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By imaging twinkling neurons that light up in response to pain, NIDCR researchers found that blocking the Cdk5 protein dampens pain signaling in mice. The findings could help scientists find safer, non-opioid pain relief options.
Certain gut bacteria trigger an immune response that prompts loss of tooth-supporting bone. The findings point to a role for gut microbes in oral health and could inform treatment approaches for gum disease-associated bone loss.