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Fall 2022

In This Issue

  1. NIDCR News
  2. Science Advances
  3. Grantee News
  4. NIH/HHS News
  5. Funding Opportunities & Notices
  6. Previous Issues
  7. Subscribe to NIDCR News

NIDCR News

Jennifer Webster-Cyriaque Wins IADR Award
Dr. Jennifer Webster-Cyriaque is presented with the 2022 Distinguished Scientist Award in Oral Medicine & Pathology Research from the International Association for Dental Research (IADR).

NIDCR Deputy Director Jennifer Webster-Cyriaque, DDS, PhD, received the 2022 Distinguished Scientist Award in Oral Medicine & Pathology Research from the International Association for Dental Research (IADR). IADR CEO Christopher Fox, DMD, DMS, presented the award to Dr. Webster-Cyriaque at NIH’s Bethesda, Maryland campus; NIH Acting Director Lawrence A. Tabak, DDS, PhD, and NIDCR Director Rena D’Souza, DDS, PhD, were also in attendance. The award honors Dr. Webster-Cyriaque’s track record of outstanding research in oral immunology and mechanisms that govern health and disease in the oral cavity and related tissues.

Using Science to Solve Oral Health Inequities
Oral Health in America

NIDCR Director Dr. D’Souza penned a guest post for the NIH Director’s Blog to highlight oral health inequities in America. Drawing from the Oral Health in America: Advances and Challenges report, Dr. D’Souza emphasized the importance of achieving oral and overall health for all through efforts that include research to improve access to oral care and delineate the connections among oral health, mental illness, and addiction.

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Science Advances

Researchers Discover How Sound Reduces Pain in Mice
Mice neural mechanisms reacting to sound.

By playing sounds—classical music, unpleasant music, and white noise—at a low intensity, an international team of scientists reduced pain sensitivity in mice and identified the neural mechanisms underlying this effect. The study, co-led by NIDCR Stadtman Tenure Track Investigator Yuanyuan (Kevin) Liu, PhD, and researchers in China, may inform development of non-opioid pain therapies.

Inflammation May Curb, Not Cause, Chronic Pain
A person sitting at a desk holding their back in pain.

Challenging previous notions about inflammation and pain, scientists found that a robust initial inflammatory response during acute pain appears to protect against chronic pain rather than contribute to it. The NIDCR-supported study suggests that suppressing inflammation to lull acute pain may be counterproductive for relieving low back and jaw pain in the long run.

Norovirus and Other Stomach Viruses Can Spread Through Saliva
Microscopic view of norovirus.

NIDCR scientists Matthew Hoffman, PhD, and John Chiorini, PhD, lent their salivary biology expertise to a National Heart, Lung, and Blood Institute study, which discovered that norovirus and other “stomach viruses” can grow in salivary glands and spread through saliva in mice. The findings point to a possible new transmission route for these viruses, which commonly cause intestinal illness in humans.

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Grantee News

New Study Presents the First Data-Driven Model of Cranial Bone Development in Children

University of Colorado - August 17, 2022

Penn Dental Medicine Study Applies Microrobotics in Endodontic Treatment, Diagnostics

University of Pennsylvania - August 5, 2022

Deconstructing the Mechanics of Bone Marrow Disease

Wyss Institute - July 11, 2022

Shapeshifting Microrobots Can Brush and Floss Teeth

University of Pennsylvania - July 5, 2022

First US Study Analyzing Tooth Survival After Root Canal in General Population

Regenstrief Institute - May 17, 2022
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NIH/HHS News

HHS Leaders Visit NIH
HHS Leaders Visit NIH

On July 22, HHS secretary Xavier Becerra, JD, toured the National Cancer Institute’s Center for Cancer Research, learning about research efforts related to the Cancer Moonshot initiative, which aims to reduce cancer deaths by 50% over the next 25 years. In June, HHS Assistant Secretary for Health Adm. Rachel Levine, MD, visited campus to deliver opening remarks for an NIH Pride event and met with leadership to discuss ongoing COVID-19 research.

NIH Solicits Ideas for New Common Fund Programs
NIH’s Common Fund, which supports bold scientific programs, is seeking new ideas that can catalyze discovery across all biomedical and behavioral research.

NIH’s Common Fund, which supports bold scientific programs, is seeking new ideas that can catalyze discovery across all biomedical and behavioral research. NIH encourages the public to share what they think is the greatest opportunity in biomedical research and why it should be pursued. The deadline for responses is Friday, September 30, 2022, at 11:59 pm ET.

In People with HIV, Treating Precancerous Anal Lesions Cuts Cancer Risk
Microscopic view of human papillomaviruses (HPV).

A large clinical trial of people living with HIV showed that treating precancerous anal growths reduces the risk of anal cancer by more than half. Nearly all cases of anal cancer are caused by cancer-causing human papillomaviruses (HPV), which also give rise to cervical and oral cancer. The findings could potentially lead to recommendations for lesion screening in people with HIV and others, including those with HPV-related pre-cancers or cancers.

Anthony Fauci to Step Down from Government Service
Dr. Anthony Fauci

Anthony S. Fauci, MD, announced his plan to step down from his federal positions in December 2022 to pursue the next chapter of his career. He is currently director of the National Institute of Allergy and Infectious Diseases (NIAID), chief of the NIAID Laboratory of Immunoregulation, and chief medical advisor to President Joe Biden. The president, HHS secretary, and NIH acting director issued statements recognizing Fauci’s long and influential career. Fauci served the public for more than 50 years by researching immune-mediated and infectious disease, advising seven presidents, and steering the nation through public health crises, including the HIV/AIDS epidemic and the COVID-19 pandemic.

White House to Appoint Monica Bertagnolli as NCI Director
Monica Bertagnolli, MD

On August 10, President Biden announced his intent to name Monica Bertagnolli, MD, as the 16th and first female director of the National Cancer Institute. A surgeon-oncologist, Bertagnolli is currently the Richard E. Wilson professor at Harvard Medical School, a surgeon at Brigham and Women’s Hospital, and a member of the Gastrointestinal and Sarcoma Treatment Centers at Dana-Farber Cancer Institute.

Nina Schor Appointed NIH Acting Deputy Director for IRP
Nina F. Schor, MD, PhD

NIH Acting Director Dr. Tabak named Nina F. Schor, MD, PhD, as the NIH acting deputy director for intramural research. Schor joined NIH as the deputy director of the National Institute of Neurological Disorders and Stroke in 2018 and assumed the role of director in 2021. She received her doctorate from Rockefeller University and her MD from Cornell University.

Kevin Williams Named NIH Office of EDI Director
Kevin D. Williams, JD

Dr. Tabak appointed Kevin D. Williams, JD, as the director of the NIH Office of Equity, Diversity, and Inclusion. He joins NIH from the U.S. Federal Trade Commission, where he served as deputy executive director, overseeing the management and administration of the agency. Williams earned his bachelor’s degree from Morehouse College and his JD from Howard University School of Law.

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Funding Opportunities & Related Notices
Title Opportunity number Extramural Scientific Topics Release Date Expiration Date
Notice of Technical Assistance Webinar for RFA-DE-23-012 Practice-Based Research Integrating Multidisciplinary Experiences in Dental Schools (PRIMED)
NOT-DE-22-017
  • Clinical Research & Clinical Trials
08/30/2022
01/01/2028
Practice-Based Research Integrating Multidisciplinary Experiences in Dental Schools (PRIMED) (U01 Clinical Trial Not Allowed)
RFA-DE-23-012
  • National Dental Practice-Based Research Network
08/22/2022
02/25/2023
HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R01 Clinical Trial Not Allowed)
RFA-DE-23-015
  • Clinical Research & Clinical Trials
  • Epidemiology
08/03/2022
02/15/2023
HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R21 Clinical Trial Not Allowed)
RFA-DE-23-016
  • Clinical Research & Clinical Trials
  • Epidemiology
08/03/2022
02/15/2023
Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (R61/R33 - Clinical Trial Not Allowed)
RFA-DE-23-006
  • Dental Materials & Biomaterials
08/02/2022
11/10/2022
Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (R42 Fast-Track - Clinical Trial Not Allowed)
RFA-DE-23-007
  • Dental Materials & Biomaterials
  • Small Business (SBIR/STTR)
08/02/2022
11/10/2022
Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (Fast-Track - R44 - Clinical Trial Not Allowed)
RFA-DE-23-008
  • Dental Materials & Biomaterials
  • Small Business (SBIR/STTR)
08/02/2022
11/10/2022
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
RFA-NS-23-003
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
08/01/2022
06/10/2025
Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required)
RFA-HL-23-017
  • Clinical Research & Clinical Trials
  • Tissue Engineering & Regenerative Medicine
07/07/2022
10/07/2022
Regenerative Medicine Innovation Projects (RMIP) Investigator- Initiated Studies (Collaborative U01 Clinical Trial Not Allowed)
RFA-HL-23-019
  • Tissue Engineering & Regenerative Medicine
07/07/2022
10/07/2022
Regenerative Medicine Innovation Projects (RMIP) Clinical Trial Planning Grant (R34 - Clinical Trials Not Allowed)
RFA-HL-23-020
  • Tissue Engineering & Regenerative Medicine
07/07/2022
10/07/2022
Harnessing Technologies to Support Oral Health Promotion and Management Outside the Dental Setting (UG3/UH3 Clinical Trial Required)
RFA-DE-23-009
  • Behavioral & Social Science
07/01/2022
11/11/2022
PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
PA-22-176
  • Small Business (SBIR/STTR)
06/02/2022
04/06/2023
PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
PA-22-178
  • Small Business (SBIR/STTR)
06/02/2022
04/06/2023
Notice of Special Interest (NOSI): Community-Based Participatory Research (CBPR) Initiative in Reducing and Eliminating Health Disparities with a focus on addressing diverse representation in research on Down syndrome (R21 Clinical Trial Optional)
NOT-OD-22-142
  • Craniofacial Skeletal Biology & Pathobiology
  • Oral Health Disparities Research
08/05/2022
03/17/2025
Notice of Special Interest (NOSI): HEAL Initiative: Clinical Translation of Diagnostic and Therapeutic Devices via Blueprint MedTech
NOT-NS-23-002
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
  • Small Business (SBIR/STTR)
  • Technology Development
08/03/2022
06/21/2024
Notice of Intent to Publish a Funding Opportunity Announcement for Practice-Based Research Integrating Multidisciplinary Experiences in Dental Schools (PRIMED) (U01 Clinical Trial Not Allowed)
NOT-DE-22-013
  • National Dental Practice-Based Research Network
07/28/2022
01/01/2028
Notice of Special Interest (NOSI): Promoting Mechanistic Research on Therapeutic and Other Biological Properties of Minor Cannabinoids and Terpenes
NOT-AT-22-027
  • Clinical Research & Clinical Trials
  • Oral Immunology, Immunopathology & Immunotherapy
  • Oral Microbiology & Metagenomics
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
07/27/2022
07/01/2025
Notice of NIDCR Participation in RFA-CA-22-040, The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed)
NOT-DE-22-014
  • Oral, Oropharyngeal & Salivary Gland Cancers
07/27/2022
01/01/2028
HEAL Initiative Notice of Special Interest (NOSI): Development and Validation of Pain-Related Models and Endpoints to Facilitate Non-Addictive Analgesic Discovery
NOT-NS-22-095
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
07/13/2022
06/25/2025
Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan
NOT-OD-22-178
  • Behavioral & Social Science
  • Clinical Research & Clinical Trials
  • Dissemination & Implementation Science
  • Oral Health Disparities Research
07/14/2022
05/08/2025
Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening
NOT-OD-22-179
  • Behavioral & Social Science
  • Clinical Research & Clinical Trials
  • Dissemination & Implementation Science
  • Oral Health Disparities Research
07/14/2022
05/08/2025
Notice of Intent to Publish a Funding Opportunity Announcement for Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN) Institutional Research Training Programs (T32)
NOT-OD-22-168
  • Career Development
  • Research Training & Fellowships
07/13/2022
01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Prevention and Management of Chronic Pain in Rural Populations (UG3/UH3, Clinical Trials Required)
NOT-NR-22-015
  • Clinical Research & Clinical Trials
  • Oral Health Disparities Research
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
07/12/2022
01/01/2028
Notice of Special Interest (NOSI): Research on Addressing Violence to Improve Health Outcomes
NOT-OD-22-167
  • Behavioral & Social Science
  • Clinical Research & Clinical Trials
  • Dissemination & Implementation Science
07/08/2022
10/05/2025
Notice of Special Interest: Alzheimers-Focused Administrative Supplements for NIH Grants that are Not Focused on Alzheimers Disease
NOT-AG-22-025
  • Parent Announcements & Trans-NIH Announcements
07/07/2022
10/02/2022
Extramural Loan Repayment Program for Clinical Researchers (LRP-CR)
NOT-OD-22-148
  • Career Development
  • Research Training & Fellowships
07/01/2022
11/17/2022
Extramural Loan Repayment Program for Pediatric Research (LRP-PR)
NOT-OD-22-149
  • Career Development
  • Research Training & Fellowships
07/01/2022
11/17/2022
Extramural Loan Repayment Program for Health Disparities Research (LRP-HDR)
NOT-OD-22-150
  • Career Development
  • Research Training & Fellowships
07/01/2022
11/17/2022
Extramural Loan Repayment Program for Research in Emerging Areas Critical to Human Health (LRP-REACH)
NOT-OD-22-153
  • Career Development
  • Research Training & Fellowships
07/01/2022
11/17/2022
Notice to Extend Expiration Date for PAR-20-276: Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
NOT-CA-22-092
  • Oral, Oropharyngeal & Salivary Gland Cancers
06/21/2022
01/08/2023
Notice of Special Interest (NOSI): Stimulating Research to Understand and Address Hunger, Food and Nutrition Insecurity
NOT-OD-22-135
  • Clinical Research & Clinical Trials
  • Oral Health Disparities Research
06/21/2022
11/29/2024
Notice to Extend Expiration Date for PAR-20-277: Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21 Clinical Trial Not Allowed)
NOT-CA-22-093
  • Gene Discovery, Genomics & Multi-Omics Analysis
  • Oral, Oropharyngeal & Salivary Gland Cancers
06/17/2022
01/01/2028
Notice of Special Interest (NOSI): Preventive Interventions to Address Cardiometabolic Risk Factors in Populations that Experience Health Disparities
NOT-OD-22-154
  • Dissemination & Implementation Science
  • Oral Health Disparities Research
06/14/2022
10/06/2025
Notice of Special Interest (NOSI): Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
NOT-OD-22-137
  • Craniofacial & Dental Developmental Biology
  • Craniofacial Skeletal Biology & Pathobiology
  • Mineralized Tissues & Mineralization
  • Parent Announcements & Trans-NIH Announcements
06/07/2022
06/02/2025
Notice of Special Interest (NOSI): Climate Change and Health
NOT-ES-22-006
  • Behavioral & Social Science
  • Epidemiology
  • Oral Health Disparities Research
06/01/2022
05/08/2025
Notice of Special Interest (NOSI): Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Support Career Enhancement Related to Clinical Research on Pain
NOT-NS-22-087
  • Clinical Research & Clinical Trials
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
  • Parent Announcements & Trans-NIH Announcements
06/01/2022
02/17/2024
Notice of Special Interest (NOSI): Developing Academic Research Enhancement Award (AREA) and Research Enhancement Award Program (REAP) for Institutions with an emphasis on Down syndrome research (R15 Clinical Trial Not Allowed)
NOT-OD-22-136
  • Parent Announcements & Trans-NIH Announcements
05/31/2022
04/11/2025
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