Tenure Track Clinical Investigator
Sjögren’s Syndrome Clinic
Building 10 Room 1N110
10 Center Drive MSC 1190
Bethesda, MD 20892
Sjögren’s syndrome is an autoimmune disorder that affects the exocrine glands, which control production of tears and saliva. Salivary gland inflammation is a frequent sign of Sjögren’s syndrome, yet there is poor correlation between inflammation severity and the loss of glandular function. Although about 80% of Sjögren’s patients have exocrine gland dysfunction, most do not exhibit extensive inflammation in the glands. The syndrome’s diverse effects have led to poor diagnostic methodology and therapeutic options.
Dr. Alevizos’ primary research interest is salivary gland dysfunction in Sjögren’s syndrome. The overall objective is to decipher functional changes that accompany the disorder as related to the salivary glands. The goal is to discover diagnostic and other biomarkers and to develop better therapeutic interventions. This research employs both basic mechanistic laboratory studies and clinical studies. Since Sjögren’s has diverse symptoms, high-throughput assays are used to characterize the protein, RNA, and DNA profiles of affected people.
Dr. Ilias Alevizos received a DMD from Tufts University, an MMSc from Harvard University (specializing in oral and maxillofacial pathology), an MHS in clinical research from Duke University, and a PhD from the University of Athens Medical School. He completed postdoctoral research appointments at MIT and the University of Padova, Italy, and a clinical research fellowship at NIH. His postdoctoral work focused on use of high-throughput genomic testing to correlate disease development with genetic signatures that might identify biomarkers of Sjögren’s syndrome and point to targets for pharmacologic intervention. Dr. Alevizos is director of the multidisciplinary Sjögren’s syndrome medical team at NIH. He possesses extensive clinical experience in the diagnosis and management of oral diseases, especially those related to salivary glands. His basic science focus is on salivary gland physiology, and more specifically on how alterations in the expression of non-coding genes contribute to diseases that impair salivary gland function.
- Tandon M, Perez P, Burbelo PD, Calkins C, Alevizos I. Laser microdissection coupled with RNA-seq reveal cell-type and disease-specific markers in the salivary gland of Sjögren’s syndrome patients. Clin Exp Rheumatol. 2017 Apr 18. [Epub ahead of print].
- Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Billings ME, Goldsmith CM, Tandon M, Helmerhorst EJ, Catalán MA, Danielides SJ, Perez P, Nikolov NP, Chiorini JA, Melvin JE, Oppenheim FG, Illei GG, Baum BJ. Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction. Gene Ther. 2017 Mar;24(3): 176-186.
- Billings M, Dye BA, Iafolla T, Baer AN, Grisius M, Alevizos I. Significance and Implications of Patient-reported Xerostomia in Sjögren's Syndrome: Findings from the National Institutes of Health Cohort. EBioMedicine. 2016 Oct;12:270-279.
- Gallo A, Jang SI, Ong HL, Perez P, Tandon M, Ambudkar I, Illei G, Alevizos I. Targeting the Ca(2+) Sensor STIM1 by Exosomal Transfer of Ebv-miR-BART13-3p is Associated with Sjögren's Syndrome. EBioMedicine. 2016 Aug;10:216-26.
- Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I. IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep. 2015 Sep 14;5:13953.
- Zheng C, Baum BJ, Liu X, Goldsmith CM, Perez P, Jang SI, Cotrim AP, McCullagh L, Ambudkar IS, Alevizos I. Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter. Gene Ther. 2015 Sep;22(9):758-66.
- Jang SI, Ong HL, Gallo A, Liu X, Illei G, Alevizos I. Establishment of functional acinar-like cultures from human salivary glands. J Dent Res. 2015 Feb;94(2):304-11.
- Baum BJ, Alevizos I, Zheng C, Cotrim AP, Liu, S, McCullagh L, Goldsmith CM, Burbelo PD, Citrin DE, Mitchell JB, Nottingham LK, Rudy SF, Van Waes C, Whatley MA, Brahim, Chiorini, JA, Danielides S, Turner RJ, Patronas NJ, Chen CC, Nikolov NP, Illei GG. Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19403-7.
- Alevizos I, Alexander S, Turner RJ, Illei GG. MicroRNA profiling of minor salivary glands of Sjögren’s syndrome patients and normal controls reveals potential diagnostic and functional biomarkers. Arthritis and Rheumatism. 2011 Feb;63(2):535-44.
- Alevizos I, Gabor GG. MicroRNAs as biomarkers in rheumatic diseases. Nat Rev Rheumatol. 2010 Jul;6(7):391-8.