NIDCR News 2018

An unhealthy population of microbes in the mouth triggers specialized immune cells that inflame and destroy tissues, leading to the type of bone loss associated with a severe form of gum disease, according to a new study in mice and humans. This NIDCR-supported research could have implications for new treatment approaches for the condition.
Researchers discovered a self-renewing human skeletal stem cell. The findings may one day lead to ways to restore bone, cartilage, and supportive tissues for organs.
NIDCR Director Dr. Martha J. Somerman and NIDCR coauthors outline recent scientific advances that open the door to development of new autotherapies, which represent a minimally invasive approach to enhance tissue healing.

Many cancer researchers look for ways to stop the growth of cancer. J. Silvio Gutkind, PhD, is trying a different angle. He aims to piece together the steps needed to build a cancer—specifically head and neck cancer.

Marian Young, PhD, a senior investigator and chief of the molecular biology of bones and teeth section in NIDCR’s Division of Intramural Research, has been appointed deputy scientific director of DIR.
The U.S. Department of Health and Human Services, the Office of the Surgeon General, the National Institutes of Health (NIH), and the U.S. Public Health Service’s Oral Health Coordinating Committee have commissioned a new Surgeon General's Report on oral health.

When severe oral pain strikes, opioids are often prescribed for pain relief. But misuse of opioids is a growing problem that poses both economic and public health consequences. Even when prescribed by a health professional, regular opioid use can lead to dependence, and opioid misuse can cause addiction, overdose, and sometimes death.

NIDCR’s newest on-campus investigator, biochemist Achim Werner, has long been fascinated by the inner workings of cells. He recognized that examining the vast, largely unexplored molecular landscapes within cells could fill much-needed gaps in the field.
A collaborative team of researchers used NIDCR's FaceBase data to demonstrate a powerful new approach to understanding the genetics of face shape.
NIDCR-supported research helps to uncover the molecular underpinnings of “touch,” which can cause sensations of pain or pleasure and affect our experience of the foods we eat.
​​​​​​​NIDCR training award supports PhD student’s work revealing new brain circuit for facial pain.
In an ongoing clinical trial, NIDCR researchers examine how gene transfer might reverse a troubling side effect of cancer treatment.

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