James Melvin, PhD, DDS

Photo of James Melvin

Co-Director, Dental Clinical Research Fellowship Program
Senior Investigator, Secretory Mechanisms & Dysfunctio​n Section

Building 10, Room 1N-117B
Bethesda, MD 20892-4320
United States

(301) 402-1706
Research Interests

Dr. Melvin’s laboratory investigates the molecular nature and function of the ion transport mechanisms involved in the fluid and electrolyte secretion process in the exocrine salivary gland. Studies are probing the structure-function relationships of cotransporter, exchanger, and channel proteins using a combination of molecular biology, gene modification, transcriptomics, proteomics, electrophysiology, and other functional studies in mouse and human salivary glands. High-throughput approaches are being used to identify and compile a comprehensive list of the plasma membrane proteins critical for normal salivary gland physiology and to also function as biomarkers for human diseases.

Biographical Sketch

Dr. James Melvin received his DDS from Case Western Reserve University, a PhD in neurobiology from the University of Rochester, and postdoctoral training in NIDR's former Clinical Investigation and Patient Care Branch. A former director of the Center for Oral Biology and professor of pharmacology and physiology at the University of Rochester, Dr. Melvin has made numerous contributions to the field of salivary gland physiology and has played a key role in the research consortium that decoded the saliva proteome. He has directed a number of Ruth L. Kirschstein Institutional National Research Award programs at the pre-doctoral, doctoral, and postdoctoral level. Since joining NIDCR in 2010, Dr. Melvin has served as clinical director, deputy scientific director and acting chief of the Oral and Pharyngeal Cancer Branch. Dr. Melvin is currently the co-director of the Dental Clinical Research Fellowship. Dr. Melvin is an elected Fellow of the American Association for the Advancement of Science.

Selected Publications
Last Reviewed on
February 2018