Funding Opportunities & Related Notices

The table below lists all active NIDCR funding opportunities and notices. Use the filters to sort by funding type, topic, or activity code. Use the search box to find funding opportunities that include specific keywords. Click on title to see more details.

 

291 Results
Title Release Date Expiration Date
Emergency Awards: HEAL Initiative: Coordinating Center for National Pain Scientists Career Development (R24 Clinical Trial Not Allowed)

There is an urgent need for more research to establish best practices in the pain management field, however, there is a limited workforce pipeline of pain researchers to meet NIHs long-term goals of providing effective non-opioid options for the treatment of pain conditions and better pain management overall. The Interagency Pain Research Coordinating Committee (IPRCC) has identified the workforce problem as a barrier for new pain research, and has identified factors that contributed to it such as barriers to entry into the field of pain research that have constricted growth high departure rate of senior investigators and mentors. The IPRCC also identified a need for more structured opportunities for early-stage investigators to learn from and be mentored by experienced investigators. The pain management field has further recognized that basic, translational, and clinical researchers do not regularly collaborate when developing grant applications. If pain management researchers across all disciplines were to work together, it would enhance the innovation, relevance, and practical application of pain management research. To support the NIH HEAL Initiatives response supporting new investigators, promoting multidisciplinary collaborations among pain researchers, and identifying innovate treatments to manage pain, this FOA invites applications for the Coordinating Center for National Pain Scientists (CCNPS). The CCNPS will be a central facilitator for integrating training and mentoring across a network of mentors and early-stage investigators funded by NIH (e.g., NIH trainees, NIH fellows, and Career Development Awardees). The main purpose of the CCNPS is to enhance the training experience of new pain researchers across the continuum of basic, translational, and clinical research and create a vast network of NIH-funded pain researchers to promote multidisciplinary collaborations in pain research. The CCNPS will create and run a coordination center to connect NIH-fund

Topics: Career Development, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology, Training & Fellowships

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Understanding the Basic Mechanisms of Immune-related Adverse Events (irAEs) in Cancer Immunotherapy

Topics: Career Development, Oral Immunology, Immunopathology & Immunotherapy, Oral, Oropharyngeal & Salivary Gland Cancers, Training & Fellowships

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NIH Director’s Early Independence Awards (DP5 Clinical Trial Optional)

Topics: Common Fund Programs

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Notice of Special Interest: Achieving Tissue Robustness Through Harnessing Immune System Plasticity

Topics: Oral Immunology, Immunopathology & Immunotherapy

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Notice of Special Interest (NOSI): Availability of Administrative Supplements for Helping to End Addiction Long-term (HEAL) Initiative awardees to make data Findable, Accessible, Interoperable, and Reusable (FAIR) through the HEAL Data Ecosystem

Topics: Bioinformatics, Computational Biology & Data Science, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed)

This funding opportunity announcement (FOA) is part of a suite of FOAs to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal of this FOA is to support team-based research projects to develop assays, screening and early optimization work to develop a non-addictive therapeutic to treat pain. Discovery and validation of pharmacodynamic markers efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies are also responsive. The result of the project should be to advance a hit or lead to the point where they can meet the entry criteria for RFA-NS-21-010 HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) within the 5 years of the award. Applications should propose a plan that will lead to the development of analgesics with a rigorous biological rationale and scientifically sound assays. If the data does not currently exist, the proposal must include a strong plan for developing data linking the putative therapeutic target(s) to the proposed pain indication and supporting the hypothesis that altering the target activity will produce desirable outcomes for the disease. This FOA is not specific for any one or group of pain conditions. Projects to develop therapeutics for acute pain, chronic pain, painful neuropathy, musculoskeletal pain, headache disorders, osteoarthritis, diabetic neuropathy, chemotherapy-induced neuropathy, eye pain, sickle-cell pain, post-surgical pain, cancer pain, visceral pain, obstetric pain, gynecologic pain, post stroke pain, myofascial pain, painful disorders of the orofacial region and other conditions will be considered.

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Planning Grant for Fogarty HIV Research Training Program for Low- and Middle-Income Country Institutions (D71 Clinical Trial Not Allowed)

The Fogarty HIV Research Training Program supports research training that strengthens HIV research capacity of institutions in low-and middle-income countries (LMICs). This FOA offers an opportunity for LMIC institutions to submit a planning grant application to prepare to participate in the Fogarty HIV Research Training Program.These applications must propose a plan to develop a research training program and the subsequent application that will be submitted in response to the companion D43 FOA (PAR-19-283). The planned research training program should strengthen research capacity in a defined high priority HIV scientific area (NOT-OD-15-137) at an LMIC institution(s).

Topics: Career Development, HIV/AIDS & Oral Health, Training & Fellowships

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Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications for research training programs to strengthen the scientific capacity of institutions in low- and middle-income countries (LMICs) to conduct HIV research relevant to the evolving HIV epidemic in their country. This FOA can support training for conducting research in a broad range of HIV research areas across HIV prevention, treatment, care, and quality of life continuum. This includes basic, epidemiologic, clinical, behavioral and social sciences, community-based, implementation, operations, health services, and health systems research. Cross-disciplinary research as well as HIV associated comorbidities and coinfections affecting the HIV epidemic will be supported under this FOA. An application should focus the proposed training program to strengthen research capacity in a defined high priority HIV scientific area aligned with NIH HIV/AIDS research priorities (NOT-OD-20-018) at a specific LMIC institution and collaborating LMIC partner institutions.

Topics: Career Development, HIV/AIDS & Oral Health, Training & Fellowships

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Infrastructure Development Training Programs for Critical HIV Research at Low-and Middle-Income Country Institutions (G11 Clinical Trials Not Allowed)

The overall goal of the Fogarty International Center (FIC) HIV Research Training Program is to strengthen the scientific capacity of institutions in low- and middle-income countries (LMICs) to conduct HIV research on the evolving HIV epidemic in their countries.This FOA encourages collaborative applications from U.S. and LMIC institutions to support training to achieve technical, administration and financial management expertise required for one of the six research infrastructure functions considered critical to a successful high quality research environment:Research administration and management;Research integrity oversight;Ethical review of research for the protection of human subjects;Laboratory animal welfare oversightHealth sciences library and information services; andInformation and communications technology systems (ICT) for researchResearch infrastructure training programs will maximize previous investments and further strengthen the LMIC institution's research capabilities, and provide more accessible research infrastructure training opportunities to others in their own country and in other LMICs.

Topics: Career Development, HIV/AIDS & Oral Health, Training & Fellowships

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Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)

Topics: Common Fund Programs

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Notice of Intent to Publish a Funding Opportunity Announcement for NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed)

Topics: Behavioral & Social Science, Bioinformatics, Computational Biology & Data Science, Clinical Research & Clinical Trials, COVID-19, Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology, Dental Caries, Dental Materials & Biomaterials, Dissemination & Implementation Science, Epidemiology, Fluoride & Fluorosis, Gene Discovery, Genomics & Multi-Omics Analysis, Global Health, HIV/AIDS & Oral Health, International Research Activities, Mineralized Tissues & Mineralization, Mucosal Diseases, Oral & Comprehensive Health, Oral Health Disparities & Inequities, Oral Immunology, Immunopathology & Immunotherapy, Oral Microbiology & Metagenomics, Oral Microbiota and Bacterial Disease, Oral Opportunistic Pathogens and Viral Disease, Oral, Oropharyngeal & Salivary Gland Cancers, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology, Periodontal Diseases, Salivary Biology & Dysfunction, Statistical Analysis & Data Science, Technology Development, Tissue Engineering & Regenerative Medicine, Women's Health

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NIH Director’s Pioneer Award Program (DP1 Clinical Trial Optional)

Topics: Common Fund Programs

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IND-enabling Studies of Somatic Genome Editing Therapeutic Leads (U19, Clinical Trial Not allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Somatic Cell Genome Editing Program Translational Coordination and Dissemination Center (TCDC) (U24 - Clinical Trial Not Allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Technologies and Assays for Therapeutic Genome Editing INDs (U01, Clinical Trial Not Allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis, Technology Development

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Platform Clinical Trials of Genome Editors in Multiple Diseases (UG3/UH3, Clinical Trial Required)

Topics: Clinical Research & Clinical Trials, Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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NIH Director’s New Innovator Award Program (DP2 Clinical Trial Optional)

Topics: Common Fund Programs

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Notice of Special Interest (NOSI): Administrative Supplements for Research on Womens Health in the IDeA States

Topics: Behavioral & Social Science, Bioinformatics, Computational Biology & Data Science, Career Development, Clinical Research & Clinical Trials, Common Fund Programs, Conferences & Meetings, COVID-19, Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology, Dental Caries, Dental Materials & Biomaterials, Dissemination & Implementation Science, Epidemiology, Fluoride & Fluorosis, Gene Discovery, Genomics & Multi-Omics Analysis, Global Health, HIV/AIDS & Oral Health, International Research Activities, Mineralized Tissues & Mineralization, Mucosal Diseases, National Dental Practice-Based Research Network, Oral Health Disparities & Inequities, Oral Immunology, Immunopathology & Immunotherapy, Oral Microbiology & Metagenomics, Oral Microbiota and Bacterial Disease, Oral Opportunistic Pathogens and Viral Disease, Oral, Oropharyngeal & Salivary Gland Cancers, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology, Parent Announcements & Trans-NIH Announcements, Periodontal Diseases, Salivary Biology & Dysfunction, Small Business (SBIR/STTR), Statistical Analysis & Data Science, Technology Development, Tissue Engineering & Regenerative Medicine, Training & Fellowships, Women's Health

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Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Funding Opportunity Announcement (FOA) is soliciting Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the nations research workforce. Individuals from diverse backgrounds, including those from underrepresented groups and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Topics: Dissemination & Implementation Science

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Notice of Special Interest: NIDCR Administrative Supplements to NCATS CTSA Programs for Scholars Pursuing Dental, Oral, and Craniofacial Clinical and Translational Research Career Development

Topics: Career Development, Training & Fellowships

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Notice of Change to Correct Eligibility Information under RFA-RM-22-008; "NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program: FIRST Cohort (U54 Clinical Trial Optional)"

Topics: Common Fund Programs

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Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43 Clinical Trial Optional)

This funding opportunity announcement (FOA) is a reissue due to an omission of TRAINING RECORD review questions in Section V. This FOA encourages applications for the Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) D43 program for institutional research training programs in low-and middle-income countries (LMICs, as defined by the World Bank classification system). Applications may be for collaborations between institutions in the U.S and an eligible LMIC or may involve just LMIC institutions if there is a previous track record of externally funded research and/or research training programs by the lead LMIC institution. The proposed institutional research training program is expected to sustainably strengthen the NCD research capacity of the LMIC institutions, and to train in-country experts to develop and conduct research on NCDs across the lifespan, with the long-range goal of developing and implementing evidence-based interventions relevant to their countries. The main focus of research training covered in the application must be relevant to the interests of at least one of the participating NIH ICs as stated by each in this FOA. Other NCD topics may be included as secondary and complementary focus areas. This Funding Opportunity Announcement (FOA) allows support of trainees as the lead investigator of an independent clinical trial; or a separate ancillary study to an existing trial; or to gain research experience in a clinical trial led by another investigator, as part of their research and career development.

Topics: Global Health

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Advancing HIV/AIDS Research at the Intersection of Oral and Mental Health (R21 Clinical Trial Not Allowed)

Topics: HIV/AIDS & Oral Health

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Advancing HIV/AIDS Research at the Intersection of Oral and Mental Health (R01 Clinical Trial Not Allowed)

Topics: HIV/AIDS & Oral Health

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Notice of Intent to Publish a Funding Opportunity Announcement for Technologies and Assays for Therapeutic Genome Editing INDs (U01, Clinical Trial Not Allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Notice of Intent to Publish a Funding Opportunity Announcement for Platform Clinical Trials of Somatic Genome Editing for Multiple Diseases (UG3/UH3, Clinical Trial Required)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Notice of Intent to Publish a Funding Opportunity Announcement for Somatic Cell Genome Editing Translational Coordination and Dissemination Center (U24, Clinical Trial Not Allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Notice of Intent to Publish a Funding Opportunity Announcement for IND-enabling Studies of Somatic Genome Editing Therapeutic Leads (U19, Clinical Trial Not allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)

Topics: Bioinformatics, Computational Biology & Data Science, Common Fund Programs, Craniofacial & Dental Development, Disorders, Gene Discovery, Genomics & Multi-Omics Analysis

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Somatic Mosaicism across Human Tissues (SMaHT) Program: Data Analysis Center (UM1 Clinical Trial Not Allowed)

Topics: Bioinformatics, Computational Biology & Data Science, Common Fund Programs, Craniofacial & Dental Development, Disorders, Gene Discovery, Genomics & Multi-Omics Analysis

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Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (U24 Clinical Trial Not Allowed)

Topics: Bioinformatics, Computational Biology & Data Science, Common Fund Programs, Craniofacial & Dental Development, Disorders, Gene Discovery, Genomics & Multi-Omics Analysis

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Somatic Mosaicism across Human Tissues (SMaHT) Program: Organizational Center (U24 Clinical Trial Not Allowed)

Topics: Bioinformatics, Computational Biology & Data Science, Common Fund Programs, Craniofacial & Dental Development, Disorders, Gene Discovery, Genomics & Multi-Omics Analysis

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Somatic Mosaicism across Human Tissues (SMaHT) Program: Tool Development Projects (UG3/UH3 Clinical Trial Not Allowed)

Topics: Bioinformatics, Computational Biology & Data Science, Common Fund Programs, Craniofacial & Dental Development, Disorders, Gene Discovery, Genomics & Multi-Omics Analysis

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NIDCR Notice of Participation in PAR-20-076, "Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program in the Neurosciences (T32 Clinical Trial Not Allowed)"

Topics: Career Development, Training & Fellowships

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Limited Competition: Transformative Research to Address Health Disparities and Advance Health Equity at Minority Serving Institutions (U01 Clinical Trial Optional)

Topics: Common Fund Programs, Oral Health Disparities & Inequities

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Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R01 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) solicits grant applications proposing to utilize bacteria, archaebacteria, bacteriophages, or other non-oncolytic viruses and their natural products to study the underlying mechanisms of the complex interactions between microorganisms, tumors, and the immune system, and to explore their clinical potential for cancer imaging, therapeutics or diagnostics. Projects can focus on using microorganisms as anti-tumor agents, as activators of anti-tumor immunity, or as delivery vehicles for treatment, diagnosis, or imaging, complementing or synergizing with existing tools and approaches. This FOA will support basic mechanistic and preclinical studies in cell culture and animal models. Applicants are encouraged to address both the microbial and tumor aspects of microbial tumor interactions relevant to microbial-based cancer therapy (including therapies for oral cancer), tumor imaging, tumor detection, or diagnosis. This funding opportunity is part of broader NCI-sponsored research on microbial-based cancer therapy. (link to OCCAM)

Topics: Oral, Oropharyngeal & Salivary Gland Cancers

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Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R21 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) solicits grant applications proposing to utilize bacteria, archaebacteria, bacteriophages, or other non-oncolytic viruses and their natural products to study the underlying mechanisms of the complex interactions between microorganisms, tumors, and the immune system, and to explore their clinical potential for cancer imaging, therapeutics or diagnostics. Projects can focus on using microorganisms as anti-tumor agents, as activators of anti-tumor immunity, or as delivery vehicles for treatment, diagnosis, or imaging, complementing or synergizing with existing tools and approaches. This FOA will support basic mechanistic and preclinical studies in cell culture and animal models. Applicants are encouraged to address both the microbial and tumor aspects of microbial tumor interactions relevant to microbial-based cancer therapy (including therapies for oral cancer), tumor imaging, tumor detection, or diagnosis. The R21 FOA is intended to encourage exploratory projects that are at an early conceptual stage feasibility study (inception through preliminary development) to demonstrate the core functional capabilities of the proposed approach. The proposed projects may involve considerable risk and should be aimed at producing breakthroughs in microbial-based cancer therapy, imaging, or diagnosis. This funding opportunity is part of broader NCI-sponsored research on microbial-based cancer therapy.

Topics: Oral, Oropharyngeal & Salivary Gland Cancers

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In utero Treatments of Congenital Dental and Craniofacial Disorders Using Precision Medicine Approaches (R21 Clinical Trial Not Allowed)

Topics: Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology

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In utero Treatments of Congenital Dental and Craniofacial Disorders Using Precision Medicine Approaches (R01 Clinical Trial Not Allowed)

Topics: Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology

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NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program: FIRST Cohort (U54 Clinical Trial Optional)

Topics: Career Development, Training & Fellowships

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NIDCR Mentored Career Development Award to Promote Diversity (K01 Independent Clinical Trial Not Allowed)

Topics: Career Development, Training & Fellowships

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NIDCR Mentored Career Development Award to Promote Diversity (K01 Independent Basic Experimental Studies with Humans Required)

Topics: Career Development, Training & Fellowships

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NIDCR Mentored Career Development Award to Promote Diversity (K01 Clinical Trial Required)

Topics: Career Development, Training & Fellowships

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Notice of Intent to Publish a Funding Opportunity Announcement for a Data Management and Coordinating Center for Diagnostic Centers of Excellence (U2C Clinical Trial Not Allowed)

Topics: Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology, Gene Discovery, Genomics & Multi-Omics Analysis

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Notice of Intent to Publish a Funding Opportunity Announcement for Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)

Topics: Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology, Gene Discovery, Genomics & Multi-Omics Analysis

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HEAL Initiative: Discovery of Biomarkers and Biomarker Signatures to Facilitate Clinical Trials for Pain Therapeutics (UG3/UH3 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery of strong candidate biomarkers or biomarker signatures for pain that can be used to facilitate the testing of non-opioid pain therapeutics in Phase II clinical trials.The biomarkers or biomarker signature will be developed through clinical research specifically focused on the identification of pain biomarkers or biosignatures that predict and/or monitor response to pain therapeutics. The resulting biomarkers or biomarker signatures may be focused on a single pain condition or on several pain conditions with common underlying pathophysiology. Applications to identify biomarkers or biomarker signatures that predict or monitor a therapeutic response across several related pain conditions should feature Multiple Principal Investigator (MPI)-led teams that represent each of the related pain conditions and associated clinical networks. The MPI-led teams are expected to decide upon a single set of measures or biomarker modalities (i.e., combination of omics, QST, actigraphy, EEG, digital measures, etc.) as components of the biosignature for all pain conditions represented in the application. Applications should feature centralized resource groups that will coordinate clinical trials and standardize all sample or data collection methods, technology development, statistical analysis and algorithm development across the pain conditions under investigation. Applications seeking to develop biomarkers or biomarker signatures that will be used to predict and/or monitor a therapeutic response for a single pain condition must also feature MPI-led teams that represent the cross functional expertise necessary for biomarker and/or signature development, along with the same types of centralized resource groups that coordinate clinical trials and standardize sample or data collection methods, technology development and statistical analysis.

Topics: Clinical Research & Clinical Trials

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Notice of Information Reissuance of PA-18-932 Increasing Uptake of Evidence-Based Screening in Diverse Adult Populations (R01 Clinical Trial Optional) as a Notice of Special Interest (NOSI)

Topics: Dissemination & Implementation Science, Epidemiology

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Notice of Clarification for PAR-19-164 "Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)"

Topics: Career Development, Training & Fellowships

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NIDCR Dental Specialty and PhD Program (K12 Clinical Trial Not Allowed)

Topics: Career Development, Training & Fellowships

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HEAL Initiative: Human Pain-associated Genes and Cells Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)

The goal of this funding opportunity announcement is to support a Human Pain-associated Genes and Cells Data Coordination and Integration Center as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of Human Pain (PRECISION Human Pain).The Data Coordination and Integration Center will curate, harmonize, and integrate comprehensive -omics and cellular function datasets generated by companion U19 Centers for Discovery and Functional Evaluation of Human Pain-associated Genes and Cells, which include the characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain signal transduction, transmission and processing. The Human Pain-associated Genes and Cells Data Coordination and Integration Center will lead efforts to establish spatial and semantic standards for managing heterogeneous human pain-associated data types and information, collect and register multimodal human pain-associated data to common neural tissue coordinate systems, and establish a web-accessible information system that can be widely used throughout the research community. A central goal of the PRECISION Human Pain network is to generate comprehensive, integrated datasets, maps, and other resources on human genes and cellular function phenotypes underlying the heterogeneity, pathogenesis and susceptibility to specific pain conditions.

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Further Continuation of Temporary Extension of Eligibility for the NIH K99/R00 Pathway to Independence Award During the COVID-19 Pandemic

Topics: Career Development, Training & Fellowships

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HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes and Cells (U19 Clinical Trial Not Allowed)

The purpose of this funding opportunity announcement is to support research that uses human tissue or cells to generate comprehensive datasets for the discovery and characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain transduction, transmission, and processing. This FOA will support concerted multidisciplinary team science efforts that apply large-scale high-throughput approaches on tissues involved in human pain processing as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins, and the Nature of Human Pain (PRECISION Human Pain). U19 Centers will operate as a cooperative network to promote collaboration and coordination of research activities. U19 Centers will also coordinate with the U24 HEAL Initiative: Human Pain-associated Genes and Cells Data Coordination and Integration Center in order to curate, harmonize, and integrate datasets generated by this U19 research program.

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)

This FOA encourages applications for the Lasker Clinical Research Scholars Program for the purpose of supporting the research activities during the early stage careers of independent clinical researchers. The program offers the opportunity for a unique bridge between the NIH intramural and extramural research communities and contains two phases. In the first phase, Lasker Scholars will receive appointments for up to 5-7 years as tenure-track investigators within the NIH Intramural Research Program with independent research budgets. In the second phase, successful scholars will receive up to 3 years of NIH support for their research at an extramural research facility; or, the Scholar can be considered to remain as an investigator within the intramural program.

Topics: Career Development

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Notice of Participation of the National Institute of Dental and Craniofacial Research (NIDCR) in RFA-MD-22-004 Innovations for Healthy LivingImproving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

Topics: Oral Health Disparities & Inequities

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Notice of Technical Assistance Webinar for RFA-AR-22-009, HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN)

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Notice to Extend Eligibility for Submission of Pathway to Independence Award Applications (K99/R00) to NIDCR due to Covid-19 disruptions

Topics: Career Development, Training & Fellowships

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Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)

The purpose of this engineering-oriented funding opportunity announcement (FOA) is to encourage submissions of exploratory/developmental Bioengineering Research Grant (EBRG) applications to demonstrate feasibility and potential utility of new capabilities or improvements in quality, speed, efficacy, operability, costs, and/or accessibility of solutions to problems in basic biomedical, pre-clinical, or clinical research, clinical care delivery, or accessibility.

Topics: Oral, Oropharyngeal & Salivary Gland Cancers

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NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Basic Experimental Studies Involving Humans Required)

Topics: Career Development, Training & Fellowships

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NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Basic Experimental Studies Involving Humans Required)

Topics: Career Development, Training & Fellowships

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NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Required)

Topics: Career Development, Training & Fellowships

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NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)

Topics: Career Development, Training & Fellowships

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NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed)

Topics: Career Development, Training & Fellowships

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NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

Topics: Career Development, Training & Fellowships

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HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies to demonstrate the robustness of the target as a pain treatment target. This will lower the risk of adopting the target in translational projects to develop small molecules, biologics, natural substances, or devices that interact with this target for new pain treatments. Translational research to develop new medical devices are not the focus of this FOA. Basic science studies of pain and related systems in the body are responsive to this FOA and are encouraged in the context of novel pain therapeutic target discovery. This FOA is not specific for any one or group of pain conditions. Projects to identify novel targets for acute pain, chronic pain, migraine, other headache disorders, osteoarthritis, diabetic neuropathy, chemotherapy-induced neuropathy, sickle-cell pain, post stroke pain, etc. will be considered. Projects to identify novel targets for a combination of chronic overlapping pain conditions or for specific pathological conditions will be considered. Projects that seek to identify novel targets in specific populations such as women, children, older adults or other underrepresented groups will also be responsive to this FOA.

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)

This Funding Opportunity Announcement (FOA) invites applications from early and mid-career investigators (i.e. postdoctoral fellow/associates associate professor) who strive to expand their research trajectories through the acquisition of new knowledge and skills in the areas of therapeutic drug, biologic, or device development. The development of novel treatments for pain, addiction, and overdose is a vital component to address the ongoing opioid epidemic. This development will be most effective if performed by scientists with training in translational science. Translation is defined as the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public from diagnostics and therapeutics to medical procedures and behavioral changes, with translational science representing the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process (https://ncats.nih.gov/translation). Traditional academic training provides deep knowledge of a relatively narrow scientific discipline. While domain expertise is an important characteristic of a proficient translational scientist, a comprehensive understanding of the stages of therapeutic development is also necessary. For many trainees, acquiring needed expertise through participatory training in the various fields that are required to compile an investigational new drug (IND), investigational device exemption (IDE), or new drug application (NDA) is extraordinarily difficult given the diversity of these domains.

Topics: Career Development, Training & Fellowships

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Notice of Information: Multi-Institute Interest in Pain Research

Topics: Clinical Research & Clinical Trials, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Notice of Special Interest (NOSI): Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities

Topics: Behavioral & Social Science, COVID-19, Dissemination & Implementation Science, Oral Health Disparities & Inequities

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Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed)

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)

Topics: Oral Health Disparities & Inequities, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Notice of Special Interest (NOSI): Electronic Nicotine Delivery Systems (ENDS) and Alternative Nicotine and Tobacco Delivery Systems: Basic Mechanisms of Health Effects

Topics: Mucosal Diseases, Oral, Oropharyngeal & Salivary Gland Cancers

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Notice of Special Interest (NOSI): Electronic Nicotine Delivery Systems (ENDS) and Alternative Nicotine and Tobacco Delivery Systems: Population, Clinical and Applied Prevention Mechanisms of Health Effects

Topics: Epidemiology, Mucosal Diseases, Oral, Oropharyngeal & Salivary Gland Cancers

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Notice of Special Interest (NOSI): Administrative Supplements for Research on Sex and/or Gender Influences (Admin Supp Clinical Trial Optional)

Topics: Oral Health Disparities & Inequities, Women's Health

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Notice of Special Interest (NOSI): Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations (Admin Supp Clinical Trial Optional)

Topics: Oral Health Disparities & Inequities, Women's Health

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Notice of Special Interest (NOSI): Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp Clinical Trial Optional)

Topics: Oral Health Disparities & Inequities

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Continuation or Revision of NIDCR Clinical Trial Implementation Cooperative Agreement (UH3 Clinical Trial Required)

Topics: Behavioral & Social Science, Clinical Research & Clinical Trials

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Notice of Intent to Publish a Funding Opportunity Announcement for NIH Neuroscience Doctoral Readiness Program (DR. Program) (R25 Clinical Trial Not Allowed)

Topics: Career Development, Training & Fellowships

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Notice of Correction to Award Information for RFA-RM-22-006, " Expert-Driven Small Projects to Strengthen Gabriella Miller Kids First Discovery (R03 Clinical Trial Not Allowed)"

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Notice of Special Interest (NOSI): Basic and Translational Oral Health Research Related to HIV/AIDS

Topics: HIV/AIDS & Oral Health

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Measures and Methods to Advance Research on Minority Health and Health Disparities-Related Constructs (R01 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to support research that will advance the measurement and assessment of complex constructs relevant to minority health and health disparities.

Topics: Oral Health Disparities & Inequities

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Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02 Clinical Trial Optional)

The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs). Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance translational science by promoting partnerships between NIH intramural investigators (e.g., those conducting research within the labs and clinics of the NIH) and extramural investigators (e.g., those conducting research in labs outside the NIH), and by providing support for extramural investigators to take advantage of the unique research opportunities available at the NIH Clinical Center by conducting clinical research projects in collaboration with NIH intramural investigators.

Topics: Clinical Research & Clinical Trials

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Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)

Through this I-Corps at NIH program Funding Opportunity Announcement (FOA), NIH and CDC provide administrative supplement awards to active SBIR (NIH and CDC) and STTR Phase I (NIH only) grantees/awardees. The I-Corps at NIH mission is to empower entrepreneurs in developing and validating a strategic business model through diverse customer discovery in order to meet unmet clinical needs. I-Corps enables and accelerates the transformation of invention to impact SBIR and STTR Phase I awardees in a no-cost extension are eligible as long as, if selected, their no cost extension covers the entire duration of I-Corps at NIH cohort. The program provides three-member project teams with access to instruction and mentoring to accelerate the translation of technologies currently being developed with NIH and CDC SBIR and STTR funding. It is anticipated that outcomes for the I-Corps teams participating in this program will include significantly refined commercialization plans and well-informed pivots in their overall commercialization strategies. Prospective applicants are strongly encouraged to contact Scientific/Research staff for more information about the program before applying.

Topics: Small Business (SBIR/STTR)

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Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)

Through this I-Corps at NIH program Funding Opportunity Announcement (FOA), NIH and CDC provide administrative supplement awards to active SBIR (NIH and CDC) and STTR Phase I (NIH only) grantees/awardees. The I-Corps at NIH mission is to empower entrepreneurs in developing and validating a strategic business model through diverse customer discovery in order to meet unmet clinical needs. I-Corps enables and accelerates the transformation of invention to impact SBIR and STTR Phase I awardees in a no-cost extension are eligible as long as, if selected, their no cost extension covers the entire duration of I-Corps at NIH cohort. The program provides three-member project teams with access to instruction and mentoring to accelerate the translation of technologies currently being developed with NIH and CDC SBIR and STTR funding. It is anticipated that outcomes for the I-Corps teams participating in this program will include significantly refined commercialization plans and well-informed pivots in their overall commercialization strategies. Prospective applicants are strongly encouraged to contact Scientific/Research staff for more information about the program before applying.

Topics: Small Business (SBIR/STTR)

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Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs). Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance translational science by promoting partnerships between NIH intramural investigators (e.g., those conducting research within the labs and clinics of the NIH) and extramural investigators (e.g., those conducting research in labs outside the NIH), and by providing support for extramural investigators to take advantage of the unique research opportunities available at the NIH Clinical Center by conducting clinical research projects in collaboration with NIH intramural investigators.

Topics: Clinical Research & Clinical Trials

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Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs). Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance translational science by promoting partnerships between NIH intramural investigators (e.g., those conducting research within the labs and clinics of the NIH) and extramural investigators (e.g., those conducting research in labs outside the NIH), and by providing support for extramural investigators to take advantage of the unique research opportunities available at the NIH Clinical Center by conducting clinical research projects in collaboration with NIH intramural investigators.

Topics: Clinical Research & Clinical Trials, Parent Announcements & Trans-NIH Announcements

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Notice of Special Interest (NOSI): The Functional Oral Microbiome

Topics: Oral Microbiology & Metagenomics

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Expert-Driven Small Projects to Strengthen Gabriella Miller Kids First Discovery (R03 Clinical Trial Not Allowed)

Topics: Common Fund Programs, Gene Discovery, Genomics & Multi-Omics Analysis

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Notice of Intent to Publish a Funding Opportunity Announcement for Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) FOA

Topics: Parent Announcements & Trans-NIH Announcements

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Notice of Intent to Publish the "Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15, Clinical Trial Required)" FOA
Notice of Special Interest: SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed)

Topics: Small Business (SBIR/STTR)

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Request for Information (RFI): Joint Pain and Innervation Research

Topics: Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology

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Notice to Extend Expiration Date for PAR-19-145 "NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03)

Topics: Behavioral & Social Science, Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology, Dental Caries, Epidemiology, HIV/AIDS & Oral Health, Mucosal Diseases, Oral Health Disparities & Inequities, Oral, Oropharyngeal & Salivary Gland Cancers, Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology, Periodontal Diseases, Salivary Biology & Dysfunction

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Notice of Participation of the National Institute of Dental and Craniofacial Research (NIDCR) in PAR-21-287 Effectiveness of School-Based Health Centers to Advance Health Equity (R01 Clinical Trial Optional)

Topics: Oral Health Disparities & Inequities

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Notice of Pre-Application Webinar for Cellular Senescence Network (SenNet) RFAs: RFA-RM-22-003, RFA-RM-22-004, RFA-RM-22-005

Topics: Common Fund Programs, Technology Development

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Notice of Special Interest (NOSI): Biologic Factors Underlying Dental, Oral, and Craniofacial Health Disparities

Topics: Oral Health Disparities & Inequities

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Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed)

This funding opportunity announcement (FOA) invites research projects that seek to model the underlying mechanisms, processes, and trajectories of social relationships and how these factors affect outcomes in health, illness, recovery, and overall wellbeing. Both animal and human subjects research projects are welcome. Researchers proposing basic science experimental studies involving human participants should consider the companion FOA TEMP-14931 "Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)".

Topics: Behavioral & Social Science

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Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed)

This funding opportunity announcement (FOA) invites research projects that seek to model the underlying mechanisms, processes, and trajectories of social relationships and how these factors affect outcomes in health, illness, recovery, and overall wellbeing. Both animal and human subjects research projects are welcome. Researchers proposing basic science experimental studies involving human participants should consider the companion FOA TEMP-14931 "Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)".

Topics: Behavioral & Social Science

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Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)

This funding opportunity announcement (FOA) invites research projects that seek to explain the underlying mechanisms, processes, and trajectories of social relationships and how these factors affect outcomes in human health, illness, recovery, and overall wellbeing. Types of projects submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical and/or behavioral outcomes in humans to understand fundamental aspects of phenomena related to social connectedness and isolatedness. NIH considers such studies as prospective basic science studies involving human participants that meet the NIH definition of basic research and fall within the NIH definition of clinical trials (see, e.g., NOT-OD-19-024) Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Applications proposing studies that include but not limited to model animal research or observational studies involving humans should submit under the companion Clinical Trials Not Allowed version of this FOA.

Topics: Behavioral & Social Science

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Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)

This funding opportunity announcement (FOA) invites research projects that seek to explain the underlying mechanisms, processes, and trajectories of social relationships and how these factors affect outcomes in human health, illness, recovery, and overall wellbeing. Types of projects submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical and/or behavioral outcomes in humans to understand fundamental aspects of phenomena related to social connectedness and isolatedness. NIH considers such studies as prospective basic science studies involving human participants that meet the NIH definition of basic research and fall within the NIH definition of clinical trials (see, e.g., NOT-OD-19-024) Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Applications proposing studies that include but not limited to model animal research or observational studies involving humans should submit under the companion Clinical Trials Not Allowed version of this FOA.

Topics: Behavioral & Social Science

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INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Topics: Behavioral & Social Science, Craniofacial & Dental Development, Disorders, Craniofacial Skeletal Biology & Pathobiology, Epidemiology

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Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)

The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) hereby notify Small Business Concerns (SBCs) holding Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants that funds are available for administrative supplements to improve the diversity of the research workforce by recruiting and supporting students, postdoctorates, and eligible investigators from groups that have been shown to be nationally underrepresented in health-related research or in the SBIR and STTR programs. This supplement opportunity is also available to PD(s)/PI(s) of research grants who are or become disabled and need additional support to accommodate their disability in order to continue to work on the research project. Administrative supplements must support work within the scope of the original project. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

Topics: Small Business (SBIR/STTR)

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