Ilias Alevizos, DMD, MMSc, MHS, PhD

Ilias Alevizos, D.M.D., M.M.Sc.

Tenure Track Clinical Investigator
Sjögren’s Syndrome Clinic

Building 10 Room 1N110
10 Center Drive MSC 1190
Bethesda, MD 20892
United States

(301) 496-6207
Research Interests

Sjögren’s syndrome is an autoimmune disorder that affects the exocrine glands, which control production of tears and saliva. Salivary gland inflammation is a frequent sign of Sjögren’s syndrome, yet there is poor correlation between inflammation severity and the loss of glandular function. Although about 80% of Sjögren’s patients have exocrine gland dysfunction, most do not exhibit extensive inflammation in the glands. The syndrome’s diverse effects have led to poor diagnostic methodology and therapeutic options.  

Dr. Alevizos’ primary research interest is salivary gland dysfunction in Sjögren’s syndrome. The overall objective is to decipher functional changes that accompany the disorder as related to the salivary glands. The goal is to discover diagnostic and other biomarkers and to develop better therapeutic interventions. This research employs both basic mechanistic laboratory studies and clinical studies. Since Sjögren’s has diverse symptoms, high-throughput assays are used to characterize the protein, RNA, and DNA profiles of affected people. 

Biographical Sketch

Dr. Ilias Alevizos received a DMD from Tufts University, an MMSc from Harvard University (specializing in oral and maxillofacial pathology), an MHS in clinical research from Duke University, and a PhD from the University of Athens Medical School. He completed postdoctoral research appointments at MIT and the University of Padova, Italy, and a clinical research fellowship at NIH. His postdoctoral work focused on use of high-throughput genomic testing to correlate disease development with genetic signatures that might identify biomarkers of Sjögren’s syndrome and point to targets for pharmacologic intervention.  Dr. Alevizos is director of the multidisciplinary Sjögren’s syndrome medical team at NIH. He possesses extensive clinical experience in the diagnosis and management of oral diseases, especially those related to salivary glands. His basic science focus is on salivary gland physiology, and more specifically on how alterations in the expression of non-coding genes contribute to diseases that impair salivary gland function.

Selected Publications
Last Reviewed on
February 2018