Yoshihiko Yamada, PhD

Yoshihiko Yamada, Ph.D.

Senior Investigator
Molecular Biology Section

Building 30, Room 407
30 Convent Dr MSC 4370
Bethesda, MD 20892-4370
United States

(301) 496-2111
Research Interests

The overall goal of the Molecular Biology Section is to discover novel molecular mechanisms that underlie the development of hard tissues and ectodermal organs by identifying novel functions of previously unstudied genes and defining the roles of the extracellular matrix (ECM). The laboratory has focused on the novel roles of protein factors and ECM components in proliferation, differentiation, and cell adhesion during development of teeth, cartilage, and other tissues. These studies are aimed at developing reagents useful for diagnostic and therapeutic applications. Most recently, Dr. Yamada’s group identified several novel proteins from a tooth germ cDNA library, including the transcription factor epiprofin, the adhesion protein fibulin7 (TM14), and the gap junction protein pannexin 3. These proteins are expressed in teeth as well as in tissues such as cartilage, bone, and skin. Identification of common and distinct molecular mechanisms for the function of these proteins in specific tissue types will uncover key concepts that underlie both normal development and disease.

Biographical Sketch

Dr. Yoshihiko Yamada received a PhD from Osaka University Faculty of Science, Japan. After receiving his PhD, Dr. Yamada began postdoctoral training at the University of Pittsburgh, where he investigated gene regulation of bacteriophages and plasmids. In 1978, Dr. Yamada came to the National Cancer Institute (NCI) at NIH to study gene evolution and regulation of collagen genes. In 1983, he joined NIDCR, where he has been studying the functions of basement membrane components, cartilage matrices, and other extracellular matrices during development and diseases. Dr. Yamada is a recipient of a Young Investigator Research Grant from the University of Pittsburgh, as well as an NIH Director's Award, the CRADA, Eli Lilly and Company Award, a research grant from Seikagaku Corporation, the Debio Peptide Award, and the William J. Gies Award.

Selected Publications


  • "Peptides with laminin activity" by Y. Yamada, J. Graf, Y., Iwamoto, F. Robey, H.K. Kleinman, M. Sasaki, and G.R. Martin, U.S. Patent 5,092,885.
  • ”Laminin A chain: deduced amino acid sequence, Expression vectors and active synthetic
  • peptides" by Y. Yamada, H.K. Kleinman, M. Sasaki, and G.R. Martin, U.S. Patent 5,211,657.

Invention Report

  • Teneurin-4-deficient mice as a tremor model, E-209-2009
Last Reviewed on
February 2018