Director's Report to Council: September 2015

ACTIVITIES OF THE NIDCR DIRECTOR

Since the last meeting of the National Advisory Dental and Craniofacial Research Council (NADCRC) in May 2015, NIDCR Director Martha J. Somerman, DDS, PhD, and Acting Deputy Director John Kusiak, PhD, maintained an active schedule of attending research symposia, delivering presentations to stakeholders, and meeting with working groups and other organizations. In addition, Drs. Somerman and Kusiak continued to play an active role in pain-related activities, such as serving on the Interagency Pain Research Coordinating Committee.

Federal Service Educators Workshop – Bethesda, MD

On May 18, Dr. Somerman participated in the Federal Service Educators Workshop at the Uniformed Services University (USU) of the Health Sciences in Bethesda, Maryland. This annual workshop brings together postgraduate dental educators in the Army, Navy, Air Force, and Veterans Administration to discuss various topics related to dental education in the federal services. Dr. Somerman opened the session with an overview of NIDCR’s research interests, and Lynn King, PhD, chief of the Research Training and Career Development Branch in NIDCR’s Division of Extramural Activities, spoke about training programs funded by NIDCR.

10th Annual NIH Pain Consortium Symposium – Bethesda, MD

Dr. Somerman, who is a member of the NIH Pain Consortium Executive Committee, took part in "Looking Back and to the Future," the 10th Annual NIH Pain Consortium Symposium, on May 26 and 27 in Bethesda, MD. Panel sessions focused on cognitive and emotional aspects of pain, genetics and epigenetics of pain, pain signatures and predictors from imaging research, and neuroglial mechanisms of chronic pain. The keynote address on modeling pain in vitro using nociceptor neurons was delivered by Clifford Woolf, MB, BCh, PhD, director of the F.M. Kirby Neurobiology Center and Program in Neurobiology at Boston Children’s Hospital and professor of neurology and neurobiology at Harvard Medical School.

On the second day of the symposium, Dr. Somerman introduced the Mitchell Max Award and oral presentations by junior investigators, announced the presentation of the poster awards, and made closing remarks. Presentation slides and videos of the two-day symposium are accessible at painconsortium.nih.gov​.

50th Anniversary of the UCLA School of Dentistry – Los Angeles, CA

In May and June, the University of California, Los Angeles School of Dentistry celebrated their 50th anniversary with a series of events, and Dr. Somerman was the keynote speaker at a research symposium on June 3. Her talk -- "NIDCR: The Research Catalyst for Transforming Oral Health" -- highlighted some of the many exciting and innovative research areas supported by NIDCR and emphasized the advances made in accelerating diagnosis, prevention, and treatment of dental, oral, and craniofacial disorders.

University of Connecticut School of Dental Medicine – Farmington, CT

On June 8, Dr. Somerman spoke at the annual Skeletal, Craniofacial and Oral Biology Trainee Research Symposium at the University of Connecticut. Her talk -- "The Future of Biomedical Research as Seen through the Eyes of NIH/NIDCR" -- provided perspectives on the future of research efforts and funding over the next decade and how NIDCR will influence those directions through funding priorities and new or special programs. In addition, Dr. Somerman participated in the day-long symposium by discussing career options with the trainees, attending research presentations, and viewing research posters.

Strategic Collaborations of Dental Organizations for Precision Medicine Initiative – Bethesda, MD

On June 23 on the NIH campus, Drs. Somerman and Kusiak met with leaders from several dental organizations and the Centers for Medicare and Medicaid Services to discuss ways they could collaborate to further the objectives of President Obama’s Precision Medicine Initiative. Of particular interest was the use of electronic dental records and big data sets for research and health promotion. The meeting was organized by Kathryn A. Atchison, DDS, MPH, who is vice provost for New Collaborative Initiatives at the University of California, Los Angeles (UCLA) and professor at the UCLA School of Dentistry and who has been serving as a consultant to NIDCR in this area, and Lois K. Cohen, PhD, NIDCR consultant and former associate director for International Health and director of the Division of Extramural Research.

The following leaders participated in the discussion: David Preble, DDS, JD, vice president of the American Dental Association (ADA) Practice Institute; Richard Valachovic, DMD, MPH, president and chief executive officer of the American Dental Education Association (ADEA); Christopher Fox, DMD, DMSc, executive director of the International Association for Dental Research (IADR); and Lynn Mouden, DDS, MPH, chief dental officer of the Centers for Medicare and Medicaid Services (CMS). Also in attendance were the following NIDCR staff members: Jane Atkinson, DDS, chief of the Center for Clinical Research; Lynn King, PhD, chief of the Research Training and Career Development Branch; Dena Fischer, DDS, MSD, MS, program director of the Clinical Research and Epidemiology Program; Steve Scholnick, PhD, program director of the Developmental Biology and Genetics Program; Melissa Riddle, PhD, chief of the Behavioral and Social Sciences Research Branch; and John Prue, director of the Office of Information Technology.

Documentary on Dentistry with Daniel Bydlowski – Bethesda, MD

On July 6, Dr. Somerman was interviewed by Daniel Bydlowski, a writer, producer, and director in Los Angeles, California, who is making a documentary on how dentistry can be used to improve overall health. The film will explore how dentistry benefits from an interdisciplinary approach with medicine.

First Annual Glycoscience Investigators Meeting – Bethesda, MD

On July 10 at the first Participating Investigators Meeting for the NIH Common Fund Glycoscience Program, Dr. Somerman and National Institute of General Medical Sciences (NIGMS) Director Jon Lorsch, PhD, met with awardees and described the purpose of the NIH glycoscience program, its significance, and desired outcomes. The meeting provided an opportunity for glycoscience investigators to discuss their research projects.

Amanda Melillo, PhD, director of the Salivary Biology and Immunology Program in NIDCR’s Division of Extramural Research, is the communications point of contact for the Common Fund Glycoscience program. The glycoscience program coordinator is Doug Sheeley, ScD, senior scientific officer in the Division of Biomedical Technology, Bioinformatics, and Computational Biology at NIGMS. The project team leaders are Pamela Marino, PhD, chief of the Biochemistry and Biorelated Chemistry Branch at NIGMS, and Karl Krueger, program director for the National Cancer Institute’s Cancer Biomarkers Research Group. In July, the Glycoscience Program released three Funding Opportunity Announcements (RFA-RM-15-007, RFA-RM-15-008, RFA-RM-15-009) to accelerate the development and accessibility of new tools for studying carbohydrates.

NIDCR Career Day and Panel Discussion – Bethesda, MD

On July 17, Drs. Somerman and Kusiak were panelists for the "Future Careers in Oral Health Research and Dentistry" discussion for NIDCR summer students. The panel was led by Deborah Philp, PhD, director of NIDCR’s Division of Intramural Research Office of Education. Other panel members included Janice Lee, DDS, MD, MS, clinical director in NIDCR’s Division of Intramural Research; Dena Fischer, DDS, MSD, MS, program director of NIDCR’s Clinical Research and Epidemiology Program; and Lorena Brito de Souza, DDS, PhD, an NIDCR postdoctoral fellow.

International Consultation Meeting: HPV-Associated Oral Cancer – Washington, DC

On July 27, Dr. Somerman spoke at a Pan American Health Organization/World Health Organization (PAHO/WHO) international consultation meeting that focused on the scientific gaps that exist for HPV-associated oropharyngeal cancer research. This conference was held to appraise PAHO and multiple national and international stakeholders on the state of the science for HPV-associated oropharyngeal cancer. PAHO will use this technical information to develop public health policy on HPV-associated oropharyngeal cancer for the Americas and the Caribbean. PAHO/WHO sponsored the two-day meeting through its Regional Oral Health, Cancer, and Non-Communicable Diseases programs together with support from NIDCR, the International Association for Dental Research, the American Dental Association, and the American Dental Association Foundation. Dr. Somerman spoke on the topic of "NIH/NIDCR Efforts in Oral HPV-associated Research."

Dr. Isaac Rodriguez-Chavez, PhD, director of the AIDS and Immunosuppression Program in NIDCR’s Division of Extramural Research, co-organized this international meeting and presented a talk titled "Overview of Oral HPV/HIV Infections and NIDCR Efforts." In addition, he chaired sessions on "Outlining an HPV-OPC Public Health Policy" and "Group Presentations, Recommendations and Discussion for Public Health Policy Draft on HPV-OPC."

Meeting with the Chief Dental Officer of Chile – Bethesda, MD

On July 29, Dr. Elizabeth López, the chief dental officer of Chile, and Jessica Guthrie, an intern with the Pan American Health Organization, visited with Dr. Somerman and staff and toured NIDCR clinical facilities on the NIH campus. Dr. Lopez also met with Lois Cohen, PhD, former NIDCR associate director for international health; Dr. Janice Lee; Dr. Isaac Rodriguez-Chavez; Silvio Gutkind, PhD, chief of the Oral and Pharyngeal Cancer Branch in NIDCR’s Intramural Research Program; Emily Harris, PhD, chief of the Translational Genomics Research Branch in the Division of Extramural Research; and Loreto Abusleme and Nicolas Dutzan, Chilean dental students.

BUDGET UPDATE

FY 2015

The FY 2015 enacted budget for NIDCR is $399,886,000. This amount has been reduced by a transfer out (HIV/AIDS) for $2.186 million, yielding an operating level of $397,700,000.

FY 2016

The President’s Budget Request would provide $397.1 million for NIDCR. However, it is expected that NIDCR and the rest of NIH will begin FY 2016 under a continuing resolution at levels most likely approximating what was received for FY 2015.

Read the complete NIDCR Budget Justification.

HHS/NIH UPDATE

NIH to Submit Strategic Plan to Congress

In response to a request from Congress, NIH is developing a 5-year NIH-wide Strategic Plan to advance its mission of supporting biomedical research and applying that knowledge to promote health. The Strategic Plan will outline major trans-NIH themes, rather than describe important disease-specific research opportunities, which are detailed in the strategic plans of institutes and centers. NIH aims to outline unifying principles to guide NIH in pursuit of its mission. For example, the Strategic Plan will describe how NIH sets priorities and how NIH enhances stewardship of the research enterprise. The key areas of opportunity are the following: promote basic science because it is the foundation for progress; improve health promotion and disease prevention; and advance treatments and cures.

Senior leadership contributed to the content of the Strategic Plan, and external stakeholder input about the framework for the Plan was encouraged this summer through several public Webinars and a Request for Information. NIH plans to deliver the Strategic Plan to Congress in late December 2015.

NIH Precision Medicine Update

Videos of recent public workshops regarding the NIH Precision Medicine Initiative are available on the NIH website​. Three recent public workshops covered the following topics: cohorts and electronic health records (held May 28 and 29); participants and community engagement (held July 1 and 2); and mHealth (held July 27 and 28).

NIH Selects Walter J. Koroshetz, MD, as Director of the National Institute of Neurological Disorders and Stroke

On June 11, NIH Director Francis S. Collins, MD, PhD, announced the selection of Walter J. Koroshetz, MD, as the director of the National Institute of Neurological Disorders and Stroke (NINDS). Dr. Koroshetz has served as acting director of the NINDS since October 2014. As the new director of the NINDS, Dr. Koroshetz will oversee an annual budget of $1.6 billion.

Before coming to NIH as the NINDS deputy director in 2007, Dr. Koroshetz was a Harvard professor of neurology and the vice chair of neurology at Massachusetts General Hospital (MGH), director of Stroke and Neurointensive Care, and a member of the Huntington’s disease unit. He was also a professor of neurology at Harvard Medical School and led neurology resident training at MGH from 1990 until 2007. A native of Brooklyn, New York, Dr. Koroshetz graduated from Georgetown University and received his MD from the University of Chicago. He trained in internal medicine at the University of Chicago and in both internal medicine and neurology at MGH, after which he completed postdoctoral studies in cellular neurophysiology at MGH and the Harvard neurobiology department.

NIH Appoints William T. Riley, PhD, as Director of the Office of Behavioral and Social Sciences Research

In August, William T. Riley, PhD, was appointed as the new director of NIH’s Office of Behavioral and Social Sciences Research (OBSSR) after serving as acting director of the OBSSR since May 2014. Previously, he was a health scientist administrator and deputy director in the Division of AIDS and Health Behavior Research at the National Institute of Mental Health, a program director at the National Heart, Lung, and Blood Institute, and chief of the Science of Research and Technology Branch in the Division of Cancer Control and Population Sciences at the National Cancer Institute. He is also a professorial lecturer in the School of Public Health at George Washington University.

Before joining NIH in 2005, Dr. Riley worked in the private sector as director of research at PICS, Inc., and taught at Virginia Commonwealth University and the Medical College of Georgia. He earned a doctorate in clinical psychology from the Florida State University.

Fogarty International Center Selects Peter Kilmarx as New Deputy Director

On July 30, the Fogarty International Center announced the selection of Peter Kilmarx, MD, as the new deputy director. A captain in the U.S. Public Health Service, Dr. Kilmarx has held a variety of leadership positions at the Centers for Disease Control and Prevention. As deputy director of Fogarty, Dr. Kilmarx will help advance international collaborations and prepare the next generation of leaders in global health research.

NIH Analysis Shows Prevalence of Pain in the United States

In August, NIH released a data analysis from the 2012 National Health Interview Survey showing that about 25 million American adults had pain every day for the preceding 3 months and that nearly 40 million adults experience severe levels of pain. The analysis, which was funded by the NIH’s National Center for Complementary and Integrative Health, was published in The Journal of Pain.

NIH BRAIN Initiative Update

In July, the Multi-Council Working Group members of the BRAIN Initiative met with NIH institute directors and staff, as well as representatives from non-federal foundations, to ensure a strong and coordinated research effort across NIH. A videocast of that meeting can be accessed at braininitiative.nih.gov. In October, the Brain Initiative will have a Town Hall & Reception at the 2015 Society for Neuroscience Meeting in Chicago, Illinois.

NIDCR UPDATE

Institute News

NIDCR Proposes FY 2017 Research Initiatives
Over the summer, NIDCR requested public input about research areas for new initiatives for Fiscal Year 2017. Each year, NIDCR identifies broad research topic areas and develops a specific initiative proposal for each area. Many proposed initiatives from previous years have become funding opportunities. The deadline for input was September 4. The five research initiatives proposed for FY 2017 were as follows:

  • Factors Underlying Differences in Female and Male Incidence Rates for Certain Dental, Oral, and Craniofacial Diseases
  • Glycoprofiling HIV and HIV/AIDS-related Oral Pathogens that Persist During Antiretroviral Therapy
  • Tailoring Dental Treatment Guidelines for Patients with Genetic Disorders and Other Conditions Known to Impact Oral Health
  • Three-dimensional Dental, Oral, and Craniofacial Tissue Models to Mimic Human Diseases
  • Wireless Biosensors in the Oral Cavity for Precise, Individualized Medical Care

NIDCR Announces R01 for Enhanced Dental Restorative Materials for Class V Lesions
On June 11, NIDCR announced a funding opportunity to stimulate research on the development of novel or enhanced dental restorative materials for Class V lesions that demonstrate superiority in clinical service life over the currently used restorative options. The requirements of Class V restorative materials (those placed within the gingival third of the exposed tooth) are complex because of the unique material characteristics required by the oral environment and the complications hindering dental treatment in this region. For these reasons, this funding opportunity encourages research that will produce fundamental improvements in Class V restorative dental materials.

NIDCR and Fogarty International Center Co-sponsor 2015 Barmes Lecture 
On July 29, Dr. Agnes Binagwaho, the Republic of Rwanda’s Minister of Health, delivered the 2015 David E. Barmes Global Health Lecture. The title of her talk was "Medical Research and Capacity Building for Development: The Experience of Rwanda." NIDCR and the Fogarty International Center cosponsored the event.

Personnel Update

Yolanda Vallejo-Estrada, PhD, Becomes Director of NIDCR’s Molecular and Cellular Neuroscience Program
On June 29, Yolanda Vallejo-Estrada, PhD, joined NIDCR as the director of the Molecular and Cellular Neuroscience Program in the Division of Extramural Research. Previously, Dr. Vallejo-Estrada served at the National Cancer Institute as a program director at the Center to Reduce Cancer Health Disparities. Before that, she was a health program specialist at the National Institute of Neurological Disorders and Stroke. Dr. Vallejo-Estrada earned her PhD from the Department of Neurobiology, Pharmacology and Physiology at the University of Chicago where she examined molecular and cellular mechanisms of neuronal nicotine receptor-mediated signaling. She continued the same line of investigation during her postdoctoral training at the University of Chicago and authored a number of publications in high impact journals.

Karina Boehm, MPH, Selected as Director of NIDCR’s Office of Communications and Health Education
In August, Karina Boehm, MPH, was selected as director of NIDCR’s Office of Communications and Health Education (OCHE). As acting director of OCHE for nearly two years, Ms. Boehm oversaw the office’s reorganization, recruited two staff members, and positioned the office to expand digital outreach.

Before becoming chief of OCHE’s Health Education Branch in 1999, she was the education coordinator for the Office of Policy and Communication at NHGRI. Before joining NIH, she did community outreach for the Genome Education Program and the Genome Ethics Committee at the University of Michigan (U-M). She also worked as a research assistant in Dr. Francis Collins’ U-M laboratory where she contributed to research on cystic fibrosis and Huntington’s disease. Karina earned an MPH in health behavior and health education from the U-M School of Public Health.

Jonathan Horsford, PhD, Named Acting Director of the Office of Science Policy and Analysis
In July, D. Jonathan Horsford, PhD, was named the acting director of the Office of Science Policy and Analysis (OSPA). Before joining OSPA as a science policy analyst, Dr. Horsford was a scientific review officer and then acting branch chief in NIDCR’s Scientific Review Branch in the Division of Extramural Activities. Before joining NIDCR in 2006, Dr. Horsford was a program director and analyst in the NINDS Neurogenetics Cluster. He received a PhD in developmental neurogenetics from the University of Toronto in 2003.

Margo Adesanya, DDS, MPH, Becomes Science Policy and Planning Branch Chief
After two years as acting director of the Office of Science Policy and Analysis, Margo Adesanya, DDS, MPH, turned her full attention to her role as Chief of OSPA’s Science Policy and Planning Branch, where she will continue to lead the Institute in strategic planning activities and focus on her interests in health disparities and public health. As acting director, Dr. Adesanya led the Institute in development of the 2014-2019 Strategic Plan, directed and facilitated development of fiscal year research initiatives, served as co-director of the NIDCR Residency Program in Dental Public Health, led the OSPA reorganization, and served as the Institute contact for delivering high-profile Agency-level reports about NIDCR accomplishments.

Margo Adesanya Selected for NIH Tribal Consultation Advisory Committee
Dr. Adesanya has been selected to be the NIDCR representative and point of contact for the recently formed NIH Tribal Consultation Advisory Committee (TCAC) as outlined in the NIH Guidance on the Implementation of the HHS Tribal Consultation Policy. Dr. Somerman will serve as the alternate. The TCAC was established to serve as a complementary venue to required annual tribal consultation. As an advisory committee, the NIH TCAC will provide recommendations on the development of relevant NIH policies, programs, and priorities. The NIH TCAC also will seek to ensure that NIH policies or activities that affect Indian Country are brought to the attention of tribal leaders. The Committee will convene the first in-person TCAC meeting on September 29 and 30, 2015.

Melissa Riddle, PhD, Continues Activities for Science of Behavior Change
Melissa Riddle, PhD, chief of the Behavioral and Social Sciences Research Branch in NIDCR’s Division of Extramural Research, continues her participation in the trans-NIH initiative called the Science of Behavior Change (SOBC) funded by the NIH Common Fund. The SOBC initiative aims to implement a mechanisms-focused, experimental medicine approach to behavior change research and to develop the tools required to implement such an approach. The goal of the SOBC initiative is to encourage a mechanistic approach to behavior change research moving forward. Dr. Riddle’s recent participation in SOBC activities include:

  • Dr. Riddle and other members of the SOBC working group organized a breakfast roundtable discussion at the Association for Psychological Science Convention in New York, NY, May 22. Brief presentations by leaders in behavior change research were followed by smaller group discussions about how to take a mechanistic approach to behavior change research in participants’ programs of research.
  • Dr. Riddle and Dr. Rebecca Ferrer of the National Cancer Institute authored an overview of the Science of Behavior Change initiative in the magazine of the Association for Psychological Science (The Observer, in press). The article is titled, "The Science of Behavior Change at the NIH: Promoting an Experimental Medicine Approach to Behavior Change."
  • On behalf of the SOBC working group, Dr. Riddle submitted an invited column in the journal Translational Behavioral Medicine: Practice, Policy, Research. The article is titled, "News from the NIH: Using an Experimental Medicine Approach to Facilitate Translational Research," and is scheduled to be published in the September issue.

Chantelle Ferland-Beckham Joins NIDCR as AAAS Fellow
In August, NIDCR welcomed AAAS Science and Technology Policy Fellow Chantelle Ferland-Beckham, PhD, to work in OSPA. Dr. Ferland-Beckham will assist with scientific planning and priority setting, policy research development and coordination, science policy briefings, and scientific programmatic and funding activity reports. She earned a PhD in neuroscience from Tulane University.

2014–2015 Dental Public Health Residents Graduate
This summer two NIDCR Dental Public Health (DPH) Residents gave final presentations on their studies and received their graduation certificates from Bruce Dye, DDS, MPH, director of the NIDCR Dental Public Health Residency Program. On May 22, Marushka Silveira MPH, BDS, PhD, presented "Cultural Factors and Oral Health-related Quality of Life: Hispanic Community Health Study/Study of Latinos." On June 16, Sayo Adunola, DDS, MPH, presented "Recent oral cavity and oropharyngeal cancer trends and disparities in the United States: 2000–2010" and "The Association between Self-perceived Oral Health Status, Normative Need, and Utilization of Dental Services among Dentate Adults in the United States: NHANES 2011-2012." Her Field Experience Project was titled: "Descriptive Analyses: Survey of Primary Care Physicians on Oral Health." Both events were attended by Drs. Somerman, Kusiak, Dye, Adesanya, and other NIDCR staff.

NIDCR Welcomes 2015–2016 Dental Public Health Residents
In June, Dr. Steffany Chamut and Dr. Amrita Muherjee joined the NIDCR Dental Public Health Residency Program. They will be with NIDCR for one year to complete the educational requirements for board certification in dental public health.

Dr. Chamut received her DDS degree in 2006 from the dental school of Universidad Autonoma de Coahuila in Torreon, Coahuila, Mexico. She completed post-graduate studies in advanced theoretical and clinical training in dental prosthetics at the University of Texas Health Science Center at San Antonio, where she served also as adjunct faculty at the Dental Laboratory Sciences program. She received her MPH at A.T. Still University. Her research interest is focused on aging and oral health.

Dr. Muherjee finished her dental education and training in Kolkata, India in 2011. While in private practice in India, she worked for non-profit organizations and conducted dental and medical camps in rural India, which sparked her interest in public health for underserved populations. Dr. Mukherjee received her MPH from the University of Alabama at Birmingham with a concentration in epidemiology. Her research interests include policies and practices that affect the oral health status of the underserved.

Guo Zhang, PhD, MPH, Joins Scientific Review Branch
In June, Guo (Gary) Zhang, PhD, MPH, returned to NIDCR to work in the Scientific Review Branch. Previously, he was a lead scientific review officer at the National Center for Advancing Translational Sciences. Before NCATS (from 2000 to 2003), he was a program officer overseeing the Chronic Diseases Program in NIDCR’s Extramural Programs, Division of Basic and Translational Research.

Gary received his MPH and PhD in nutrition and physiology from Beijing Medical University. He completed postdoctoral training at the University of Texas Medical School at Houston and at the University of Rochester. From 1992 to 1995, he was a research assistant professor at the University of Rochester, and an assistant professor at the University of Texas Health Science Center at San Antonio from 1995 to 2000. Gary has published more than 70 peer-reviewed manuscripts and book chapters, been a reviewer for a number of scientific journals, and given numerous invited lectures.

David Vannier, PhD, Appointed Chief of Science Communication and Digital Outreach Branch
In August, David Vannier, PhD, was appointed as chief of the new Science Communication and Digital Outreach Branch in NIDCR’s Office of Communications and Health Education. Dr. Vannier oversees science communication, media relations, web content, social media, and digital analytics. He joined NIDCR in May 2014 to help engage clinicians as consumers of research information, and he has worked in policy, education, and public outreach at NIH since 2001. In NIH’s Office of Science Education, he developed multimedia classroom resources on biomedical discoveries.

Trained as a molecular biologist, he earned his PhD from Columbia University and studied developmental neurobiology at the University of Washington. After his postdoctoral fellowship, Dr. Vannier served as a AAAS Policy Fellow in the National Science Foundation’s Office of Legislative and Public Affairs. In 2012, Dave traveled to New Zealand through a Fulbright Fellowship to understand how certain schools succeed in teaching science. Recently, he assisted NHGRI in creating biology lessons inspired by the Smithsonian exhibit "Genome: Unlocking Life’s Code."

Praveen Arany, BDS, MDS, MMSc, PhD, Leaves NIDCR for University of Buffalo
In August, Praveen Arany, BDS, MDS, MMSc, PhD, became an assistant professor at the University of Buffalo’s School of Dental Medicine after three years as an assistant clinical investigator in NIDCR’s Oral and Pharyngeal Cancer Branch.

George Coy Leaves NIDCR for NCATS
In August, NIDCR Budget Officer George Coy transferred to the National Center for Advancing Translational Sciences, where he will serve as budget officer.

Training and Career Development News

NIDCR Fellows Retreat
The NIDCR Office of Education hosted the ninth annual NIDCR Fellows Scientific Retreat on May 14 and 15 at the Hilton Hotel and Executive Meeting Center in Rockville, MD. Eighty-two graduate students, pre-doctoral IRTAs, postdoctoral trainees, clinical fellows, staff scientists, biologists, and core facility staff were in attendance for the retreat along with the Division of Intramural Research scientific director, deputy scientific director, clinical director, and Office of Education staff.

Activities at the event included:

  • Keynote address by Songtao Shi, DDS, PhD, professor and department chair, University of Pennsylvania School of Dental Medicine (former CSDB clinical fellow, research fellow, and staff scientist)
  • Career development workshop led by Sharon Milgram, PhD, director of NIH’s Office of Intramural Training and Education, titled "Emotional Intelligence as a Tool for Personal and Career Growth"
  • 15-minute oral presentations by five attendees
  • Four 3-minute oral presentations
  • Two attendee poster session

In addition, a panel of former trainees discussed their careers after training at NIDCR. The panelists were Dr. Songtao Shi; Brooke Currie, MPH, senior research associate for Evidera’s Outcomes Research Group (former NIDCR postbaccalaureate IRTA); Tamizchelvi (Chelvi) Thyagarajan, PhD, scientific review officer at the National Institute of Nursing Research, NIH (former NIDCR postdoctoral fellow); and Chi-Feng (Jeff) Hsu, PhD, patent examiner at the U.S. Patent and Trade Office (former NIDCR postdoctoral fellow).

NIH Science Communication Competition
On July 16, the NIDCR Office of Education participated for the first time in the NIH Three Minute Talk Science Communication Competition. Fourteen graduate students, postdoctoral fellows, and clinical fellows from three institutes competed as finalists in this event: five from NHGRI, five from NICHD, and four from NIDCR. Participants in this session received professional training to effectively communicate their scientific research to a broad scientific audience using a single presentation slide. They attended two training sessions lead by the Alan Alda Center for Communicating Science and had two one-on-one professional coaching sessions in public speaking. A panel of judges -- including Ashok Kulkarni, PhD, chief of NIDCR’s Functional Genomics Section and Karina Boehm, MPH, NIDCR’s acting communications director-- scored each presentation. Winners were from NICHD (first place) and NHGRI (second and third place). NIDCR plans to participate in the competition again in 2016.

NIDCR FARE Award Recipients
On June 25, two of NIDCR’s trainees -- Tomoko Ikeuchi, PhD, DDS, in the Laboratory of Cell and Developmental Biology and Huanyu Xu, PhD, in the Laboratory of Sensory Biology — received the 2016 NIH Fellows Awards for Research Excellence (FARE). This competition provides recognition for outstanding scientific research performed by intramural postdoctoral fellows. All abstracts were peer reviewed in a blind competition, and the winners of the 2016 FARE awards received a $1,000 stipend to attend a scientific meeting where they will present their research findings. The NIH Fellows Committee, the Scientific Directors, and the NIH Office of Intramural Training and Education sponsor this annual award.

Grant Writing Seminar
On July 14, 70 people took part in a grant writing seminar cohosted by the NIDCR Office of Education, NEI, NHGRI, NICHD, and NIAMS. Training was provided by Grant Writers’ Seminars and Workshops, LLC. The morning session featured a seminar on the key changes in preparation of NIH applications. Participants were shown how to write and submit successful research grant applications using the latest NIH guidelines for grants submission. The presenter also discussed possible pitfalls that they may encounter and good draft review strategies. Ten people (two from NIDCR) took part in the afternoon workshop on developing the specific aims portion of a grant application. Before the session, the participants had submitted drafts of their project specific aims prior to the session for review. Each reviewed draft was discussed with the group.

NIDCR Summer Program
Of the 29 high school, undergraduate, dental, and medical students participating in the NIH Summer Internship Program, 12 were NIDCR Summer Dental Student Award (SDSA) recipients. In fostering our outreach efforts, the Office of Education provided summer internship opportunities for two outstanding students from underrepresented groups in biomedical research as a part of this group. These students pursued internships at NIH as a direct result of either meeting Dr. Philp at a minority student conference or discussing training opportunities with other recruiting staff from NIH at different venues.

NIDCR Summer Dental Student Award
The 2015 NIDCR Summer Dental Student Award Program hosted 12 dental students from across the United States. Award recipients were selected from nine dental schools: University of Connecticut School of Dental Medicine, Missouri School of Dental and Oral Health, University of Texas Health Science Center at San Antonio Dental School, University of Nebraska Medical Center, Boston University Henry M. Goldman School of Dental Medicine, University of Pennsylvania School of Dental Medicine, University of Minnesota School of Dentistry, University of Iowa College of Dentistry, and A.T. Still University of Arizona School of Dentistry and Oral Health.

Highlights of this summer’s activities included the following:

  • Summer student research introduction and welcome reception
  • Field trips to the Samuel D. Harris National Dental Museum and the University of Maryland Baltimore Dental School to hear research presentations from students participating in their program
  • Career panel discussion on "Future Careers in Research and Dentistry"
  • Tour of the NIDCR animal facility and Veterinary Resources Core (cohosted with Lauren Davidson, DVM, director of the VRC)
  • Summer project oral presentations by six of our summer dental students for the NIDCR research community
  • NIDCR and NIH Poster Day sessions

The American Dental Association, American Dental Education Association, and American Student Dental Association helped raise awareness about this award, and NIDCR sent printed and electronic information about this award to all of the accredited dental schools in the United States to encourage students to apply for training opportunities at NIDCR.

NIH High School Scientific Training and Enrichment Program (HiSTEP)
As a member of the planning committee for the creation of the NIH High School Scientific Training and Enrichment Program (HiSTEP), Dr. Philp mentored three HiSTEP students. The goal of HiSTEP is to expand the pipeline of students interested in biomedical and healthcare careers by expanding opportunities for high school students from schools with a large population of financially disadvantaged students. High school sophomores, juniors, and seniors interested in STEM-M (science, technology, engineering, mathematics, and medically related) fields participated in a five-week summer program that allowed students to explore scientific research and current topics in human health disparities. In addition, students received coaching in college preparation and career advising.

Outreach
Drs. Lynn King and Leslie Frieden of the NIDCR Research Training and Career development branch continue to reach out to the extramural research community to encourage predoctoral and postdoctoral students and junior investigators to apply for NIDCR research training and career development funding.

Drs. King and Frieden, accompanied by Ms. Dede Rutberg, the NIDCR Grants Management Officer, visited the University of California, Los Angeles on June 16 and the University of Southern California on June 17. After speaking about NIDCR funding opportunities and research career pathways, they met one-on-one with predoctoral and postdoctoral students and junior faculty, including trainees supported on UCLA and USC institutional T90/R90 training grants and NIDCR F and K awardees and potential applicants. During these programmatic site visits, current trainees presented their research, and NIDCR staff met with grant administrators. They discussed research training programs and opportunities and gaps with the leadership of the graduate programs, dental schools, and oral and craniofacial research training faculty and mentors.

Dr. King attended the Hispanic-Serving Health Professions Schools (HSHPS) Professional Development Workshop for students and faculty held on the NIH campus June 29 and 30. The HSHPS is composed of academic institutions that strive to achieve equitable health and well-being for the Hispanic community and provide opportunities for health and diversity outreach. Goals of the Professional Development Workshop were to assist scholars to perform analytical studies of public health datasets, provide networking opportunities, and enhance their career opportunities. Dr. King participated in the Speed Networking session and discussed research careers and research career pathways in public health and biomedical and behavioral research with undergraduate, graduate, and medical students.

On June 23 and 24, Dr. King attended the National Library of Medicine’s (NLM’s) Informatics Training Conference. The NLM supports research trainees in biomedical informatics at 14 educational institutions throughout the United States. These programs offer graduate education and postdoctoral research experiences in a wide range of areas including: health care informatics, translational bioinformatics, clinical research informatics, and public health informatics. Several programs also offer a track in dental informatics that is funded by the NIDCR. This conference is convened yearly to bring NLM trainees together to showcase their work, to evaluate the full scope of current work in the field, and to provide an opportunity for trainees to meet their peers. Dr. King attended sessions, met with trainees, and participated in the Executive Session of Training Directors.

On July 28, Dr. Frieden presented NIDCR research training opportunities at the American Dental Education Association, Academic Dental Careers Fellowship Program (ADCFP) monthly webinar. The title of Dr. Frieden’s presentation was "NIDCR Opportunities for Support of Dental, Oral and Craniofacial Research Career Pathways."

New Investigators
Former NIDCR K99/R00 awardee Ryan Demmer, PhD, has received his first R01 (DK102932) titled, "The Subgingival Microbiome and Impaired Glucose Regulation." Dr. Demmer is an assistant professor in the Department of Epidemiology at Columbia University.

Former NIDCR T32 postdoctoral trainee Xiaozhe Han, DDS, MSc, PhD, has received his first R01 (DE025255) titled, "Regulatory B cells in the amelioration of immune-mediated periodontal disease." Dr. Han is an assistant member of the staff in the Department of Immunology and Infectious Diseases at The Forsyth Institute.

Former NIDCR K23 awardee Dorota Kopycka-Kedzierawski, DDS, MPH, has received her first R01 (DE024985) titled, "Integrating Oral Biology and Behavioral and Social Mechanisms for ECC Onset." Dr. Kopycka-Kedzierawski is an associate professor in the Division of Community Dentistry and Oral Disease Prevention, Eastman Department of Dentistry, University of Rochester.

Former NIDCR T32 predoctoral trainee Christy McKinney, PhD, MPH, has received her first R01 (DE025229) titled, "The Dental Composite Restorations & Preventive Sealant Safety (DeCoRPS) study." Dr. McKinney is a clinical assistant professor in the Department of Oral Health Sciences, School of Dentistry, University of Washington.

Former NIDCR K22 awardee Guang Zhou, PhD, has received his first R01 award (AR068361) titled, "Coupling of Jab1 and Sox9 in limb development." Dr. Zhou is an assistant professor in the Department of Genetics and Genome Sciences at Case Western Reserve University.

Pathway to Independence Awards
NIDCR K99/R00 awardee Justin Cotney, PhD, has successfully transitioned to the independent phase of his award by accepting a tenure track position as an assistant professor in the Department of Genetics and Genome Sciences at the University of Connecticut Health Center. The title of his R00 phase project is "Identification of human orofacial enhancers and their role in orofacial clefts."

NIDCR Dentist Scientist K99/R00 awardee Marcelo Freire, DDS, PhD, has successfully transitioned to the independent phase of his award by accepting a tenure track position as an assistant member of staff in the Department of Applied Oral Science at The Forsyth Institute. The title of his R00 phase project is "Regulation of ChemR23 in Resolution of Inflammation."

NIDCR K99/R00 awardee Christopher King, PhD, has successfully transitioned to the independent phase of his award by accepting a tenure track position as an assistant professor in the Department of Anesthesia at Cincinnati Children’s Hospital. The title of his R00 phase project is, "Physiological correlates of endogenous pain mod in healthy individuals with TMJD."

On August 1, K99/R00 awardee Isabelle Lombaert, PhD, formerly a postdoctoral researcher in Matthew Hoffman’s laboratory in NIDCR’s Division of Intramural Research, successfully transitioned to the independent phase of her award by accepting a tenure track position as an assistant professor in the Department of Biological and Materials Science at the University of Michigan. The title of her R00 phase project is "Identifying Stem Cells for Future Salivary Gland Stem Cell Therapy."

NIDCR Dentist Scientist K99/R00 awardee Simon Young, DDS, MD, PhD, has successfully transitioned to the independent phase of his award by accepting a tenure track position as an assistant professor in the Department of Oral and Maxillofacial Surgery at the University of Texas Health Science Center in Houston. The title of his R00 phase project is "The Use of Novel Implantable Cancer Vaccines for the Treatment of Oral Cancer."

Former NIDCR F31 predoctoral fellow Fatima Syed-Picard, PhD, has received an NIH K99/R00 Pathway to Independence Award (DE025088) titled, "Scaffold-free Tissue Engineering: Using Principles from Developmental Biology to Support Craniofacial Regeneration." Dr. Syed-Picard is a postdoctoral research associate in the Department of Bioengineering at the University of Pittsburgh.

Transitions from Institutional Training Grant Support to Individual Awards
One of the goals of the Research Training and Career Development Branch is for trainees supported on institutional training grants to apply for individual fellowships or career development awards and achieve their own independent funding. Recently, two dual degree dentist scientist trainees, Nicholas Dybdal-Hargreaves and Kaitlin Katsura, who were previously supported by NIDCR institutional T32 training grants at University of Texas Health Science Center at San Antonio and University of California San Francisco, respectively, have successfully competed for NIDCR F30 fellowships. In addition, Allison Doyle, a predoctoral PhD student at University of Texas Health Science Center San Antonio recently transitioned from an institutional T32 award to an individual NIDCR F31 diversity predoctoral fellowship.

Meetings and Conferences

NIDCR Continues the Building Bridges Travel Award
From May 21 through 24, David Clark, PhD, and Melissa Riddle, PhD, of the Behavior and Social Sciences Research Branch in NIDCR’s Division of Extramural Research, hosted three awardees at the 2015 Association for Psychological Science Convention in New York, NY. This activity was the third annual installment of the NIDCR Building Bridges Travel Award initiative, which is meant to build bridges between two research communities -- researchers in psychological science and researchers in oral health -- that have not traditionally interacted.

The NIDCR-sponsored new investigators presented posters:

  • Dr. Linda Slowik, University of Detroit-Mercy, presented "An Exploration of Dental Anxiety Among Periodontal Patients."
  • Dr. Jeff Boissoneault, University of Florida, presented "Physicians Weigh Virtual Human Patient Characteristics More Heavily than Dentists When Making Pain-Related Clinical Judgments."
  • Dr. Jason Clague, University of California, Los Angeles, presented "Dental Self-Image as a Potential Trigger for Motivational Interventions in Dental Settings."

Nadya Lumelsky, PhD, Attends Organ Bioengineering and Banking Roadmap Workshop
On May 27 and 28 in Washington, DC, Nadya Lumelsky, PhD, director of the Tissue Engineering and Regenerative Medicine Research Program in NIDCR’s Division of Extramural Research, took part as an invited discussant in Organ Bioengineering and Banking Roadmap Workshop. The goal of this workshop was to develop a critical-path roadmap toward solutions to organ disease and injury, encompassing solid organs and other complex tissues.

Isaac Rodriguez-Chavez, PhD, co-chaired the 2015 Annual AIDS Clinical Trials Group/Oral HIV/AIDS Alliance
On June 22 through 26 in Washington, DC, Isaac Rodriguez-Chavez, PhD, director of the AIDS and Immunosuppression Program in the NIDCR’s Division of Extramural Research co-chaired the 2015 Annual AIDS Clinical Trials Group/Oral HIV/AIDS Alliance (ACTG/OHARA) session on oral HIV-AIDS-related clinical studies conducted by OHARA. This meeting included more than 400 ACTG professionals.

Behavioral and Social Sciences Research Branch Staff Members Attend Trans-NIH Event
On June 24 on Capitol Hill, Dave Clark, PhD, Dawn Morales, PhD, and Melissa Riddle, PhD, of the Behavioral and Social Sciences Research Branch in NIDCR’s Division of Extramural Research, participated in a trans-NIH event sponsored by the Consortium of Social Science Associations (COSSA). The event featured a poster session highlighting the behavioral and social sciences programs of many NIH institutes, centers, and offices.

James Drummond, DDS, PhD, Organizes a Meeting for Composite Materials Initiative
James Drummond, DDS, PhD, director of the Dental Materials and Biomaterials Program of NIDCR’s Division of Extramural Research, organized the second annual grantee meeting for the novel dental composite materials initiative. Six teams of U01 grantees as well as NIDCR staff and several external scientists attended the meeting in Portland, Oregon, on July 12-14. Each team presented an update of their research accomplishments, and real or potential bottlenecks in polymer development. The group discussed solutions and milestones for the next year.

Nadya Lumelsky, PhD, Attends NIH-DARPA-supported Microphysiological Systems Program Meeting
On August 26 to 28 on the NIH campus in Bethesda, Nadya Lumelsky, PhD, director of the Tissue Engineering and Regenerative Medicine Research Program in NIDCR’s Division of Extramural Research, participated in a semi-annual meeting of the NIH-DARPA-supported Microphysiological Systems (MPS) Program. Dr. Lumelsky represents NIDCR on the trans-NIH Working Group responsible for the programmatic leadership of the MPS. The goal of the meeting was to evaluate the progress of the MPS Program during the last 6 months of the award period.

Behavioral and Social Sciences Research Branch Staff Members Attend the 20th Anniversary NIH Poster Session
In commemoration of the NIH Office of Behavioral and Social Science’s 20th anniversary, Dave Clark, PhD, Dawn Morales, PhD, and Melissa Riddle, PhD, of the Behavioral and Social Sciences Research Branch in NIDCR’s Division of Extramural Research, participated in a poster session highlighting the activities of NIDCR’s BSSRB. Mary Northridge, PhD, MPH, of New York University was an invited attendee at the event, and presented a poster of results from an NIDCR-funded grant on using social network analysis to identify intervention points to improve oral health for older adults.

Emily Harris, PhD, Attends the Gordon Research Conference on Human Genetics and Genomics
Emily Harris, PhD, chief of the Translational Genetics and Genomics Branch in NIDCR’s Division of Extramural Research, attended the Gordon Research Conference on Human Genetics & Genomics in Newport, Rhode Island, July 19-24, which focused on controversies in state-of-the-art human genome science. In addition to participating in the continuing education aspect, she networked with investigators and trainees interested in or conducting research relevant to NIDCR’s mission.

Division of Intramural Research Staff Members Speak at the MAGIC Foundation
In July in Lombard, Illinois, Michael Collins, MD, Andrea Burke, MD, and Alison Boyce, MD, of the Craniofacial and Skeletal Diseases Branch (CSDB) were speakers at the Annual Meeting of the MAGIC Foundation, a patient support group. They discussed various aspects of McCune-Albright syndrome and fibrous dysplasia of bone.

Tim Iafolla, DMD, MPH, Participates in the American Dental Association’s Expert Panel
On August 25, Tim Iafolla, DMD, MPH, chief of the Program Analysis and Reporting Branch from NIDCR’s Office of Science Policy and Analysis, attended the second expert panel meeting of the American Dental Association’s Center for Evidence Based Dentistry. The purpose of the panel is to update the ADA’s national clinical practice guidelines on the use of pit and fissure sealants, last updated in 2008.

Dental Public Health Residents Attend National Health Policy Forum
In July, the NIDCR Dental Public Health Residents participated in a National Health Policy Forum in Washington, D.C., titled, "Community Health: Seeing the Big Picture by Measuring Health and Its Many Determinants." They were introduced to many public health issues facing the nation at the federal, state, and local levels, and gained valuable insights from leaders across the country.

Other meetings/conferences/workshops attended by staff:

  • Several Precision Medicine Initiative Workshops, including Digital Health Data in a Million-Person Precision Medicine Initiative Cohort, Participant Engagement and Health Equity Workshop, and Mobile and Personal Technologies in Precision Medicine Workshop, held in May and July at various locations and webcasted.
  • Action Plan for Lupus Research Meeting, held May 27 via webinar, Bethesda, MD
  • NIH & FDA Glycoscience Research Day held May 28 in Bethesda, MD
  • 10th Annual NIH Pain Consortium Symposium: Looking Back and to the Future, held May 26-27 in Bethesda, MD
  • Development of Monoclonal Antibodies for HIV Treatment and Cure held June 3–4 in Rockville, MD
  • DIA (Develop Innovate Advance) 2015 51st Annual Meeting held June 14–18 in Washington, DC
  • Structural Biology Related to HIV/AIDS held June 18-19 in Bethesda, MD
  • NHLBI workshop on "Cardiovascular and Pulmonary Disease and the Emergence of E-cigarettes" held June 29-30 in Rockville, MD
  • 74th Annual Meeting of the Society for Developmental Biology held in July in Snowbird, UT
  • Linking Disease Model Phenotypes to Human Conditions Workshop held September 10–11 in Rockville, MD​

Communications Update

New Communication Service: GovDelivery
Since the last meeting of Council, NIDCR launched GovDelivery, a service that will automate and streamline the management of the Institute’s email distribution lists and will enable the Institute to communicate more easily with subscribers via email, text messages, and RSS feeds. More than 1,000 public sector organizations around the world use GovDelivery to communicate with their constituents. NIDCR uses GovDelivery to send e-newsletters and notices to subscribers. For example, anyone can sign up for messages from NIDCR ​ about Grants and Funding, NIDCR Updates, or Science News.

NIDCR receives reports for every email message sent through GovDelivery. The Office of Communications and Health Education is monitoring the number of subscriptions, how many messages are delivered, how many messages are opened, and how many times that links within a message are opened. Collecting and analyzing such data will help NIDCR understand which topics are most appealing to subscribers so that we can better target future communications.

Grantee News Releases
The most recent grantee news releases about NIDCR-supported research posted on the NIDCR website include the following:

NIDCR Exhibits
Since the last meeting of Council, NIDCR exhibited and distributed patient and health professional education materials at the following conferences:

  • Pacific Northwest Dental Conference, Bellevue, WA, June 10–13
  • American Dental Hygienists’ Association, Nashville, TN, June 18–20
  • NIMHD Health Fair at Omega Psi Phi Fraternity Leadership Conference, Jacksonville, FL, July 7
  • National Dental Association, Chicago, IL, July 24–26

PUBLICATIONS

Selected Division of Intramural Research Publications: Peer-Reviewed

Abuhatzira L, Xu H, Tahhan G, Boulougoura A, Schäffer AA, Notkins AL. Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65. FASEB J. 2015 Jul 6. pii: fj.15-273649. [Epub ahead of print]

de Souza LB, Ong HL, Liu X, Ambudkar IS. Fast endocytic recycling determines TRPC1-STIM1 clustering in ER-PM junctions and plasma membrane function of channel. Biochim Biophys Acta. 2015 Jul 30. pii: S0167-4889(15)00256-6. doi: 10.1016/j.bbamcr.2015.07.019. [Epub ahead of print]

Dillenburg-Pilla P., Patel V., Mikelis C.M., Zárate-Bladés C.R., Doçi C.L., Amornphimoltham P., Wang Z., Martin D., Leelahavanichkul K., Dorsam R.T., Masedunskas A., Weigert R., Molinolo A.A., Gutkind J.S. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB J., 29:1056-1068, 2015.

Gafni RI, Guthrie LC, Kelly MH, Brillante BA, Christie CM, Reynolds JC, Yovetich NA, James R, Collins MTTransient increased calcium and calcitriol requirements after discontinuation of human synthetic parathyroid hormone 1-34 (hPTH 1-34) replacement therapy in hypoparathyroidism. J Bone Miner Res. 2015 May 19. doi: 10.1002/jbmr.2555. [Epub ahead of print]

Iglesias-Bartolome R., Torres D., Marone R., Feng X., Martin D., Simaan M., Chen M., Weinstein L.S., Taylor S.S., Molinolo A.A., and Gutkind J.S. Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nature Cell Biol., 17:793-803, 2015.

Koide H, Holmbeck K, Lui JC, Guo XC, Driggers P, Chu T, Tatsuno I, Quaglieri C, Kino T, Baron J, Young MF, Robey PG, Segars JH. Mice deficient in AKAP13 (BRX) are osteoporotic and have impaired osteogenesis. J Bone Miner Res. 2015 Apr 18. doi: 10.1002/jbmr.2534. [Epub ahead of print]

Madera D., Vitale-Cross L., Martin D., Schneider A., Molinolo A.A., Gangane N., Carey T.E., McHugh J.B., Komarck C.M., Walline H.M., William Jr. W.N., Seethala R.R., Ferris R., and Gutkind J.S. Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3. Cancer Prevention Res. (AACR), 8:197-207, 2015.

Nemeth K, Wilson TM, Ren JJ, Sabatino M, Stroncek DM, Krepuska M, Bai Y, Robey PG, Metcalfe DD, Mezey EImpaired function of bone marrow stromal cells in systemic mastocytosis. Stem Cell Res. 2015 Jul;15(1):42-53. doi: 10.1016/j.scr.2015.04.005.

Zheng C, Baum BJ, Liu X, Goldsmith CM, Perez P, Jang SI, Cotrim AP, McCullagh L, Ambudkar IS, Alevizos IPersistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter. Gene Ther. 2015 Jul 16. doi: 10.1038/gt.2015.55. [Epub ahead of print]

Review Article

Yamada KM, Hall A. Reproducibility and cell biology. J Cell Biol. 2015: 209(2): 191-193.

Recent Publications from K Awardees

Khariwala SS, Carmella SG, Stepanov I, Bandyopadhyay D, Nelson HH, Yueh B, Hatsukami DK, Hecht SS. Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer. Laryngoscope. 2015 Aug;125(8):1844-8.

Moshaverinia A, Chen C, Xu X, Ansari S, Zadeh HH, Schricker SR, Paine ML, Moradian-Oldak J, Khademhosseini A, Snead ML, Shi S. Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation System with an Anti-Inflammatory Drug. Adv Funct Mater. 2015 Apr 15;25(15):2296-2307.

Nakao S, Scott JM, Masterson EE, Chi DL. Non-traumatic Dental Condition-Related Emergency Department Visits and Associated Costs for Children and Adults with Autism Spectrum Disorders. J Autism Dev Disord. 2015 May;45(5):1396-407.

Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2015 Aug 6;6:7808.

Strojny C, Boyle M, Bartholomew A, Sundivakkam P, Alapati S. Interferon Gamma-treated Dental Pulp Stem Cells Promote Human Mesenchymal Stem Cell Migration In Vitro. J Endod. 2015 Aug;41(8):1259-64.

Taichman LS, Inglehart MR, Giannobile WV, Braun T, Kolenic G, Van Poznak C. Periodontal Health in Women With Early-Stage Postmenopausal Breast Cancer Newly on Aromatase Inhibitors: A Pilot Study. J Periodontol. 2015 Jul;86(7):906-16.

Zielins ER, Luan A, Brett EA, Longaker MT, Wan DC. Therapeutic applications of human adipose-derived stromal cells for soft tissue reconstruction. Discov Med. 2015 Apr;19(105):245-53.

Recent Publications from F Fellows

Abbruzzese G, Gorny AK, Kaufmann LT, Cousin H, Kleino I, Steinbeisser H, Alfandari D. The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity. J Cell Sci. 2015 Mar 15;128(6):1139-49.

Abramyan J. Lineage-specific loss of FGF17 within the avian orders Galliformes and Passeriformes. Gene. 2015 Jun 1;563(2):180-9.

Buitrago-Delgado E*, Nordin K*, Rao A, Geary L, LaBonne C. NEURODEVELOPMENT. Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells. Science. 2015 Jun 19;348(6241):1332-5. *authors contributed equally to this work

Kaspar J, Ahn SJ, Palmer SR, Choi SC, Stanhope MJ, Burne RA. A unique open reading frame within the comX gene of Streptococcus mutans regulates genetic competence and oxidative stress tolerance. Mol Microbiol. 2015 May;96(3):463-82.

Kumar VA, Taylor NL, Shi S, Wickremasinghe NC, D'Souza RN, Hartgerink JD. Self assembling multidomain peptides tailor biological responses through biphasic release. Biomaterials. 2015 Jun;52:71-8.

Lee RC, Darling CL, Fried D. Assessment of remineralization via measurement of dehydration rates with thermal and near-IR reflectance imaging. J Dent. 2015 Aug;43(8):1032-42.

Lindner HB, Felmly LM, Demcheva M, Seth A, Norris R, Bradshaw AD, Vournakis J, Muise-Helmericks RC. pGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1. PLoS One. 2015 May 8;10(5):e0127876.

McCall AD, Baker OJ. Characterization of Angiogenesis and Lymphangiogenesis in Human Minor Salivary Glands with Sjögren's Syndrome. J Histochem Cytochem. 2015 May;63(5):340-9.

Metzler MA, Venkatesh SG, Lakshmanan J, Carenbauer AL, Perez SM, Andres SA, Appana S, Brock GN, Wittliff JL, Darling DS. A systems biology approach identifies a regulatory network in parotid acinar cell terminal differentiation. PLoS One. 2015 Apr 30;10(4):e0125153.

Padovano JD, Ravindran S, Snee PT, Ramachandran A, Bedran-Russo AK, George A. DMP1-derived peptides promote remineralization of human dentin. J Dent Res. 2015 Apr;94(4):608-14.

Porto A, Sebastião H, Pavan SE, VandeBerg JL, Marroig G, Cheverud JM. Rate of evolutionary change in cranial morphology of the marsupial genus Monodelphis is constrained by the availability of additive genetic variation. J Evol Biol. 2015 Apr;28(4):973-85.

Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May 5;11(5):673-80.

Tasca A, Stemig M, Broege A, Huang B, Davydova J, Zwijsen A, Umans L, Jensen ED, Gopalakrishnan R, Mansky KC. Smad1/5 and Smad4 expression are important for osteoclast differentiation. J Cell Biochem. 2015 Jul;116(7):1350-60.

Vo TN, Ekenseair AK, Spicer PP, Watson BM, Tzouanas SN, Roh TT, Mikos AG. In vitro and in vivo evaluation of self-mineralization and biocompatibility of injectable, dual-gelling hydrogels for bone tissue engineering. J Control Release. 2015 May 10;205:25-34.

Recent Publications from T32/T90/R90 Trainees and K12 Scholars

Akinkugbe AASaraiya VM, Preisser JS, Offenbacher S, Beck JD. Bias in estimating the cross-sectional smoking, alcohol, obesity and diabetes associations with moderate-severe periodontitis in the Atherosclerosis Risk in Communities study: comparison of full versus partial-mouth estimates. J Clin Periodontol. 2015 Jul;42(7):609-21.

Aubrecht TG, Jenkins R, Nelson RJ. Dim light at night increases body mass of female mice. Chronobiol Int. 2015 May;32(4):557-60.

Han BB, Li S, Tong M, Holpuch AS, Spinney R, Wang D, Border MB, Liu Z, Sarode S, Pei P, Schwendeman SP, Mallery SR. Fenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions. Cancer Prev Res (Phila). 2015 May;8(5):419-30.

Kim J, Wu B, Niedzielski SM, Hill MT, Coleman RM, Ono A, Shikanov A. Characterizing natural hydrogel for reconstruction of three-dimensional lymphoid stromal network to model T-cell interactions. J Biomed Mater Res A. 2015 Aug;103(8):2701-10.

Lainoff AJ, Moustakas-Verho JE, Hu D, Kallonen A, Marcucio RS, Hlusko LJ. A comparative examination of odontogenic gene expression in both toothed and toothless amniotes. J Exp Zool B Mol Dev Evol. 2015 May;324(3):255-69.

Martin A, Xiong J, Koromila T, Ji JS, Chang S, Song YS, Miller JL, Han CY, Kostenuik P, Krum SA, Chimge NO, Gabet Y, Frenkel B. Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. Bone. 2015 Jun;75:96-104.

Nam J, Perera P, Gordon R, Jeong YH, Blazek AD, Kim DG, Tee BC, Sun Z, Eubank TD, Zhao Y, Lablebecioglu B, Liu S, Litsky A, Weisleder NL, Lee BS, Butterfield T, Schneyer AL, Agarwal S. Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening. Bone. 2015 Sep;78:62-70.

Patel JJ, Flanagan CL, Hollister SJ. Bone Morphogenetic Protein-2 Adsorption onto Poly-ε-caprolactone Better Preserves Bioactivity In Vitro and Produces More Bone In Vivo than Conjugation Under Clinically Relevant Loading Scenarios. Tissue Eng Part C Methods. 2015 May;21(5):489-98.

Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr;17(4):386-96.

Selected Extramurally Funded Science Advances

Behavioral and Social Science Research
Waller N, John MT, Feuerstahler L, Baba K, Larsson P, Peršić S, Kende D, Reißmann DR, Rener-Sitar K. A 7-day recall period for a clinical application of the oral health impact profile questionnaire.​  Clin Oral Investig. 2015;May6. [Epub ahead of print] Link to PDF Article

Northridge ME, Yu C, Chakraborty B, et al. A community-based oral public health approach to promote health equity. Am J Public Health. 2015;105 Suppl 3:S459-65.

Ramoni RB, Walji MF, Kim S, Tokede O, Mcclellan L, Simmons K, Skourtes E, Yansane A, White JM, Kalenderian E. Attitudes toward and beliefs about the use of a dental diagnostic terminology: A survey of dental care providers in a dental practice.  J Am Dent Assoc. 2015;146(6):390-7.

Gray KE, Kapp-Simon KA, Starr JR, Collett BR, Wallace ER, Speltz ML. Predicting developmental delay in a longitudinal cohort of preschool children with single-suture craniosynostosis: is neurobehavioral assessment important? Dev Med Child Neurol. 2015;57(5):456-62.

Parish CL, Pereyra MR, Pollack HA, et al. Screening for substance misuse in the dental care setting: findings from a nationally representative survey of dentists. Addiction. 2015;110(9):1516-23.

Center for Clinical Research
Kranz AM, Preisser JS, Rozier G. Effects of physician-based preventive oral health services on dental caries. Pediatrics. 2015;136(1):107-14.

Ghazal T, Levy SM, Childers NK, Broffitt B, Cutter GR, Wiener HW, Kempf MC, Warren J, Cavanaugh JE. Factors associated with early childhood caries incidence among high caries-risk children. Community Dent Oral Epidemiol. 2015;43(4):366-74.

Chaturvedi AK, Graubard BI, Broutian T, Pickard RKL, Tong Z-Y, Xiao W, Kahle L, Gillison ML. NHANES 2009-2012 Findings: Association of Sexual Behaviors with Higher Prevalence of Oral Oncogenic Human Papillomavirus Infections in U.S. Men. Cancer Res. 2015;75:2468-77.

Law AS, Nixdorf DR, Aguirre AM, Reams GJ, Tortomasi AJ, Manne BD, Harris DR, National Dental PBRN Collaborative Group. Predicting severe pain after root canal therapy in the National Dental PBRN . J Dent Res. 2015;94(3):37S-43S.

Ludlow JB, Timothy R, Walker C, Hunter R, Benavides E, Samuelson DB, Scheske MJ. Effective dose of dental CBCT – a meta analysis of published data and additional data for nine CBCT units. Dentomaxillofac Radiol. 2015;44(1):20140197.

Bandyopadhyay D, Galvis DM, Lachos VH. Augmented mixed models for clustered proportion data. Stat Methods Med Res. 2014;0(0):1-18.

Kamer AR, Pirraglia E, Tsui W, Rusinek H, Vallabhajosula S, Mosconi L, Yi L, McHugh P, Craig RG, Svetcov S, Linker R, Shi C, Glodzik L, Williams S, Corby P, Saxena D, de Leon MJ. Periodontal disease associates with higher brain amyloid load in normal elderly . Neurobiol Aging. 2015;36(2):627-33.

Warren JJ, Weber-Gasparoni K, Tinanaoff N, Batliner TS, Jue B, Santo W, Garcia RI, Gansky SA, and the Early Childhood Caries Collaborating Centers. Examination criteria and calibration procedures for prevention trials of the Early Childhood Caries Collaborating Centers . J Public Health Dent. 2015;May22:[Epub ahead of print]

Integrative Biology and Infectious Disease
Szczerba BM, Kaplonek P, Wolska N, Podsiadlowska A, Rybakowska PD, Dey P, Rasmussen A, Grundahl K, Hefner KS, Stone DU, Young S, Lewis DM, Radfar L, Scofield RH, Sivils KL, Bagavant H, Deshmukh US (2015). Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice . Ann Rheum Dis. 2015 Feb 5. pii: annrheumdis-2014-206297. doi:10.1136/annrheumdis-2014-206297. [Epub ahead of print].

Aure MH, Konieczny SF, Ovitt CE. Salivary gland homeostasis is maintained through acinar cell self-duplication . Dev Cell. 2015;33(2):231-7.

Tapaltsyan V, Eronen Jt, Lawing Am, Sharir A, Janis C, Jernvall J, Klein OD. Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years . Cell Rep. 2015;11(5);673-680.

Zhang Y, Strehin I, Bedelbaeva K, Gourevitch D, Clark L, Leferovich J, Messersmith PB, Heber-Katz E. Drug-induced regeneration in adult mice . Science Transl Med. 2015;7(290):290ra92.

Kaspar J, Ahn S, Palmer SR, Choi SC, Stanhope MJ, Burne RJ. A unique open reading frame within the comX gene of Streptococcus mutans regulates genetic competence and oxidative stress tolerance​ . Mol Microbiol. 2015;96:463-82.

Miller JH, Avilés-Reyes A, Scott-Anne K, Gregoire S, Watson GE, Sampsone E, Progulske-Fox A, Koo H, Bowen WH, Lemos JA, Abranches J. The Collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175 . Infect Immun. 2015;83:2001-10.

Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS. Different immune cells mediate mechanical pain hypersensitivity in male and female mice . Nat Neurosci. 2015;Aug;18(8):1081-85.

Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors . Sci Transl Med. 2015;7(287):287ra72.

Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, and Elledge SJ. Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science. 2015;348(6239):aaa0698. doi: 10.1126/science.aaa0698.

Liu Y, Shetty AC, Schwartz JA, Bradford LL, Xu W, Phan QT, Kumari P, Mahurkar A, Mitchell AP, Ravel J, Fraser CM, Filler SG, and Bruno VM. New signaling pathways govern the host response to C. albicans infection in various niches . Genome Res. 2015;25(5):679-89.

Scanlon CS, Banerjee R, Inglehart RC, Liu M, Russo N, Hariharan A, van Tubergen EA, Corson SL, Asangani IA, Mistretta CM, Chinnaiyan AM, D'Silva NJ. Galanin modulates the neural niche to favour perineural invasion in head and neck cancer . Nat Commun. 2015;6:6885.

Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano JA, Eisele DW, Fakhry C, Gourin CG, Ha PK, Kang H, Kiess A, Koch WM, Myers JN, Quon H, Richmon JD, Sidransky D, Tufano RP, Westra WH, Bettegowda C, Diaz LA Jr, Papadopoulos N, Kinzler KW, Vogelstein B, Agrawal N. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas . Sci Transl Med. 2015;7(293):293ra104.

Maciej Podgórski, Eftalda Becka, Shunsuke Chatani, Mauro Claudino, and Christopher N. Bowman. Ester-free Thiol-X Resins:New Materials with Enhanced Mechanical Behavior and Solvent Resistance​. Polymer Chemistry. 2015;6(12):2234-40.

Ning Zhang, Jianfeng Ma, Mary A.S. Melo, Michael D. Weir, Yuxing Bai, Hockin H.K. Xu. Protein-repellent and antibacterial dental composite to inhibit biofilms and caries . J Dent. 2015;43:234-1331.

Mobley CG, Kuzynsk M, Zhang H, Jani P, Qin C, Napierala D. Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin Formation. J Dent Res. 2015;94(8):1128-34.

Park S, Kanayama K, Kaur K, Tseng HC, Banankhah S, Quje DT, Sayre JW, Jewett A, Nishimura I. Osteonecrosis of the jaw developed in mice: disease variants regulated by γδ T cells in oral mucosal barrier immunity . J Biol Chem. 2015;290(28):17349-66.

Translational Genomics Research
Delahaye-Sourdeix M, Oliver J, Timofeeva MN, Gaborieau V, Johansson M, Chabrier A, Wozniak MB, Brenner DR, Vallee MP, Anantharaman D, Lagiou P, Holcatova I, Richiardi L, Kjaerheim K, Agudo A, Castellsague X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Mates IN, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wunsch-Filho V, Eluf-Neto J, Boffetta P, Garrote LF, Serraino D, Lener M, Jaworowska E, Lubinski J, Boccia S, Rajkumar T, Samant TA, Mahimkar MB, Matsuo K, Franceschi S, Byrnes G, Brennan P, McKay JD. The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract.  PLoS One. 2015;Mar20;10(3):e0117639. doi: 10.1371/journal.pone.0117639;eCollection:2015.

Delahaye-Sourdeix M, Anantharaman D, Timofeeva MN, Gaborieau V, Chabrier A, Vallée MP, Lagiou P, Holcátová I, Richiardi L, Kjaerheim K, Agudo A, Castellsagué X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Mates IN, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Eluf-Neto J, Boffetta P, Fernández Garrote L, Polesel J, Lener M, Jaworowska E, Lubiński J, Boccia S, Rajkumar T, Samant TA, Mahimkar MB, Matsuo K, Franceschi S, Byrnes G, Brennan P, McKay JD. A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer.  J Natl Cancer Inst. 2015;Apr2;107(5). pii: djv037. doi:10.1093/jnci/djv037.

Vasudevan HN, Mazot P, He F, Soriano P. Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. eLIFE. 2015;May7;4. doi:10.7554/eLife.07186.

Division of Extramural Research Staff Publication

Lunsford RD, Melillo AA, and Somerman MJ. Guest Editorial for Special Oral Microbes Edition . Microbes Infect. 2015;Jul;17(7):471-2. PMID: 25797397

Office of Science Policy and Analysis Staff Publications

Dye BA, Harrell L, Murphy DA, Belin T, Shetty V. Performance of a quality assurance program for assessing dental health in methamphetamine users. BMC Oral Health. 2015. Jul 5; 15:76.

Dye BA, Hsu KC, Afful J. Prevalence and Measurement of Dental Caries in Young Children. Pediatr Dent. 2015; 37: 200-216.

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