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Nikolay P. Nikolov, M.D.

NIDCR, NIH, 10 Center Drive
Bldg. 10, Room 1N-114, MSC 1190
Bethesda, MD 20892
Tel: (301) 402-3118
Fax: (301) 402-1228

Research Interests:

Clinical and translational research on the pathogenesis and treatment of Sjögren's syndrome, systemic lupus erythematosus and other rheumatic diseases

ABIM, Internal Medicine Certified
ABIM, Rheumatology Certified


M.D., Medical University Sofia, Bulgaria
M.H.S., NIH-Duke Clinical Research Training Program

Current Position:

Staff Clinician, Sjögren's Syndrome Clinic, NIDCR, MPTB, NIH, Bethesda, MD


Fellows Award for Research Excellence (FARE) 2007, NIH, Bethesda, MD
NIH Bench-to-Bedside Award, Pathogenesis of and risk factors for autoimmunity in the Wiskott-Aldrich Syndrome, NIAMS, NIH, Bethesda, MD
RSDC Fellow's Forum Podium Presentation Award, Bethesda, MD
Summa Cum Laude -Medical University Sofia, Bulgaria
Golden Hippocrates Award-Medical University Sofia, Bulgaria
NUFFIC (The Netherlands Organization for Cooperation in Higher Education) Scholarship

August 2006
July 2005

May 2005
Nov. 1995
Nov. 1995
Sept. 1995

Current Research:
Principal Investigator: Clinical and Laboratory Evaluation of the Autonomic Nervous System in Primary Sjögren's Syndrome, NIDCR, NIH (08-D-0018)

Lead Associate Investigator: Open-label, Dose escalation study of AdhAQP1 parotid gene transfer for radiation-induced salivary gland dysfunction, NIDCR, NIH (06-D-0206)

Lead Associate Investigator: A Randomized, Placebo Controlled, Proof of Concept, Study of Raptiva, a Humanized Anti-CD11a Monoclonal Antibody, in Patients with Sjogren's Syndrome, NIDCR, NIH (06-D-0181)

Associate Investigator: A Pilot Study of Intensified Lymphodepletion Followed by Autologous Hematopoietic Stem Cell Transplantation in Patients with Severe SLE, NIAMS, NIH (04-C-0095),


Nikolov NP, Pavletic, SZ-Haematopoietic Stem Cell Transplantation for Systemic Rheumatic Diseases-Nature, Clinical Practice Rheumatology-in press

Siegel RM, Vioritto ICB, Nikolov NP-Autoimmunity versus tolerance: Can dying cells tip the balance?-Journal of Clinical Immunology- 2007 Feb;122(2):125-34

Nikolov NP, Smith JA, Patronas NJ, Illei GG-SLE-Associated CNS Vasculitis-Nature, Clinical Practice Rheumatology-2006 Nov;2(11):627-33

Nikolov NP, Bailey D, Candotti F, Schwartzberg PL, Strom T, Siegel RM-Autoimmunity and Impaired T Cell Apoptosis in
Wiskott-Aldrich Syndrome Protein Deficiency: A Fas Ligand Connection-Arthritis and Rheumatism, Vol. 54:9, 2006, S749

Nikolov NP, Illei GG, Yarboro C, Hakim F, Leitman S, Balow J, Austin H, Gea-Banacloche J, Muraro P, Babb R, Sportes C,
Lipsky PE, Gress R, Pavletic SZ-Effective Immune Depletion Following Novel Lymphoablative Regimen for Autologous Hematopoietic Stem Cell Transplantation in SLE-Arthritis and Rheumatism, Vol. 54:9, Sept. 2006, S790

Muraro P, Nikolov NP, Butman JA, Abati A, Gea-Banacloche J, Gress R, Lipsky PL, Illei GG, Pavletic S-Granulocytic invasion of the CNS after Autologous Hematopoietic Stem Sell Transplantation for Severe Lupus-Haematologica 2006 Jun;91(6 Suppl):ECR21

Nikolov NP, Siegel RM-All in the family: The TNF-TNFR superfamily in the pathogenesis and treatment of rheumatoid arthritis and other inflammatory diseases, Current Medicinal Chemistry-Vol.4:6, Dec. 2005, 587-596

Yazici Y, Erkan D, Harrison MJ, Nikolov NP, Paget SA-MTX use in RA is associated with few clinically significant liver function test abnormalities-Clinical and Experimental Rheumatology 23(4), 2005, 517-520

Ward J, Nikolov NP, Tschetter J, Kopp J, Gonzalez F, Kimura S, Siegel RM-Progressive Glomerulonephritis and Histiocytic Sarcoma Associated With Macrophage Functional Defects in CYP1B1 Deficient Mice-Toxicologic Pathology, 32:710–718, 2004

Nikolov NP, Siegel RM-Cytochrome P450 1B1 Enzyme Deficiency and Autoimmunity in Mice-Arthritis and Rheumatism, Vol. 50: 9, Sept 2004, S683-84

Ramaswamy D, Gnanarekaran I, Nikolov NP, Efthimiou P, Gour N, Paget S-Musculoskeletal Manifestations in Patients on Hemodialysis for ESRD: A Profound Change in the Character and Incidence Associated with Advancements in Dialysis Therapy, Arthritis and Rheumatism, Vol. 48:9, Sept 2003, S533


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This page last updated: February 26, 2014