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Submandibular Salivary Gland

Submandibular Salivary Gland

Submandibular Salivary Gland

The photo shows a section of submandibular gland from a heterozygous Ascl3 EGFP-Cre 12month-old female mouse stained with antibody to Cre recombinase (red). The slide has also been stained with TO-PRO, which stains all cell nuclei. Secretory acinar cell nuclei are rounded, and appear bright blue, while duct cell nuclei are smaller, darker blue, and appear more like beaded necklaces. The Ascl3 EGFP-Cre mice carry an EGFP-Cre fusion protein that was inserted into the Ascl3 gene locus by homologous recombination. Consequently, Cre recombinase expression is driven by the Ascl3 promoter, and recapitulates the expression pattern of the Ascl3 transcription factor. The photo reveals that Ascl3 expression is localized to a subset of cells found only in the ducts of the salivary glands.

Drs. Tara Bullard and Catherine Ovitt, Center for Oral Biology, University of Rochester

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This page last updated: February 26, 2014