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Cell Regulation and Control Unit

Praveen R. Arany, B.D.S., M.D.S., M.M.Sc., Ph.D., Chief


SEM connective tissue with vessel

The Cell Regulation and Control Unit has two major focus areas. Firstly, the basic science is focused on exploring the mechanistic basis of cell regulation with an emphasis on biological signal transduction pathways.  The lab uses wound healing as a biological model as it represents a fascinating dichotomy of ‘loss of regulation’ observed in the early post-wounding phase similar to tumors with profuse migration, proliferation and often, dedifferentiation, which is eventually replaced by a strict, exquisite control involving differentiation, organization and functional competency as noted during embryonic development.
Mice ear wound phenotypes
Second, our previous work has elucidated an extrinsic modality, low power lasers, which can activate the TGF-beta pathway in a controlled spatiotemporal manner. Low power light therapy is a distinct form of phototherapy that can be used for clinical benefit termed Photobiomodulation (PBM). Activation of latent TGF-β1 by low power laser therapy mediates its potent PBM effects on wound healing, stem cell differentiation and tissue regeneration. The clinical- translation aspect of the lab is in the process of moving these lab observations to human clinical trials utilizing this novel modality to promote oral healing and regeneration. 



  • Heather Lenker (Summer 2013), University of Pennsylvania School of Dental Medicine

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This page last updated: February 26, 2014