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Jacqueline W. Mays, D.D.S, M.H.Sc., Ph.D.

Jacqueline W. Mays Assistant Clinical Investigator
Chief, Oral Immunobiology Unit​

BETHESDA MD 20892-4326

Phone: (301) 496-8800
Fax: (301) 402-0823

Biographical Sketch

Dr. Jacqueline W. Mays completed her DDS and PhD work at The Ohio State University, College of Dentistry, and holds a B.S. in Biology and Chemistry from Valparaiso University. She was a post-doctoral fellow in the Lab of Viral Diseases at the National Institute of Allergy and Infectious Diseases, NIH and then continued to complete both a Clinical Research Fellowship at the NIDCR, NIH and a Master of Health Sciences degree in Clinical Research through the Duke University College of Medicine. Dr. Mays is an immunologist and a clinical trials dentist whose research is focused on better understanding chronic graft-versus-host disease (cGVHD) in the salivary glands and oral mucosa, an alloimmune disease process that occurs following allogeneic hematopoietic stem cell transplantation. She presently heads the Oral Immunobiology Unit within the Division of Intramural Research at NIDCR.

  • 2001            B.S. in Biology and Chemistry, Valparaiso University, Valparaiso, IN
  • 2009          D.D.S. and Ph.D. in Oral Biology, Ohio State University, Columbus, OH
  • 2009-2011   Postdoctoral Intramural Research and Training Award Fellow, NIAID, Bethesda, MD
  • 2011-2015   Dental Clinical Research Fellow, NIDCR, Bethesda, MD
  • 2015              Master of Health Sciences in Clinical Research, Duke University School of Medicine, Durham, NC

Research Interests/Scientific Focus

The Oral Immunobiology Unit is elucidating the immune mechanisms underlying oral mucosal and salivary gland destruction that can be a component of chronic graft-versus-host disease resulting from allogeneic hematopoietic stem cell transplantation. Dr. Mays’ goal is to translate research findings into the development of non-invasive methods for serial post-transplant screening/diagnosis and improved targeted therapies for oral chronic graft-versus-host disease.

Selected Publications

  1. Hakim, FT, Memon, S, Jin, P, Imanguli, MM, Wang, H, Rehman,N, Yan, X, Rose,J, Mays, JW, Dhamala, S, Kapoor,V Telford, W, Dickinson, J, Davis, S, Halverson, D, Naik, HB, Baird,K, Fowler,D, Stroncek, D, Cowen, EW, Pavletic, SZ, Gress, RE. Upregulation of Interferon-inducible and damage response pathways in chronic graft versus-host disease. Journal of Immunology, 2016 Sep 30. PMID: 27694491
  2. Pirsl F Curtis LM, Steinberg SM, Tella SH, Katić M, Dobbin M, Hsu J, Hakim FT, Mays JW, Im AP, Pulanić D, Mitchell SA, Baruffaldi J, Masuch L, Halverson DC, Gress RE, Barsony J, Pavletic SZ. Characterization and Risk Factor Analysis of Osteoporosis in a Large Cohort of Patients with Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2016 Apr 23. PMID: 27118572
  3. Curtis, LM, Datiles, MB, Steinberg, SM, Mitchell, SA, Bishop, RJ, Cowen, EW, Mays, JW, McCarty, JM, Kuzmina, Z, Pirsl, F, Fowler, DH, Gress, RE, Pavletic, SZ. Predictive models for ocular chronic graft-versus-host disease diagnosis and disease activity in transplant clinical practice. Haematologica 2015 Sep;100(9):1228-36. PMID: 26088932
  4. Bassim CW, Fassil H, Mays JW, Edwards DA, Baird K, Steinberg SM, Cowen EW, Naik H, Datiles M, Gress RE, Pavletic SZ. Oral Disease Profiles in Chronic Graft versus Host Disease. Journal of Dental Research, Journal of Dental Research 2015 Apr;94(4):547-5. PMID: 25740857
  5. Kuzmina, Z, Gounden, V, Curtis, LM, Avila, D, Taylor, T, Baruffaldi, J, Cowen, EW, Naik, NB, Hasni, SA, Mays, JW, Mitchell, SA, Baird, K, Steinberg, SM, Pavletic, SZ. Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria. American Journal of Hematology 2015 Feb;90(2):114-9. PMID: 5363867
  6. Curtis, LM, Grkovic, L, Mitchell, SA, Baird, K, Steinberg, SM, Cowen, EW, Datiles, MB, Williams, K, Mays, JW, Bassim, CW, Joe, G, Comis, L, Berger, A, Avila, D, Taylor, T, Pulanic, D, Cole, K, Baruffaldi, J, Fowler, DH, Gress, RE, Pavletic, SZ. NIH response criteria measures are associated with important parameters of disease severity in patients with chronic Graft-versus-Host Disease. Bone Marrow Transplantation. 2014 Dec;49(12):1513-20. PMID: 25153693
  7. Bassim CW, Fassil H, Dobbin M, Steinberg SM, Baird K, Cole K, Joe G, Comis LE, Mitchell SA, Grkovic L, Edwards D, Mays JW, Cowen EW, Pulanic D, Williams KM, Gress RE, Pavletic SZ. Malnutrition in patients with chronic GVHD. Bone Marrow Transplant. 2014 Oct;49(10):1300-6. PMID:25029231
  8. Bassim CW, Fassil H, Mays JW, Edwards D, Baird K, Steinberg SM, Williams KM, Cowen EW, Mitchell SA, Cole K, Taylor T, Avila D, Zhang D, Pulanic D, Grkovic L, Fowler D, Gress RE, Pavletic SZ. Validation of the National Institutes of Health chronic GVHD Oral Mucosal Score using component-specific measures. Bone Marrow Transplant. 2014 Jan;49(1):116-21. PMID: 23995099
  9. Baird K, Steinberg SM, Grkovic L, Pulanic D, Cowen EW, Mitchell SA, Williams KM, Datiles MB, Bishop R, Bassim CW, Mays JW, Edwards D, Cole K, Avila DN, Taylor T, Urban A, Joe GO, Comis LE, Berger A, Stratton P, Zhang D, Shelhamer JH, Gea-Banacloche JC, Sportes C, Fowler DH, Gress RE, Pavletic SZ. National Institutes of Health Chronic Graft-versus-Host Disease Staging in Severely Affected Patients: Organ and Global Scoring Correlate with Established Indicators of Disease Severity and Prognosis. Biol Blood Marrow Transplant. 2013 Apr;19(4):632-9. PMID: 23340040
  10. Bassim CW, Ambatipudi KS, Mays JW, Edwards DA, Swatkoski S, Fassil H, K, Baird K, Gucek M, Melvin JE, Pavletic SZ. Quantitative Salivary Proteomic Differences in Oral Chronic Graft-versus-Host Disease. Journal of Clinical Immunology. 2012 Dec;32(6):1390-9. PMID: 22806177
  11. Mays, Jacqueline W., Ambatipudi, Kiran S., Bassim, Carol W., Melvin, James E. Emerging technologies for oral diagnostics: lessons from chronic graft-versus-host disease. SPIE 8723, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, 87230F (May 29, 2013); doi:10.1117/12.2020014
  12. Mays J, Fassil H, Edwards D, Pavletic S, Bassim C. Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research. Oral Diseases. 2013 May;19(4):327-46. PMID: 23107104
  13. Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management. Journal of Evidence Based Dental Practice. 2012 Sep;12(3 Suppl):265-82. PMID: 23040353
  14. Fassil H, Bassim CW, Mays J, Edwards D, Baird K, Steinberg SM, Williams KM, Cowen EW, Mitchell SA, Hakim FT, Taylor T, Avila D, Zhang D, Grkovic L, Datiles M, Gress RE, Pavletic SZ. Oral chronic graft-vs.-host disease characterization using the NIH scale. Journal of Dental Research. 2012 Jul;91(7 Suppl):45S-51S. PMID: 22699667
  15. Mays JW, Powell ND, Hunzeker JT, Hanke ML, Bailey MT, Sheridan JF. Stress and the anti-influenza immune response: repeated social defeat augments clonal expansion of CD8+T cells during primary influenza A viral infection. Journal of Neuroimmunology, 2012 Feb 29;243(1-2):34-42.. PMID: 22244573
  16. Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, Yewdell JW. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. Journal of Experimental Medicine. 2011 Nov 21;208(12):2511-24. PMID: 22042976
  17. Mays, Jacqueline W., Powell, Nicole D., Bailey, Michael T. and Sheridan, John F. “Environmental Challenges and the Neuroendocrine Mechanisms of Stress-Induced Modulation of Host Resistance to Microbial Infection.” Chapter 12, Eco-Immunology, Oxford University Press, USA, December 9, 2011. ISBN-10: 0199737347
  18. Mays J and Butts CL. Intercommunication between the neuroendocrine and immune systems: focus on myasthenia gravis. Neuroimmunomodulation: Special Issue on Neuroendocrinology of the Thymus. 2011;18:320-327. PMID: 21952684
  19. Avitsur R, Mays JW, Sheridan JF. Sex differences in the response to influenza virus infection: Modulation by stress. Horm Behav. 2011 Feb;59(2):257-64. PMID: 21167165
  20. Powell ND, Mays JW, Bailey MT, Hanke ML, Sheridan JF. Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus. Brain Behav Immun. 2011 Jan;25(1):46-52. PMID: 20656014
  21. Mays JW, Bailey MT, Hunzeker JT, Powell ND, Papenfuss TL, Karlsson EA, Padgett DA, Sheridan JF. Influenza virus-specific immunological memory is enhanced by repeated social defeat. Journal of Immunology. 2010 Feb15; 184 (4): 2014-2025. Note: article figure featured on journal cover. PMID: 20083672
  22. Powell ND, Bailey MT, Mays JW, Stiner-Jones LM, Hanke ML, Padgett DA, Sheridan JF. Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion. Brain Behav Immun. 2009 Feb;23(2):225-3. PMID: 18848983
  23. Siddiqui RA, Jenski LJ, Harvey KA, Wiesehan JD, Stillwell W, Zaloga GP. Cell-cycle arrest in Jurkat leukemic cells: a possible role for docosahexaenoic acid. Biochem J 2003 Apr 15;371(Pt 2):621-629. PMID: 12492401
  24. Siddiqui, RA., Jenski, L., Wiesehan, J., Hunter, M., Kovacs, RJ., Stillwell, W. Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1. Biochimica et Biophysica Acta 1541 (2001) 188-200. PMID: 11755213

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This page last updated: November 22, 2016