which dental schools could partner with NIDCR to further the mission and goals of the Institute, and advances in the development of electronic health records and their potential role in dental research.
Dr. Kusiak and Lynn Mertens King, PhD, chief of the Research Training and Career Development Branch in NIDCR’s Division of Extramural Activities, also took part in discussions about partnerships aimed at developing a dental research workforce, incorporating research into dental schools, using electronic health records in dental research, providing robust research opportunities and collaborations with experienced mentors, and communicating research career pathways to engage a broad range of individual career levels.
Friends of the NIDCR Annual Conference and Awards – Washington, DC
On January 28, Drs. Somerman and Kusiak attended the Friends of the NIDCR (FNIDCR) Annual Conference and Awards event held in Washington, DC. Before the conference, FNIDCR, in cooperation with the Congressional Oral Health Caucus, sponsored a morning briefing on Capitol Hill called “Driving Innovation through Dental Research.” This briefing provided a forum for Congressional staff, oral health researchers, students, and educators to learn about the important role of the NIDCR in advancing oral health. Presentations given by Dr. Somerman, Director of Extramural Research Lillian R. Shum, PhD, and NIDCR Senior Investigator John A. Chiorini, PhD, described how dental, oral, and craniofacial research drives innovation.
Later in the day at the annual conference awards ceremony, FNIDCR presented Pamela Gehron Robey, PhD, chief of NIDCR’s Craniofacial and Skeletal Diseases Branch, with the Outstanding NIDCR Career Research Award. Dr. Robey, who began her scientific career at NIH nearly four decades ago, studies the activity of skeletal stem cells and their role in skeletal diseases, and the potential application of stem cells in tissue engineering and regenerative medicine.
In the afternoon after the awards ceremony, FNIDCR presented education sessions by representatives of NIDCR, dental schools, private industry, and patient advocacy organizations. Several members of the National Advisory Dental and Craniofacial Research Council took part in the FNIDCR education sessions, either by making presentations or introducing speakers. The Council members who participated were Teresa A. Dolan, DDS, MPH, vice president and chief clinical officer of DENTSPLY International; Anne C. R.Tanner, BDS, PhD, senior member of the staff in the Department of Microbiology at the Forsyth Institute and associate professor in Oral Medicine, Infection, and Immunity at Harvard School of Dental Medicine; and J. Leslie Winston, DDS, PhD, director of Global Professional and Scientific Relations at Procter & Gamble.
As part of the session called “Securing a Pipeline of Next Generation Investigators,” Dr. Lynn King presented on NIDCR-supported research training funding opportunities and research training pathways for dentists pursuing independent research careers. She was joined by Nisha D’Silva, BDS, MSD, PhD, professor of dentistry and associate professor of pathology at the University of Michigan School of Dentistry, who provided the perspective of an NIDCR awardee. Dr. D’Silva described her postdoctoral research training under an institutional training grant, a mentored research career development award, and subsequent research project grants that supported the development of her research career.
In the session called “The Latest in NIDCR-funding Research,” Reuben H. Kim, DDS, PhD, associate professor at the UCLA School of Dentistry, spoke about “Osteomucosal Healing: an old concept, but new approach to ONJ pathophysiology.” Dr. Kim is an NIDCR R01-funded Early Stage Investigator whose research training was supported by an NIDCR institutional training grant postdoctoral position and an individual mentored research career development award. In addition, Dr. Tanner spoke about the oral microbiome, and Jeff Shaefer, DDS, assistant professor of oral and maxillofacial surgery at Harvard School of Dental Medicine, spoke about facial pain and temporomandibular joint disease.
Mary Fete, RN, MSN, executive director of the National Foundation for Ectodermal Dysplasias, co-chaired the panel called “Bench to Bedside: Expediting Scientific Discovery to Improve Oral Health.” During that session, Terrie Cowley, founder of The TMJ Association, talked about how patient advocacy organizations can push the translation of research into clinical practice, and Dr. Shum spoke about NIH’s perspective for commercializing innovations. Later, Kathryn A. Atchison, DDS, MPH, the vice provost for New Collaborative Initiatives at the University of California, Los Angeles (UCLA) and professor at the UCLA School of Dentistry, spoke about technology transfer and intellectual property. Dr. Atchison is devoting a percentage of her time to NIDCR to help formulate a strategy to strengthen the translational pipeline for new product development and to help identify potential public-private and public-public partnerships. Finally, Dr. Teresa A. Dolan spoke about corporations partnering with NIH to expedite clinical translation.
Ad Hoc Group for Medical Research - Bethesda, MD
On February 6, Drs. Somerman and Kusiak met with the Ad Hoc Group for Medical Research as they began the planning process for their advocacy efforts related to the Fiscal Year 2016 budget for NIH. The group is a coalition of more than 300 patient and voluntary health groups, medical and scientific societies, academic and research organizations, and industry representatives that support enhancing the federal investment in the biomedical, behavioral, and population-based research conducted and supported by the NIH. Also in attendance were Dr. Shum; Dr. Margo Adesanya, acting director of the Office of Science Policy and Analysis (OSPA); Ms. Kathleen Stephan, associate director for management; Mr. George Coy, director of the Financial Management Branch (FMB); Ms. Carol Loose from FMB; and Drs. Jonathan Horsford and Wendy Knosp from OSPA.
Center for Medicaid and Medicare Services – Bethesda, MD
On February 25, Dr. Somerman, Dr. Kusiak, and Dr. Kathryn Atchison, the Vice Provost for New Collaborative Initiatives at the University of California, Los Angeles (UCLA) and Professor at the UCLA School of Dentistry, met with Chief Dental Officer Lynn Mouden, DDS, MPH, and colleagues from the Centers for Medicaid and Medicare Services (CMS). They discussed possible opportunities for using Medicaid and Medicare datasets for dental, oral, and craniofacial research.
2015 IADR/AADR/CADR General Session and Exhibition - Boston, MA
From March 11 to 14, NIDCR leadership and program staff attended the 2015 General Session and Exhibition of the International Association for Dental Research (IADR), American Association for Dental Research (AADR), and Canadian Association for Dental Research (CADR) in Boston, MA. This annual meeting provides meaningful opportunities for NIDCR staff to engage with scientific investigators, research trainees, and students. Staff members from the Center for Clinical Research, Division of Extramural Activities, Division of Extramural Research, Division of Intramural Research, and Office of Science Policy and Analysis actively took part in the meeting by giving presentations, chairing symposia, conducting training events, and participating as panelists. A schedule listing NIDCR presentations is available on the NIDCR website.
Drs. Somerman and Kusiak
Dr. Somerman provided opening remarks for the NIDCR Trainee Poster Session. In addition, Drs. Somerman and Kusiak attended the NIDCR T32 and T90/R90 Training Directors meeting. She viewed posters, attended presentations and workshops, and had the opportunity to connect with colleagues to share information about the Institute and learn about ongoing research and training.
On Friday, Dr. Somerman was the welcoming speaker at the “Opportunities in the National Dental Practice-Based Research Network" symposium, which was organized by Cyril Meyerowitz, DDS, MS, director of the Eastman Institute for Oral Health and Professor and Chair of Dentistry at the University of Rochester School of Medicine and Dentistry in New York. Gregg Gilbert, the national network director of the National Dental Practice-Based Research Network (PBRN), provided a brief overview of the PBRN. The two keynote presentations were "Resolving uncertainty in suspicious occlusal lesions through practice-based research" by Sonia Makhija, DDS, MPH, national director of communications and dissemination for the National Dental PBRN and associate professor at the University of Alabama at Birmingham, and James Bader, DDS, MPH, a research professor at the University of North Carolina School of Dentistry. The other keynote presentation was "Understanding how patients develop persistent pain following root canal therapy," by Donald Nixdorf, DDS, MS. The keynote presentations were followed by 12 interactive breakout sessions, and a panel discussion. The presence of participants from Australia, Brazil, Canada, Chile, China, England, Finland, Germany, Hong Kong, Iraq, Japan, Korea, Mexico, the Netherlands, Nigeria, Norway, Saudi Arabia, Singapore, South Africa, Sweden, Taiwan, and the United Arab Emirates indicated a worldwide interest in replicating the dental PBRN.
On Saturday, Drs. Somerman, Kusiak, and Shum participated in a special workshop titled “Big Data for Oral Health Knowledge: How to Get the Big Answers.” Also taking part were Dave Clark, DrPH, from NIDCR’s Behavioral and Social Sciences Research Branch, and Steven Scholnick, PhD, from the Developmental Biology and Genetics Program. The workshop focused on emerging challenges for dental researchers related to the increased use of large data sets. Topics included developing standards for storage and retrieval of health data (electronic dental and health records), bringing team science to bear on big data research questions, data security, use of mobile devices to collect data in real time, and computational needs for big data analysis.
IADR Presents Matthew Hoffman, BDS, PhD, with Distinguished Scientist Award
Senior Investigator Matthew Hoffman, BDS, PhD, received the 2015 IADR Distinguished Scientist Award for Salivary Research. Dr. Hoffman is chief of the Matrix and Morphogenesis Section in NIDCR’s Division of Intramural Research.
IADR Neuroscience Group Elects Ashok Kulkarni, PhD, as Secretary/Treasurer
At the IADR/AADR/CADR General Session, Ashok Kulkarni, PhD, chief of NIDCR’s Functional Genomics Section in the Division of Intramural Research, was elected as the Secretary/ Treasurer of the IADR-Neuroscience Group, and he represented the Neuroscience Group at the AADR Council Meeting.
Isaac Rodriguez-Chavez, PhD, Co-chairs HPV Symposium
NIDCR’s AIDS and Immunosuppression Program Director Isaac Rodriguez-Chavez, PhD, organized and co-chaired a symposium titled “HPV Drives Cancer: Epidemiology, Mechanisms and Prevention” at the IADR/AADR/CADR General Session. In addition, he gave a talk titled “NIDCR Research Efforts on HPV-driven Oral Cancer & HIV Malignancies.”
Dwayne Lunsford, PhD, Chairs Small Business Symposium
NIDCR’s Microbiology Program Director R. Dwayne Lunsford, PhD, organized and chaired a small business symposium titled “Fostering Innovation and Commercialization with the NIDCR Small Business Programs.” The symposium outlined NIDCR efforts to bring new products to market through the SBIR/STTR small business programs and CRADA mechanisms, and speakers described case studies. Dr. Atchison spoke about the university perspective of small business programs, and Dr. Chiorini spoke about the CRADA mechanism.
Training and Career Events at IADR/AADR/CADR
NIDCR sponsored a number of training and career events at the 2015 IADR/AADR/CADR General Session:
- Poster and oral sessions: Lynn King, PhD, chief of Research Training and Career Development Branch, and Leslie Frieden, PhD, the extramural training officer, organized NIDCR trainee research presentation sessions. Individuals receiving current NIDCR training support through institutional T32/T90/R90 and K12 awards, or individual fellowship (F) or career development (K) awards were invited to present their research in a poster format or an oral session. The NIDCR Trainee Day Poster Session featured the research of 110 NIDCR-supported trainees, fellows, and career development awardees. This year, NIDCR offered an oral session for the first time. During the “Open Microphone” Session, 10 speakers gave four-minute presentations on their research with four slides. This event was open to the public, and attendees to the session included training program directors, NIDCR staff, and other scientists. NIDCR-supported trainees were able to network with colleagues, talk to potential mentors and collaborators, and discuss research grants and training opportunities with NIDCR program staff.
- Presentation on intramural opportunities: NIDCR’s Intramural Training Director Deborah Philp, PhD, gave a presentation with NIDCR Scientific Director Robert Angerer, PhD, and then NIDCR Deputy Clinical Director Janice Lee, DDS, MD, MS, on intramural research training opportunities.
- Presentation on extramural opportunities: Drs. King and Frieden gave a presentation on “NIDCR Research Training and Career Development Opportunities.”
- Individual consultations: Many attendees took advantage of the opportunity for individual consultation with Drs. King, Frieden, and Philp, and other NIDCR program staff at the NIDCR exhibit booth.
In addition, Dr. King spoke at a symposium on “Glass Ceiling or Sticky Floor: Barriers for Women in Academia,” and a workshop on “Clinician Scientist Training: Towards Defining Best Principles.”
U.S. Senate Committee on Appropriations – Bethesda, MD
On March 30, Dr. Somerman met with Democratic Staff Director Alex Keenan and Laura Friedel, staff director and clerk, both of the Senate Appropriations Subcommittee for Labor, Health and Human Services, Education and Related Agencies. As in 2014, Dr. Somerman was one of several NIH directors to meet with the Senate clerks on the NIH campus in Bethesda, MD. The goal of the meetings was to give the clerks an opportunity to interact in person with directors that they or other members of the Subcommittee had not recently interacted with, allowing them to discuss major priorities, initiatives, goals, challenges, and opportunities.
Dr. Somerman described NIDCR’s mission, exciting scientific discoveries and advances supported by our Institute, and NIDCR’s future plans and goals. Included in the presentation was information on precision medicine research as an emerging approach for dental, oral, and craniofacial disease prevention and treatment.
Also in attendance were Dr. Kusiak; Ms. Anne Houser, senior legislative analyst in the NIH Office of Legislative Policy and Analysis; Neil K. Shapiro, JD, MBA, associate director of the NIH Office of Budget; and Dr. Jonathan Horsford from the NIDCR Office of Science Policy and Analysis.
Research Day at the Oregon Health & Science University School of Dentistry – Portland, OR
On April 2, Dr. Somerman was the keynote speaker for the Oregon Health and Science University School of Dentistry Research Day. The title of her talk was “NIDCR/NIH: A Catalyst for Advancing Heath through Research.” She spoke to faculty and students about her research, the importance of research in dental education, and the many exciting advances in dental, oral, and craniofacial research supported by NIDCR. In addition, Dr. Somerman spoke with faculty about the vision of NIH for oral health research in the future.
American Association for Dental Research (AADR) and the American Dental Education Association (ADEA) Advocacy Day – Washington, DC
On April 14, Drs. Somerman, Kusiak, Horsford, and Knosp attended a briefing on Capitol Hill sponsored by the American Association for Dental Research and the American Dental Education Association. This briefing provided a forum for oral health researchers, students and educators to learn about the important role of NIDCR in advancing oral health. Dr. Somerman provided an update on NIDCR and NIH activities, successful translational research projects funded by NIDCR, and future research directions.
Interview with LabTV – Bethesda, MD
On April 22, Dr. Somerman was interviewed by David Hoffman, who is the LabTV executive producer and an acclaimed documentary filmmaker. Founded by TedMed chairman Jay Walker, LabTV is meant to inspire young people to consider biomedical research careers. Their online collection of video interviews with NIH scientists and NIH-funded researchers around the country is designed to help students—especially women and minorities—find role models and hear their stories. In the future, Dr. Somerman’s interview will be accessible to the public at www.labtv.com .
NIDCR Diversity and Inclusion Panel Event – Bethesda, MD
On April 24, Dr. Somerman provided both opening and closing remarks for a three-hour event on the NIH campus called, “Enhancing Diversity and Inclusion: Insights from the Experts.” The event was organized by members of the NIDCR Committee on Diversity and Inclusion, in collaboration with representatives of the National Institute on Alcohol Abuse and Alcoholism, National Institute of Biomedical Imaging and Bioengineering, and National Institute on Drug Abuse.
A panel of five speakers discussed enhancing diversity and inclusion at NIDCR and NIH. The invited panelists were:
- Victoria Plaut, PhD, professor of law and social science; director, Culture, Diversity & Intergroup Relations Lab at the University of California, Berkeley School of Law
- Brian Nosek, PhD, professor of psychology at the University of Virginia
- Kim D ’Abreu, MPH, senior vice president for Access, Diversity and Inclusion at the American Dental Education Association
- Debra Chew, Esq., chief of the NIH Office of Equality, Diversity and Inclusion
- Hannah Valantine, chief of the NIH Office of Scientific Workforce Diversity
NIH diversity catalysts and other participants learned about initiatives being implemented by the NIH Office of the Director and the Office of Equity, Diversity and Inclusion. The speakers described current issues in diversity and inclusion in the biomedical research workforce, and they described evidence-based approaches for enhancing diversity.
2015 NIDCR Seymour J. Kreshover Lecture – Bethesda, MD
Dr. Somerman renewed the Seymour J. Kreshover Lecture Series by inviting Linda R. Watkins, PhD, a University of Colorado President's Teaching Scholar and the director of the Interdepartmental Neuroscience PhD Program, to be the first honoree since 2005. The lecture — “Targeting Glia to Treat Chronic Pain: Moving from Concept to Clinical Trials”— took place on May 4, and the video is archived at http://videocast.nih.gov.
Dr. Watkins’ research is focused on the influence of glial cells on pain sensitivity, the transition of acute pain to chronic conditions, and controlling chronic pain and enhancing the effectiveness of analgesics. In addition to NIDCR research grants, she has been awarded grants from the National Institute on Drug Abuse, National Institute of Mental Health, and National Institute of Neurological Diseases and Stroke.
The NIDCR Seymour J. Kreshover Lecture series was established in 1983 to recognize outstanding scientific accomplishment in basic and clinical research and to honor distinguished scientists who made important contributions in areas of research directly related to the interests of NIDCR. The lecture was named for Seymour J. Kreshover, DDS, MD, PhD, who served as director of the National Institute of Dental Research from 1966 until his retirement from the United States Public Health Service Commissioned Corps in 1975. He was known for his outstanding leadership, his marked dedication to public service, and his valuable contributions to the broad field of Dental Medicine.
In the audience on May 4 were two of Dr. Kreshover’s children, Mr. Douglas Kreshover and Ms. Karen Davis, their spouses, and several of their children. Mr. Kreshover offered opening remarks in which he reminisced about his father. NIH Principal Deputy Director and former NIDCR Director Dr. Lawrence Tabak attended the lecture as well and also introduced Dr. Watkins.
The Consolidated Appropriations Act, 2014 provided an operating budget of $397.833 million. See the table below for distribution by budget mechanism.
National Institute of Dental and Craniofacial Research
FY 2014 Actuals
(Dollars in Thousands)
Biomedical Research Support
Subtotal, Other Research
TOTAL Research Grants
Research & Development Contracts
Research Management and Support
The FY 2015 enacted budget for NIDCR is $399,886,000. This amount is reduced by a transfer out (HIV/AIDS) for $2.186 million, leaving NIDCR with an operating level of $397,700,000.
Currently, no budget information for 2016 is available.
Public Health Service Recommendation for Fluoride Concentration in Drinking Water
On April 27, the Department of Health and Human Services released the final Public Health Service recommendation for the optimal fluoride level in drinking water to prevent tooth decay. The new recommendation is for a single level of 0.7 milligram of fluoride per liter of water. It updates and replaces the previous recommended range, which was 0.7 to 1.2 milligrams per liter, issued in 1962. The change was recommended because Americans now have access to more sources of fluoride, such as toothpaste and mouth rinses, than they did when water fluoridation was first introduced in the United States. As a result, the prevalence of fluorosis has increased, which, in most cases, manifests as barely visible lacy white spots on the tooth enamel. The new recommended level will maintain the protective decay prevention benefits of water fluoridation and reduce the occurrence of dental fluorosis.
A federal panel reviewed the scientific evidence related to fluoride concentration in drinking water. Members of the federal panel included Isabel Garcia, DDS, MPH (then deputy director of NIDCR), Amit Chattopadhyay, BDS, MDS, MPH, PhD (then epidemiologist in NIDCR/OSPA), and Timothy Iafolla, DMD, MPH, of OSPA.
Jack Whitescarver, PhD, Steps Down as Director of NIH’s Office of AIDS Research
Jack Whitescarver, PhD, who has led the Office of AIDS Research at NIH since 2000, will step down from his post, effective July 1, 2015. He also serves as NIH Associate Director for AIDS Research. The NIH will appoint an acting director for the office while it seeks to recruit a new director.
Douglas Lowy, MD, Becomes Acting Director of the National Cancer Institute
On April 1, Douglas Lowy, MD, was named the National Cancer Institute’s (NCI) acting director. Lowy has served as NCI’s deputy director since July 2010, helping lead NCI’s key scientific initiatives since that time. Harold Varmus, MD, who led NCI for nearly five years, stepped down from his post, effective March 31, 2015. From 1993-1999, Dr. Varmus served as the director of NIH under President Bill Clinton. After leaving NIH and before returning to run NCI in 2010, Varmus served as president of Memorial Sloan-Kettering Cancer Center in New York.
NIH Names Dr. Eliseo Pérez-Stable Director of the National Institute on Minority Health and Health Disparities
On April 28, NIH announced that Eliseo J. Pérez-Stable, MD, will become director of the National Institute on Minority Health and Health Disparities (NIMHD) in September. Currently, he is at the University of California, San Francisco (UCSF) where he is a professor of medicine, chief of the Division of General Internal Medicine, and director of the Center for Aging in Diverse Communities. NIMHD is the lead organization at the NIH for planning, reviewing, coordinating and evaluating minority health and health disparities research activities conducted by the NIH institutes and centers.
Yvonne T. Maddox, PhD, has been the acting director of the National Institute on Minority Health and Health Disparities (NIMHD) since April 2014. NIH Director Francis Collins, MD, PhD, recognized Dr. Maddox for her exemplary and dedicated service of leading NIMHD over the past year. She will become the vice president for research at the Uniformed Services University of the Health Sciences in Bethesda, Maryland.
Dr. Maddox has a long history of leadership with the NIH, including serving as the deputy director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development since 1995 and as acting deputy director of the NIH from 2000 - 2002. She also leads several committees to advance medical research for affected communities to improve their health. Among her many committee memberships, she has served as executive director of the HHS Cancer Health Disparities Progress Review Group, and co-chaired the HHS Initiative to Reduce Infant Mortality in Minority Communities. In addition, she co-chaired the first NIH Strategic Plan to “Reduce and Ultimately Eliminate Health Disparities.”
NIH Dedicates Lowell P. Weicker Building
On May 5, NIH dedicated Building 4 on the Bethesda campus in honor of Lowell P. Weicker, Jr., the former U.S. Senator and former Governor of Connecticut. In 1970, Weicker was elected to the U.S. Senate where he served for three terms, from 1971 to 1989. Weicker served as chairman of the Senate Labor, Health and Human Services and Education Appropriations Subcommittee from 1983 to 1986. During his tenure, he successfully protected and defended the NIH budget and increased the appropriation for the NIH. In the 1980s, Weicker was instrumental in helping to increase awareness and funding for NIH research to combat HIV/AIDS. He saw the importance of government involvement in research, prevention, education, and treatment and was deeply concerned about the impact this disease was having on our most vulnerable populations.
On February 23, Carrie Wolinetz, PhD, began her tenure as the new associate director for science policy at NIH. Previously, Dr. Wolinetz was the deputy vice president for federal relations with the Association of American Universities, the president of United for Medical Research, and director of Scientific Affairs and Public Relations at the Federation of American Societies for Experimental Biology.
NIH has established the NIH Language Access Plan, which is a comprehensive strategy to help people with limited English proficiency access NIH programs and activities. The Language Access Plan will help ensure that individuals, regardless of their language ability, can access important health information and participate in clinical trials. The plan is now being implemented at institutes across NIH, including at NIDCR.
NIH Holds Precision Medicine Workshops
NIH is holding workshops in May and July as part of a series of events to gather input from participant, scientific, and other stakeholder groups as it plans the development of the President’s Precision Medicine Initiative and the vision for building the national participant group. All public workshops are videocast live, and workshops held in April can be viewed at http://www.videocast.nih.gov. The upcoming schedule includes the following:
- Public workshop on cohorts and electronic health records
Thursday, May 28 – Friday, May 29, 2015
Vanderbilt University, Nashville, Tennessee
- Public workshop on participants and community engagement
Wednesday, July 1 – Thursday, July 2, 2015
National Institutes of Health, Bethesda, MD
- Public workshop on mHealth
Monday, July 27 – Tuesday, July 28, 2015
Intel Corp., Santa Clara, California
In April, NIH announced that 55 talented and diverse students, representing 37 U.S.-accredited universities, were selected for the fourth class of the Medical Research Scholars Program (MRSP). Of the 55 students, one is a dental student (Tarek Metwally of the University of Michigan School of Dentistry), 25 are female, and 13 are from underrepresented minority groups. The MRSP introduces medical, dental, and veterinary students to cutting-edge research, which is part of NIH's goal of training the next generation of clinician-scientists and biomedical researchers. The program places creative, research-oriented students in NIH laboratories and clinics, including within the NIH Clinical Center, to conduct basic, clinical, or translational research in areas that match their career interests and research goals.
The MRSP is co-sponsored by the NIH and other partners, including the American Association for Dental Research, Doris Duke Charitable Foundation, Howard Hughes Medical Institute, Colgate-Palmolive Company, and other private donors, via contributions to the Foundation for the NIH.
NIH Promotes Rigor and Reproducibility in Research
The advancement of science requires rigor in designing and performing scientific research and the ability to reproduce biomedical research findings. In April, NIH launched a web portal as a resource for online trainings, publications, and meetings related to rigor and reproducibility. The portal is located at http://www.nih.gov/science/reproducibility/index.htm.
NIH Celebrates Rare Disease Day
Rare Disease Day was established to raise awareness with the public about rare diseases, the challenges encountered by those affected, the importance of research to develop diagnostics and treatments, and the impact of these diseases on patients' lives. On February 27, NIH celebrated the 8th annual Rare Disease Day with a day-long celebration and recognition of the various rare diseases research activities supported by the NIH Office of Rare Diseases Research; the NIH Clinical Center; other NIH Institutes and Centers; the Food and Drug Administration’s Office of Orphan Product Development; other Federal Government agencies; the National Organization for Rare Disorders; and the Genetic Alliance. The event was held in the Masur Auditorium, and attendance was free and open to the public.
Dr. Somerman is scheduled to introduce oral presentations by junior investigators, announce poster awards, and make closing remarks at the annual NIH Pain Consortium Symposium on May 27, 2015.
The Cancer Genome Atlas Reports Molecular Alterations in Head and Neck Cancers
Investigators with NIH’s The Cancer Genome Atlas (TCGA) Research Network discovered genomic differences—with potentially important clinical implications—in head and neck cancers caused by human papillomavirus (HPV) infection. The study is the most comprehensive examination to date of genomic alterations in these cancers. TCGA is jointly supported and managed by the National Cancer Institute and the National Human Genome Research Institute.
In February, researchers supported by the NIH Common Fund’s Roadmap Epigenomics Program reported that they have mapped the epigenomes of more than 100 types of cells and tissues, providing new insight into which parts of the genome are used to regulate cell functions and changes in cellular activity. Changes in the epigenome induced by environmental and other factors modify how genes are turned on and off in different types of cells. The National Institute of Drug Abuse, National Institute of Environmental Health Sciences, and the National Institute on Deafness and Other Communication Disorders are co-administrators of the NIH Common Fund’s Epigenomics Program.
Tom Joyner Morning Show Interviews Timothy Iafolla, DDS, MPH
On April 22, during Oral Cancer Awareness Month, NIDCR’s Timothy Iafolla, DDS, MPH, of OSPA, discussed oral cancer among African American men on the “Get Well Wednesday” segment of the nationally syndicated Tom Joyner morning show. The audio and transcript are online .
NIDCR Hosts Webinars about NHANES Data about Health
NIDCR collaborates with CDC’s National Center for Health Statistics to incorporate an oral health component in the National Health and Nutrition Examination Survey (NHANES), and these data are used by NIDCR to help monitor the nation’s oral health. On March 5, CDC’s National Center for Health Statistics released a data brief called “Dental Caries and Sealant Prevalence in Children and Adolescents in the United States, 2011-12.” Lead author Bruce A. Dye, DDS, MPH, a dental epidemiology officer in NIDCR‘s Office of Science Policy and Analysis (OSPA), presented the findings via a live Webinar hosted by NIDCR and CDC.
The source of the data is the 2011-2012 National Health and Nutrition Examination Survey (NHANES), and this new report is the most current and reliable source of information on children’s oral health in America. Tim Iafolla, DMD, MPH, also with OSPA, was a co-author on the brief. The Webinar was called, “Oral Health in U.S. Children and Adolescents, 2011-12.”
On May 13, NIDCR and CDC held another live webinar to release adult and older adult oral health data from the 2011-2012 NHANES. The Children’s Oral Health Webinar and the Adult Oral Health Webinar are archived online.
NIDCR Names James Melvin, DDS, PHD, as Deputy Scientific Director and Janice Lee, DDS, MD, MS, as Clinical Director
James E. Melvin, DDS, PhD, who has been the clinical director in NIDCR’s Division of Intramural Research (DIR) since 2010, recently became DIR’s deputy scientific director, and Janice S. Lee, DDS, MD, MS, was appointed the new clinical director. During his five-year tenure as clinical director, Dr. Melvin established an active clinical fellows training program to provide a strong mentored experience grounded in basic research. In addition, he created a competitive K22 grant mechanism to support fellows’ mentored transition to independent research, and he built support mechanisms and staffing for development, review, and execution of clinical research protocols.
Dr. Melvin is an internationally renowned researcher who has made landmark contributions to the field of salivary gland physiology. As a senior investigator in the Division’s Secretory Mechanisms and Dysfunction Section, Melvin focuses on elucidating the ion transport mechanisms of salivary glands. Before becoming clinical director, Melvin was professor of pharmacology and physiology in the Center for Oral Biology at the University of Rochester School of Medicine and Dentistry in New York. He held numerous appointments at the University of Rochester, where he received tenure in 1997 and where he published more than 92 papers. Dr. Melvin received a DDS from Case Western Reserve University in Ohio, earned a PhD in Neurobiology from the University of Rochester in New York, and completed a postdoctoral fellowship at what was then called the National Institute of Dental Research at NIH.
Dr. Lee, a board-certified oral and maxillofacial surgeon, joined NIDCR as the deputy clinical director in 2013, after a decade at the University of California San Francisco. Dr. Lee’s clinical and translational research program is exploring the natural history and genetic etiology of craniofacial anomalies and growth abnormalities. Her research interests include bone regeneration and stem cell biology, craniofacial congenital anomalies, fibrous dysplasia, and McCune-Albright syndrome.
Before joining NIDCR, she was professor of clinical oral and maxillofacial surgery and departmental vice chair at the UCSF Department of Oral & Maxillofacial Surgery. Dr. Lee has published nearly 50 peer-reviewed journal articles, dozens of abstracts and poster presentations, and several book chapters. Dr. Lee earned a DDS and an MS from the
University of California, Los Angeles School of Dentistry and an MD from Harvard Medical School. She completed a residency in oral and maxillofacial surgery at Massachusetts General Hospital/Harvard University and a two-year research fellowship in NIDCR’s Craniofacial and Skeletal Diseases Branch.
University of Illinois at Chicago Selects James Melvin, DDS, PhD, as Keynote Speaker
Dr. Melvin was the keynote speaker for Clinic and Research Day 2015 at the University of Illinois at Chicago. His presentation was called "Clinical Research Studies at the NIDCR Division of Intramural Research."
Niki Moutsopoulos, DDS, PhD, Becomes Tenure Track Investigator
In March, Niki Moutsopoulos, DDS, PhD, head of the Oral Immunity and Infection Unit in the Oral and Pharyngeal Cancer Branch, was promoted to tenure track investigator. Her ongoing studies interrogate basic mechanisms of oral immunity and inflammation through the study of patients with single gene disruptions. She began her career at NIDCR as a predoctoral Intramural Research Training Award fellow and later became a research fellow, then a clinical fellow, and in 2010, an assistant clinical investigator. Dr. Moutsopoulos earned her DDS from the Aristotle University of Thessaloniki in Greece and a certificate in periodontics from the University of Maryland, School of Dentistry. She obtained a PhD in oral and experimental pathology with a focus in immunology from a joint program between the University of Maryland and NIDCR.
Jason Horton, PhD, Receives New Investigator Research Award
Jason Horton, a postbaccalaureate Intramural Research Training Award fellow in the Craniofacial and Skeletal Diseases Branch received a New Investigator Research Award at the Annual Meeting of the Orthopedic Society, held in Las Vegas, NV, in March 2015, for his abstract and presentation entitled “MT1-MMP Mediates Plasticity and Divergence of the Osteoblast and Adipocyte Lineages Through Cleavage of DLK1.”
Loan Ta Joins NIDCR as a Program Analyst
Program Analyst Loan Ta joined NIDCR’s Office of Science Planning and Analysis after 19 years with the National Institute of Aging. She has been a program analyst for the past 10 years, and before that she was an information technology specialist in the NIA Office of Planning, Analysis and Evaluation. She designed, created, and maintained a new research coding and reporting system that allowed them to effectively generate scientific reports. She was instrumental in NIA’s participation in the activities of the NIH Research, Condition, and Disease Categorization System.
NIDCR Appoints Amanda Melillo, PhD, as Director of Salivary Biology and Immunology Program
In January, Amanda Melillo, PhD, was appointed director of the NIDCR Salivary Biology and Immunology Program. Previously, she had been acting director of the program, and before that, she was a health specialist in NIDCR’s Integrative Biology and Infectious Diseases Branch. Before joining NIH, Dr. Melillo was a postdoctoral fellow from 2010-2012 at the Food and Drug Administration, Division of Bacterial Products, Center for Biologics Evaluation and Research, where she also served as a technology transfer coordinator assistant. She received her PhD in microbial disease in 2010 from Albany Medical College in Albany, New York.
Jeannine Helm Becomes Health Specialist for Division of Extramural Research
Jeannine Helm has been promoted to serve as health specialist at the division level in the Division of Extramural Research. She will take on major duties helping with planning and tracking of the extramural research budget and operating budget. Ms. Helm will coordinate with branches and centers to conduct portfolio analyses and track programmatic outcomes. Jeannine joined NIDCR in 2011 as a health specialist with the Translational Genomics Research Branch. Previously, Jeannine served as biologist in the intramural program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases and as a regulatory project manager at the FDA.
Grants Management Specialist Gabriel Hidalgo Returns to NIDCR
In March, Gabriel Hidalgo returned to NIDCR as the lead grants management specialist in the Grants Management Branch. He started his NIH career in 2008 as a program analyst. While working, he earned his MBA from George Washington University, concentrating in project management and health service administration. In 2013, he transferred from NIDCR to the National Center for Advancing Translational Sciences, where he was the Office of Grants Management division coordinator.
Crina Frincu, PhD, Joins the Scientific Review Branch
Crina Frincu, PhD, joined the Scientific Review Branch at NIDCR as a scientific review officer in March. Previously, Dr. Frincu served as a health specialist at NINDS, Office of Clinical Research where she assisted in planning, coordination, and evaluation of NeuroNEXT and the NINDS Stroke Trials Network. Before NINDS, she served as a clinical research/regulatory specialist at NCI’s Cancer Therapy Evaluation Program (CTEP). Dr. Crina received her PhD in chemistry in 2005 from Georgetown University.
Dawn Morales, PhD, Joins the Behavioral and Social Sciences Research Branch
The Behavioral and Social Sciences Research Branch welcomed Dr. Dawn A. Morales as a health specialist. Most recently, Dr. Morales was a data analyst and statistician at the WJB Dorn VA Medical Center in Columbia, South Carolina. She earned her PhD in experimental psychology from the University of California, San Diego, and completed a Ruth L. Kirschstein postdoctoral fellowship at the Center for Cognitive Neuroscience, University of Pennsylvania. Dr. Morales brings expertise in research methods, statistical analysis, health disparities research, and neuroscience.
Health Specialist Laura Hsu, PhD, Joins the Center for Clinical Research
In March, Dr. Laura Hsu joined the Center for Clinical Research as a health specialist. Dr. Hsu completed her PhD in public health, translational and community-based research, followed by a fellowship at CDC in Atlanta. She has broad expertise in process, formative, and outcome monitoring and evaluation, survey design, quantitative and qualitative research methods, analyses, and reporting, and database management.
Health Specialist Preethi Chander, PhD, Joins the Integrative Biology and Infectious Disease Branch
The Integrative Biology and Infectious Disease Branch welcomed Dr. Preethi Chander as a health specialist. Dr. Chander came to NIDCR from the National Eye Institute (NEI) and from the Common Fund’s Nanomedicine Program where she served as program analyst, and has been involved in many high-visibility NEI and trans-NIH projects. Dr. Chander obtained her PhD from Purdue University where she majored in structural biology, and she conducted her postdoctoral research in the intramural NEI investigating the biology of retinal pigment epithelium and visual cycle proteins in blinding disorders.
Health Specialist Kathryn Stein, PhD, Joins the Translational Genomics Research Branch
The Translational Genomics Research Branch welcomed Dr. Kathryn (Katie) Stein, who joined TGRB as health specialist. Dr Stein came to the NIDCR from the National Cancer Institute (NCI), where she was a scientific health analyst in the Knowledge Management and Special Projects Branch, Center for Strategic Scientific Initiatives. Dr. Stein earned a PhD in cell and developmental biology from the University of California, Davis. She was a postdoctoral fellow at the National Institute of Diabetes and Digestive and Kidney Diseases, and later worked at the National Cancer Institute.
Clinical Trials Office Director Michele Culp, BSN, MPH, Leaves NIDCR for NCATS
In February, Michele Culp, BSN, MPH transferred from NIDCR to the National Center for Advancing Translational Sciences (NCATS), where she is now the director of Clinical Operations in the Division of Clinical Innovation. The Division of Clinical Innovation plans, conducts and supports research across the clinical phases of the translational science spectrum. Ms. Culp joined NIDCR in 2008 and was the director of the Office of Clinical Trials and Operations Management. During her tenure she contributed to the institute’s commitment to protection of human subjects and data quality, and to setting the highest standards for the conduct of clinical research studies. Before joining NIDCR, she was with the National Institute of Allergy and Infectious Diseases.
Scientific Review Officer Raj Krishnaraju, PhD, Transfers from NIDCR to CSR
After serving as a scientific review officer at NIDCR for more than 10 years, Raj Krishnaraju, PhD, left the Scientific Review Branch in March for a new SRO position at the Center for Scientific Review at NIH.
Training and Career Development News
The NIDCR Research Training and Career development branch continues to reach out to the extramural research community to encourage predoctoral and postdoctoral students and junior investigators to apply for NIDCR research training and career development funding. In addition, the NIDCR Office of Education participates in many activities to recruit student and postdoctoral researchers.
In addition to the outreach at FNIDCR annual conference and awards described in “Activities of the NIDCR Director,” recent outreach included the following activities:
- On April 17, Dr. Frieden gave a seminar to NIH clinical fellows on “Preparing a Career Transition Award--Tips for Intramural Applicants” at the NIH Clinical Center in Bethesda, MD.
- On May 8, Dr. King presented on NIDCR funding opportunities to support research careers at the 2015 New Investigators' Day Program sponsored by the American Association of Oral and Maxillofacial Surgeons and the Oral and Maxillofacial Surgery Foundation. The New Investigators' Day program promotes careers in education and research and provides mentoring opportunities for new faculty and residents and includes presentations on academic surgery as a career path.
NIH Grant Writing Course
The NIDCR Office of Education continues to provide support for career development of our postdoctoral community. Two NIDCR trainees were selected to participate in a grant-writing course titled “NIH Grant Writing Course - An In-Depth Workshop.” The seven-part course was led by Paula Gregory, PhD, who is an associate professor in the Department of Genetics at Louisiana State University. It gives participants the opportunity to write a rough draft of an NIH grant using their own data. In addition to this workshop, our trainees also participated in an NIH grant mock study section. For the mock study section, trainees scored NIH grants that had been previously reviewed and scored to learn about the key aspects of a successful application. Attendees found these sessions extremely useful.
2015 NIDCR Summer Dental Student Award
The Office of Education continues its recruitment efforts for students interested in oral health training opportunities. Dental students from across the country were selected to receive the 2015 NIDCR Summer Dental Student Award. The following students will complete an 8-week translational research project at NIDCR: Faith Adewusi of the University of Connecticut School of Dental Medicine, Joshua Coffey of the Missouri School of Dentistry and Oral Health, Kim Do of the UTHSC San Antonio Dental School, Andrew Emery of the University of Connecticut School of Dental Medicine, Grant Essink of the University of Nebraska Medical Center, Michael Faibish of the Boston University Henry M. Goldman School of Dental Medicine, Aalia Farukhi of the University of Texas Health Science Center San Antonio, Amber Gilbert of the Howard University College of Dentistry, Mehrdad Hairani of the School of Dentistry, University of Minnesota-TC, Lovika Kalra of the University of Pennsylvania School of Dental Medicine, Sean McGivern of the University of Iowa College of Dentistry, Charles Taylor of the AT Still University, Arizona School of Dentistry & Oral Health, and Teresa Yang of the University of Pennsylvania School of Dental Medicine.
Highlights from Former Trainees
Former NIDCR T32 predoctoral trainee, Peter Lillehoj, PhD has received his first R01 (AI113257) titled, “Rapid in-field malaria diagnosis, prognosis and monitoring using a mobile phone.” Dr. Lillehoj is an assistant professor in the Department of Mechanical Engineering at Michigan State University.
Former NIDCR T90 postdoctoral trainee, Hope Amm, PhD has received an NIH K99/R00 Pathway to Independence Award (DE023826) titled, “Hedgehog Pathway Activity and Targeting in KCOT.” Dr. Amm is a postdoctoral fellow in the Institute of Oral Health Research at University of Alabama at Birmingham.
Trainees supported on institutional training grants can apply for individual fellowships or career development awards to obtain their own independent funding. Recently, four trainees successfully competed for fellowships:
- F30 fellowship: Two dual degree dentist scientist trainees, Insoon Chang and Megan Michalski, who were previously supported by NIDCR institutional T32/T90 training grants at University of California Los Angeles and University of Michigan, respectively, have successfully competed for NIDCR F30 fellowships.
- F31 fellowship: Two predoctoral trainees, Maria Kuzynski and Sabrina Martinez-Anz, who were previously supported by NIDCR institutional T32/T90 training grants at University of Alabama at Birmingham and University of Texas Health Science Center San Antonio, respectively, have successfully competed for NIDCR F31 predoctoral fellowships.
Meetings and Conferences
Jason Wan, PhD, Organizes Remineralization Workshop
Jason Wan, PhD, organized the “Workshop on Remineralization: Current State of the Science and Future Directions” held April 13 in Bethesda, MD. The purpose of this one-day workshop was to gauge the capacity of the research community to further move enamel research into clinical applications. The workshop addressed a list of core questions about the clinical need for enamel remineralization, the current state of the science, and the hurdles and barriers for translation to the clinic. Nineteen panelists, including clinicians, researchers, representatives from industry, and regulatory experts, provided their input and perspectives on how to overcome existing hurdles and move the field forward.
David Clark, DrPH, Organizes Implementation Science Agenda Panel
Dave Clark, DrPH, organized an expert panel meeting on “Developing an Implementation Science Agenda to Advance Dental, Oral and Craniofacial Health” held April 22 in Bethesda, MD. Implementation science is focused on identifying, understanding, and overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, tools, policies, and guidelines. The goal of the meeting was to explore opportunities for research and partnerships. This meeting was jointly planned with staff from the National Institute on Alcohol Abuse and Alcoholism.
Common Fund Glycoscience Program Reviews Funding Opportunity Announcements
The NIH Common Fund Glycoscience Program encourages new strategies and high-risk approaches for methods and tool development with the ultimate goal of rapid transition of successful projects to commercialization. In March, Amanda Melillo, PhD, director of NIDCR’s Salivary Biology and Immunology Program, and NIH colleagues reviewed the four funding opportunity announcements that were released on September 30 (RFA-RM14-012, RFA-RM14-013, RFA-RM14-014, and RFA-RM14-015). Dr. Somerman and NIGMS Director Dr. Jon Lorsch are the Institute leaders of this Common Fund program.
Melissa Riddle, PhD, Visits St. Jude’s Children’s Research Hospital
Melissa Riddle, PhD, met with clinical researchers and presented talks on behavioral intervention research, and on the fundamentals of NIH grant writing at St. Jude’s Children’s Research Hospital in Memphis, TN, on February 23.
Nadya Lumelsky, PhD, Is Panelist at Cell Manufacturing Workshop
Nadya Lumelsky, PhD, participated as an invited panelist in the interdisciplinary Cell Manufacturing Workshop organized by the National Institute of Standards and Technology (NIST)-funded Cell Manufacturing AMTech Project Consortium on February 27. The goal of this workshop was to identify technical challenges for maintaining and advancing the United States lead in the global cell manufacturing industry to enable large-scale production and availability of affordable and effective cell products.
Isaac Rodriguez-Chavez, PhD, Co-chairs Sensing Technologies Conference
Isaac Rodriguez-Chavez, PhD, co-organized and co-chaired the “2015 Advances in Global Health through Sensing Technologies Conference” at the International Society for Optics and Photonics (SPIE) Meeting, held April 20–24 in Baltimore, MD. At this event, Dr. Rodriguez-Chavez gave a talk titled “Non-invasive Disease Diagnostics Based on Oral Biospecimens: Lessons Learned and Future Directions”.
Ruth Nowjack-Raymer, PhD, Serves as NIMHD Workshop Session Moderator
Ruth Nowjack-Raymer, PhD, served as a session moderator for the National Institute of Minority Health and Health Disparities Workshop on the Science of Prevention and Health Promotion to Address Health Disparities “Preventing Disparities in Chronic Diseases” Community-based Multilevel Interventions, which was held on March 30 and 31.
Aging and Disability Federal Partners Working Group
In January, the Aging and Disability Federal Partners Working Group invited NIDCR to participate, and Timothy Iafolla, DDS, MPH, of the Office of Science Policy and Analysis represented the institute. The group’s goal is to accelerate the translation of scientific findings into evidence-based practices that benefit older adults and individuals with long-term disabilities. The focus of the group is to establish mechanisms to foster the exchange of relevant research findings and practices among partner agencies and to promote joint dissemination and knowledge translation.
Preventing Disparities in Chronic Disease: Community-based Multilevel Interventions
Margo Adesanya, DDS, the acting director of the Office of Science Policy and Analysis, attended the NIMHD Workshop on the Science of Prevention and Health Promotion to address Health Disparities held March 30-31 in Bethesda, MD. The purpose of the workshop was to explore the scientific validity of community-based multilevel interventions in reducing significant population-level burden of chronic morbidity and premature death in health disparity populations. The keynote speaker was Dr. Regina M. Benjamin, the 18th United States Surgeon General.
Healthy People 2020 Law and Health Policy Project
Dr. Timothy Iafolla was invited to represent NIDCR in a working group called “Healthy People 2020 Law and Health Policy Project,” which is led within HHS by the Office of Disease Prevention and Health Promotion (ODPHP) with support from the Centers for Disease Control and Prevention. The project aims to demonstrate the value of evidence-based legal and policy interventions and/or strategies in improving health within the context of the Healthy People 2020 initiative. Subject matter experts will work with federal partners to develop 10 to 15 evidence-based reports during the next three years to highlight the state of laws and policies related to specific topic areas within the Healthy People 2020 initiative. This effort will provide critically needed practical information to public health officials and associations, health-related industries, legal practitioners, non-profit organizations, policymakers, and individuals about the use of law and policy to address health factors.
- Salivary Glands & Exocrine Biology Gordon Research Conference held February 15-20 in Galveston, TX
- American Association for Dental Research held March 11-14 in Boston, MA
- Transcriptional and Epigenetic Influences on Stem Cell States Keystone Symposium held March 23-28 in Steamboat Spring, CO
- Fifth American Institute for Medical and Biological Engineering /NIH Workshop on “Validation and Qualification of New In Vitro Tools and Models for the Pre-Clinical Drug Discovery Process” held February 12 in Bethesda, MD
- NIMHD Planning Workshop on “AIDS Behavioral Interventions among Diverse Young MSM” held February 13 in Bethesda, MD
- Big Data for Oral Health Knowledge: How to get the Big Answers, IADR/AADR, held March 10-14 in Boston, MA
- NIH's Rare Disease Day 2015, NIH Main Campus held February, 27 in Bethesda, MD
- First HIV Microbiome Workshop held April 7-8 in Bethesda, MD
- NIH Intramural Symposium “Omics in the Characterization, Classification and Treatment of Autoimmune Diseases and Cancer” held April 13 in Bethesda, MD
- NIAID workshop on “Improvements and Limitations of Humanized Rodent Models for AIDS”, held April 15 in Rockville, MD
- NCI Symposium on Chromosome Biology: Chromatin, ncRNA, Methylation & Disease, held April 16-17 in Bethesda, MD
- American Academy of Oral and Maxillofacial Pathology/American Academy of Oral Medicine (AAOMP/AAOM) Joint Annual Meeting held April 18-24 in San Diego, CA
- American Association of Cancer Research special conference entitled “Translation of the Cancer Genome” held June 7-9 in San Francisco, CA.
- Regional meetings of the National Dental Practice-Based Research Network
- National Oral Health Conference held April 25-29 in Kansas City, MO
NIDCR Science Briefs and NIH News Release
During the first part of 2015, NIDCR’s communications staff released four Science News in Brief pieces about journal articles recently published by intramural and extramural investigators. The pieces are in plain language on the NIDCR website and provide links to the journal articles.
- Spying on Cellular Cross Talk
- Changing the Face of Cherubism
- Shared Pathways
- Improving Materials for Tooth-colored Fillings
In addition, NIH disseminated a news release about a study funded in part by NIDCR that was called, “For Most Children with HIV and Low Immune Cell Count, Cells Rebound After Treatment."
Grantee News Releases
The most recent group of grantee news releases about NIDCR-supported research posted on the NIDCR website includes the following:
- Evolution of Stem Cells Traced in Study of Fossilized Rodent Teeth (University of California San Francisco)
- Telegram & Gazette: Shriver Center Projects Aim to Improve Dental Care for Those with Disabilities (University of Massachusetts Medical School)
- Stem Cells that Prevent Birth Defect Also Repair Facial Injuries (University of Southern California)
- NYU Researchers Find Diabetes Perceptions Vary According to Risk Factors (New York University)
- New Genomics Tool Could Help Predict Tumor Aggressiveness, Treatment Outcomes (Ohio State University)
- International Team of Researchers Led by UC Davis Receives $4 million NIH Grant to Study Skull Disorder in Infants (UC Davis)
- UMKC Research Results in Cancer Patients’ Dental Care Protocols (University of Missouri-Kansas City)
- Ostrow researcher Yang Chai’s Scientific Discovery Could Lead to Effective Biological Treatment for a Common Birth Defect (Ostrow School of Dentistry)
- UMMS Working to Improve Oral Health for People with Intellectual Disabilities (University of Massachusetts Medical School)
- Grant to Boost Head and Neck Lymphedema Research (Vanderbilt University)
- NYU Study Successfully Screens for Diabetes at Dental Visits Using Oral Blood (New York University)
- New Reporter System to Study Bone-related Regenerative Medicine Generated by UMN Labs (University of Minnesota Health Sciences)
- Penn Dental Medicine Team Shows Why Wound Healing Is Impaired in Diabetics (University of Pennsylvania School of Dental Medicine)
- Study Shows Diabetic Patients Can Benefit from Dental Implants (University of Texas Health Science Center San Antonio)
- Contrary to Popular Belief, Dental Care for Baby Teeth is Vital (Case Western Reserve University School of Dental Medicine)
- A Baby Tooth Guided Penn Dental Medicine’s Songtao Shi to Stem Cell Insights (University of Pennsylvania)
Since the last meeting of Council, NIDCR exhibited and distributed patient and health professional education materials at the following conferences:
- Hinman Dental Meeting, Atlanta, GA, March 26-28
- National Head Start Association, Washington, DC, March 30-April 2
- Developmental Disabilities Nurses Association, May 2-4, Atlanta, GA
In addition, NIDCR’s communications staff used social media and website content to raise awareness about NIDCR’s presence at IADR/AADR/CADR in March. Communications staff created a comprehensive schedule listing NIDCR presentations The schedule, which featured photographs of NIDCR staff for easy recognition by stakeholders, was posted at http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/aadr-2015.htm.
Selected Division of Intramural Research Publications: Peer-Reviewed
Artym VV, Swatkoski S, Matsumoto K, Campbell CB, Petrie RJ, Dimitriadis EK, Li X, Mueller SC, Bugge TH, Gucek M, Yamada KM. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol. 2015 Feb 2;208(3):331-50.
Betts K, Abusleme L, Freeman A.F, Sarmadi M, Fahle G, Pittaluga S, Cuellar-Rodriguez J, Hickstein D, Holland SM, Su H, Moutsopoulos N.M.: 2015. A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis - A case of virally induced periodontitis? J Clin Virol. 63: 46-50
Catalán MA, Kondo Y, Peña-Münzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015: 112(7):2263-8.
Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP. Submandibular parasympathetic gangliogenesis requires sprouty-dependent wnt signals from epithelial progenitors. Dev Cell. 2015: 32(6):667-77. doi: 10.1016/j.devcel.2015.01.023.
Kondo Y, Nakamoto T, Jaramillo Y, Choi S, Catalan MA, Melvin JE. Functional Differences in the Acinar Cells of the Murine Major Salivary Glands. J Dent Res. 2015 Feb 13. pii: 0022034515570943. [Epub ahead of print]
Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny E, Tantillo M, Kohn D, Lyons KM, Robey PG, Young MF. WNT1 induced secreted protein-1 (WISP1) : A novel regulator of bone turnover and Wnt signaling. J Biol Chem. 2015 Apr 11. pii: jbc.M114.628818.
Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015 Apr 10;6:6725. doi: 10.1038/ncomms7725.
Nakamura T, Yoshitomi Y, Sakai K, Vyomesh P, Fukumoto S, Yamada Y.
Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation
J Cell Sci 2014: 127 (24): 5261-72.
Ong HL, de Souza LB, Zheng C, Cheng KT, Liu X, Goldsmith CM, Feske S, Ambudkar IS. STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions. Sci Signal. 2015: 8(359):ra3. doi: 10.1126/scisignal.2005748.
Peña-Münzenmayer G, Catalán MA, Kondo Y, Jaramillo Y, Liu F, Shull GE, Melvin JE. Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. J Biol Chem. 2015 Mar 5. pii: jbc.M114.612895. [Epub ahead of print]
Petrie RJ, Koo H, Yamada KM. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science. 2014 Aug 29;345(6200):1062-5. yes
Willoughby D, Ong HL, De Souza LB, Wachten S, Ambudkar IS, Cooper DM. TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases. Biochem J. 2014;464(1):73-84. doi: 10.1042/BJ20140766
Bianco P, Robey PG. Skeletal stem cells. Development. 2015;142(6):1023-1027.
Recent Publications from K Awardees
Chang EH, Tang XX, Shah VS, Launspach JL, Ernst SE, Hilkin B, Karp PH, Abou Alaiwa MH, Graham SM, Hornick DB, Welsh MJ, Stoltz DA, Zabner J. Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. Int Forum Allergy Rhinol. 2015 Feb;5(2):178-81.
Cotney J, Muhle RA, Sanders SJ, Liu L, Willsey AJ, Niu W, Liu W, Klei L, Lei J, Yin J, Reilly SK, Tebbenkamp AT, Bichsel C, Pletikos M, Sestan N, Roeder K, State MW, Devlin B, Noonan JP. The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat Commun. 2015 Mar 10;6:6404.
Diniz IM, Chen C, Xu X, Ansari S, Zadeh HH, Marques MM, Shi S, Moshaverinia A. Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells. J Mater Sci Mater Med. 2015 Mar;26(3):153.
Garza RM, Rennert RC, Paik KJ, Atashroo D, Chung MT, Duscher D, Januszyk M, Gurtner GC, Longaker MT, Wan DC. Studies in Fat Grafting: Part IV. Adipose-Derived Stromal Cell Gene Expression in Cell-Assisted Lipotransfer. Plast Reconstr Surg. 2015 Apr;135(4):1045-55.
Huang X, Schulte RM, Burne RA, Nascimento MM. Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms. Caries Res. 2015;49(2):165-76
Ioannidou E, Rosania A. Under-representation of women on dental journal editorial boards. PLoS One. 2015 Jan 30;10(1):e0116630.
Jones TD, Naimipour H, Sun S, Cho M, Alapati SB. Mechanical changes in human dental pulp stem cells during early odontogenic differentiation. J Endod. 2015 Jan;41(1):50-5.
Rothenberg SM, Concannon K, Cullen S, Boulay G, Turke AB, Faber AC, Lockerman EL, Rivera MN, Engelman JA, Maheswaran S, Haber DA. Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways. Elife. 2015 Feb 16;4.
Simões-Costa M, Bronner ME. Establishing neural crest identity: a gene regulatory recipe. Development. 2015 Jan 15;142(2):242-57.
Recent Publications from F Fellows
Adhami MD, Rashid H, Chen H, Clarke JC, Yang Y, Javed A. Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis. J Bone Miner Res. 2015 Jan;30(1):71-82
Culp DJ, Robinson B, Cash MN, Bhattacharyya I, Stewart C, Cuadra-Saenz G. Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva. J Biol Chem. 2015 Jan 30;290(5):2993-3008.
Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrímsson B, Williams T. Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015 Jan;8(1):31-43.
Hirakawa MP, Martinez DA, Sakthikumar S, Anderson MZ, Berlin A, Gujja S, Zeng Q, Zisson E, Wang JM, Greenberg JM, Berman J, Bennett RJ, Cuomo CA. Genetic and phenotypic intra-species variation in Candida albicans. Genome Res. 2015 Mar;25(3):413-25.
Kumar VA, Taylor NL, Shi S, Wickremasinghe NC, D'Souza RN, Hartgerink JD. Self-assembling multidomain peptides tailor biological responses through biphasic release. Biomaterials. 2015 Jun;52:71-8.
Kumar VA, Taylor NL, Shi S, Wang BK, Jalan AA, Kang MK, Wickremasinghe NC, Hartgerink JD. Highly angiogenic peptide nanofibers. ACS Nano. 2015 Jan 27;9(1):860-8.
Recent Publications from T32/T90/R90 Trainees and K12 Scholars
Aubrecht TG, Jenkins R, Magalang UJ, Nelson RJ. Influence of gonadal hormones on the behavioral effects of intermittent hypoxia in mice. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 15;308(6):R489-99
Billington CJ Jr, Schmidt B, Marcucio RS, Hallgrimsson B, Gopalakrishnan R, Petryk A. Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice. Dis Model Mech. 2015 Feb;8(2):139-46.
Blackiston DJ, Anderson GM, Rahman N, Bieck C, Levin M. A novel method for inducing nerve growth via modulation of host resting potential: gap junction-mediated and serotonergic signaling mechanisms. Neurotherapeutics. 2015 Jan;12(1):170-84.
Cataldo G, Rajput S, Gupta K, Simone DA. Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain. 2015 Apr;156(4):722-30.
Chiang SH, Thomas GA, Liao W, Grogan T, Buck RL, Fuentes L, Yakob M, Laughlin MJ, Schafer C, Nazmul-Hossain A, Wei F, Elashoff D, Slowey PD, Wong DT. RNAPro•SAL: a device for rapid and standardized collection of saliva RNA and proteins. Biotechniques. 2015 Feb 1;58(2):69-76.
Leslie EJ, Taub MA, Liu H, Steinberg KM, Koboldt DC, Zhang Q, Carlson JC, Hetmanski JB, Wang H, Larson DE, Fulton RS, Kousa YA, Fakhouri WD, Naji A, Ruczinski I, Begum F, Parker MM, Busch T, Standley J, Rigdon J, Hecht JT, Scott AF, Wehby GL, Christensen K, Czeizel AE, Deleyiannis FW, Schutte BC, Wilson RK, Cornell RA, Lidral AC, Weinstock GM, Beaty TH, Marazita ML, Murray JC. Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci. Am J Hum Genet. 2015 Mar 5;96(3):397-411.
Gaca AO, Colomer-Winter C, Lemos JA. Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis. J Bacteriol. 2015 Apr 1;197(7):1146-1156.
Heim KP, Sullan RM, Crowley PJ, El-Kirat-Chatel S, Beaussart A, Tang W, Besingi R, Dufrene YF, Brady LJ. Identification of a Supramolecular Functional Architecture of Streptococcus mutans Adhesin P1 on the Bacterial Cell Surface. J Biol Chem. 2015 Apr 3;290(14):9002-19.
Jung SH, Wang Y, Kim T, Tarr A, Reader B, Powell N, Sheridan JF. Molecular mechanisms of repeated social defeat-induced glucocorticoid resistance: Role of microRNA. Brain Behav Immun. 2015 Feb;44:195-206.
Klein MI, Hwang G, Santos PH, Campanella OH, Koo H. Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. Front Cell Infect Microbiol. 2015 Feb
Lainoff AJ, Moustakas-Verho JE, Hu D, Kallonen A, Marcucio RS, Hlusko LJ. A comparative examination of odontogenic gene expression in both toothed and toothless amniotes. J Exp Zool B Mol Dev Evol. 2015 Feb 11.
Lannan KL, Sahler J, Kim N, Spinelli SL, Maggirwar SB, Garraud O, Cognasse F, Blumberg N, Phipps RP. Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles. Front Immunol. 2015 Feb 13;6:48.
McNerny EM, Gong B, Morris MD, Kohn DH. Bone fracture toughness and strength correlate with collagen cross-link maturity in a dose-controlled lathyrism mouse model. J Bone Miner Res. 2015 Mar;30(3):455-64.
Momeni SS, Tomlin N, Ruby JD. Isolation of Raoultella planticola from refillable antimicrobial liquid soap dispensers in a dental setting. J Am Dent Assoc. 2015 Apr;146(4):241-5.
Oghumu S, Terrazas CA, Varikuti S, Kimble J, Vadia S, Yu L, Seveau S, Satoskar AR. CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15. FASEB J. 2015 Mar;29(3):1019-28.
Puri S, Li R, Ruszaj D, Tati S, Edgerton M. Iron binding modulates candidacidal properties of salivary histatin 5. J Dent Res.2015 Jan;94(1):201-8.
Scoffield JA, Wu H. Oral streptococci and nitrite-mediated interference of Pseudomonas aeruginosa. Infect Immun. 2015 Jan;83(1):101-7.
Segovia JA, Tsai SY, Chang TH, Shil NK, Weintraub ST, Short JD, Bose S. Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol Cell Biol. 2015 Feb;35(3):582-97.
Sullivan LC, Berg KA, Clarke WP. Dual regulation of δ-opioid receptor function by arachidonic acid metabolites in rat peripheral sensory neurons. J Pharmacol Exp Ther. 2015 Apr;353(1):44-51.
Tu M, Wei F, Yang J, Wong D. Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM). J Vis Exp. 2015 Jan 23;(95):52439.
Valerio MS, Herbert BA, Basilakos DS, Browne C, Yu H, Kirkwood KL. Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine. 2015 Jan;71(1):71-80.
Selected Extramurally Funded Science Advances
Behavioral and Social Science Research
Bartley EJ, Boissoneault J, Vargovich AM, Wandner LD, Hirsh AT, Lok BC, Heft MW, Robinson ME. The Influence of Health Care Professional Characteristics on Pain Management Decisions. Pain Medicine. 2015;16:99-111. Link to PDF Article
Lyons DN, Kniffin TC, Zhang L, Danaher RJ, Miller CS, Bocanegra JL, Carlson CR, Westlund KN. Trigeminal Inflammatory Compression (TIC) Injury Induces Chronic Facial Pain and Susceptibility to Anxiety-Related Behaviors. Neuroscience. 2015; 295:126-138. Link to PDF Article
Manski RJ, Moeller JF, Chen H, et al. Dental Use and Expenditures for Older Uninsured Americans: The Simulated Impact of Expanded Coverage.Health Services Research. 2015;50(1):117-35. Link to PDF Article
Strauss SM, Rosedale MT, Pesce MA, Rindskopf DM, Kaur N, Juterbock CM, Wolff MS, Malaspina D, Danoff A. The potential for glycemic control monitoring and screening for diabetes at dental visits using oral blood. Am J Public Health. 2015; 105(4):796-801. Link to PDF Article
Sanders AE, Divaris K, Naorungroj S, Heiss G, Risques RA. Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study. J Clin Periondol. 2015; 42:12-20. Link to PDF Article
Chantaracherd P, John, MT, Hodges JS, Schiffman EL . Temporomandibular joint disorders’ impact on pain, function, and disability. J Dent Res. 2015; 94(3), suppl 1:79S-86S. Link to PDF Atrticle
Finlayson TL, Gansky SA, Shain SG, Weintraub JA. Dental utilization by children in Hispanic agricultural worker families in California. J Dent Oral Craniofac Epidemiol. 2015; 2(1-2):15-24. Link to PDF Article
Integrative Biology and Infectious Disease
Sukumaran P, Sun Y, Vyas M, Singh BB. TRPC1-mediated Ca(2+) entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy. Cell Death Dis. 2015; 6:e1674. Link to PDF Article
Benakanakere M, Abdolhosseini M, Hosur K, Finoti LS, Kinane DF. TLR2 promoter hypermethylation creates innate immune dysbiosis. J Dent Res. 2015; 94(1) 183–19. Link to PDF Article
Chan CKF, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, Tevlin R, Seita J, Vincent-Tompkins J, Wearda T, Lu W-J, Senarath-Yapa K, Chung MT, Marecic O, Tran M, Yan KS, Upton R, Walmsley GG, Lee AS, Sahoo D, Kuo CJ, Weissman IL, Longaker MT. Identification and Specification of the Mouse Skeletal Stem Cell. Cell. 2015; 160(1-2):285-98. Link to PDF Article
Jeffers LK, Burger-Calderon R, Webster-Cyriaque J. Effect of Leflunomide, Cidofovir and Ciprofloxacin on replication of BKPyV in a salivary gland in vitro culture system. Antiviral Res. 2015; 118:46-55. Link to PDF Article
Koch AT, Love-Homan L, Espinosa-Cotton M, Stanam A, Simons AL. MyD88-dependent signaling decreases the anti-tumor efficacy of epidermal growth factor receptor inhibition in head and neck cancer cells. Cancer Res. 2015; 75(8):1-11. Link to PDF Article
Owen JH, Graham MP, Chinn SB, Darr OF, Chepeha DB, Wolf GT, Bradford CR, Carey TE, Prince ME. A Novel Method of Cell Line Establishment Utilizing Fluorescence-Activated Cell Sorting Resulting in Six New Head and Neck Squamous Cell Carcinoma Lines. Head Neck. 2015; Feb 9. doi: 10.1002/hed.24019. Link to PDF Article
He X, McLean JS, Edlund A, Yooseph S, Hall AP, Liu SY, Dorrestein PC, Esquenazi E, Hunter RC, Cheng G, Nelson KE, Lux R, Shi W. Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle. PNAS. 2015; 112(1):244-9. Link to PDF Article
Liu N, Niu G, Xie Z, Chen Z, Itzek A, Kreth J, Gillaspy A, Zeng L, Burne R, Qi F, Merritt J. The Streptococcus mutans irvAgene encodes a trans-acting riboregulatory mRNA. Mol Cell. 2015; 57(1):179-90. Link to PDF Article
Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GC, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015; 85(4):833-46. Link to PDF Article
McKelvey R, Berta T, Old E, Ji RR, Fitzgerald M. Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. J Neurosci, 2015; 35(2):457-66.
Link to PDF Article
de Molon RS, Shimamoto H, Bezouglaia O, Pirih FQ, Dry SM, Kostenuik P, Boyce RW, Dwyer D, Aghaloo TL, Tetradis S. OPG-Fc but not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice. J Bone Miner Res, 2015; doi: 10.1002/jbmr.2490. [Epub ahead of print] Link to PDF Article
Padovano JD, Ravindran S, Snee PT, Ramachandran A, Bedran-Russo AK, George A. DMP1-derived Peptides Promote Remineralization of Human Dentin. J Dent Res. 2015; 94(4) 608-14. Link to PDF Article
Translational Genomics Research
Leslie EJ, Taub MA, Liu H, Steinberg KM, Koboldt DC, Zhang Q, Carlson JC, Hetmanski JB, Wang H, Larson DE, Fulton RS, Kousa YA, Fakhouri WD, Naji A, Ruczinski I, Begum F, Parker MM, Busch T, Standley J, Rigdon J, Hecht JT, Scott AF, Wehby GL, Christensen K, Czeizel AE, Deleyiannis FW, Schutte BC, Wilson RK, Cornell RA, Lidral AC, Weinstock GM, Beaty TH, Marazita ML, Murray JC. Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci. Am J Hum Genet, 2015; 96(3):397-411. Link to PDF Article
Wolf ZT, Brand HA, Shaffer JR, Leslie EJ, Arzi B, Willet CE, Cox TC, McHenry T, Narayan N, Feingold E, Wang X, Sliskovic S, Karmi N, Safra N,Sanchez C, Deleyiannis FW, Murray JC, Wade CM, Marazita ML, Bannasch DL. Genome-Wide Association Studies in Dogs and Humans Identify ADAMTS20 as a Risk Variant for Cleft Lip and Palate. PLoS Genet, 2015; 11(3):e1005059. Link to Online Article
Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol, 2015;17:386-96. Link to PDF Article
Division of Extramural Research Staff Publication
Hunziker R, Lumelsky N, Wang F. Editorial: Scaffolds for Regenerative Medicine. Annals of Biomedical Engineering, Special Issue 2015; (43):3. Link to PDF Article
Office of Science Policy and Analysis Staff Publication
Dye BA, Thornton-Evans G, Li X, Iafolla TJ. Dental caries and sealant prevalence in children and adolescents in the United States, 2011–2012. NCHS data brief, no 191. Hyattsville, MD: National Center for Health Statistics. 2015.
Dye BA, Thornton-Evans G, Li X, Iafolla TJ. Dental caries and tooth loss in adults in the United States, 2011–2012. NCHS data brief, no 197. Hyattsville, MD: National Center for Health Statistics. 2015.
Eke PI, Dye BA, Wei L, Slade GD, Thornton-Evans GO, Borgnakke WS, Taylor GW, Page RC, Beck JD, Genco RJ. Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012. J Periodontol. 2015 May;86(5):611-22. [Epub 2015 Feb 17]
Holtfreter B, Albandar JM, Dietrich T, Dye BA, Eaton KA, Eke PI, Papapanou PN, Kocher T. Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies Proposed standards from the Joint EU/USA Periodontal Epidemiology Working Group. J Clin Periodontol. 2015 Mar 23. [Epub ahead of print]
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