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Ilias Alevizos, D.M.D., M.M.Sc.

Ilias Alevizos, D.M.D., MMSc.Tenure-Track Investigator
Sjogren's Syndrome Clinic
Molecular Physiology & Therapeutics Branch

NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 10 ROOM 1N110
10 CENTER DR MSC 1190
BETHESDA MD 20892

Phone: (301) 496-6207
E-mail: alevizosi@mail.nih.gov

Biographical Sketch

Dr. Ilias Alevizos received his B.S. in biology from Adelphi University, his D.M.D. from Tufts University, his MMSc. from Harvard University, and specialized in oral and maxillofacial pathology at Harvard University. He has completed postdoctoral research appointments at MIT and University of Padova, Italy, and a clinical research fellowship at NIH. During his postdoctoral appointments he focused on the exploration of high throughput genomics for disease development of genetic signatures that would allow for the identification of early cellular changes that can serve as biomarkers or pharmacologic targets. Dr. Alevizos is a member of the multidisciplinary Sjogren's syndrome medical team at NIH. He possesses extensive clinical experience in the diagnosis and management of oral diseases, especially ones related to salivary glands. He is currently participating in many clinical research protocols at NIH. His basic science focus is on salivary gland physiology, and more specifically on how alterations in the expression of non-coding genes participate in the development of diseases impairing the function of salivary glands.

Research Interests/Scientific Focus

  • Mechanisms of salivary gland secretion
  • Role of Regulatory RNAs in function
  • Gene therapy
  • Genomics
  • Oral disease biomarkers

Selected Publications

  1. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. Gallo A, Tandon M, Alevizos I, Illei GG. PLoS One. 2012;7(3):e30679. Epub 2012 Mar 9. http://www.ncbi.nlm.nih.gov/pubmed/22427800
  2. Deep sequencing of short RNAs reveals novel microRNAs in minor salivary glands of patients with Sjögren's syndrome. Tandon M, Gallo A, Jang SI, Illei G, Alevizos I. Oral Dis. 2011 Aug 9. doi: 10.1111/j.1601-0825.2011.01849.x. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/21895886
  3. MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjögren's syndrome. Alevizos I, Alexander S, Turner RJ, Illei GG. Arthritis Rheum. 2011 Feb;63(2):535-44. doi: 10.1002/art.30131. http://www.ncbi.nlm.nih.gov/pubmed/21280008
  4. MicroRNAs as biomarkers in rheumatic diseases. Alevizos I, Illei GG.Nat Rev Rheumatol. 2010 Jul;6(7):391-8. Epub 2010 Jun 1. Review. http://www.ncbi.nlm.nih.gov/pubmed/20517293
  5. Exosomes from human saliva as a source of microRNA biomarkers. Michael A, Bajracharya SD, Yuen PS, Zhou H, Star RA, Illei GG, Alevizos I.Oral Dis. 2010 Jan;16(1):34-8. Epub 2009 Jul 15. http://www.ncbi.nlm.nih.gov/pubmed/19627513
  6. Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice. Alevizos I, Misra J, Bullen J, Basso G, Kelleher J, Mantzoros C, Stephanopoulos G. Cell Cycle. 2007 Jul 1;6(13):1631-8. Epub 2007 May1. http://www.ncbi.nlm.nih.gov/pubmed/17603298
  7. Linking physiology and transcriptional profiles by quantitative predictive models.Misra J, Alevizos I, Hwang D, Stephanopoulos G, Stephanopoulos G. Biotechnol Bioeng. 2007 Sep 1;98(1):252-60. http://www.ncbi.nlm.nih.gov/pubmed/17551988
  8. Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Alevizos I, Mahadevappa M, Zhang X, Ohyama H, Kohno Y, Posner M, Gallagher GT, Varvares M, Cohen D, Kim D, Kent R, Donoff RB, Todd R, Yung CM, Warrington JA, Wong DT. Oncogene. 2001 Sep 27;20(43):6196-204. http://www.ncbi.nlm.nih.gov/pubmed/11593428

Clinical Trials

  • Dexamethasone Irrigation of the Parotid Glands in Primary Sjogren's Syndrome Subjects. (NCT01316770)
  • Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer (NCT00372320)

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This page last updated: April 01, 2014