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John O. Cisar, Ph.D.

John O. Cisar, Ph.D.Senior Investigator
Chief, Microbial Receptors Section

BETHESDA MD 20892-4352

Phone: (301) 496-1822
Fax: (301) 402-1064

Biographical Sketch

Dr. Cisar received his Ph.D. in microbiology from Oregon State University and 3 years postdoctoral training in quantitative immunochemistry at Columbia University in the laboratory of the late Elvin A. Kabat. From 1975-1977, he was assistant professor of oral biology, University of Colorado in Denver where he initiated studies into the structural basis of oral microbial adhesion, with support from a young investigator research grant from NIDR. He continued this work at NIH as a senior staff fellow from 1977-1981, as a research microbiologist from 1981-1996, and as a senior investigator and chief of the Microbial Receptors Section, NIDCR, from 1996 to the present.

Research Interests/Scientific Focus

Research in the Microbial Receptors Section focuses on the identification and characterization of bacterial surface components that mediate primary colonization of the tooth surface, dental plaque biofilm formation and the initiation of inflammation at surrounding sites. Specific research interests include structural and molecular characterization of streptococcal receptor polysaccharides and closely related pneumococcal capsular polysaccharides, adhesins of gram-positive oral bacteria and cell surface glycoside hydrolases that function in cooperative degradation and utilization of salivary glycoconjugates for biofilm growth and development.

Selected Publications

Co-localization of receptor polysaccharide-bearing streptococci (Red) and type 2 fimbriae-bearing actinomyces (green) in dental plaque biofilm.

  1. Palmer Jr., R. J., Gordon, S. M., Cisar, J. O., Kolenbrander, P. E.: Coaggregation-mediated interactions of streptococci and actinomyces detected in initial human dental plaque. J. Bacteriol. 185:3400-3409, 2003. [PMID: 12754239]
  2. Yoshida, Y., Ganguly, S., Bush, C. A, Cisar, J.O.: Carbohydrate engineering of the recognition motifs in streptococcal coaggregation receptor polysaccharides. Mol. Microbiol. 58:244-256, 2005. [PMID: 16164562]
  3. Yoshida, Y., Yang, J., Peaker, P.-E., Kato, H., Bush, C. A., Cisar, J. O.: Molecular and antigenic characterization of a Streptococcus oralis coaggregation receptor polysaccharide by carbohydrate engineering in Streptococcus gordonii. J. Biol. Chem. 283:12654-64, 2008. [PMID: 18303023]
  4. Mishra, A., Wu, C., Yang, J., Cisar, J. O., Das, A., Ton-That, H.: The Actinomyces oris type 2 fimbrial shaft FimA mediates co-aggregation with oral streptococci, adherence to red blood cells and biofilm development. Mol. Micro. 77:841-54, 2010. [PMID: 20545853]
  5. Yang, J., Shelat, N. Y., Bush, C. A., Cisar, J. O.: Structure and molecular characterization of Streptococcus pneumoniae capsular polysaccharide 10F by carbohydrate engineering in Streptococcus oralis. J. Biol. Chem. 285:24217-27, 2010. [PMID: 20507989]
  6. Yang, J., Nahm, M., Bush C. A., Cisar J. O.: Comparative structural and molecular characterization of Streptococcus pneumoniae capsular polysaccharide Serogroup 10. J. Biol. Chem. 286:35813-22, 2011. [PMID: 21859716]

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This page last updated: February 26, 2014