Matrigel® and 3D Cell Culture

Before the 1980s it was difficult to grow three-dimensional cells in vitro. Then NIDR scientist Hynda Kleinman produced a viscous matrix derived from a mouse tumor which proved receptive to the growth and differentiation of cells of many types. NIH applied for a patent in 1985. Known as Matrigel®, Kleinman's innovation remains the industry standard today.