Neuroscience of Orofacial Pain & Temporomandibular Disorders Program

The Neuroscience of Orofacial Pain and Temporomandibular Disorders Program supports basic, translational, and clinical research on:
  • Orofacial pain and neuropathies
  • Temporomandibular joint and muscle disorders
  • Development of biomarkers for diagnostics and prognostics
  • development of therapeutics.
In addition, the program encourages research that is responsive to trans-NIH initiatives including the NIH Pain Consortium, the NIH Neuroscience Blueprint, and the NIH Common Fund.
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Grantee News

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Funding Opportunities & Notices

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Title Staff Contact Opportunity number Activity Code Expiration Date
Notice of Special Interest (NOSI): Research supplements to enhance utility and usage of Common Fund datasets NOT-RM-23-006 332, 333, 666
Notice of Special Interest (NOSI): Research supplements to promote workforce diversity and enhance utility and use of Common Fund datasets NOT-RM-23-005 R16, R21/R33, R41/R42
Promoting Research on Music and Health: Phased Innovation Award for Music Interventions (R61/R33 Clinical Trial Optional) PAR-20-266 R33, R61
Successor-in-Interest (Type 6 Parent Clinical Trial Optional) PA-20-275 666
NIH Director’s New Innovator Award Program (DP2 Clinical Trial Optional) RFA-RM-23-005 DP2
NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) RFA-RM-23-006 R01
Advancing Research to Develop Improved Measures and Methods for Understanding Multimorbidity (R01 Clinical Trial Optional) PAR-20-179 R01
NIH Director’s Pioneer Award Program (DP1 Clinical Trial Optional) RFA-RM-23-004 DP1
Notice of Special Interest (NOSI): Alzheimers-Focused Administrative Supplements for NIH Grants that are Not Focused on Alzheimers Disease NOT-AG-23-015 332, 333, 666
HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed) RFA-NS-22-052 U19
HEAL Initiative: Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed) RFA-NS-21-015 U19
HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed) RFA-NS-21-029 R61
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) PA-20-272 333
HEAL Initiative: Discovery of Biomarkers and Biomarker Signatures to Facilitate Clinical Trials for Pain Therapeutics (UG3/UH3 Clinical Trial Optional) RFA-NS-24-018 UG3/UH3
NIH Blueprint for Neuroscience Research: Tools and Technologies to Explore Nervous System Biomolecular Condensates (R21 Clinical Trial Not Allowed) RFA-DA-24-039 R21
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) PAR-21-038 R01
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Humans Required) PAR-21-039 R01
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed) PAR-21-084 R03
NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-21-151 R13
Notice of Special Interest (NOSI): Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp Clinical Trial Optional) NOT-OD-22-032 333
HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain(R01 Clinical Trial Not Allowed) RFA-NS-22-070 R01
HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain (RM1 Clinical Trial Optional) RFA-NS-22-069 RM1
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) PAR-21-233 U44
Notice of Special Interest (NOSI): Promoting Research on Interoception and Its Impact on Health and Disease NOT-AT-21-002 R01, R21
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) PAR-21-163 UG3/UH3
Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) PAR-21-155 R15
Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional) PAR-21-315 UG3/UH3
Notice of Special Interest (NOSI): HEAL Initiative: Clinical Translation of Diagnostic and Therapeutic Devices via Blueprint MedTech NOT-NS-23-002 U44, UG3/UH3
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) PA-21-268 777
Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed) RFA-OD-22-009 R01
HEAL Initiative: EPPIC-Net Pain Research Asset Application (OT2) OTA-21-005 OT2
Notice of Special Interest (NOSI): Administrative Supplements for Research on Womens Health in the IDeA States NOT-GM-22-005 333
Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional) PAR-22-167 UG3/UH3
The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional) RFA-OD-22-028 R01
HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) RFA-NS-22-034 R01
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed) PAR-22-090 R21
Notice of Special Interest (NOSI): Developing Academic Research Enhancement Award (AREA) and Research Enhancement Award Program (REAP) for Institutions with an emphasis on Down syndrome research (R15 Clinical Trial Not Allowed) NOT-OD-22-136 R15
Notice of Special Interest (NOSI): NIH Research Project Grants on Down Syndrome (R01) for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project NOT-OD-22-123 R01
NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed) PAR-22-160 R03
Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed) PAR-23-138 S10
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) RFA-NS-23-003 RM1
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) RFA-NS-23-028 RM1
HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) RFA-EB-22-002 R18
HEAL Initiative Notice of Special Interest (NOSI): Development and Validation of Pain-Related Models and Endpoints to Facilitate Non-Addictive Analgesic Discovery NOT-NS-22-095 R61/R33
Notice of Special Interest (NOSI): Promoting Mechanistic Research on Therapeutic and Other Biological Properties of Minor Cannabinoids and Terpenes NOT-AT-22-027 R21, R01, UG3/UH3
Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed) NOT-DE-21-012 R43/R44, R41/R42
Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards NOT-OD-23-032 333
Notice of National Institute of Dental and Craniofacial Research (NIDCR) Participation in PA-18-935 Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional) NOT-DE-20-020
Notice to Extend Expiration Date for PAR-19-145 "NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03) NOT-DE-21-017
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Planning Studies for Initial Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] NOT-NS-21-034
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required) NOT-NS-22-040
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint Medtech: Small Business Translator (U44) NOT-DA-22-050
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint MedTech: Translator (UG3/UH3 Clinical Trial Optional) NOT-NS-21-057
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management NOT-AT-21-012
Notice of NIDCR's participation in PAR-18-714, Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15-Clinical Trial Not Allowed) NOT-DE-18-015
Notice of Intent to Publish a Funding Opportunity Announcement for NIH Blueprint for Neuroscience Research Short Courses in Neurotherapeutics Development (R25 Clinical Trial Not Allowed) NOT-NS-22-023
Notice of Change: Clarification of Budget for PA-20-227 "Administrative Supplements for Research on Dietary Supplements (Admin Supp Clinical Trial Not Allowed)" NOT-OD-20-148
Notice of Intent to Publish a Funding Opportunity Announcement for Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) FOA NOT-DE-21-020
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) NOT-NS-21-031
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed) NOT-AR-22-015
NIH Blueprint for Neuroscience Research: Request for Information (RFI) on Neuroimmune Interactions in the Healthy CNS NOT-AA-21-012
RESCINDED - Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint MedTech: Prototype Developer (U18 Clinical Trial Not Allowed) NOT-EB-21-018
Notice of Early Termination of RFA-NS-21-016, HEAL Initiative: Planning Studies for Initial Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (R34 Clinical Trial Not Allowed) NOT-NS-21-061
Notice of Change Regarding Institutional Eligibility for PAR-19-134 and PAR-19-135 "Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools" NOT-DE-20-019
Request for Information (RFI): Joint Pain and Innervation Research NOT-AR-22-008
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) NOT-NS-21-032
Notice of Information: Multi-Institute Interest in Pain Research NOT-NS-22-057
Notice of Technical Assistance Webinar for RFA-AR-22-009, HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) NOT-AR-22-016
Notice of Intent to Publish a Funding Opportunity Announcement for NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed) NOT-DE-22-008
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint MedTech: Incubator Hubs (U54 Clinical Trial Not Allowed) NOT-EB-21-019
Request for Information (RFI): Investigators interests in and barriers to research studies on the health effects of cannabis and its constituents NOT-AT-22-026
Notice of Special Interest (NOSI): Targeting the Endocannabinoid System for Brain Health and Acute and Chronic Diseases NOT-DA-22-048
Notice of Special Interest (NOSI): NIDCR Support for Research on the Physiological Involvement of Oral Cavity in Coronavirus Disease 2019 (COVID-19) NOT-DE-23-004
Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional) PAR-23-122 R01
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed) PAR-23-162 U01

Previously Funded Grants

NIH RePORTER - Research Portfolio Online Reporting Tool (RePORT)