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Oral Immunobiology Unit

Jacqueline W. Mays​, D.D.S, M.H.S., Ph.D., Chief
 
 

Mission

The Oral Immunobiology Unit is dedicated to the investigation of oral mucosal immunity through the lens of chronic graft-versus-host disease (cGVHD), an autoimmune-like condition that manifests after allogeneic hematopoietic stem cell transplantation. Following transplant, many patients develop cGVHD that includes salivary gland dysfunction, oral lesions (ulcerations, mucoceles, lichenoid lesions, or erythema), or limited mouth-opening from perioral fibrosis. However, the underlying immunologic events targeting the oral cavity and the mechanisms that drive the pathogenic process, particularly in salivary glands, are not well-understood.  Consequently, targeted therapeutics are limited.  Our research program endeavors to elucidate the underlying immune process of cGVHD in the oral cavity with a focus on the salivary glands, and to translate this knowledge to improved monitoring and therapeutics in our cGVHD patients.

Personnel

 

  • Ana Costa da Silva, PhD (visiting research fellow)
  • Josh Dodge (post baccalaureate fellow) 
  • Jesse Herche (post baccalaureate fellow) 

 

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This page last updated: June 21, 2017