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NIH National Institute of Dental and Craniofacial Research (NIDCR) Home page
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OPPERA and TMD Disorders

Timeline Display Date
2006

Temporomandibular (TMD) Disorders were little understood when NIDCR began funding "Orofacial Pain: Prospective Evaluation and Risk Assessment," the first ever longitudinal study of a chronic pain condition. OPPERA established that TMD was much more than a localized dental/jaw disorder and that women were more likely than men to progress from an acute to a chronic condition. Read the initial results here.

A woman eating an apple holds her jaw in pain.
Edward Hamppand Trench Mouth
Explore an Interactive Timeline of NIDCR's History

Learn about important events, scientific breakthroughs, and publications starting in 1945.

Last Reviewed
December 15, 2025
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