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NIDCR supports a varied range of programs and grant mechanisms and is committed to funding as many meritorious projects as possible, while allowing the flexibility needed to support selected program priorities and respond to emerging scientific opportunities.

The appropriations committee reports that accompany a House or Senate appropriations bill contain requests or recommendations from Congress, called Significant Items (SIs). SIs are published alongside the CJ for the fiscal year that follows the fiscal year of the committee report containing the request. For example, NIDCR's FY 2024 Significant Items, which were published alongside the FY 2024 CJ, were in response to requests in the FY 2023 Congressional appropriations reports.

Recent NIDCR SIs are presented below.

I. Roles and Responsibilities

The Data and Safety Monitoring Board (DSMB) is an independent group of experts that advises NIDCR. The members of the DSMB serve in an individual capacity and provide their expertise and recommendations. The primary responsibilities of the DSMB are to 1) periodically review and evaluate the accumulated study data for participant safety, study conduct and progress, and, when appropriate, efficacy, and 2) make recommendations to NIDCR concerning the continuation, modification, or termination of the trial.