Mechanoregulation via Biomaterials

NIDCR Grand Rounds Lecture

Biomaterials that enhance cell and protein therapies
Mooney's lab designs biomaterials that enhance cell- and protein-based regenerative therapies.

Presenter: David J. Mooney, PhD, Harvard Paulson School of Engineering and Applied Sciences

Friday, March 1, 2019
10:00 –11:00 am
Lipsett Amphitheater, Building 10
NIH Main Campus, Bethesda, MD

View Online



Dr. David Mooney’s research is based on the question, “How do mammalian cells receive information from the materials in their environment?” By using the tools of bioengineering and cell and molecular biology, he studies the mechanisms by which chemical or mechanical signals are sensed by cells, and how these signals alter cellular proliferation and specialization to either promote tissue growth or destruction. His research results inform the design and synthesis of new biomaterials that regulate the gene expression of interacting cells for a variety of tissue engineering and drug delivery projects. Current projects focus on therapeutic angiogenesis, regeneration of musculoskeletal tissues, and cancer therapies. 

Presenter’s Bio:

Dr. David Mooney is the Robert P. Pinkas Family Professor of Bioengineering, School of Engineering and Applied Sciences, and a Core Faculty Member of the Wyss Institute for Biologically Inspired Engineering at Harvard University. His laboratory designs biomaterials that enhance cell and protein therapies for effective and practical approaches to treat human diseases. He has received funding from NIDCR, NHLBI, NIBIB, and NCI, as well as several national organizations and pharmaceutical companies. He has mentored over 60 postdoctoral fellows and over 100 postbaccalaureate, dental, and medical students. Dr. Mooney is a member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors. He has authored more than 350 scientific papers and is an inventor of more than 40 issued U.S. patents. He has won numerous awards and has been elected as a Fellow of the National Academy of Inventors. 

Selected References:

Raimondo TM, Mooney DJ. Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice. Proc Natl Acad Sci USA. 2018 Oct 16;115(42):10648-10653. doi: 10.1073/pnas.1806908115. PMCID: PMC6196479.

Darnell M, O'Neil A, Mao A, Gu L, Rubin LL, Mooney DJ. Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci USA. 2018 Sep 4;115(36): E8368-E8377. doi: 10.1073/pnas.1802568115. PMCID: PMC6130338.

Kwee BJ, Budina E, Najibi AJ, Mooney DJ. CD4 T-cells regulate angiogenesis and myogenesis. Biomaterials. 2018 Sep; 178:109-121. doi: 10.1016/j.biomaterials.2018.06.003. PMCID: PMC6090550.

Brudno Y, Pezone MJ, Snyder TK, Uzun O, Moody CT, Aizenberg M, Mooney DJ. Replenishable drug depot to combat post-resection cancer recurrence. Biomaterials. 2018 Sep; 178:373-382. doi: 10.1016/j.biomaterials.2018.05.005. PMCID: PMC6075722.

About the NIDCR Clinical Research Fellowship Grand Rounds:
NIDCR Clinical Research Fellowship Grand Rounds occur quarterly each year. Leading scientists and clinicians address advances in clinical, translational, and basic research in areas related to the dental, oral, and craniofacial complex and bone metabolism.

Watch the lecture online.

Sign language interpreters will be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Barbara Hardy, NIDCR/OCD Office Manager at (301) 827-1647 or and/or the Federal Relay (1-800-877-8339).

Last Reviewed
February 2019

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