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Winter 2021

In This Issue

  1. NIDCR News
  2. Science Advances
  3. Grantee News
  4. NIH/HHS News
  5. Funding Opportunities & Notices
  6. Previous Issues
  7. Subscribe to NIDCR News

NIDCR News

NIDCR Major Announcement: Save the Date!
Save the Date calendar image

Mark your calendar for Tuesday, December 21, at 1pm for a major webcast announcement from NIDCR. Look for log-in instructions, coming in a separate NIDCR email next week.

Jennifer Webster-Cyriaque Joins NIDCR as Deputy Director
Jennifer Webster-Cyriaque, DDS, PhD

NIDCR welcomed Jennifer Webster-Cyriaque, DDS, PhD, as the institute’s new deputy director on December 6. Prior to joining NIDCR, Webster-Cyriaque served as a faculty member for 21 years at the University of North Carolina (UNC) schools of dentistry and medicine, where she practiced dentistry and studied the role of viruses like HIV and herpes simplex virus in oral lesions and cancers. She received her bachelor’s and DDS degrees from the University at Buffalo and her doctorate from UNC.

Q&A With Capt. Renee Joskow, NIDCR’s New Senior Advisor
Renee W. Joskow, DDS, MPH, FAGD

Capt. Renee Joskow, DDS, MPH, a dentist and medical epidemiologist, joined NIH as the senior advisor to the NIDCR director on October 24. She shared elements of her professional journey and discussed her new role in a Q&A format. Prior to NIDCR, Joskow served as the chief dental officer at the Health Resources and Services Administration, where she led oral health initiatives and collaborated with stakeholders and colleagues. She earned her DDS and master’s in public health from Columbia University and serves in the US Public Health Service Commissioned Corps.

NIDCR Funded Winners of 2021 Nobel Prize in Physiology or Medicine
Nobel Prize

David Julius, PhD, of UC San Francisco, and Ardem Patapoutian, PhD, of Scripps Research Institute, won the Nobel Prize in physiology or medicine on October 4 for their discoveries of thermal and mechanical receptors. The discoveries provided a foundation for understanding pain and proprioception, offering new opportunities to identify therapeutic targets. Both scientists received NIDCR funding in support of their winning research.

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Science Advances

New Mechanism May Influence Infectivity of SARS-CoV-2 Variants
New Mechanism May Influence Infectivity of SARS-CoV-2 Variants

Scientists in the lab of NIDCR’s Kelly Ten Hagen, PhD, have found an enzyme process in cells that may limit the infectivity of SARS-CoV-2 by adding a bulky sugar molecule that reduces the activation of the spike protein. Mutations in the alpha and delta variants seem to overcome this effect, potentially boosting the virus’s ability to spread. The knowledge could inform future efforts to develop new interventions.

Developing a Smart Mask to Surveil Coronavirus
Developing a Smart Mask to Surveil Coronavirus

NIDCR-funded researchers demonstrated the feasibility of developing a color-changing “smart” mask to detect viruses like SARS-CoV-2 in wearers’ saliva. The masks could one day be used to monitor infection and prevent outbreaks, especially in group settings like nursing homes, rehab facilities, schools, and assembly lines. The project is part of NIH’s Rapid Acceleration of Diagnostics Radical (RADx-rad) initiative.

Scientists Identify a Culprit for Chronic Itch
Person with itchy skin

A research team led by NIDCR scientist Mark Hoon, PhD, identified an immune substance called oncostatin M (OSM) that sensitizes and enhances the activity of itch-sensing neurons. In a mouse model of chronic itch, scratching was virtually eliminated by blocking OSM activity, suggesting a therapeutic strategy for persistent itchy skin conditions like psoriasis.

Robotic Massage Helps Regenerate Muscles in Mice
Robotic Massage Helps Regenerate Muscles in Mice

In a recent study funded in part by NIDCR, researchers found that massage therapy performed by a robotic device helped heal severely injured muscles in mice by clearing immune cells from the tissue. The finding adds to evidence that mechanical therapies can aid tissue regeneration.

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Grantee News

A Stunning 3D Map of Blood Vessels and Cells in a Mouse Skull Could Help Scientists Make New Bones

Johns Hopkins University - November 18, 2021

Study Identifies Cancer Features That Could Guide Personalized Radiotherapy

University of Pittsburgh - November 3, 2021

‘Nanozyme’ Therapy Prevents Harmful Dental Plaque Buildup

University of Pennsylvania - October 25, 2021

Massage Doesn’t Just Make Muscles Feel Better, it Makes Them Heal Faster and Stronger

Harvard University - October 6, 2021

Darwin’s Short-Beak Enigma Solved

University of Utah - September 21, 2021

Nerve Repair, With Help From Stem Cells

University of Pennsylvania - September 7, 2021

UMass Amherst Research Finds 'Very low Rates' of Recommended Dental Fluoride Varnish Treatment for Young Children

University of Massachusetts Amherst - August 30, 2021

Study of East Africans Illuminates new Genetic Factors Underlying Human Faces

PLOS - August 19, 2021
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NIH/HHS News

Francis Collins To Step Down as NIH Director
Francis Collins, MD, PhD

After 12 years of service, Francis S. Collins, MD, PhD, will step down as the director of NIH by the end of 2021. During his tenure under three US presidents, Dr. Collins established bold initiatives to tackle some of the most pressing health issues facing the nation, including Alzheimer’s disease, cancer, opioid use disorder, rare diseases, and the COVID-19 pandemic. He has also bolstered policies and activities to address workforce diversity, equity, and inclusion. Dr. Collins will continue to lead his research laboratory at NIH’s National Human Genome Research Institute.

NIH, FDA Join Private Partners to Increase Gene Therapies for Rare Diseases
NIH, FDA Join Private Partners to Increase Gene Therapies for Rare Diseases

NIH and FDA have partnered with 10 pharmaceutical companies and five non-profit organizations to launch the Bespoke Gene Therapy Consortium (BGTC), part of the NIH Accelerating Medicines Partnership program. BGTC aims to optimize and streamline the gene therapy development process to help fill the unmet medical needs of the 25-30 million Americans with rare diseases. NIDCR is one of nine NIH institutes and centers participating in the program.

NIH Builds Network to Study Long-Term Effects of COVID-19
NIH Builds Network to Study Long-Term Effects of COVID-19

To support large-scale studies on the long-term effects of COVID-19, NIH awarded nearly $470 million to build a national study population of tens of thousands of diverse research volunteers. The award from the NIH REsearching COVID to Enhance Recovery (RECOVER) Initiative will support more than 100 researchers at more than 30 institutions.

NIH to Catalyze Data Science Research in Africa
NIH to Catalyze Data Science Research in Africa

NIH is investing about $74.5 million over five years to advance data science, catalyze innovation, and spur health discoveries across Africa. The Harnessing Data Science for Health Discovery and Innovation in Africa (DS-I Africa) program will establish a data science research and training network across the continent. The 19 awards issued under DS-I Africa were supported in part by NIDCR and other NIH institutes, centers, and offices. The program aims to use data science to develop solutions to the continent’s most pressing public health problems.

Research Awards to Advance Health Equity
Research Awards to Advance Health Equity

Disadvantaged populations experience higher rates of certain diseases and more negative health outcomes. To support bold new research ideas that focus on interventions to address these issues, NIH has awarded 11 grants through the Common Fund’s Transformative Research to Address Health Disparities and Advance Health Equity initiative. The awards, totaling $58 million over five years, will be administered by NIDCR on behalf of NIH.

NIH Program To Map Rare, Non-Dividing Cells
NIH Program To Map Rare, Non-Dividing Cells

To study senescent cells, a type of rare and non-dividing cells that plays both positive and negative roles in biological processes, NIH’s Common Fund launched the Cellular Senescence Network program. The program aims to identify and characterize senescent cells across the body, in various states of human health, and across the lifespan. A deeper understanding of senescent cells could lead to therapies that encourage the cells’ beneficial effects while suppressing tissue-damaging effects.

Vaping Levels Off Among College-Aged Adults
Vaping Levels Off Among College-Aged Adults

Among adults ages 19 to 22, the use of vaped marijuana and vaped nicotine leveled off in 2020 after sharp yearly increases since 2017, according to survey results from the Monitoring the Future study, funded by the National Institute on Drug Abuse. Marijuana use in general reached a historic high, but cigarette smoking continued to drop, the researchers found.

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Funding Opportunities & Related Notices
Title Opportunity number Extramural Scientific Topics Release Date Expiration Date
Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)
PAR-21-343
  • Clinical Research & Clinical Trials
  • Parent Announcements & Trans-NIH Announcements
11/19/2021
04/19/2024
Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02 Clinical Trial Optional)
PAR-21-342
  • Clinical Research & Clinical Trials
11/19/2021
12/14/2023
Expert-Driven Small Projects to Strengthen Gabriella Miller Kids First Discovery (R03 Clinical Trial Not Allowed)
RFA-RM-22-006
  • Common Fund Programs
  • Gene Discovery, Genomics & Multi-Omics Analysis
11/17/2021
06/11/2022
HEAL Initiative: Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)
RFA-AT-22-003
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
11/16/2021
02/12/2022
Clinical Research Education and Career Development (CRECD) Program (R25-Independent Clinical Trial Not Allowed)
PAR-21-347
  • Career Development
  • Research Training & Fellowships
10/19/2021
12/16/2021
NIH Blueprint for Neuroscience Research Short Courses in Neurotherapeutics Development (R25 Clinical Trial Not Allowed)
RFA-NS-21-025
  • Career Development
  • Research Training & Fellowships
10/15/2021
12/10/2021
HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
RFA-NS-22-002
  • Oral Health Disparities Research
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
  • Women's Health
10/08/2021
12/10/2021
SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41 Clinical Trial Not Allowed)
RFA-RM-21-024
  • Common Fund Programs
10/07/2021
01/13/2022
Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)
PAR-21-349
  • Behavioral & Social Science
10/05/2021
06/22/2024
INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed)
RFA-OD-21-007
  • Behavioral & Social Science
  • Craniofacial & Dental Developmental Biology
  • Craniofacial Skeletal Biology & Pathobiology
  • Epidemiology
09/24/2021
07/04/2024
Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
PA-21-345
  • Small Business (SBIR/STTR)
09/10/2021
09/10/2024
NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
PAR-21-317
  • Behavioral & Social Science
  • Clinical Research & Clinical Trials
  • Dissemination & Implementation Science
09/01/2021
05/08/2024
Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)
PAR-21-315
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
08/20/2021
06/21/2024
Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)
PAR-21-271
  • Career Development
  • Research Training & Fellowships
08/17/2021
09/08/2024
Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Clinical Trial Required)
PAR-21-272
  • Career Development
  • Research Training & Fellowships
08/17/2021
09/08/2024
Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Basic Experimental Studies with Humans Required (BESH))
PAR-21-273
  • Career Development
  • Research Training & Fellowships
08/17/2021
09/08/2024
Notice of Special Interest (NOSI): The Functional Oral Microbiome
NOT-DE-21-015
  • Oral Microbiology & Metagenomics
11/19/2021
09/07/2025
Notice of Intent to Publish a Funding Opportunity Announcement for Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) FOA
NOT-DE-21-020
  • Parent Announcements & Trans-NIH Announcements
11/17/2021
01/01/2028
Notice of Intent to Publish the "Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15, Clinical Trial Required)" FOA
NOT-HD-21-047
11/15/2021
01/01/2027
Notice of Special Interest: SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed)
NOT-NS-22-017
  • Small Business (SBIR/STTR)
11/12/2021
01/08/2025
Notice of Change to Review Dates of PAR-22-054, “Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)”
NOT-RM-22-003
  • Common Fund Programs
  • Craniofacial & Dental Developmental Biology
  • Gene Discovery, Genomics & Multi-Omics Analysis
11/01/2021
02/24/2022
Notice of Participation of the National Institute of Dental and Craniofacial Research (NIDCR) in PAR-21-287 Effectiveness of School-Based Health Centers to Advance Health Equity (R01 Clinical Trial Optional)
NOT-DE-21-016
  • Oral Health Disparities Research
10/19/2021
01/01/2028
NIDCR Guidance on Applications for Investigator-Initiated Clinical Trials
NOT-DE-21-014
  • Behavioral & Social Science
  • Clinical Research & Clinical Trials
09/23/2021
01/01/2028
Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed)
NOT-DE-21-012
  • Small Business (SBIR/STTR)
  • Technology Development
09/01/2021
09/05/2025
Notice of Special Interest (NOSI): Social, Behavioral, and Economic Impact of COVID-19 in Underserved and Vulnerable Populations
NOT-MH-21-330
  • Behavioral & Social Science
  • Dissemination & Implementation Science
  • Women's Health
08/20/2021
09/08/2024
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Previous Issues

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Spring 2025
2024
Winter 2024
Fall 2024
Summer 2024
Spring 2024
2023
Winter 2023
Fall 2023
Summer 2023
2022
Winter 2022
Fall 2022
Summer 2022
Last Reviewed
December 2024
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