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Biomarkers for Root Resorption

Biomarkers for Root Resorption

Biomarkers for Root Resorption

Resorption of the root is a pathological process. It develops when the natural protection of the predentin and odontoblasts in the root canal or the cementum and the cementoblasts on the root surface are damaged or removed. The following reasons are proposed for the etiology of root resorption, namely:

  • Genetic predisposition
  • Hormonal disturbances
  • Duration of orthodontic treatment
  • Root shape and length

Currently, radiography is the only method used to detect root resorption in the clinics. Our goal was to develop an alternative molecular method to assess ongoing root resorption in active orthodontic patients. With this in mind, gingival crevicular fluid was obtained from control subjects and patients undergoing orthodontic treatment and used to identify biomarkers for root resorption. The Figure is a representation of the western blot analysis of control subjects and patients with different levels of root resorption. Antibody against osteopontin a key bone matrix protein was used to detect this protein in the crevicular fluid. The western blot analysis results suggest that the amount of osteopontin and its degradation varied with the level of root resorption.

Development of an easy and reliable screen test using such biomarkers could be used by the orthodontist in the office to monitor root resorption and identify patients at risk of severe resorption.

This work was supported by NIDCR, the Brodie Endowment fund, and the Department of Orthodontics, University of Illinois at Chicago. Photo courtesy of Dr. Anne George, University of Illinois at Chicago

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This page last updated: April 07, 2014