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For more information about the clinical research toolkit and training materials, contact the Office of Clinical Trials Operations and Management at NIDCR-OCTOM@nidcr.nih.gov.

Potential applicants should contact the appropriate NIDCR Program Official prior to submitting grant applications that involve human subjects research.

Mission

The NIH Dental Clinic and Consult Service provides clinical expertise in managing and characterizing diseases of the dental, oral, and craniofacial complex.

1. Introduction

The National Institute of Dental and Craniofacial Research (NIDCR) Clinical Terms of Award (CToA) applies to all grant and cooperative agreement awards conducting human subjects research that have been determined by NIDCR to need additional oversight (as defined in Section 2) and/or accrual and retention monitoring. NIH defines clinical research as research with human subjects that is:

Overview

People with human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), are at special risk for oral health problems. Some of the most common oral health problems for people with HIV/AIDS are chronic dry mouth, gum disease (gingivitis), bone loss around the teeth (periodontitis), canker sores, oral warts, fever blisters, thrush (oral candidiasis), hairy leukoplakia (which causes a rough, white patch on the tongue), and tooth decay.