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FaceBase 2: Extending the Functional Genomics of Craniofacial Development and Disease

Developmental Biology and Genetics Program
Translational Genomics Research Branch
Division of Extramural Research
 

OBJECTIVE

To stimulate the study of functional genomics of craniofacial development and disease through building on the contributions of the initial FaceBase Consortium. The FaceBase resource will be broadened and deepened by generating and disseminating datasets not covered by the original consortium such as additional areas of the developing face or skull, disorders of these developmental processes, along with additional data related to midface development and orofacial clefts, and novel ways of displaying, integrating and searching current and new FaceBase datasets. 

BACKGROUND

The FaceBase consortium was designed  to advance craniofacial research through the creation and wide dissemination of a variety of datasets that would normally be outside  the grasp of individual R01-funded labs, with an ultimate goal of managing and integrating those data in such a way that they could be readily searched and potentially analyzed using the approaches of systems biology.  With its initial focus on mid-face development and cleft lip and palate, the FaceBase RFA attracted a talented group of investigators with diverse projects, all of whom are contributing their data to the FaceBase resource.  Funding for the current projects, including the data management and integration hub, began in September of 2009 and will end in April of 2014. 

Although the current consortium is producing a diverse collection of data, there are still areas of research and relevant large datasets whose dissemination to the wider community should accelerate craniofacial research.

Examples of potential research topics could include but are not limited to:

1)    Epigenetic regulation of craniofacial development.

2)    Proteomics of craniofacial development.

3)    Expansion of the current normative facial shape database beyond Caucasians and to other parts of the skull.

4)    Broad scale functional analysis of signaling pathway activity to complement the consortium’s existing gene expression maps.

5)    Genomic studies of craniofacial dysmorphies beyond orofacial clefting.

6)    Development of new animal models for use by the wider community.

7)    Development of novel informatics techniques for integrating, visualizing, and analyzing FaceBase’s data.

 

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This page last updated: February 26, 2014