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Translational Genetics and Genomics Program

Contact: Dr. Kathryn Stein, 301-827-4653, kathryn.stein@nih.gov  


The Translational Genetics and Genomics Program supports research designed to identify the genetic and molecular mechanisms underlying oral health problems and craniofacial disorders. Craniofacial abnormalities, such as cleft lip and cleft palate, ectodermal dysplasias, craniosynostosis, and amelogenesis and dentinogenesis imperfecta, may be the result of spontaneous or inherited genetic mutations. Often, the etiology is complex, involving environmental factors and gene-gene and gene-environment interactions. Oral health problems, such as dental caries, oral cancer, periodontal diseases, Sjögren’s syndrome, and temporomandibular joint disorder, often result from the complex interplay of genetic and environmental factors as well. Research focusing on genetics or on the interplay of genetic and environmental factors to improve understanding of genetic and molecular mechanisms underlying oral health problems and craniofacial disorders is supported by this program. In addition, the program encourages research that is responsive to the NIH Common Fund initiatives.

The program supports research on:

Gene Discovery and Characterization

  • Gene discovery studies using candidate gene or genome-wide high-throughput technologies and epidemiologic or family-based approaches
  • Replication, fine-mapping, functional, and translational studies of promising genes and variants
  • Clinical studies of genotype/phenotypic correlation

Statistical Methodology Development

  • Statistical methodology development for and secondary data analyses of genome-wide data, relevant to oral, dental, and craniofacial research

Additional Information

Kathryn Stein
Acting Program Director, Translational Genomics Research Program
6701 Democracy Blvd., 6th floor, MSC 4878
Bethesda, MD 20892-4878 (regular mail)
Bethesda, MD 20817 (overnight mail or courier service)
Phone: 301-827-4653
Fax: 301-480-8319
E-mail: kathryn.stein@nih.gov  ​

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This page last updated: October 26, 2017