Position Description: We are seeking a postdoctoral researcher to study ubiquitin-dependent regulation of stem cell maintenance and differentiation in normal and disease states. Our lab is in the National Institute of Dental and Craniofacial Research’s Division of Intramural Research, which is part of the vibrant research community on the NIH’s main campus in Bethesda, Maryland.
Our major goal is to understand novel molecular mechanisms that control cell-fate choices during development. For this, our studies focus on ubiquitylation, an essential posttranslational modification that regulates the stability, activity, localization, and interaction landscape of target proteins. Specifically, by combining biochemical, biophysical, and proteomic approaches with human embryonic stem cell culture, we are studying the functions and mechanisms of CUL3-based E3 ligases. This large family of ubiquitylation enzymes regulates important aspects of development, and misregulation of its members is tightly linked to diverse human diseases including neuropathies, autism, and cancer.
Current projects are geared towards dissecting the role of a particular Cul3-based E3 ligase in ribosome biogenesis during neural crest and craniofacial development, and towards identifying novel functions of CUL3 E3s in stem cell maintenance and differentiation.
Qualifications: We are seeking creative and highly motivated candidates with Ph.D. and/or DDS or MD, strong verbal skills, experience with some of the methods we use (e.g., cell and molecular biology techniques, mammalian tissue culture, siRNA/shRNA, CRISPR, biochemical methods, proteomics), and a previous track record of successful research. Bioinformatical skills and prior experience with hESC culture are a plus. Salary is commensurate with research experience and accomplishments.
To Apply: Please submit your CV, bibliography, a brief statement of research interests, and the names of three references to:
Achim Werner, Ph.D.
Chief – Stem Cell Biochemistry Unit
National Institute of Dental and Craniofacial Research (NIDCR)
Building 30, 30 Convent Dr MSC 4340
Bethesda MD 20892-4340
NIH/NIDCR is dedicated to building an inclusive and diverse community in its training and employment programs. Individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH/NIDCR employment. DHHS and NIH are equal opportunity employers.