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NIH National Institute of Dental and Craniofacial Research (NIDCR) Home page
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The Discovery of Procollagen

Timeline Display Date
1971

NIDR scientists led the field of connective tissue research during the 1960s and 1970s. In February 1971, a team led by Dr. George Martin announced the discovery of soluble collagen, or procollagen, which gives rise to collagen, the protein forming skin, bone, and connective tissue in the entire human body.

Karl Piez (left) and George Martin.
NIDCR
Karl Piez (left) and George Martin led NIDR’s collagen research efforts during the 1960s and 1970s.
Edward Hamppand Trench Mouth
Explore an Interactive Timeline of NIDCR's History

Learn about important events, scientific breakthroughs, and publications starting in 1945.

Last Reviewed
December 4, 2025
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