Ashok Kulkarni, PhD

Ashok Kulkarni, Ph.D.

Senior Investigator
Functional Genomics Section
Director, Gene Transfer Facility

NIH NIDCR
Building 30, Room 130
30 Convent Dr MSC 4395
Bethesda, MD 20892-4395
United States

(301) 435-2887
Research Interests

Dr. Ashok Kulkarni’s research focuses on characterizing the molecular role of Cdk5 in orofacial pain. His laboratory has shown that the activity of Cdk5 is upregulated due to inflammation that,  in turn, modulates peripheral pain signaling. Current research efforts are  centered on delineating how Cdk5 and its two activators, p35 and p39, affect pain signaling specifically in the orofacial region. Orofacial pain differs from peripheral pain because the dense innervation of facial structures leads to increased sensitivity to pain, which makes orofacial pain difficult to diagnose and treat.  His group uses an array of approaches to investigate the molecular mechanisms involved in how Cdk5 activity modulates orofacial pain signaling. Their research approaches include using genetically engineered mouse models for behavioral, genomic and proteomic analyses. Their current studies will contribute to a greater understanding of the molecular roles of Cdk5 in pain signaling, and also help future efforts to effectively treat pain.

Selected Publications
Last Reviewed on
February 2018