Translational Genetics & Genomics Program
Overview
The Translational Genetics and Genomics Program supports research designed to identify the genetics and genomics underlying health, diseases, and conditions of the dental, oral, and craniofacial (DOC) complex. The program supports human and clinical genetics and genomics projects that aim to elucidate the biological and molecular mechanisms of DOC conditions to further the fundamental understanding of genes, including a focus on the interplay of genetic and environmental factors that contribute to DOC health and disease. In addition, the program promotes translational and clinical research to apply this knowledge to inform prevention, diagnosis, and treatment strategies to advance DOC and overall health for all individuals. Relevant research topics include, but are not limited to:
- Discovery of genes and genetic variants of DOC disorders using genome-wide sequencing, deep phenotyping, epidemiologic, family-based approaches, or multi-omics data analyses, with functional characterization
- Development of methods to assess individual- and population-level DOC disease risk, including methods based on polygenic risk scores and biometrics
- Systems biology research powered by Big Data, multi-omics, synthetic biology, bioengineering, and data science methods (e.g., machine learning, deep learning, artificial intelligence) to achieve a holistic understanding of disease mechanisms and the interplay of factors underlying DOC biology and health
- Development of methods and resources to facilitate genetics and multi-omics research of priority to the National Institute of Dental and Craniofacial Research
- Development of methods and products for early and reliable detection and diagnosis of DOC disorders, as well as systemic disorders with distinct craniofacial features
- Development of precision therapies for congenital dental and craniofacial disorders
- Research on bioethics issues relevant to genetic and genomic research of DOC health and disorders
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