Co-Director, Dental Clinical Research Fellowship Program
Senior Investigator, Secretory Mechanisms & Dysfunction Section
Building 10, Room 1N-117B
Bethesda, MD 20892-4320
Dr. Melvin’s laboratory investigates the molecular nature and function of the ion transport mechanisms involved in the fluid and electrolyte secretion process in the exocrine salivary gland. Studies are probing the structure-function relationships of cotransporter, exchanger, and channel proteins using a combination of molecular biology, gene modification, transcriptomics, proteomics, electrophysiology, and other functional studies in mouse and human salivary glands. High-throughput approaches are being used to identify and compile a comprehensive list of the plasma membrane proteins critical for normal salivary gland physiology and to also function as biomarkers for human diseases.
Dr. James Melvin received his DDS from Case Western Reserve University, a PhD in neurobiology from the University of Rochester, and postdoctoral training in NIDR's former Clinical Investigation and Patient Care Branch. A former director of the Center for Oral Biology and professor of pharmacology and physiology at the University of Rochester, Dr. Melvin has made numerous contributions to the field of salivary gland physiology and has played a key role in the research consortium that decoded the saliva proteome. He has directed a number of Ruth L. Kirschstein Institutional National Research Award programs at the pre-doctoral, doctoral, and postdoctoral level. Since joining NIDCR in 2010, Dr. Melvin has served as clinical director, deputy scientific director and acting chief of the Oral and Pharyngeal Cancer Branch. Dr. Melvin is currently the co-director of the Dental Clinical Research Fellowship. Dr. Melvin is an elected Fellow of the American Association for the Advancement of Science.
- Yang, C., V. Gonzalez-Perez, T. Mukaibo, J.E. Melvin, X. Xia and C.J. Lingle. Knockout of the BK γ1 (LRRC26) subunit reveals a primary role of LRRC26-containing BK channels in non-excitable secretory epithelial cells. Proc. Natl. Acad. Sci. U S A 2017 May 2;114(18)
- Wang, CS, Wee Y, Yang CH, Melvin JE, Baker OJ. ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. Sci. Rep. 2016 Apr 11;6:24244.
- Peña-Münzenmayer George AT, Shull GE, Melvin JE, Catalán MA. Ae4 (Slc4a9) is an electroneutral monovalent cation Cl-/HCO3- exchanger. J. Gen. Physiol. 2016 May;147(5):423-436.
- Catalán MA, Kondo Y, Peña-Münzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc. Natl. Acad. Sci. U S.A. 2015 Feb 17;112(7):2263-2268.
- Kondo Y, Nakamoto T, Jaramillo, Y, Choi S, Catalán MA, Melvin JE. Functional differences in the acinar cells of the murine major salivary glands. J. Dent. Res. 2015 May;94(5):715-721.
- Peña-Münzenmayer G, Catalán MA, Kondo Y, Jaramillo Y, Liu, F, Shull GE Melvin JE. Ae4 (Slc4a9) Anion Exchangers Drive Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. J. Biol. Chem. 2015 Apr 24;290(17):10677-10688.
- Catalán MA, Scott-Anne KM, Klein MI, Koo H, Bowen WH, Melvin JE. Elevated Incidence of Dental Caries in a Mouse Model of Cystic Fibrosis. PLoS One. 2011 Jan 31;6(1):e16549.
- Catalán MA, Flores CA, González-Begne M, Zhang Y, Sepúlveda FV, Melvin JE. Severe Defects in Absorptive Ion Transport in the Distal Colon of Mice Lacking ClC-2 Channels. Gastroenterology. 2012 Feb;142(2):346-354.
- Zhang Y, Catalán MA, Melvin JE. TRPV4 Activation in Mouse Submandibular Gland Modulates Ca2+ Influx and Salivation. Am. J. Physiol. Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1365-72.
- Catalán MA, Peña-Munzenmayer G, Melvin JE. 2014. Ca2+-dependent K+ channels in exocrine salivary glands. Cell Calcium. 2014 Jun;55(6):362-8.