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Spring 2022

In This Issue

  1. NIDCR News
  2. Science Advances
  3. Grantee News
  4. NIH/HHS News
  5. Funding Opportunities & Notices
  6. Previous Issues
  7. Subscribe to NIDCR News

NIDCR News

NIH & NIDCR Release Oral Health in America: Advances and Challenges
Oral Health in America: Advances and Challenges

In December, NIDCR announced the release of a report that provides a comprehensive snapshot of oral health in America, detailing 20 years of advances and challenges and drawing on data from public research and evidence-based practices. For more on the report, including a video message from the NIDCR director, monthly report snapshots, and more, visit NIDCR’s Oral Health in America webpage.

DSouza & NIH, HHS Leaders Call for Action on Oral Health Inequities
Child smiling at the camera

Drawing on findings and recommendations from Oral Health in America: Advances and Challenges, NIDCR Director Rena D’Souza, DDS, PhD, Science Advisor to the President and former NIH Director Francis S. Collins, MD, PhD, and US Surgeon General Vivek H. Murthy, MD, MBA, write in a recent New England Journal of Medicine Perspective that addressing oral health disparities will require changes that include a better understanding of the intersection of oral, overall, and mental health, as well as efforts to make oral health care accessible and affordable for all Americans.

2022 AADOCR/CADR Annual Meeting & Exhibition
AADOCR Annual Meeting

From March 21 to 26, NIDCR leadership, program staff, investigators, and trainees will be attending the 2022 AADOCR/CADR Annual Meeting, a hybrid event held virtually and in person in Atlanta, Georgia. Attendees are welcome to make an appointment to meet one-on-one with NIDCR program officers and other staff. To learn more about NIDCR-sponsored symposia and other events, access the schedule on NIDCR’s website or follow @NIDCR on Twitter.

Boldly Forward: NIDCR Charts Five-Year Course
Strategic Plan 2021-2026

NIDCR has released a new strategic plan outlining its research and training priorities for the next five years. The plan aims to advance fundamental knowledge about dental, oral, and craniofacial health and disease, and to translate these findings into prevention, early detection, and treatment strategies that improve overall health for all individuals and communities across the lifespan.

Lynn King Named DEA Director
Lynn Mertens King, PhD

On January 3, Lynn Mertens King, PhD, was named director of NIDCR’s Division of Extramural Activities (DEA). Prior to her new role, King held several other positions within DEA since 2001, including chief of the Research Training and Career Development Branch, chief of the Scientific Review Branch, and scientific review officer.

NIDCR Director Reflects on Career
Dr. Rena D'Souza

Dr. Rena D’Souza reflected on her career and inaugural year as NIDCR director in a recent interview published by NIH’s chapter of the Federal Asian Pacific American Council. She highlighted the importance of being proactive and setting goals in one’s career. As a leader, Dr. D’Souza works to unite people towards a shared vision through transparent communication and valuing individuals.

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Science Advances

Disarming a Blood-Clotting Protein Prevents Gum Disease in Mice
Blood clotting

In a study published in Science, a team led by NIDCR’s Niki Moutsopoulos, DDS, PhD, and Thomas Bugge, PhD, found that buildup of a blood-clotting protein, called fibrin, triggers an overactive immune response that damages the gums and underlying bone. By blocking fibrin's function, the researchers prevented bone loss in mice with gum disease.

Itching for Answers
Person scratching their skin

Recent studies led by NIDCR immunologist Wanjun Chen, MD, and neurologist Mark Hoon, PhD, indicate that not all itch is created equal. The researchers identified key immune molecules that drive wound-induced itching and chronic itch. The findings show that distinct combinations of molecules appear to underlie different types of itch, and tailored treatments may be better than a one-size-fits-all approach.

Tooth Protein Prevents Bone Loss in Mice
Mouse bone rendering

NIDCR researcher Ashok Kulkarni, PhD, and colleagues found that a tooth-hardening protein can help promote bone formation and prevent bone loss in mice through its role in bone turnover, where worn-out bone is continuously replaced by healthy new tissue to keep bones strong. The study may inform new interventions for conditions marked by bone loss, such as severe gum diseases and osteoporosis.

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Grantee News

Study Reveals How Migraine Pain Signals Are Generated—and Blocked

New York University - February 3, 2022

A Crowning Achievement in Understanding Head Development

University of Southern California - January 9, 2022

Researchers Gain Insights Into How Ultrasmall Bacteria From the Environment Have Adapted To Live Inside Humans

The Forsyth Institute - January 3, 2022

Forsyth Researchers Reveal That Oral TM7 Bacteria May Protect Humans From Pathogenic Bacteria

The Forsyth Institute - November 10, 2021
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NIH/HHS News

HHS Secretary Becerra Names Tabak Acting NIH Director
Dr. Lawrence Tabak

Lawrence A. Tabak, DDS, PhD, was tapped by HHS as the acting director of NIH on December 20, following the departure of Francis S. Collins, MD, PhD, who served in the role for more than 12 years. Dr. Tabak previously served as the principal deputy director, deputy ethics counselor, and headed NIDCR as the director from 2000-2010.

CDC To Update Opioid Prescribing Guideline
CDC Clinical Practice Guideline for Prescribing Opioids

CDC is updating its 2016 Clinical Practice Guideline for Prescribing Opioids based on new evidence. A draft of the 2022 Guideline, which NIDCR provided input on, is now open for public comment through April 11, 2022. Patients, caregivers, providers, and others are encouraged to review the draft and submit their feedback.

NIH Scientists Urge Pursuit of Universal Coronavirus Vaccine
Coronavirus

In a December commentary in The New England Journal of Medicine, experts from the National Institute of Allergy and Infectious Diseases called for international collaboration to counter future coronavirus outbreaks. Efforts should include characterizing coronavirus genetic diversity in wild and farmed animals, and investigating disease mechanisms to develop long-lasting, broadly protective vaccines.

NIH Awards $170 Million for Precision Nutrition Study
Woman shopping in the grocery store

NIH is investing $170 million over five years, pending availability of funds, for a new study that will develop algorithms that predict individual responses to food and dietary patterns. The program, managed by the NIH Common Fund, will leverage advances in artificial intelligence and microbiome research, as well as the large and diverse participant group from the All of Us Research Program, to advance personalized and precision nutrition.

Adolescent Nicotine & Marijuana Vaping Declined in 2021
Children in school

The percentage of adolescents reporting substance use decreased in 2021, marking the steepest one-year decline reported by the Monitoring the Future Survey since 1975. The study, funded by the National Institute on Drug Abuse, showed a drop in vaping for both marijuana and tobacco in 2021, following sharp increases in use between 2017 and 2019, which then leveled in 2020.

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Funding Opportunities & Related Notices
Title Opportunity number Extramural Scientific Topics Release Date Expiration Date
Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R01 Clinical Trial Not Allowed)
PAR-22-085
  • Oral, Oropharyngeal & Salivary Gland Cancers
02/18/2022
05/08/2025
Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R21 Clinical Trial Not Allowed)
PAR-22-086
  • Oral, Oropharyngeal & Salivary Gland Cancers
02/18/2022
05/08/2025
Limited Competition: Transformative Research to Address Health Disparities and Advance Health Equity at Minority Serving Institutions (U01 Clinical Trial Optional)
RFA-RM-22-001
  • Common Fund Programs
  • Oral Health Disparities Research
02/18/2022
05/24/2022
NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program: FIRST Cohort (U54 Clinical Trial Optional)
RFA-RM-22-008
  • Career Development
  • Research Training & Fellowships
02/17/2022
07/13/2022
Emergency Award: RADx-UP Community-Engaged Research on Rapid SARS-CoV-2 Testing among Underserved and Vulnerable Populations (U01 Clinical Trial Optional)
RFA-OD-22-006
  • Behavioral & Social Science
  • COVID-19
  • Dissemination & Implementation Science
  • Oral Health Disparities Research
02/17/2022
05/03/2022
Emergency Awards: RADx-UP - Social, Ethical, and Behavioral Implications (SEBI) Research on Disparities in COVID-19 Testing among Underserved and Vulnerable Populations (U01 Clinical Trial Optional)
RFA-OD-22-005
  • Behavioral & Social Science
  • COVID-19
  • Dissemination & Implementation Science
  • Oral Health Disparities Research
02/17/2022
05/03/2022
In utero Treatments of Congenital Dental and Craniofacial Disorders Using Precision Medicine Approaches (R21 Clinical Trial Not Allowed)
RFA-DE-23-005
  • Craniofacial & Dental Developmental Biology
  • Craniofacial Skeletal Biology & Pathobiology
02/17/2022
06/15/2022
In utero Treatments of Congenital Dental and Craniofacial Disorders Using Precision Medicine Approaches (R01 Clinical Trial Not Allowed)
RFA-DE-23-004
  • Craniofacial & Dental Developmental Biology
  • Craniofacial Skeletal Biology & Pathobiology
02/17/2022
06/15/2022
NIDCR Mentored Career Development Award to Promote Diversity (K01 Independent Clinical Trial Not Allowed)
PAR-22-050
  • Career Development
  • Research Training & Fellowships
02/11/2022
01/08/2025
NIDCR Mentored Career Development Award to Promote Diversity (K01 Clinical Trial Required)
PAR-22-051
  • Career Development
  • Research Training & Fellowships
02/11/2022
01/08/2025
NIDCR Mentored Career Development Award to Promote Diversity (K01 Independent Basic Experimental Studies with Humans Required)
PAR-22-052
  • Career Development
  • Research Training & Fellowships
02/11/2022
01/08/2025
Limited Competition: NIH Neuroscience Doctoral Readiness Program (DR. Program) (R25 Clinical Trial Not Allowed)
RFA-NS-22-035
  • Career Development
  • Research Training & Fellowships
02/10/2022
04/20/2022
HEAL Initiative: Discovery of Biomarkers and Biomarker Signatures to Facilitate Clinical Trials for Pain Therapeutics (UG3/UH3 Clinical Trial Optional)
RFA-NS-22-050
  • Clinical Research & Clinical Trials
02/08/2022
02/24/2023
NIDCR Dental Specialty and PhD Program (K12 Clinical Trial Not Allowed)
RFA-DE-23-001
  • Career Development
  • Research Training & Fellowships
02/07/2022
07/08/2022
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)
PAR-22-090
  • Oral, Oropharyngeal & Salivary Gland Cancers
01/11/2022
01/08/2025
HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed)
RFA-AR-22-009
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
01/10/2022
04/12/2022
NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
PAR-22-041
  • Career Development
  • Research Training & Fellowships
01/10/2022
01/08/2025
NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)
PAR-22-042
  • Career Development
  • Research Training & Fellowships
01/10/2022
01/08/2025
NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Basic Experimental Studies Involving Humans Required)
PAR-22-043
  • Career Development
  • Research Training & Fellowships
01/10/2022
01/08/2025
NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed)
PAR-22-044
  • Career Development
  • Research Training & Fellowships
01/10/2022
01/08/2025
NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Required)
PAR-22-045
  • Career Development
  • Research Training & Fellowships
01/10/2022
01/08/2025
NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Basic Experimental Studies Involving Humans Required)
PAR-22-046
  • Career Development
  • Research Training & Fellowships
01/10/2022
01/08/2025
HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
RFA-NS-22-034
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
01/07/2022
12/07/2024
HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed)
RFA-DA-22-044
  • Bioinformatics, Computational Biology & Data Science
12/20/2021
03/11/2022
HEAL Initiative: Exploratory Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R21- Clinical Trial Not Allowed)
RFA-DA-22-045
  • Bioinformatics, Computational Biology & Data Science
12/20/2021
03/11/2022
SPARC VNS Endpoints from Standardized Parameters (VESPA) (U54 Clinical Trial Required)
RFA-RM-22-002
  • Common Fund Programs
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
12/14/2021
04/02/2022
Notice of Intent to Publish a Funding Opportunity Announcement for a Data Management and Coordinating Center for Diagnostic Centers of Excellence (U2C Clinical Trial Not Allowed)
NOT-NS-22-071
  • Craniofacial & Dental Developmental Biology
  • Craniofacial Skeletal Biology & Pathobiology
  • Gene Discovery, Genomics & Multi-Omics Analysis
02/09/2022
01/01/2027
Notice of Intent to Publish a Funding Opportunity Announcement for Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)
NOT-NS-22-072
  • Craniofacial & Dental Developmental Biology
  • Craniofacial Skeletal Biology & Pathobiology
  • Gene Discovery, Genomics & Multi-Omics Analysis
02/09/2022
01/01/2027
Notice of Clarification for PAR-19-164 "Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)"
NOT-NS-22-058
  • Career Development
  • Research Training & Fellowships
02/08/2022
01/01/2028
Notice of Information Reissuance of PA-18-932 Increasing Uptake of Evidence-Based Screening in Diverse Adult Populations (R01 Clinical Trial Optional) as a Notice of Special Interest (NOSI)
NOT-OD-22-075
  • Dissemination & Implementation Science
  • Epidemiology
02/08/2022
01/01/2028
HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Increase Participant Diversity, Inclusion and Engagement in Clinical Studies
NOT-NS-22-066
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
02/08/2022
05/01/2022
Notice of Special Interest (NOSI): Administrative Supplements to Support Enhancement of Software Tools for Open Science
NOT-OD-22-068
  • Bioinformatics, Computational Biology & Data Science
02/07/2022
04/13/2022
Notice to Extend Eligibility for Submission of Pathway to Independence Award Applications (K99/R00) to NIDCR due to Covid-19 disruptions
NOT-DE-21-021
  • Career Development
  • Research Training & Fellowships
01/11/2022
01/01/2028
Notice of Special Interest (NOSI): Administrative Supplements for NIDCR Grants to Support Pain-Focused High Priority Research Areas
NOT-DE-22-002
  • Career Development
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
  • Research Training & Fellowships
01/10/2022
05/03/2022
Notice of Information: Multi-Institute Interest in Pain Research
NOT-NS-22-057
  • Clinical Research & Clinical Trials
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
12/27/2021
01/01/2028
Notice of Special Interest (NOSI): Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities
NOT-MD-22-006
  • Behavioral & Social Science
  • COVID-19
  • Dissemination & Implementation Science
  • Oral Health Disparities Research
12/21/2021
01/08/2023
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed)
NOT-AR-22-015
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
12/20/2021
01/01/2027
Notice of Special Interest (NOSI): Administrative Supplement for Research and Capacity Building Efforts Related to Bioethical Issues (Admin Supp Clinical Trial Optional)
NOT-OD-22-026
  • Parent Announcements & Trans-NIH Announcements
12/16/2021
03/08/2022
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOT-NS-22-040
  • Oral Health Disparities Research
  • Orofacial Pain, Temporomandibular Joint Disorder & Neurobiology
12/13/2021
01/01/2028
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