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Developmental Glycobiology Section

Kelly Ten Hagen, Ph.D., Chief


The goal of the Developmental Glycobiology Section is to understand the biological role of a conserved protein modification during eukaryotic development. In particular, we are studying the gene family responsible for initiating mucin-type O-linked glycosylation of proteins. Through studies examining the effects of mutations within members of this gene family in Drosophila melanogaster, we have demonstrated that this is an essential modification that is required in specific cells and tissues during development.  Current research is aimed at further defining the role this protein modification in secretion, secretory vesicle formation, cell adhesion and cell signaling, in both Drosophila and mammals. Ultimately, our studies will elucidate how O-glycans regulate key cellular processes and further our understanding of the role of this protein modification in both development and disease.




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This page last updated: April 11, 2016