Selected Publications
- Silva LM, Doyle AD, GreenWell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum A, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM. Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier. Science. 2021, 374:6575.
- Williams D, Wild T, Brenchley L, Dutzan N, Overmiller A, Webb S, Daniel M, Morell R, Hajishengallis G, Divaris K, Morass M, Haniffa M, Moutsopoulos NM. Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell. 184(15):4090-4104.e15. doi: 10.1016/j.cell.2021.05.013.
- Break T, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison O, Alejo J, Williams DW, Pittaluga S, Lee C, Bouladoux N, Muthulekha S, Hoffman K, Greenwell-Wild T, Bruno V, Rosen LB, Lwin W, Renteria A, Pontejo S, Shannon JP, Myles IA, Olbrich P, Ferré E, Schmitt M, Martin D, Barber D, Solis N, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Mark S. Anderson, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis M. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science.15;371(6526): eaay5731.
- Gaffen SL, Moutsopoulos NM. (R) Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity. Science Immunology. 2020 Jan 3;5(43).
- Dutzan N, Kajikawa T, Abusleme L, Greenwell-Wild T, Zuazo CE, Ikeuchi T, Brenchley L, Abe T, Hurabielle C, Martin D, Morell RJ, Freeman AF, Lazarevic V, Trinchieri G, Diaz PI, Holland SM, Belkaid Y, Hajishengallis G, Moutsopoulos NM. Dysbiotic microbiome triggers Th17 cells to mediate oral mucosal immunopathology in mice and humans. 2018. Sci. Transl. Med.10(451). pii: eaap8798.
- Moutsopoulos NM, Zerbe CS, Wild T, Dutzan N, Brenchley L, Uzel G, Chandler KC, Lisco A, Notarangelo LD, Hajishengallis G, Notarangelo LD, Holland SM. Interleukin-12 and Interleukin-23 blockade in leukocyte adhesion deficiency type 1. N Engl J Med. 2017 Mar 23;376(12);1141-1146.
- Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Fife M, Bouladoux N, Hong B-Y, Break TJ, Bowdish DME, Lionakis MS, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM. On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier. Immunity. 2017 Jan 17; 46(1):133-147.
- Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Kevon AR, Sampson PA, Nigrovic J, Sokolove J, Giles JT, Moutsopoulos NM, Adrade F. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med. 2016 Dec 14;8(369):369ra176.
- Dutzan N, Konkel JE, Wild T, Moutsopoulos NM. Characterization of the human immune cell network at the gingival barrier. Mucosal Immunology. 2016 Sep;9(5):1163-72.
- Moutsopoulos NM, Konkel J, Sarmadi M, Eskan MA, Wild T, Dutzan N, Abusleme L, Zenobia C, Hosur KB, Abe T, Uzel G, Chen W, Chavakis T, Holland SM, Hajishengallis G. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17–driven inflammatory bone loss. Sci Transl Med. 2014 Mar 26;6(229):229ra40.
