Novel Light-Based Technologies for the Detection, Diagnosis, & Selective Removal of Dental Decay

NIDCR Grand Rounds Lecture

dentist using a dental laser
Dental lasers can alter the chemical composition of tooth enamel, making it stronger. ǀ UCSF

Presenter: Daniel Fried, PhD, Professor, Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, San Francisco

Friday, November 16, 2018

10:00 –11:00 am
Lipsett Amphitheater, Building 10

NIH Main Campus, Bethesda, MD

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High-precision light-based technologies are leading the way to a new era of minimally invasive dentistry. Optical methods developed by Dr. Daniel Fried’s group can instantly image dental caries, an approach shown to have higher performance than X-rays for diagnosis of tooth decay. Novel diagnostic and therapeutic devices built by Dr. Fried’s team take advantage of the optical properties of hard tissues exposed to long wavelengths of light in the near-infrared and infrared. Dental enamel becomes highly transparent near an infrared wavelength of 1300 nm, which is ideally suited for capturing images via techniques such as transillumination and optical coherence tomography. Lasers operating in the infrared most efficiently remove dental hard tissues, while near-infrared light is well-suited for guiding these lasers to selectively remove eroded enamel from tooth surfaces.

Presenter’s Bio:
Daniel Fried is a professor at the University of California, San Francisco School of Dentistry. He is a physical chemist and spectroscopist, and his research interests lie in the area of caries detection and therapeutic intervention with lasers. Over the past two decades his research group has pioneered three areas of biophotonic research related to dentistry: near-infrared transillumination and reflectance imaging, polarization-sensitive optical coherence tomography, and selective laser ablation. All three project areas have enjoyed extensive support from NIDCR, and multiple commercial devices based on his group’s work are used in dentistry. Dr. Fried has published more than 100 peer reviewed papers. Last year, he was selected for the 2017 International Association for Dental Research  Distinguished William H. Bowen Research Scientist. He has been elected to the 2018 class of the American Institute for Medical and Biological Engineering College of Fellows, one of the highest professional distinctions accorded to a medical and biological engineer, for his outstanding contributions to the diagnosis, management, and treatment of dental caries using imaging and laser ablation techniques.

Selected References:
Yang, V. B, Curtis, D. A., Fried, D., Use of Optical Clearing Agents for Imaging Root Surfaces with Optical Coherence Tomography  J. Sel. Topics Quant. Elect.  25(1), 1-7 (2018).

Chan, K. H., Fried, D., Multispectral cross-polarization reflectance measurements suggest high contrast of demineralization on tooth surfaces at wavelengths beyond 1300 nm due to reduced light scattering in sound enamel,  J. Biomed. Opt. 23(6), 060501 (2018).

About the NIDCR Clinical Research Fellowship Grand Rounds:
NIDCR Clinical Research Fellowship Grand Rounds began in early 2014 and occur four times a year.  Leading scientists and clinicians address advances in clinical, translational, and basic research in areas related to the dental, oral, and craniofacial complex and bone metabolism. 

Watch the lecture online.

Sign language interpreters will be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Rebecca Gallery, NIDCR/OCD 301-827-7759 or and/or the Federal Relay (1-800-877-8339).

Last Reviewed
November 2018

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