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Matrix and Morphogenesis Section

Matthew P. Hoffman, B.D.S., Ph.D., Chief


The overall goal of the Matrix and Morphogenesis Section is to understand the diverse regulatory inputs that drive organogenesis from the earliest stages of stem/progenitor cell commitment, maintenance, and differentiation, to growth, morphogenesis, and the formation of a functional organ. We explore interactions among the various cell types, including epithelial, neuronal, endothelial, and mesenchymal cells, and investigate how these cells are influenced by their extracellular matrix (ECM) microenvironment. Our primary model system is the developing mouse submandibular gland. We focus on fibroblast growth factors, remodeling of ECM molecules in the basement membrane, and the genetic regulation of branching morphogenesis. We aim to design therapeutic approaches for the functional regeneration of damaged adult salivary tissue through our understanding of the developmental mechanisms that occur during organogenesis. 



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This page last updated: January 24, 2017