OPPERA and TMD Disorders

Temporomandibular (TMD) Disorders were little understood when NIDCR began funding "Orofacial Pain: Prospective Evaluation and Risk Assessment," the first ever longitudinal study of a chronic pain condition. OPPERA established that TMD was much more than a localized dental/jaw disorder and that women were more likely than men to progress from an acute to a chronic condition. Read the initial results here.

Lawrence A. Tabak

Lawrence Tabak was NIDCR director from 2000 to 2010, encouraging work on salivary gland biology and salivary diagnostics as well as research into the neuroscience of chronic pain and head and neck cancer. Tabak took NIDCR into the genomics revolution and adapted the Institute to social change with the first NIDCR health disparities plan. His Practice-Based Research Network (PBRN) initiative promoted greater scientific and programmatic involvement by practitioners.

Harold C. Slavkin

Harold Slavkin became director in 1995, stepping up research in oral cancer, genetics, craniofacial defects, promoting tissue engineering, and expanding the centers program. Slavkin fostered new institutional partnerships, coordinating with dental practitioners and patient advocacy groups, leading NIH efforts to diversify the workforce, and pushing to rename NIDR the National Institute of Dental and Craniofacial Research (NIDCR). He retired in 2000.

HIV-AIDS Breakthrough by Female Scientists

During the 1980s, it became increasingly clear that HIV-AIDS did not spread through saliva, but the mechanism was unknown. During the early 1990s a team including Stephen Eisenberg of Synergen, Inc., and Tessie McNeely and Sharon Wahl of the NIDR Laboratory of Immunology discovered the protein, secretory leukocyte protease inhibitor (SLPI), that blocks salivary transmission of HIV. They announced their discovery in early 1995.

Centers for Minority Oral Health

In September, NIDR launched its Regional Research Centers for Minority Oral Health Initiative. Intended to strengthen minority representation in the field, the regional centers were partnerships between minority programs and larger research-intensive institutions. The NIDR minority research centers were the first created by an NIH institute and the model for subsequent efforts.